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Article ; Online: Study on the Development Path of Green Low-Carbon Environmental Protection Industry under the New Situation

Wang Yin / Ding Yao

E3S Web of Conferences, Vol 394, p

2023 Volume 01015

Abstract: This paper aims to study the development path of green, low-carbon and environmental protection industries under the new situation. Currently, the green, low-carbon and environmental protection industry has become an important field for economic and ... ...

Abstract	This paper aims to study the development path of green, low-carbon and environmental protection industries under the new situation. Currently, the green, low-carbon and environmental protection industry has become an important field for economic and social development. This paper proposes two key development paths, namely strengthening policy guidance and promoting technological innovation, by outlining the current status of the green, low-carbon and environmental protection industry. In terms of policy guidance, it is recommended that the government develop supportive policies and regulatory measures to guide and promote industry development. In terms of technological innovation, it is recommended that enterprises strengthen independent innovation and technological cooperation to promote the innovation and application of green, low-carbon and environmental protection technologies. Through comprehensive analysis and empirical research, new ideas and references can be provided for the development of the green, low-carbon and environmental protection industry.
Keywords	green ; low-carbon ; environmental protection industry ; development path ; policy guidance ; technological innovation ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impact of Sharing Drug Rebates at the Point of Sale on Out-of-Pocket Payments for Enrollees in Employer-Sponsored Insurance.

Ding, Yao / Miller, G Edward

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

2022 Volume 26, Issue 2, Page(s) 226–233

Abstract: Objectives: This study aimed to estimate the impact of sharing drug rebates at the point of sale on out-of-pocket spending by linking estimated rebates to administrative claims data for employer-sponsored insurance enrollees in 2018.: Methods: We ... ...

Abstract	Objectives: This study aimed to estimate the impact of sharing drug rebates at the point of sale on out-of-pocket spending by linking estimated rebates to administrative claims data for employer-sponsored insurance enrollees in 2018. Methods: We applied the drug rebate rate to the retail price of each brand name drug fill, allocated the reductions to out-of-pocket spending based on cost-sharing provisions, and aggregated each individual's out-of-pocket spending across drug fills. We assumed that generic drugs have no rebates for employer-sponsored insurance. We assessed the impact of sharing rebates at the point of sale on out-of-pocket spending overall, for the therapeutic classes and specific drugs with the highest average out-of-pocket spending per user, and by health plan type. Results: Across 4 simulations with different assumptions about the degree of cross-fill effects, we found that 10.4% to 12.2% of enrollees in our sample would have realized savings on out-of-pocket spending if rebates were shared to the point of sale. Among those with savings, approximately half would save $50 or less, and 10% would save > $500 annually. We calculated that a premium increase of $1.06 to $1.41 per member per month among the continuously enrolled, insured population would be sufficient to finance the out-of-pocket savings in our sample. Conclusions: Our study suggests that, for a small percentage of enrollees, sharing drug rebates at the point of sale would likely improve the affordability of high-priced brand name drugs, especially drugs that face significant competition.
MeSH term(s)	Humans ; United States ; Health Expenditures ; Cost Sharing
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1471745-1
ISSN	1524-4733 ; 1098-3015
ISSN (online)	1524-4733
ISSN	1098-3015
DOI	10.1016/j.jval.2022.08.001
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Article ; Online: 1,25D/VDR inhibits pancreatic β cell ferroptosis by downregulating FOXO1 expression in diabetes mellitus.

Ding, Yao / Wu, Qinan

Cellular signalling

2022 Volume 105, Page(s) 110564

Abstract: Background: Type 2 diabetes mellitus (T2DM) is a global health problem that seriously threatens human health. Vitamin D (VD) has antidiabetic effects. However, the protective mechanism of 1,25-dihydroxyvitamin D3 (1,25D) on T2DM is still unclear.: ... ...

Abstract	Background: Type 2 diabetes mellitus (T2DM) is a global health problem that seriously threatens human health. Vitamin D (VD) has antidiabetic effects. However, the protective mechanism of 1,25-dihydroxyvitamin D3 (1,25D) on T2DM is still unclear. Methods: A rat model of T2DM was constructed using a high-fat diet combined with intraperitoneal injection of streptozotocin (STZ). Glucose tolerance was assessed by an oral glucose tolerance test (OGTT). Insulin secretion in blood and cell supernatant was determined by ELISA. Cell viability was analysed by CCK-8 assay. The level of ROS was detected by the DCFH-DA fluorescent probe method. The iron level in pancreatic tissues and cells was detected by an iron assay kit. Immunofluorescence staining was used to detect the expression of the pancreatic β cell marker CD49a. Furthermore, the protein expression levels of ferroptosis pathway-related proteins and vitamin D receptor (VDR) were detected by western blot. Downstream VDR targets were screened by proteomic sequencing. Results: The DM group had increased glucose levels and decreased insulin secretion, while 1,25D treatment decreased glucose levels and increased insulin secretion. 1,25D also suppressed DM-induced ferroptosis in pancreatic tissues in vivo. In addition, 1,25D significantly enhanced the viability of pancreatic β cells and reduced the levels of ROS and iron. 1,25D significantly upregulated the expression of VDR and the ferroptosis-related pathway protein GPX4 and downregulated the expression of ACSL4. Furthermore, knockdown of VDR reversed the effects of 1,25D on cell viability, ROS and iron levels, and ferroptosis-related protein expression in pancreatic β cells. Proteomic sequencing revealed that FOXO1 was the downstream target gene of VDR. Knockdown of FOXO1 reduced pancreatic β cell death, decreased ROS, iron and ACSL4 levels, and increased GPX4 levels. Conclusion: 1,25D/VDR inhibited pancreatic β cell ferroptosis in T2DM by downregulating the expression of FOXO1. This study provides a new theoretical basis for basic research on T2DM and is expected to establish a new idea for the treatment of T2DM.
MeSH term(s)	Animals ; Rats ; Diabetes Mellitus, Type 2/metabolism ; Ferroptosis ; Forkhead Box Protein O1/metabolism ; Glucose/metabolism ; Insulin-Secreting Cells/metabolism ; Proteomics ; Reactive Oxygen Species/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism
Chemical Substances	Forkhead Box Protein O1 ; Foxo1 protein, rat ; Glucose (IY9XDZ35W2) ; Reactive Oxygen Species ; Receptors, Calcitriol
Language	English
Publishing date	2022-12-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110564
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Article ; Online: Assessment of future flood risk induced by sea level rise and tropical cyclones under global warming in the Xiamen Bay, Fujian, China

Wenyun Guo / Ding Yao / Zhi Chen / Pingxing Ding / Jianzhong Ge

Frontiers in Marine Science, Vol

2023 Volume 10

Abstract: Tropical cyclone (TC)-induced coastal flooding can lead to severe hazards in low-lying lands and is expected to be exacerbated by sea level rise and TC climatology changes related to the warming climate. Since the dense population in Xiamen Bay, Fujian, ... ...

Abstract	Tropical cyclone (TC)-induced coastal flooding can lead to severe hazards in low-lying lands and is expected to be exacerbated by sea level rise and TC climatology changes related to the warming climate. Since the dense population in Xiamen Bay, Fujian, China, it is highly valuable in understanding coastal flooding of it, but little studies involved this topic. In this study, we establish a high-resolution numerical model covering all coastal low-lying land in Xiamen Bay based on FVCOM. This model is then used to assess the flood risk in Xiamen Bay under TCs with 10-, 100-, and 1000-year pressures by applying a multi-tracks blend method. The results show that 126 km2 of low-lying area can be flooded periodically by astronomical tides; and 388, 504, and 598 km2 of low-lying area can be flooded under TCs with 10-, 100-, and 1000-year pressures, accompanied by increased average flood depths of 2.3, 2.8, and 3.4 m, respectively. By 2100 under SSP5-8.5, the well-protected Xiamen Island becomes impacted by TCs with 10-year pressure, and flood areas under TCs with 100-year pressure are estimated to be nearly equivalent to that under TCs with 1000-year pressure at the current climate. The most increased exposure area by climate change are artificial surfaces and agricultural areas, showing the potential higher flood disasters in future.
Keywords	coastal flood ; FVCOM ; tropical cyclone climatology ; Xiamen Bay ; multi-tracks blend ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	910
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Learning Unified Anchor Graph for Joint Clustering of Hyperspectral and LiDAR Data.

Cai, Yaoming / Zhang, Zijia / Liu, Xiaobo / Ding, Yao / Li, Fei / Tan, Jinhua

IEEE transactions on neural networks and learning systems

2024 Volume PP

Abstract: The joint clustering of multimodal remote sensing (RS) data poses a critical and challenging task in Earth observation. Although recent advances in multiview subspace clustering have shown remarkable success, existing methods become computationally ... ...

Abstract	The joint clustering of multimodal remote sensing (RS) data poses a critical and challenging task in Earth observation. Although recent advances in multiview subspace clustering have shown remarkable success, existing methods become computationally prohibitive when dealing with large-scale RS datasets. Moreover, they neglect intrinsic nonlinear and spatial interdependencies among heterogeneous RS data and lack generalization ability for out-of-sample data, thereby restricting their applicability. This article introduces a novel unified framework called anchor-based multiview kernel subspace clustering with spatial regularization (AMKSC). It learns a scalable anchor graph in the kernel space, leveraging contributions from each modality instead of seeking a consensus full graph in the feature space. To ensure spatial consistency, we incorporate a spatial smoothing operation into the formulation. The method is efficiently solved using an alternating optimization strategy, and we provide theoretical evidence of its scalability with linear computational complexity. Furthermore, an out-of-sample extension of AMKSC based on multiview collaborative representation-based classification is introduced, enabling the handling of larger datasets and unseen instances. Extensive experiments on three real heterogeneous RS datasets confirm the superiority of our proposed approach over state-of-the-art methods in terms of clustering performance and time efficiency. The source code is available at https://github.com/AngryCai/AMKSC.
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2024.3392484
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Article: High Performance GaN-Based Ultraviolet Photodetector via Te/Metal Electrodes.

Lin, Sheng / Lin, Tingjun / Wang, Wenliang / Liu, Chao / Ding, Yao

Materials (Basel, Switzerland)

2023 Volume 16, Issue 13

Abstract: Photodetectors (PDs) based on two-dimensional (2D) materials have promising applications in modern electronics and optoelectronics. However, due to the intralayer recombination of the photogenerated carriers and the inevitable surface trapping stages of ... ...

Abstract	Photodetectors (PDs) based on two-dimensional (2D) materials have promising applications in modern electronics and optoelectronics. However, due to the intralayer recombination of the photogenerated carriers and the inevitable surface trapping stages of the constituent layers, the PDs based on 2D materials usually suffer from low responsivity and poor response speed. In this work, a distinguished GaN-based photodetector is constructed on a sapphire substrate with Te/metal electrodes. Due to the metal-like properties of tellurium, the band bending at the interface between Te and GaN generates an inherent electric field, which greatly reduces the carrier transport barrier and promotes the photoresponse of GaN. This Te-enhanced GaN-based PD show a promising responsivity of 4951 mA/W, detectivity of 1.79 × 10
Language	English
Publishing date	2023-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16134569
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Article ; Online: Titanium-based substrate modified with nanoenzyme for accelerating the repair of bone defect.

Tan, Yingying / Ding, Yao / Liu, Shaopeng / Liu, Peng / Cai, Kaiyong

Colloids and surfaces. B, Biointerfaces

2023 Volume 234, Page(s) 113737

Abstract: Titanium (Ti) and titanium alloy are the most common metal materials in clinical orthopedic surgery. However, in the initial stage of surgery and implantation, the production of excessive reactive oxygen species (ROS) can induce oxidative stress (OS) ... ...

Abstract	Titanium (Ti) and titanium alloy are the most common metal materials in clinical orthopedic surgery. However, in the initial stage of surgery and implantation, the production of excessive reactive oxygen species (ROS) can induce oxidative stress (OS) microenvironment. OS will further inhibit the growth of new bone, resulting in surgical failure. In this study, based on the fact that nanoscale manganese dioxide (MnO
MeSH term(s)	Osteogenesis ; Titanium/pharmacology ; Titanium/chemistry ; Manganese Compounds/pharmacology ; Reactive Oxygen Species/metabolism ; Oxides/pharmacology ; Hydrogen Peroxide/pharmacology ; Osseointegration ; Surface Properties
Chemical Substances	Titanium (D1JT611TNE) ; Manganese Compounds ; Reactive Oxygen Species ; Oxides ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-12-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113737
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Thesis ; Online: Decision Making and Decision Support for Selecting Assistive/Access Technology

Ding, Yao

2018

Abstract: Computer access has become essential for everyone to fully and equally participate in the society. Due to disability, aging, literacy or computer literacy related barriers, many people need to use an assistive/access technology (AT) to gain computer ... ...

Abstract	Computer access has become essential for everyone to fully and equally participate in the society. Due to disability, aging, literacy or computer literacy related barriers, many people need to use an assistive/access technology (AT) to gain computer access. However, a majority of people facing access barriers are not getting proper AT partly due to a shortage of sufficiently trained professionals and difficulties in selecting AT by consumers themselves. Work of this dissertation was carried out as an effort to bridge knowledge gaps in the area of decision-making and decision-support for AT selection, and to provide design implications for a decision support tool that facilitates consumers in AT selection—the Shopping/Alerting Interface. This dissertation consists of 3 studies. Study 1 investigated how individual consumers (N = 8) select AT by themselves and how professionals (N = 10) select AT for clients, identified information needs, and drew implications for decision support design. This study inspired a support design that enables consumers to browse AT products by access needs/difficulties, in addition to browsing by product types/features (as in most shopping sites today). This study also highlighted the need of consumers to be able to search in their lay language, which led to Study 2—a vocabulary study on collecting words and phrases that consumers (N = 368) would naturally use to describe access needs/difficulties and access solutions. This vocabulary was integrated into the Shopping/Alerting Interface to enhance its free-text searching. As a result of Study 1 & 2, the user can browse and search for AT products by product types/features (feature-based support), or by access needs/difficulties (need-based support ). Study 3 empirically compared AT selection when consumers used feature-based support alone, need-based support alone, and both support methods together (hybrid support). The participants (N = 72) made better selections using need-based support than the conventional feature-based support. With need-based support, the participants also put forth less searching effort (fewer searches and fewer products explored in depth) and made as good selections as using hybrid support. However, the consumers preferred having both available (hybrid support), even though it did not significantly improve product choices. Implications were drawn for designing decision support systems.
Keywords	Engineering\|Industrial engineering
Subject code	303
Language	ENG
Publishing date	2018-01-01 00:00:01.0
Publisher	The University of Wisconsin - Madison
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Ding Yao / Yang GangYi / Wu QiNan

Genes and Diseases, Vol 8, Iss 4, Pp 438-

2021 Volume 447

Abstract: Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the ... ...

Abstract	Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.
Keywords	Apoptosis ; Autophagic dysfunction ; Insulin resistance ; Islet beta cell dysfunction ; Type 2 diabetes mellitus ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Value-Based Pricing of US Prescription Drugs: Estimated Savings Using Reports From the Institute for Clinical and Economic Review.

Yeung, Kai / Bloudek, Lisa / Ding, Yao / Sullivan, Sean D

JAMA health forum

2022 Volume 3, Issue 12, Page(s) e224631

MeSH term(s)	Prescription Drugs ; Drug Costs ; Costs and Cost Analysis ; Income
Chemical Substances	Prescription Drugs
Language	English
Publishing date	2022-12-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2689-0186
ISSN (online)	2689-0186
DOI	10.1001/jamahealthforum.2022.4631
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