Article ; Online: Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice.
2023 Volume 14, Issue 3, Page(s) 1573–1583
Abstract: Dietary oil composition determines the pathological processes of alcoholic fatty liver disease (AFLD). Oil rich in saturated fatty acids protects, whereas oil rich in polyunsaturated fatty acids aggravates the alcohol-induced liver injury. However, ... ...
| Abstract | Dietary oil composition determines the pathological processes of alcoholic fatty liver disease (AFLD). Oil rich in saturated fatty acids protects, whereas oil rich in polyunsaturated fatty acids aggravates the alcohol-induced liver injury. However, limited studies have been conducted to address how monounsaturated fatty acids (MUFAs) enriched oil controls the pathological development of AFLD. Therefore, this study was designed to evaluate the effect of MUFA-enriched extra virgin olive oil (OO) on AFLD. Twenty C57BL/6J mice were randomly allocated into four groups and fed modified Lieber-DeCarli liquid diets containing isocaloric maltose dextrin a non-alcohol or alcohol with corn oil and OO for four weeks. Dietary OO significantly exacerbated alcohol-induced liver dysfunction, evidenced by histological examinations and disturbed biochemical parameters. Dietary OO with alcohol decreased hormone-sensitive lipase (HSL), phosphorylated 5'-AMP-activated protein kinase (p-AMPK), and carnitine palmitoyltransferase-Iα (CPT1α) expression, and increased sterol regulatory element-binding protein-1c (SREBP-1c), diacylglycerol acyltransferase-2 (DGAT2), and very low-density lipoprotein receptor (VLDLR) expression in the liver. It also promoted the expression of hepatic interleukin-6 ( |
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| MeSH term(s) | Mice ; Animals ; Olive Oil/pharmacology ; Fatty Liver, Alcoholic/etiology ; Fatty Liver, Alcoholic/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Mice, Inbred C57BL ; Liver/metabolism ; Ethanol/metabolism ; Fatty Acids/metabolism ; Corn Oil/metabolism | |||||
| Chemical Substances | Olive Oil ; Fatty Acids, Monounsaturated ; Ethanol (3K9958V90M) ; Fatty Acids ; Corn Oil (8001-30-7) | |||||
| Language | English | |||||
| Publishing date | 2023-02-06 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2612033-1 | |||||
| ISSN | 2042-650X ; 2042-6496 | |||||
| ISSN (online) | 2042-650X | |||||
| ISSN | 2042-6496 | |||||
| DOI | 10.1039/d2fo03323b | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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