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Article ; Online: Bridging-induced densification strategy based on biomass-derived aldehyde tanning integrated with terminal Al(III) crosslinking towards high-performance chrome-free leather production.

Ding, Wei

2022 Volume 307, Page(s) 114554

Abstract: Chrome-free leather manufacturing has been acknowledged as a desirable option to eliminate potential environmental and human health risks of conventional chrome tanning. This work applied a sequential bridging-induced densification strategy to produce ... ...

Abstract	Chrome-free leather manufacturing has been acknowledged as a desirable option to eliminate potential environmental and human health risks of conventional chrome tanning. This work applied a sequential bridging-induced densification strategy to produce high-performance chrome-free leather with high crosslinking density derived from the biomass-derived aldehyde (BAT) crosslinking (BAT tanning of leather), followed by terminal Al(III) crosslinking (TAC). The TAC conditions for BAT tanned leather were optimized and the results suggested that the optimized conditions were as follows: the fixation pH was 4.2, the pre-penetration time was 180 min, the fixation temperature was 40 °C, and the dosage of the aluminum tanning agent (ATA) was 0.5% (based on Al
MeSH term(s)	Aldehydes ; Biomass ; Chromium/analysis ; Humans ; Tanning
Chemical Substances	Aldehydes ; Chromium (0R0008Q3JB)
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.114554
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Article ; Online: Ink Animation VR Design Based on Wireless Sensor and HTML5 Interactive Technology.

Ding, Wei

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 7574231

Abstract: Ink element is one of the unique cultural symbols in China, which has profound cultural heritage and spiritual connotation. Animation is a form of art design, and it is a good way to convey and express information in an intuitive artistic image. The use ... ...

Abstract	Ink element is one of the unique cultural symbols in China, which has profound cultural heritage and spiritual connotation. Animation is a form of art design, and it is a good way to convey and express information in an intuitive artistic image. The use of ink and wash elements for animation design has important value and significance in the start of Chinese culture. It can develop animation design, innovate animation creation forms, and can highlight Chinese style. In this article, we have studied the creation process, creation format, and creation method of using angular digital technology to make ink VR design. It combines art and technology and combines practical experience with wireless sensors. Based on HTML5 interactive technology, we have studied its advantages more deeply, better introduced the theme of ink element animation, solved the problem of realizing ink effect in 3D virtual environment, and better introduced ink animation in virtual reality environment. During the production process, students will learn how to simulate digital objects, render ink and wash effects, build a virtual environment in the later stage, and explore the knowledge, operation, and meaning of ink and wash elements and the animation design process. This paper studies the wireless sensor and HTML5 interactive technology and applies it to the design of ink and wash animation VR, aiming to promote its vigorous development and application.
MeSH term(s)	Humans ; Ink ; Learning ; Technology ; User-Computer Interface ; Virtual Reality
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/7574231
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Article ; Online: The Ongoing Unmet Needs in Chronic Lymphocytic Leukemia: TP53 Disruption, Richter, and Beyond.

Ding, Wei

Hematology/oncology clinics of North America

2021 Volume 35, Issue 4, Page(s) 739–759

Abstract: Despite recent success in regard to targeted therapies in chronic lymphocytic leukemia (CLL), patients with TP53 disruption (including deletion and/or mutation) continue to have poor outcomes compared with other patients with CLL. In this article, a ... ...

Abstract	Despite recent success in regard to targeted therapies in chronic lymphocytic leukemia (CLL), patients with TP53 disruption (including deletion and/or mutation) continue to have poor outcomes compared with other patients with CLL. In this article, a review of common TP53 mutations in CLL, and recent trials using novel targeted agents in CLL patients with TP53 disruption, is provided with the goal of emphasizing the need to continuously focus on this area of research. In addition, limited but available data on double refractory CLL to BTK inhibitor and BCL-2 inhibitor, and on Richter syndrome, are reviewed.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2021.04.001
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Article ; Online: Protein Arginine Methyltransferases in Pancreatic Ductal Adenocarcinoma: New Molecular Targets for Therapy.

Bhandari, Kritisha / Ding, Wei-Qun

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant disease with a low 5-year overall survival rate. It is the third-leading cause of cancer-related deaths in the United States. The lack of robust therapeutics, absence of effective biomarkers ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant disease with a low 5-year overall survival rate. It is the third-leading cause of cancer-related deaths in the United States. The lack of robust therapeutics, absence of effective biomarkers for early detection, and aggressive nature of the tumor contribute to the high mortality rate of PDAC. Notably, the outcomes of recent immunotherapy and targeted therapy against PDAC remain unsatisfactory, indicating the need for novel therapeutic strategies. One of the newly described molecular features of PDAC is the altered expression of protein arginine methyltransferases (PRMTs). PRMTs are a group of enzymes known to methylate arginine residues in both histone and non-histone proteins, thereby mediating cellular homeostasis in biological systems. Some of the PRMT enzymes are known to be overexpressed in PDAC that promotes tumor progression and chemo-resistance via regulating gene transcription, cellular metabolic processes, RNA metabolism, and epithelial mesenchymal transition (EMT). Small-molecule inhibitors of PRMTs are currently under clinical trials and can potentially become a new generation of anti-cancer drugs. This review aims to provide an overview of the current understanding of PRMTs in PDAC, focusing on their pathological roles and their potential as new therapeutic targets.
MeSH term(s)	Humans ; Protein-Arginine N-Methyltransferases/genetics ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Immunotherapy ; Arginine
Chemical Substances	Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073958
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Article: Bridging-induced densification strategy based on biomass-derived aldehyde tanning integrated with terminal Al(III) crosslinking towards high-performance chrome-free leather production

Ding, Wei

Journal of environmental management. 2022 Apr. 01, v. 307

2022

Abstract	Chrome-free leather manufacturing has been acknowledged as a desirable option to eliminate potential environmental and human health risks of conventional chrome tanning. This work applied a sequential bridging-induced densification strategy to produce high-performance chrome-free leather with high crosslinking density derived from the biomass-derived aldehyde (BAT) crosslinking (BAT tanning of leather), followed by terminal Al(III) crosslinking (TAC). The TAC conditions for BAT tanned leather were optimized and the results suggested that the optimized conditions were as follows: the fixation pH was 4.2, the pre-penetration time was 180 min, the fixation temperature was 40 °C, and the dosage of the aluminum tanning agent (ATA) was 0.5% (based on Al₂O₃). Under the optimized conditions, the resultant BAT-TAC crust leather exhibited favorable overall performances compared with BAT crust leather in terms of higher hydrothermal stability, mechanical strengths, more pleasant uniform color, and comparable smooth grain surface. The obtained high-performance chrome-free leather is scalable, providing an avenue for designing and rationalizing other engineering technology towards high-performance eco-leather production.
Keywords	aldehydes ; aluminum ; color ; crosslinking ; environmental management ; human health ; leather ; pH ; temperature
Language	English
Dates of publication	2022-0401
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.114554
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MEMS strapdown inertial attitude measurement system using rotational modulation technology.

Sun, Wei / Huang, Heng / Sun, Peilun / Ding, Wei

PloS one

2024 Volume 19, Issue 2, Page(s) e0298168

Abstract: Attitude determination involves the integration of methodologies and systems for estimating the time varying attitude of moving objects. Strapdown Inertial Attitude Measurement System (SIAMS) is among the most widely used navigation systems. The ... ...

Abstract	Attitude determination involves the integration of methodologies and systems for estimating the time varying attitude of moving objects. Strapdown Inertial Attitude Measurement System (SIAMS) is among the most widely used navigation systems. The development of cost effective Micro Electro Mechanic System (MEMS) based inertial sensors has made attitude measurement system more affordable. However, MEMS sensors suffer from various errors that have to be calibrated and compensated to get acceptable attitude results. Given the auto-compensation of inertial sensor bias in rotation error modulation, the objective of this paper is to develop a MEMS-based rotary SIAMS, in which the significant sensor bias is automatically compensated by rotating the IMU, to offer comparable performance with respect to a tactical-grade Inertial Measurement Unit (IMU). With the analysis of the relationship between the MEMS error and misalignment, a MEMS calibration model is derived, and a combined calibration method of multi position rotation is applied to estimate the deterministic sensor errors such as bias, scale factor, and misalignment. Simulation and experiment results indicate that the proposed method can further modulate and compensate the MEMS errors, thereby improving the MEMS attitude accuracy.
MeSH term(s)	Micro-Electrical-Mechanical Systems ; Calibration ; Computer Simulation ; Manipulation, Osteopathic ; Technology
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298168
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Article: Progress in diagnosing and treating thyroid squamous cell carcinoma under the 5th edition of WHO classification.

Ding, Wei / Gao, Xiaofan / Ran, Xuan

Frontiers in endocrinology

2024 Volume 14, Page(s) 1273472

Abstract: Squamous cell carcinoma of the thyroid (SCCT) is a rare thyroid gland malignancy, with only a few hundred cases reported in the literature, mostly as case reports or small sample studies. In the previous WHO classification, squamous cell carcinoma of the ...

Abstract	Squamous cell carcinoma of the thyroid (SCCT) is a rare thyroid gland malignancy, with only a few hundred cases reported in the literature, mostly as case reports or small sample studies. In the previous WHO classification, squamous cell carcinoma of the thyroid was defined as a carcinoma composed entirely of squamous cells without differentiated carcinoma components. It was once included in the WHO tumor classification separately. However, the 2022 WHO classification of squamous cell carcinoma of the thyroid was reclassified as a morphologic subtype of anaplastic thyroid carcinoma (ATC). The squamous cell carcinoma pattern is similar to the other histologic types of ATC, but the phenotype associated has a poorer prognosis. The typical clinical manifestation of this condition is a cervical mass, accompanied by indications and symptoms of compression on adjacent structures such as the esophagus and trachea in advanced stages. Secondary squamous cell carcinoma of the thyroid may occur due to the spread of squamous carcinoma of the larynx or esophagus or distant metastases from other sites. Diagnosis of squamous cell carcinoma of the thyroid includes neck Ultrasound (US), Computed Tomography (CT) or Magnetic Resonance Imaging (MRI), puncture tissue biopsy, and full endoscopy to identify metastatic lesions from the nasopharynx, oropharynx, hypopharynx, larynx, esophagus, or bronchi and to help with the initial staging of the tumor. Current treatment modalities include surgery, radiotherapy, chemotherapy, or a combination. Because of the poor prognosis of patients with this disease, the short survival period, usually less than one year, and the difficulty of preoperative diagnosis, this article reviews the epidemiological features, origin, clinical features, pathological features, and differential diagnosis to improve the diagnosis and treatment of this disease by clinicians.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/therapy ; Carcinoma, Squamous Cell/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; Thyroid Neoplasms/pathology ; Diagnosis, Differential ; World Health Organization
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1273472
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Article ; Online: A novel low light object detection method based on the YOLOv5 fusion feature enhancement.

Peng, Daxin / Ding, Wei / Zhen, Tong

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4486

Abstract: Low-light object detection is an important research area in computer vision, but it is also a difficult issue. This research offers a low-light target detection network, NLE-YOLO, based on YOLOV5, to address the issues of insufficient illumination and ... ...

Abstract	Low-light object detection is an important research area in computer vision, but it is also a difficult issue. This research offers a low-light target detection network, NLE-YOLO, based on YOLOV5, to address the issues of insufficient illumination and noise interference experienced by target detection tasks in low-light environments. The network initially preprocesses the input image with an improvement technique before suppressing high-frequency noise and enhancing essential information with C2fLEFEM, a unique feature extraction module. We also created a multi-scale feature extraction module, AMC2fLEFEM, and an attention mechanism receptive field module, AMRFB, which are utilized to extract features of multiple scales and enhance the receptive field. The C2fLEFEM module, in particular, merges the LEF and FEM modules on top of the C2f module. The LEF module employs a low-frequency filter to remove high-frequency noise; the FEM module employs dual inputs to fuse low-frequency enhanced and original features; and the C2f module employs a gradient retention method to minimize information loss. The AMC2fLEFEM module combines the SimAM attention mechanism and uses the pixel relationship to obtain features of different receptive fields, adapt to brightness changes, capture the difference between the target and the background, improve the network's feature extraction capability, and effectively reduce the impact of noise. The AMRFB module employs atrous convolution to enlarge the receptive field, maintain global information, and adjust to targets of various scales. Finally, for low-light settings, we replaced the original YOLOv5 detection head with a decoupled head. The Exdark dataset experiments show that our method outperforms previous methods in terms of detection accuracy and performance.
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54428-8
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Article ; Online: Solving protein structures by combining structure prediction, molecular replacement and direct-methods-aided model completion.

Li, Zengru / Fan, Haifu / Ding, Wei

IUCrJ

2024 Volume 11, Issue Pt 2, Page(s) 152–167

Abstract: Highly accurate protein structure prediction can generate accurate models of protein and protein-protein complexes in X-ray crystallography. However, the question of how to make more effective use of predicted models for completing structure analysis, ... ...

Abstract	Highly accurate protein structure prediction can generate accurate models of protein and protein-protein complexes in X-ray crystallography. However, the question of how to make more effective use of predicted models for completing structure analysis, and which strategies should be employed for the more challenging cases such as multi-helical structures, multimeric structures and extremely large structures, both in the model preparation and in the completion steps, remains open for discussion. In this paper, a new strategy is proposed based on the framework of direct methods and dual-space iteration, which can greatly simplify the pre-processing steps of predicted models both in normal and in challenging cases. Following this strategy, full-length models or the conservative structural domains could be used directly as the starting model, and the phase error and the model bias between the starting model and the real structure would be modified in the direct-methods-based dual-space iteration. Many challenging cases (from CASP14) have been tested for the general applicability of this constructive strategy, and almost complete models have been generated with reasonable statistics. The hybrid strategy therefore provides a meaningful scheme for X-ray structure determination using a predicted model as the starting point.
MeSH term(s)	Proteins/chemistry ; Hydrolases ; Crystallography, X-Ray
Chemical Substances	Proteins ; Hydrolases (EC 3.-)
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2754953-7
ISSN	2052-2525 ; 2052-2525
ISSN (online)	2052-2525
ISSN	2052-2525
DOI	10.1107/S2052252523010291
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Article ; Online: Recent Advances in the Preparation and Application of Biochar Derived from Lignocellulosic Biomass: A Mini Review.

Wang, Kanglei / Remón, Javier / Jiang, Zhicheng / Ding, Wei

Polymers

2024 Volume 16, Issue 6

Abstract: With the rapid growth in the global population and the accelerating pace of urbanization, researching and developing novel strategies for biomass utilization is significant due to its potential for use in renewable energy, climate change mitigation, ... ...

Abstract	With the rapid growth in the global population and the accelerating pace of urbanization, researching and developing novel strategies for biomass utilization is significant due to its potential for use in renewable energy, climate change mitigation, waste management, and sustainable agriculture. In this environmental context, this review discusses the recent advances in biomass conversion technologies for biochar production, including the first carbonization process and the subsequent activation methods of the biochar derived from lignocellulosic biomass (LBC). Parallel to this, this review deals with other essential parameters in biochar production, such as feedstock types, reaction environments, and operating conditions in the pyrolysis process, to determine the production and composition of LBC. Moreover, the wide-ranging applications of LBC in areas such as adsorption, catalysts, and energy storage are discussed, offering sustainable and environmentally friendly alternatives while reducing reliance on traditional energy sources and mineral resources, thereby providing practical solutions to environmental and energy challenges. Overall, this review not only provides a comprehensive comparative analysis of different LBC preparation methods, but also facilitates a deeper understanding of the advantages and limitations of these methodologies when it comes to developing high-value materials for sustainable applications.
Language	English
Publishing date	2024-03-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16060851
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