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Article ; Online: sncRNAs in Epididymosomes: The Contribution to Embryonic Development and Offspring Health.

Luo, Jingwen / Tan, Xia / Li, Honggang / Ding, Xiaofang

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Much progress has been made in determining that paternal environmental exposures can remodel their spermatozoa small noncoding RNAs (sncRANs) and, in turn, affect the phenotypes of their offspring. Studies have shown that changes in the spermatozoa ... ...

Abstract	Much progress has been made in determining that paternal environmental exposures can remodel their spermatozoa small noncoding RNAs (sncRANs) and, in turn, affect the phenotypes of their offspring. Studies have shown that changes in the spermatozoa sncRNAs profile occur during passing through the epididymis. Due to the absence of transcription and translation in the epididymis, spermatozoa remodel their sncRNAs profile through communication with the epididymal microenvironment. Since epididymosomes contribute to the process of spermatozoa maturation by mediating the crosstalk between the epididymis and the passing spermatozoa, they are considered to be the leading candidate to mediate these changes. Previous studies and reviews on the role of epididymal transfer proteins in sperm maturation and function are myriad. This review focuses on the role and mechanisms of epididymosome-mediated transfer of sncRNAs cargoes onembryonic development and offspring health.
MeSH term(s)	Animals ; Embryonic Development ; Epididymis/metabolism ; Male ; RNA, Small Untranslated/genetics ; Semen ; Sperm Maturation ; Spermatozoa/metabolism
Chemical Substances	RNA, Small Untranslated
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810851
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Article ; Online: Effects and Safety of Sacubitril/Valsartan for Patients with Myocardial Infarction: A Systematic Review and Meta-Analysis.

Liu, Lang / Ding, Xiaofang / Han, Yaxiang / Lv, Jianfeng

publication RETRACTED

Journal of healthcare engineering

2022 Volume 2022, Page(s) 7840852

Abstract: Patients who develop heart failure (HF) after an acute myocardial infarction (AMI) are at higher risk of adverse fatal and nonfatal outcomes. Studies have shown sacubitril/valsartan can further reduce the risk of cardiovascular death or hospitalization ... ...

Abstract	Patients who develop heart failure (HF) after an acute myocardial infarction (AMI) are at higher risk of adverse fatal and nonfatal outcomes. Studies have shown sacubitril/valsartan can further reduce the risk of cardiovascular death or hospitalization for heart failure by 20% compared with enalapril. At the same time, its tolerance and safety are better. However, the current evidence regarding the efficacy of sacubitril/valsartan in patients with heart failure after acute myocardial infarction is controversial. To assess the effect of sacubitril/valsartan on heart failure after acute myocardial infarction, we conducted a systematic review of the literature and a meta-analysis of existing randomized clinical trials. Meta-analysis of randomized controlled trails is used where data are collected from PubMed, the Cochrane library, Embase, and Web of Science. Data about sacubitril/valsartan were available from 5 studies. Forest plots showed that the sacubitril/valsartan group had a 299% higher value of sacubitril/valsartan to the control group (MD = 2.99%, 95% CI: 2.01, 3.96,
MeSH term(s)	Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Biphenyl Compounds/adverse effects ; Heart Failure/drug therapy ; Humans ; Myocardial Infarction/drug therapy ; Stroke Volume/physiology ; Valsartan/therapeutic use ; Ventricular Function, Left
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; sacubitril (17ERJ0MKGI) ; Valsartan (80M03YXJ7I)
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/7840852
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Article ; Online: Preconception paternal mental disorders and child health: Mechanisms and interventions.

Tan, Xia / Luo, Jingwen / Ding, Xiaofang / Li, Honggang

Neuroscience and biobehavioral reviews

2022 Volume 144, Page(s) 104976

Abstract: Mental illness is a significant global health issue with a steady prevalence. High heritability is suspected, but genome-wide association studies only identified a small number of risk genes associated with mental disorders. This 'missing inheritance' ... ...

Abstract	Mental illness is a significant global health issue with a steady prevalence. High heritability is suspected, but genome-wide association studies only identified a small number of risk genes associated with mental disorders. This 'missing inheritance' can be partially explained by epigenetic heredity. Evidence from numerous animal models and human studies supports the possibility that preconception paternal mental health influences their offspring's mental health via nongenetic means. Here, we review two potential pathways, including sperm epigenetics and seminal plasma components. The current review highlights the role of sperm epigenetics and explores epigenetic message origination and susceptibility to chronic stress. Meanwhile, possible spatiotemporal windows and events that induce sexually dimorphic modes and effects of paternal stress transmission are inferred in this review. Additionally, we discuss emerging interventions that could potentially block the intergenerational transmission of paternal psychiatric disorders and reduce the incidence of mental illness. Understanding the underlying mechanisms by which preconception paternal stress impacts offspring health is critical for identifying strategies supporting healthy development and successfully controlling the prevalence of mental illness.
MeSH term(s)	Child ; Animals ; Humans ; Male ; Child Health ; Genome-Wide Association Study ; Semen ; Fathers ; Epigenesis, Genetic ; Mental Disorders/epidemiology ; Mental Disorders/genetics
Language	English
Publishing date	2022-11-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2022.104976
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Zs.A 1371: Show issues

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Article: 支气管镜在儿童Slide气管成形术中的应用.

Zhou, Miao / Zhong, Li-Li / Huang, Han / Lin, Lin / Chen, Min / Ding, Xiao-Fang

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2023 Volume 25, Issue 5, Page(s) 527–533

Abstract: Objectives: To study the role of bronchoscopy in slide tracheoplasty.: Methods: A retrospective analysis was conducted on the diagnosis and treatment of four children with tracheal stenosis admitted to Hunan Provincial People's Hospital from 2017 to ... ...

Title translation	The role of bronchoscopy in slide tracheoplasty in children.
Abstract	Objectives: To study the role of bronchoscopy in slide tracheoplasty. Methods: A retrospective analysis was conducted on the diagnosis and treatment of four children with tracheal stenosis admitted to Hunan Provincial People's Hospital from 2017 to 2020. The role of bronchoscopy was summarized in the preoperative evaluation, intraoperative positioning and measurement, and postoperative wound evaluation and treatment during slide tracheoplasty. Results: Bronchoscopy evaluation before slide tracheoplasty showed that 3 of the 4 children had complete trachea rings, 2 had pulmonary artery sling, and 2 had multiple stenosis. Slide tracheoplasty was performed in the hospital on 3 children, and the midpoint of the stenosis segment was judged under bronchoscopy, and the length of the stenosis segment was measured, which assisted in the resection of the stenosis segment of the trachea. The pathogens were identified by lavage after the surgery. One child who developed scar traction 9 months after slide tracheoplasty in another hospital was improved by interventional treatment under bronchoscopy. Mucosal changes were found under bronchoscopy in 2 children 4 days after surgery, and the treatment plan was adjusted. One month after surgery, 2 children had granulation hyperplasia, which was improved by cryotherapy under bronchoscopy. One child abandoned treatment due to anastomotic necrosis and died. Three survivors were followed up for over 6 months with good prognosis, but all had tracheobronchial malacia. Conclusions: Bronchoscopy can be used for the management of slide tracheoplasty in children with tracheal stenosis, which is helpful to postoperative rehabilitation and follow-up.
MeSH term(s)	Child ; Humans ; Bronchoscopy ; Constriction, Pathologic ; Retrospective Studies ; Trachea/surgery ; Tracheal Stenosis/diagnosis ; Tracheal Stenosis/surgery ; Treatment Outcome
Language	Chinese
Publishing date	2023-07-05
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2211012
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Article ; Online: Analysis of Risk Factors for in-hospital Death in Elderly Patients with TEXAS Stage 3 and 4 Diabetic Foot Ulcers after Tibial Transverse Translation: A Case-Control Study.

Ding, Xiaofang / Yuan, Yusong / Xu, Hailin / Jing, Zhengwei / Lu, Hao / Wang, Yuanli / Zhou, Junlin

Orthopaedic surgery

2023 Volume 15, Issue 12, Page(s) 3272–3278

Abstract: Objective: Chinese physicians developed the Tibial Transverse Transport (TTT) technique to treat diabetic foot ulcers with more than 90% effective rate. But this method still could not avoid the in-hospital death of patients. This study adopted a case- ... ...

Abstract	Objective: Chinese physicians developed the Tibial Transverse Transport (TTT) technique to treat diabetic foot ulcers with more than 90% effective rate. But this method still could not avoid the in-hospital death of patients. This study adopted a case-control study to explore the risk factors of in-hospital death in elderly patients with chronic ischemic diabetic foot after receiving TTT treatment. Methods: A total of 54 patients were included in the study from January 1, 2017 to April 30, 2021, by being paired with the cases in case group with their demographic data and results of blood routine, liver and kidney function. There were nine patients in case group with six male and three male. Forty-five patients were selected in control group according to gender and diabetes type with 30 male and 15 female. Single factor logics regression analysis was used to explore the risk factors and odd ratios (OR) of in-hospital death in patients. The nomogram and decision curve analysis (DCA) had been done by R Studio software. Results: The study found that age, course of diabetic foot, small dense low-density Lipoprotein (smLDL), homocysteine (Hcy), superoxide dismutase (SOD), and prealbumin (PA) were risk factors for in-hospital death of patients. The smLDL had the highest risk. The nomogram showed that PA accounted for the largest proportion in the death risk factors. The results of DCA proved that above six risk factors were the risk factors for patients with TEXAS Stage 3 and 4 diabetic foot ulcers. Conclusion: In the future diagnosis and TTT treatment for diabetic foot ulcers, doctors need to pay close attention to age, course of diabetic foot, smLDL, Hcy, SOD, and PA.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Diabetic Foot/therapy ; Case-Control Studies ; Hospital Mortality ; Risk Factors ; Superoxide Dismutase ; Diabetes Mellitus
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-10-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2503162-4
ISSN	1757-7861 ; 1757-7853 ; 1757-7861
ISSN (online)	1757-7861 ; 1757-7853
ISSN	1757-7861
DOI	10.1111/os.13908
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Zs.A 6786: Show issues

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Article ; Online: Diagnostic value of 18F-FDG PET/CT for atypical hepatic hemangioma.

Wang, Jianlin / Shi, Aiqi / Ding, Xiaofang / Liu, Jiangyan

Japanese journal of clinical oncology

2021 Volume 52, Issue 1, Page(s) 98–100

MeSH term(s)	Fluorodeoxyglucose F18 ; Hemangioma/diagnostic imaging ; Humans ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyab149
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Zs.A 1298: Show issues

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Article ; Online: Comparative clinical study of the modified Broström procedure for the treatment of the anterior talofibular ligament injury-outcomes of the open technique compared to the arthroscopic procedure.

Yang, LiLi / Wang, QingFu / Wang, YuanLi / Ding, XiaoFang / Liang, Huan

International orthopaedics

2023 Volume 48, Issue 2, Page(s) 409–417

Abstract: Purpose: To observe the clinical efficacy and safety of arthroscopic-modified Broström surgery for the treatment of anterior talofibular ligament injury.: Methods: The clinical data of 51 cases with anterior talofibular ligament injury were ... ...

Abstract	Purpose: To observe the clinical efficacy and safety of arthroscopic-modified Broström surgery for the treatment of anterior talofibular ligament injury. Methods: The clinical data of 51 cases with anterior talofibular ligament injury were retrospectively analyzed, in which 23 patients were treated by arthroscopic-modified Broström surgery (arthroscopic surgery group) and 28 patients were treated by open-modified Broström surgery (open surgery group). The time to surgery, hospital stay, visual analog scale (VAS) scores of ankle pain, American Orthopaedic Foot and Ankle Society (AOFAS) ankle and hindfoot scores, and incidence rate of complications were compared between the two groups. Results: (1) General results: compared with open surgery group, arthroscopic surgery group had shorter time to surgery and hospital stay ((33.8 ± 6.7) min, (42.1 ± 8.5) min, t = 1.468, P = 0.001; (2.2 ± 1.4) d, (5.8 ± 1.6) d, t = 1.975, P = 1.975, P = 0.002). (2) VAS scores of ankle pain: there was an interaction effect between the time and group factors (F = 0.378, P = 0.018); overall, there was no statistically significant difference in VAS scores of ankle pain between the two groups, i.e., there was no grouping effect (F = 1.865, P = 0.163); there was statistically significant difference in VAS score of ankle pain at different time points before and after operation, i.e., there was a time effect (F = 1.675, P = 0.000); the VAS scores of ankle pain showed a decreasing trend with time in both groups, but the decreasing trend was not completely consistent between the two groups ((7.78 ± 1.23), (1.23 ± 1.24), (1.03 ± 0.35), (1.01 ± 0.28), F = 0.568, P = 0.000. (7.45 ± 1.43), (1.45 ± 1.87), (1.23 ± 0.55), (1.04 ± 0.37), F = 1.358, P = 0.000); there was no statistically significant difference in VAS score of ankle joint pain between the two groups six and 12 months before and after surgery (t = 2.987, P = 0.055; t = 1.654, P = 2.542; t = 0.015, P = 0.078); the VAS scores of ankle pain in the arthroscopic surgery group was lower than that in the open surgery group three months after operation (t = 1.267, P = 0.023). (3) AOFAS ankle and hindfoot scores: there was an interaction effect between time and grouping factors (F = 2.693, P = 0.027); overall, there was no statistically significant difference in the AOFAS ankle and hindfoot scores between the two groups, i.e., there was no grouping effect (F = 1.983, P = 0.106); there was statistically significant difference in the AOFAS ankle and hindfoot scores at different time points before and after surgery, i.e., there was a time effect (F = 34.623, P = 0.000); the AOFAS ankle and hindfoot scores of the two groups showed an increasing trend with time, but the increasing trend of the two groups was not completely consistent ((48.19 ± 12.89), (89.20 ± 8.96), (90.24 ± 7.89), (91.34 ± 9.67), F = 25.623, P = 0.000; (49.35 ± 13.28), (86.78 ± 12.34), (88.78 ± 9.78),(91.43 ± 7.98), F = 33.275, P = 0.000); there was no statistically significant difference in the AOFAS ankle and hindfoot scores between the two groups 12 months before/after surgery (t = 2.145，P = 0.056；t = 2.879，P = 0.389); compared with open surgery group, the arthroscopic surgery group had higher AOFAS ankle and hindfoot scores 3/6 months after surgery (t = 1.346, P = 0.014; t = 1.874, P = 0.028). Conclusion: For the treatment of anterior talofibular ligament injury, arthroscopic surgery group is superior to open surgery group in ankle pain relief and functional recovery and has shorter operation time and hospital stay compared with open surgery group.
MeSH term(s)	Humans ; Retrospective Studies ; Joint Instability/etiology ; Lateral Ligament, Ankle/surgery ; Ankle Joint/surgery ; Arthroscopy/adverse effects ; Arthroscopy/methods ; Pain/etiology
Language	English
Publishing date	2023-09-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-023-05963-y
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Zs.A 1324: Show issues

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Article: [Clinical effect of propranolol in the treatment of respiratory hemangioma in infants and young children].

Chen, Yong-Qi / Zhong, Li-Li / Ding, Xiao-Fang

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2020 Volume 22, Issue 7, Page(s) 785–789

Abstract: Objective: To study the clinical effect of oral propranolol in the treatment of respiratory hemangioma in infants and young children.: Methods: A retrospective analysis was performed from the chart review data of children with respiratory hemangioma ... ...

Abstract	Objective: To study the clinical effect of oral propranolol in the treatment of respiratory hemangioma in infants and young children. Methods: A retrospective analysis was performed from the chart review data of children with respiratory hemangioma treated by oral propranolol and diagnosed by bronchoscopy and laryngeal plain enhanced CT/MRI from November 2012 to December 2019. Results: A total of 20 children were enrolled. All children had improvement in the symptoms of laryngeal stridor and dyspnea after oral administration of propranolol for 1-2 days. The median treatment time was 10 months (range 6-12 months). The median follow-up time was 10 months (range 3-15 months). Of the 20 children, 19 (95%) achieved regression of tumor, and 1 (5%) experienced an increase in tumor size during reexamination at 6 months after drug withdrawal and had no recurrence after the treatment with an increased dose of propranolol for 6 months. Only 1 child (5%) had adverse reactions, and 1 child (5%) was still under treatment. Conclusions: Oral propranolol can quickly relieve the symptoms such as dyspnea and achieve tumor regression, with few adverse events, and it is therefore an effective method for the treatment of respiratory hemangioma in infants and young children.
MeSH term(s)	Administration, Oral ; Adrenergic beta-Antagonists ; Child ; Child, Preschool ; Hemangioma ; Humans ; Infant ; Neoplasm Recurrence, Local ; Propranolol ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Adrenergic beta-Antagonists ; Propranolol (9Y8NXQ24VQ)
Language	Chinese
Publishing date	2020-07-15
Publishing country	China
Document type	Journal Article
ISSN	1008-8830
ISSN	1008-8830
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Article ; Online: A Rare Case of Primary Pleura Myxoid Leiomyosarcoma: FDG PET/CT Finding.

Wang, Ling / Ren, Yixuan / Ding, Xiaofang / Dong, Chi / Liu, Jiangyan

Clinical nuclear medicine

2020 Volume 45, Issue 4, Page(s) 316–318

Abstract: Myxoid leiomyosarcoma is a malignant tumor that originates from the mesenchymal tissue with extensive mucoid degeneration. It usually occurs in the uterus; occurrences from other tissues are extremely rare. Here we report the FDG PET/CT findings and ... ...

Abstract	Myxoid leiomyosarcoma is a malignant tumor that originates from the mesenchymal tissue with extensive mucoid degeneration. It usually occurs in the uterus; occurrences from other tissues are extremely rare. Here we report the FDG PET/CT findings and clinicopathological of primary pleura myxoid leiomyosarcoma in a 51-year-old man.
MeSH term(s)	Fluorodeoxyglucose F18 ; Humans ; Leiomyosarcoma/diagnostic imaging ; Male ; Middle Aged ; Pleural Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002956
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Zs.A 1276: Show issues

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Article: Modified tibial transverse transport technique for the treatment of ischemic diabetic foot ulcer in patients with type 2 diabetes.

Yuan, Yusong / Ding, Xiaofang / Jing, Zhengwei / Lu, Hao / Yang, Kun / Wang, Yuanli / Xu, Hailin

Journal of orthopaedic translation

2021 Volume 29, Page(s) 100–105

Abstract: Background: Ischemic diabetic foot ulcer is one of the terminal complications of diabetes. The high amputation rate, recurrence rate, and treatment cost have caused a huge burden on patients and society. This study designed the modified tibial ... ...

Abstract	Background: Ischemic diabetic foot ulcer is one of the terminal complications of diabetes. The high amputation rate, recurrence rate, and treatment cost have caused a huge burden on patients and society. This study designed the modified tibial transverse transport (mTTT) technology to treat diabetic ischemic diabetic foot ulcers in patients with type 2 diabetes and investigated the effectiveness and safety of this technique. Methods: This was a retrospective analysis of patients with type 2 diabetes and ischemic diabetic foot ulcers at two hospitals during January 2016-October 2019. These patients underwent mTTT surgery combined with wound debridement and vacuum sealing drainage negative pressure drainage treatment. In-hospital follow-up was performed at 1 month after the operation, while outpatient follow-up was performed at 3, 6, and 12 months after the operation. The ulcer healing time, recurrence rate, major amputation rate, and complications were analysed. Results: A total of 201 patients were enrolled in this study, including 107 males and 94 females (mean age: 68.3 ± 7.1 years). The wounds of all patients healed completely (mean healing time: 4.6 ± 1.6 months). There was no occurrence of major amputation, recurrence, and treatment-related complications in the patients. Conclusion: mTTT can effectively and safely treat ischemic diabetic foot ulcers in patients with type 2 diabetes. This technology is an important part of the ischemic diabetic foot ulcer treatment system and warrants further research. The translational potential of this article: This study introduced a new method to treat the ischemic diabetic foot ulcer which was called modified tibial transverse transport. The promising outcomes of patients indicated that this surgical method had great potential for clinical application and was worthy of further clinical research with high evidence level.
Language	English
Publishing date	2021-05-26
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2747531-1
ISSN	2214-031X
ISSN	2214-031X
DOI	10.1016/j.jot.2021.04.006
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