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Article: Potential of UVC germicidal irradiation in suppressing crown rot disease, retaining postharvest quality and antioxidant capacity of Musa AAA “Berangan” during fruit ripening

Ding, Phebe

Food Science & Nutrition, 5(5):967-980

2017

Abstract: Crown rot caused by fungal pathogen is the most prevalent postharvest disease in banana fruit that results significant economic losses during transportation, storage, and ripening period. Antifungal effects of ultraviolet C (UVC) irradiation at doses ... ...

Abstract	Crown rot caused by fungal pathogen is the most prevalent postharvest disease in banana fruit that results significant economic losses during transportation, storage, and ripening period. Antifungal effects of ultraviolet C (UVC) irradiation at doses varied from 0.01 to 0.30 kJ m−2 were investigated in controlling postharvest crown rot disease, maintenance of fruit quality, and the effects on antioxidant capacity of Berangan banana fruit during ripening days at 25 ± 2°C and 85% RH. Fruits irradiated with 0.30 kJ m−2 exhibited the highest (i.e., 62.51%) reduction in disease severity. However, the application of UVC at all doses caused significant browning damages on fruit peel except the dose of 0.01 kJ m−2. This dose synergistically reduced 46.25% development of postharvest crown and did not give adverse effects on respiration rate, ethylene production, weight loss, firmness, color changes, soluble solids concentration, titratable acidity, and pH in banana as compared to the other treatments and control. Meanwhile, the dose also enhanced a significant higher level of total phenolic content, FRAP, and DPPH values than in control fruits indicating the beneficial impact of UVC in fruit nutritional quality. The results of scanning electron micrographs confirmed that UVC irradiation retarded the losses of wall compartments, thereby maintained the cell wall integrity in the crown tissue of banana fruit. The results suggest that using 0.01 kJ m−2 UVC irradiation dose as postharvest physical treatment, the crown rot disease has potential to be controlled effectively together with maintaining quality and antioxidant of banana fruit.
Keywords	Antioxidant ; UVC ; cell wall ; crown rot ; peel browning ; physico-chemical quality
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: [Immunotherapy for microsatellite-instability-high advanced colorectal cancer].

Ding, P R

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2022 Volume 25, Issue 3, Page(s) 199–204

Abstract: Microsatellite instability-high (MSI-H) colorectal cancer accounts for approximately 10%-15% of all colorectal cancer patients, while in metastatic diseases the MSI-H population accounts for only 5% of patients. Previous studies have shown that early- ... ...

Abstract	Microsatellite instability-high (MSI-H) colorectal cancer accounts for approximately 10%-15% of all colorectal cancer patients, while in metastatic diseases the MSI-H population accounts for only 5% of patients. Previous studies have shown that early-stage MSI-H colorectal cancer patients have a good prognosis, but those with advanced disease have a poor prognosis and are not sensitive to chemotherapy. The advent of PD-1 antibodies has significantly improved the prognosis and changed treatment landscape in this population, not only achieving good outcomes in late-line therapy, but also significantly outperforming traditional chemotherapy combined with targeted therapy in first-line therapy. How to overcome primary and secondary drug resistance is a key issue in improving the outcome of MSI-H metastatic colorectal cancer, and commonly used approaches include changing chemotherapy regimens, combining with other immunotherapies, combining with anti-angiogenesis, and local treatments (surgery, radiotherapy, or interventional therapy). It is worth noting that immunotherapy has certain lifelong or even lethal toxicity, and the indications for neoadjuvant immunotherapy must be evaluated with caution. Neoadjuvant immunotherapy in MSI-H advantaged population can achieve high rates of pathological complete remission (pCR) and clinical complete remission (cCR). Therefore, for MSI-H patients with a strong intention to preserve anal sphincter and a strict evaluation of cCR after neoadjuvant immunotherapy, the Watch-and-Wait strategy offers an opportunity to preserve sphincter function and improve long-term survival quality in a subset of mid-to-low rectal cancers. Research on adjuvant immunotherapy in the field of colorectal cancer is also in full swing, and the results are worth waiting for.
MeSH term(s)	Colonic Neoplasms ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/therapy ; Humans ; Immunotherapy/methods ; Microsatellite Instability ; Microsatellite Repeats
Language	Chinese
Publishing date	2022-03-27
Publishing country	China
Document type	Journal Article
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.cn441530-20220118-00025
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Article ; Online: Nondestructive Assessment of Quality Characteristics of As-Built Additive Manufacturing Aeronautical AlSi10Mg and Inspection of Offset.

Ding, Pengcheng / Zeng, Zhiwei

3D printing and additive manufacturing

2024 Volume 11, Issue 2, Page(s) e851–e859

Abstract: AlSi10Mg is widely used in additively manufacturing aeronautical lattice and honeycomb structures. The unclear complex quality characteristics has been an obstacle of nondestructive testing of additive manufacturing (AM) AlSi10Mg, especially at its as- ... ...

Abstract	AlSi10Mg is widely used in additively manufacturing aeronautical lattice and honeycomb structures. The unclear complex quality characteristics has been an obstacle of nondestructive testing of additive manufacturing (AM) AlSi10Mg, especially at its as-built state. This article attempts to reveal the quality characteristics of as-built AM aeronautical AlSi10Mg based on its conductivity characteristics. Experimental results show that the quality of manufacturing is nonuniform. The nonuniformity of each sample surface is systematically evaluated. Along the building direction, the quality is best in the initial few layers and decreases as the built height increases. On this basis, a reference curve is obtained and used to describe the quality characteristics of as-built AM component along the building direction. Based on the quality characteristics, the inspection of small offsets caused by accidental failures during the manufacturing process is carried out. The offsets not <37 μm are detected with the help of the reference curve, whereas they are not discovered by the radiography testing. It proves that the proposed method of offset inspection is highly sensitive.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ISSN	2329-7670
ISSN (online)	2329-7670
DOI	10.1089/3dp.2022.0293
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Article: [Survival analysis on HIV/AIDS cases newly received antiretroviral therapy who coinfected with hepatitis B virus in Jiangsu Province, 2005-2020].

Qiu, T / Ding, P / Zhang, Z / Zhai, X J

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2024 Volume 45, Issue 2, Page(s) 220–224

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/complications ; Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/epidemiology ; Hepatitis B virus ; Coinfection ; Retrospective Studies ; Hepatitis B Surface Antigens ; Survival Analysis ; CD4 Lymphocyte Count ; Hepatitis B/drug therapy ; Hepatitis B/epidemiology ; Hepatitis B/complications
Chemical Substances	Hepatitis B Surface Antigens
Language	Chinese
Publishing date	2024-02-26
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20230811-00063
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Article: Application of Molecular Profiling in Colorectal Cancer Surgery

Ding, Pei-Rong

Clinics in Colon and Rectal Surgery

(Application of Molecular Profiling in Colorectal Cancer Surgery)

2023 Volume 36, Issue 06, Page(s) 367–368

Series title	Application of Molecular Profiling in Colorectal Cancer Surgery
Language	English
Publishing date	2023-04-17
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2048635-2
ISSN	1530-9681 ; 1531-0043
ISSN (online)	1530-9681
ISSN	1531-0043
DOI	10.1055/s-0043-1767702
Database	Thieme publisher's database

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Article: Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study.

Ding, Pingjian / Xu, Rong

medRxiv : the preprint server for health sciences

2023

Abstract: Recent cohort studies suggested that SARS-CoV-2 infection is associated with changes in brain structure. However, the potential causal relationship remains unclear. We performed a two-sample Mendelian randomization analysis to determine whether genetic ... ...

Abstract	Recent cohort studies suggested that SARS-CoV-2 infection is associated with changes in brain structure. However, the potential causal relationship remains unclear. We performed a two-sample Mendelian randomization analysis to determine whether genetic susceptibility of COVID-19 is causally associated with changes in cortical and subcortical areas of the brain. This 2-sample MR (Mendelian Randomization) study is an instrumental variable analysis of data from the COVID-19 Host Genetics Initiative (HGI) meta-analyses round 5 excluding UK Biobank participants (COVID-19 infection, N=1,348,701; COVID-19 severity, N=1,557,411), the Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA) Global and regional cortical measures, N=33,709; combined hemispheric subcortical volumes, N=38,851), and UK Biobank (left/right subcortical volumes, N=19,629). A replication analysis was performed on summary statistics from different COVID-19 GWAS study (COVID-19 infection, N=80,932; COVID-19 severity, N=72,733). We found that the genetic susceptibility of COVID-19 was not significantly associated with changes in brain structures, including cortical and subcortical brain structure. Similar results were observed for different (1) MR estimates, (2) COVID-19 GWAS summary statistics, and (3) definitions of COVID-19 infection and severity. This study suggests that the genetic susceptibility of COVID-19 is not causally associated with changes in cortical and subcortical brain structure.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.16.23292735
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Article ; Online: Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study.

Ding, Pingjian / Xu, Rong

Journal of the neurological sciences

2023 Volume 454, Page(s) 120864

Abstract	Recent cohort studies suggested that SARS-CoV-2 infection is associated with changes in brain structure. However, the potential causal relationship remains unclear. We performed a two-sample Mendelian randomization analysis to determine whether genetic susceptibility of COVID-19 is causally associated with changes in cortical and subcortical areas of the brain. This 2-sample MR (Mendelian Randomization) study is an instrumental variable analysis of data from the COVID-19 Host Genetics Initiative (HGI) meta-analyses round 5 excluding UK Biobank participants (COVID-19 infection, N = 1,348,701; COVID-19 severity, N = 1,557,411), the Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA) Global and regional cortical measures, N = 33,709; combined hemispheric subcortical volumes, N = 38,851), and UK Biobank (left/right subcortical volumes, N = 19,629). A replication analysis was performed on summary statistics from different COVID-19 GWAS study (COVID-19 infection, N = 80,932; COVID-19 severity, N = 72,733). We found that the genetic susceptibility of COVID-19 was not significantly associated with changes in brain structures, including cortical and subcortical brain structure. Similar results were observed for different (1) MR estimates, (2) COVID-19 GWAS summary statistics, and (3) definitions of COVID-19 infection and severity. This study suggests that the genetic susceptibility of COVID-19 is not causally associated with changes in cortical and subcortical brain structure.
MeSH term(s)	Humans ; COVID-19/genetics ; Genetic Predisposition to Disease ; Mendelian Randomization Analysis ; SARS-CoV-2 ; Brain/diagnostic imaging ; Genome-Wide Association Study
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.120864
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Article: Effects of ripening initiation on quality of double-dipped hot water 'Frangi' papaya fruit

Ding, P

Acta horticulturae. 2018 Oct. 5, , no. 1213

2018

Abstract: Hot water treatment is an effective and economical method for controlling plant pathogens, improving fruit resistance to chilling, inhibiting fruit ripening and alleviating some physiological storage disorders. ‘Frangi’ papaya is a new hybrid and the ... ...

Abstract	Hot water treatment is an effective and economical method for controlling plant pathogens, improving fruit resistance to chilling, inhibiting fruit ripening and alleviating some physiological storage disorders. ‘Frangi’ papaya is a new hybrid and the literature on its response to hot water treatment is lacking. Therefore, this study was carried out to determine the effects of ripening initiation on the quality of ‘Frangi’ papaya after double-dipped hot water treatment. Mature green papaya fruit were dipped in 42°C for 30 min, then 49°C for 20 min. This followed by cooling the fruit with running tap water of 26°C for 20 min. The fruit was then divided into two lots where one lot of fruit was allowed to undergo a natural ripening without using ethylene, while another lot of fruit was initiated to ripening using 1 mL L-1 ethylene. Fruit peel and flesh color (L, C and h°), weight loss, firmness, soluble solids concentration, titratable acidity (TA) and pH at day 0, 3 and 6 were analysed. Among all the parameters, only weight loss of fruit differed significantly with higher weight loss occurred in natural ripening fruit. As ripening progressed, all parameters showed significant changes except TA. It can be concluded that ‘Frangi’ papaya could undergo normal ripening even after treated with double-dipped hot water.
Keywords	cold treatment ; color ; ethylene ; firmness ; fruit peels ; fruits ; hot water treatment ; hybrids ; pH ; papayas ; plant pathogens ; ripening ; tap water ; titratable acidity ; total soluble solids ; weight loss
Language	English
Dates of publication	2018-1005
Size	p. 237-240.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the III Asia Pacific Symposium on Postharvest Research, Education and Extension: APS2014 held December 8, 2014 - December 11, 2014 Hochiminh City, Vietnam
ISSN	0567-7572
DOI	10.17660/ActaHortic.2018.1213.32
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The role of endothelial cell-pericyte interactions in vascularization and diseases.

Li, Gan / Gao, Junjie / Ding, Peng / Gao, Youshui

Journal of advanced research

2024

Abstract: Background: Endothelial cells (ECs) and pericytes (PCs) are crucial components of the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding capillaries to regulate blood flow and angiogenesis. Intercellular communication ... ...

Abstract	Background: Endothelial cells (ECs) and pericytes (PCs) are crucial components of the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding capillaries to regulate blood flow and angiogenesis. Intercellular communication between ECs and PCs is vital for the formation, stability, and function of blood vessels. Various signaling pathways, such as the vascular endothelial growth factor/vascular endothelial growth factor receptor pathway and the platelet-derived growth factor-B/platelet-derived growth factor receptor-β pathway, play roles in communication between ECs and PCs. Dysfunctional communication between these cells is associated with various diseases, including vascular diseases, central nervous system disorders, and certain types of cancers. Aim of review: This review aimed to explore the diverse roles of ECs and PCs in the formation and reshaping of blood vessels. This review focused on the essential signaling pathways that facilitate communication between these cells and investigated how disruptions in these pathways may contribute to disease. Additionally, the review explored potential therapeutic targets, future research directions, and innovative approaches, such as investigating the impact of EC-PCs in novel systemic diseases, addressing resistance to antiangiogenic drugs, and developing novel antiangiogenic medications to enhance therapeutic efficacy. Key scientific concepts of review: Disordered EC-PC intercellular signaling plays a role in abnormal blood vessel formation, thus contributing to the progression of various diseases and the development of resistance to antiangiogenic drugs. Therefore, studies on EC-PC intercellular interactions have high clinical relevance.
Language	English
Publishing date	2024-01-20
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1224
ISSN (online)	2090-1224
ISSN	2090-1224
DOI	10.1016/j.jare.2024.01.016
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Article ; Online: Stability of organic solar cells: toward commercial applications.

Ding, Pengfei / Yang, Daobin / Yang, Shuncheng / Ge, Ziyi

Chemical Society reviews

2024 Volume 53, Issue 5, Page(s) 2350–2387

Abstract: Organic solar cells (OSCs) have attracted a great deal of attention in the field of clean solar energy due to their advantages of transparency, flexibility, low cost and light weight. Introducing them to the market enables seamless integration into ... ...

Abstract	Organic solar cells (OSCs) have attracted a great deal of attention in the field of clean solar energy due to their advantages of transparency, flexibility, low cost and light weight. Introducing them to the market enables seamless integration into buildings and windows, while also supporting wearable, portable electronics and internet-of-things (IoT) devices. With the development of photovoltaic materials and the optimization of fabrication technology, the power conversion efficiencies (PCEs) of OSCs have rapidly improved and now exceed 20%. However, there is a significant lack of focus on material stability and device lifetime, causing a severe hindrance to commercial applications. In this review, we carefully review important strategies employed to improve the stability of OSCs over the past three years from the perspectives of material design and device engineering. Furthermore, we analyze and discuss the current important progress in terms of air, light, thermal and mechanical stability. Finally, we propose the future research directions to overcome the challenges in achieving highly stable OSCs. We expect that this review will contribute to solving the stability problem of OSCs, eventually paving the way for commercial applications in the near future.
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d3cs00492a
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