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Book: Acute kidney injury

Ding, Xiaoqiang / Ronco, Claudio

(Contributions to nephrology ; 187)

2016

Author's details	ed. Xiaoqiang Ding ; Claudio Ronco
Series title	Contributions to nephrology ; 187
Collection
Keywords	Nephrology ; Nierenversagen
Subject	Akute Niereninsuffizienz ; Akutes Nierenversagen ; Akute Nierenschädigung
Language	English
Size	VII, 147 S. : Ill., graph. Darst.
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT018921730
ISBN	978-3-318-05825-3 ; 978-3-318-05826-0 ; 3-318-05825-4 ; 3-318-05826-2
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2016 A 719	available for loan (reading room)	Lesesaal EG

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Book: Acute kidney injury

Ronco, Claudio / Ding, Xiaoqiang / Rosner, Mitchell H.

basic research and clinical practice : 23 figures, 9 in color, and 13 tables

(Contributions to nephrology ; Vol. 193)

2018

Author's details	volume editors Xiaoqiang Ding, Mitchell H. Rosner, Claudio Ronco
Series title	Contributions to nephrology ; Vol. 193
Collection
Keywords	Acute Kidney Injury ; Disease Management ; Nephrology ; Data Processing ; Intensive Care ; Nierenversagen
Subject	Akute Niereninsuffizienz ; Akutes Nierenversagen ; Akute Nierenschädigung
Subject code	616.614 ; 617.461059
Language	English
Size	VIII, 165 Seiten, Diagramme, 25 cm, 580 g
Publisher	Karger
Publishing place	Basel
Publishing country	Switzerland ; Germany
Document type	Book
HBZ-ID	HT019646615
ISBN	978-3-318-06310-3 ; 3-318-06310-X ; 9783318063110 ; 3318063118
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2018 A 470	available for loan (reading room)	Lesesaal EG

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Article ; Online: A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory.

Ding, Xiaoqiang / Tian, Xiangliang / Wang, Jinhui

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6063

Abstract: A risk assessment method for hot work based on G1-EWM and unascertained measurement theory was proposed to prevent hot work accidents in underground mines. Firstly, based on the risk influencing factors and classification criteria for underground hot ... ...

Abstract	A risk assessment method for hot work based on G1-EWM and unascertained measurement theory was proposed to prevent hot work accidents in underground mines. Firstly, based on the risk influencing factors and classification criteria for underground hot work operations in mines, a single indicator measurement matrix was constructed using unascertained measurement theory; Secondly, a risk assessment index system for mine underground hot work operations was established. The combination weight coefficient of each index was determined using the order relationship analysis method (G1) and entropy weight method (EWM) and coupled with the single index measurement evaluation vector to calculate the multi-index comprehensive evaluation vector of the evaluation object; Finally, the model was validated and examined using engineering examples, and the evaluation level was determined using confidence identification criteria. The results showed that the proposed method, when used to evaluate the risk of hot work operations in tunnels and vertical shafts in metal mines, produces risk levels that are in line with reality III (Moderate Risk) for the vertical shaft and IV (High Risk) for the tunnels. The evaluation model results are consistent with the risk evaluation results the whole process of on-site hot work, which verifies the model feasibility. A unique strategy and method for risk management in hot work operations in underground mines is provided by the combination of weighting and unascertained measure models, which has theoretical and practical value. Future research could focus on refineing this model by exploring the applicability in diverse mining environments and integrating advanced analytical techniques to enhance the predictive accuracy and operational efficiency.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56230-y
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Article ; Online: SIKD Is On the Road.

Ding, Xiaoqiang

Blood purification

2016 Volume 42, Issue 1, Page(s) I–VI

MeSH term(s)	China ; Dialysis/instrumentation ; Dialysis/trends ; Hospitals, Teaching/methods ; Hospitals, University ; Humans ; Kidney Diseases/therapy
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000442281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lipoprotein-associated phospholipase A2 predicts cardiovascular death in patients on maintenance hemodialysis: a 7-year prospective cohort study.

Lin, Lin / Teng, Jie / Shi, Yiqin / Xie, Qiwen / Shen, Bo / Xiang, Fangfang / Cao, Xuesen / Ding, Xiaoqiang / Xu, Xialian / Zhang, Zhen

Lipids in health and disease

2024 Volume 23, Issue 1, Page(s) 15

Abstract: Background: Cardiovascular diseases (CVD) is the leading cause of death among maintenance hemodialysis patients, with dyslipidemia being a prevalent complication. The paradoxical relationship between cardiovascular outcomes and established lipid risk ... ...

Abstract	Background: Cardiovascular diseases (CVD) is the leading cause of death among maintenance hemodialysis patients, with dyslipidemia being a prevalent complication. The paradoxical relationship between cardiovascular outcomes and established lipid risk markers, such as low-density lipoprotein cholesterol (LDL-C), complicates lipid management in this population. This study investigated Lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging biomarker known for its proinflammatory and proatherogenic properties, as a potential cardiovascular prognostic marker in this cohort. In this context, the association between Lp-PLA2 levels and cardiovascular outcomes was evaluated, with the aim to facilitate more accurate stratification and identification of high-risk individuals. Methods: From August 2013 to January 2014, 361 hemodialysis patients were prospectively enrolled. Lp-PLA Results: The median Lp-PLA Conclusions: High Lp-PLA
MeSH term(s)	Humans ; 1-Alkyl-2-acetylglycerophosphocholine Esterase ; Biomarkers ; Cardiovascular Diseases ; Cholesterol, LDL ; Prospective Studies ; Renal Dialysis ; Risk Factors
Chemical Substances	1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; Biomarkers ; Cholesterol, LDL ; PLA2G7 protein, human (EC 3.1.1.47)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-023-01991-0
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Article ; Online: Risk Factors and Prognosis of Acute Kidney Injury after Cardiac Surgery in Patients with Chronic Kidney Disease.

Zhang, Dong / Teng, Jie / Luo, Zhe / Ding, Xiaoqiang / Jiang, Wuhua

Blood purification

2022 Volume 52, Issue 2, Page(s) 166–173

Abstract: Introduction: Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most prevalent complications of cardiac surgery, while the renal and overall prognoses of chronic kidney disease (CKD) patients with CSA-AKI are extremely poor. However, ...

Abstract	Introduction: Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most prevalent complications of cardiac surgery, while the renal and overall prognoses of chronic kidney disease (CKD) patients with CSA-AKI are extremely poor. However, there is little published information on the occurrence of CSA-AKI in patients with CKD. The purpose of this study was to investigate the risk factors and prognostic factors of cardiac surgery-related AKI in patients with CKD. Methods: A retrospective study was performed on CKD patients who underwent cardiac surgery at a tertiary referral teaching hospital. CSA-AKI was defined based on the KDIGO criteria. The risk factors for CSA-AKI and the factors affecting renal function recovery at discharge or death in patients with AKI were investigated. Results: Among 1638 CKD patients enrolled, the incidence of CSA-AKI was 50.55%. AKI patients' in-hospital mortality was higher than patients without AKI (AKI vs. no AKI, 4.7 vs. 0.9%, p < 0.001). Multivariate logistic regression analysis showed that male (odds ratio [OR] 1.479), preoperative hypertension (OR 1.548), preoperative hemoglobin <110 g/L (OR 2.389), and aortic clamping time >58 min (OR 1.567) were independent risk factors for AKI after cardiac surgery in patients with CKD. Factors affecting renal function recovery of AKI patients included preoperative diabetes mellitus (OR 0.306), hyperchloremia (OR 0.927), estimate of the glomerular filtration rate (OR 1.034), and AKI progression. Compared with patients with AKI stage 1, the rate of renal function recovery in patients with AKI stage 2 and stage 3 was reduced by 78.9% and 82.3%, respectively. Conclusions: In the population of patients with CKD, the incidence of CSA-AKI was high, which significantly affected renal and overall prognosis. The prompt intervention of modifiable factors may help improve the prognosis of patients with CKD.
MeSH term(s)	Humans ; Male ; Retrospective Studies ; Renal Insufficiency, Chronic/complications ; Prognosis ; Acute Kidney Injury/etiology ; Risk Factors ; Cardiac Surgical Procedures/adverse effects ; Postoperative Complications
Language	English
Publishing date	2022-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000526120
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1872: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing hemodialysis.

Xiang, Fangfang / Sun, Lin / Cao, Xuesen / Li, Yang / Chen, Xiaohong / Zhang, Zhen / Zou, Jianzhou / Teng, Jie / Shen, Bo / Ding, Xiaoqiang

Clinica chimica acta; international journal of clinical chemistry

2024 Volume 555, Page(s) 117791

Abstract: Background: T cell dysfunction observed in patients undergoing hemodialysis (HD) has been linked to an extremely high morbidity of cardiovascular events (CVEs) and infections. The cell-surface 5'-nucleotidase CD73 sets the balance between pro- ... ...

Abstract	Background: T cell dysfunction observed in patients undergoing hemodialysis (HD) has been linked to an extremely high morbidity of cardiovascular events (CVEs) and infections. The cell-surface 5'-nucleotidase CD73 sets the balance between pro-inflammatory nucleotides and anti-inflammatory adenosine. Methods: A total of 395 patients who had been receiving HD for at least six months were evaluated for proportions of CD73 Results: HD was significantly related to a lower fraction of CD4 Conclusion: We identified CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing HD, which provides a potential target in future studies of uremia-related immune dysfunction.
MeSH term(s)	Humans ; 5'-Nucleotidase ; Adenosine ; CD8-Positive T-Lymphocytes ; Inflammation ; Renal Dialysis
Chemical Substances	5'-Nucleotidase (EC 3.1.3.5) ; Adenosine (K72T3FS567) ; NT5E protein, human (EC 3.1.3.5)
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2024.117791
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Article ; Online: FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.

Wang, Da-Xi / Bao, Si-Yu / Song, Na-Na / Chen, Wei-Ze / Ding, Xiao-Qiang / Walker, Robert J / Fang, Yi

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 5, Page(s) e23436

Abstract: Chronic kidney disease (CKD) is a global health burden, with ineffective therapies leading to increasing morbidity and mortality. Renal interstitial fibrosis is a common pathway in advanced CKD, resulting in kidney function and structure deterioration. ... ...

Abstract	Chronic kidney disease (CKD) is a global health burden, with ineffective therapies leading to increasing morbidity and mortality. Renal interstitial fibrosis is a common pathway in advanced CKD, resulting in kidney function and structure deterioration. In this study, we investigate the role of FTO-mediated N6-methyladenosine (m6A) and its downstream targets in the pathogenesis of renal fibrosis. M6A modification, a prevalent mRNA internal modification, has been implicated in various organ fibrosis processes. We use a mouse model of unilateral ureteral obstruction (UUO) as an in vivo model and treated tubular epithelial cells (TECs) with transforming growth factor (TGF)-β1 as in vitro models. Our findings revealed increased FTO expression in UUO mouse model and TGF-β1-treated TECs. By modulating FTO expression through FTO heterozygous mutation mice (FTO
MeSH term(s)	Mice ; Animals ; Kidney/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Transforming Growth Factor beta1/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; Ureteral Obstruction/metabolism ; Renal Insufficiency, Chronic/metabolism ; Fibrosis ; Demethylation ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Adenine/analogs & derivatives
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Transforming Growth Factor beta1 ; RNA, Messenger ; Core Binding Factor Alpha 2 Subunit ; 6-methyladenine (W7IBY2BGAX) ; FTO protein, mouse (EC 1.14.11.-) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202302041R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: Effects of p-cresol, a uremic toxin, on cancer cells.

Chen, Xiaohong / Xiang, Fangfang / Cao, Xuesen / Zou, Jianzhou / Zhang, Boheng / Ding, Xiaoqiang

Translational cancer research

2023 Volume 12, Issue 2, Page(s) 367–374

Abstract: Background: Though p-cresol exists at a low concentration in the blood, it accumulates in various organs of uremic patients. Previous research has shown that the p-cresol promoted bladder cancer cell invasion and migration. This study aims to see if p- ... ...

Abstract	Background: Though p-cresol exists at a low concentration in the blood, it accumulates in various organs of uremic patients. Previous research has shown that the p-cresol promoted bladder cancer cell invasion and migration. This study aims to see if p-cresol had similar effects on kidney cancer cells and liver cancer cells. Methods: For 48 hours, 786-O human renal cancer cells and HepG2 human liver cancer cells were treated with p-cresol at concentrations of 0, 10, 20, 40, and 70 µM. The effects of p-cresol on cell viability, apoptosis, migration, and invasion were then analyzed using the CCK-8, TUNEL, and Transwell migration/invasion assays, respectively. Results: P-cresol at 0 to 70 µM for 48 hours had no significant toxic effects on 786-O cells or HepG2 cells. We chose 40 µM p-cresol for 48 hours for the following experiment. The viability and proliferation of 786-O cells and HepG2 cells were unaffected after 48 hours of treatment, with 40 µM p-cresol. However, 40 µM p-cresol for 48 hours promoted HepG2 cell migration and invasion but did not have the same effect on the 786-O cell line. Conclusions: P-cresol may be responsible for HepG2 cells' malignant biological behavior. Because the liver is the primary site of p-cresol metabolism, it is important to study the responses of cancer cells in the liver to p-cresol.
Language	English
Publishing date	2023-01-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-22-2042
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Article ; Online: The application of new complex indicators in the detection of urine.

Li, Ying-Xiang / Li, Yang / Bao, Si-Yu / Xue, Ning / Ding, Xiao-Qiang / Fang, Yi

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 45

Abstract: Background: Accurate diagnosis and assessment of hematuria is crucial for the early detection of chronic kidney disease(CKD). As instability of urinary RBC count (URBC) often results with clinical uncertainty, therefore new urinary indexes are demanded ... ...

Abstract	Background: Accurate diagnosis and assessment of hematuria is crucial for the early detection of chronic kidney disease(CKD). As instability of urinary RBC count (URBC) often results with clinical uncertainty, therefore new urinary indexes are demanded to improve the accuracy of diagnosis of hematuria. In this study, we aimed to investigate the benefit of applying new complex indicators based on random urine red blood cell counts confirmed in hematuric kidney diseases. Methods: All patients enrolled underwent renal biopsy, and their clinical information was collected. Urinary and blood biomedical indexes were implemented with red blood cell counts to derive complex indicators. Patients were divided into two groups (hematuria-dominant renal histologic lesions and non-hematuria-dominant renal histologic lesions) based on their renal pathological manifestations. The target index was determined by comparing the predictive capabilities of the candidate parameters for hematuric kidney diseases. Hematuria stratification was divided into four categories based on the scale of complex indicators and distributional features. The practicality of the new complex indicators was demonstrated by fitting candidate parameters to models comprising demographic information. Results: A total of 1,066 cases (678 hematuria-dominant renal histologic lesions) were included in this study, with a mean age of 44.9 ± 15 years. In differentiating hematuria-dominant renal histologic lesion from the non-hematuria-dominant renal histologic lesion, the AUC value of "The ratio of the random URBC to 24-h albumin excretion" was 0.76, higher than the standard approach of Lg (URBC) [AUC = 0.744] (95% Confidence interval (CI) 0.712 ~ 0.776). The odds ratio of hematuria-dominant renal histologic lesion (Type I) increased from Q2 (3.81, 95% CI 2.66 ~ 5.50) to Q4 (14.17, 95% CI 9.09 ~ 22.72). The predictive model, composed of stratification of new composite indexes, basic demographic characteristics, and biochemical parameters, performed best with AUC value of 0.869 (95% CI 0.856-0.905). Conclusion: The new urinary complex indicators improved the diagnostic accuracy of hematuria and may serve as a useful parameter for screening hematuric kidney diseases.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Clinical Decision-Making ; Uncertainty ; Body Fluids ; Hematuria/diagnosis ; Kidney ; Renal Insufficiency, Chronic/diagnosis
Language	English
Publishing date	2023-02-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03087-4
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