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  1. AU="Ding, Yiming"
  2. AU="Sid Ahmed, Mazen A"
  3. AU="Bermudez-Lekerika, Paola"
  4. AU="Ter Hoeve, Natalie D"
  5. AU="Yang, X-D"
  6. AU="Jerry J Shih"
  7. AU=Kapil Vikas
  8. AU="Sanda Cosarca"
  9. AU=Murthy J M K
  10. AU="Ward Chiasson, Stephanie"
  11. AU="Kinsella, Paul"
  12. AU="Alyaqout, Khaled"
  13. AU="J Joshua Smith"
  14. AU="Kotak, Dinesh"
  15. AU="Michael Holland"
  16. AU="Pauline, Staelen"
  17. AU="Mouna Esmaeilzadeh"
  18. AU=Congreve Miles
  19. AU="Li, Yunfeng" AU="Li, Yunfeng"
  20. AU="Shankar, Ganesh"
  21. AU="Ruginsk, Silvia G"
  22. AU="Aquilante, Francesco"
  23. AU="Dillon, Robert C"
  24. AU="Yuan Qu"
  25. AU="Dufour, A"
  26. AU="Hannus, Jill"
  27. AU="Rieber, Julia"
  28. AU="Gulmuradov, Tashpulat"
  29. AU="Romeu Fontanillas, Teresa"
  30. AU="Fleming, Renée"
  31. AU="Cao, Fang"
  32. AU="Sally J L Moore"
  33. AU="Moreno, Yolanda"
  34. AU="Vasiliy Ya. Kolyuchkin"

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  1. Artikel ; Online: Structure-Based Virtual Screening for Novel Inhibitors Targeting KRAS G12C.

    Ding, Yiming

    Studies in health technology and informatics

    2023  Band 308, Seite(n) 568–573

    Abstract: KRAS is a protein that is critical to cell activation, but when it becomes mutated, it can contribute to the development of cancer. There is an urgent need for reliable and effective drugs to treat cancer, and KRAS G12C has been a major focus of research ...

    Abstract KRAS is a protein that is critical to cell activation, but when it becomes mutated, it can contribute to the development of cancer. There is an urgent need for reliable and effective drugs to treat cancer, and KRAS G12C has been a major focus of research in this area. In this study, we used structure-based virtual screening to search for novel inhibitors that can target KRAS G12C. Specifically, we conducted a search for inhibitors that bind to the protein's P2 pocket, which can trap the oncoprotein in an inactive GDP-bound state. Using quantitative analysis and virtual screening, we identified a set of eight potential inhibitors that have the potential to become the next generation of drugs to treat cancer. These findings offer new insights into the mechanisms underlying KRAS G12C inhibition and provide a promising avenue for future drug development efforts.
    Mesh-Begriff(e) Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Proto-Oncogene Proteins p21(ras)/therapeutic use ; Cell Line, Tumor ; Lung Neoplasms
    Chemische Substanzen Antineoplastic Agents ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-11-26
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230886
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Composite dietary antioxidant index associated with delayed biological aging: a population-based study.

    He, Huiqin / Chen, Xin / Ding, Yiming / Chen, Xiaoli / He, Xingkang

    Aging

    2024  Band 16, Heft 1, Seite(n) 15–27

    Abstract: Objective: The objective of this study was to explore the potential correlation between the composite dietary antioxidant index (CDAI) and biological aging, addressing the insufficient epidemiological evidence in this area.: Methods: Participants ... ...

    Abstract Objective: The objective of this study was to explore the potential correlation between the composite dietary antioxidant index (CDAI) and biological aging, addressing the insufficient epidemiological evidence in this area.
    Methods: Participants meeting eligibility criteria were selected from the National Health and Nutrition Examination Surveys (NHANES) conducted between 2001 and 2018. CDAI was determined based on dietary antioxidants obtained from 24-hour dietary recalls. Biological age was determined using PhenoAge algorithms incorporating various clinical features. Weighted multiple models were employed to investigate and assess the association between CDAI and biological age.
    Results: Analysis of the CDAI quartile revealed disparities in terms of age, gender, ethnicity, educational level, marital status, poverty, dietary calories intakes, smoking, drinking status, BMI, physical activity, and PhenoAge. After adjusting for potential confounding factors, a significant inverse relationship was found between CDAI and Phenotypic Age, with each standard deviation increase in CDAI score correlating with a 0.18-year decrease in Phenotypic Age. These negative correlations between CDAI and PhenoAge advancement were observed regardless of age, gender, physical activity status, smoking status, and body mass index.
    Conclusions: Our findings demonstrate a positive relationship between higher CDAI scores and delayed biological aging. These results have significant implications for public health initiatives aimed at promoting healthy aging through dietary interventions.
    Mesh-Begriff(e) Humans ; Aging ; Antioxidants ; Diet ; Ethnicity ; Nutrition Surveys
    Chemische Substanzen Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2024-01-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205232
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A robust t

    Wei, Siyuan / Ding, Yiming / Song, Kan / Liu, Zao

    Magnetic resonance in chemistry : MRC

    2023  Band 61, Heft 8, Seite(n) 473–480

    Abstract: Artefacts in high-resolution multidimensional nuclear magnetic resonance (NMR) spectra, known as ... ...

    Abstract Artefacts in high-resolution multidimensional nuclear magnetic resonance (NMR) spectra, known as t
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.5355
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Effect of Preoperative Neck Radiotherapy on the Reconstruction of Head and Neck Defects With the Supraclavicular Artery Island Flap.

    Zhou, Jing / Zuo, Erdong / Ding, Yiming / Wu, Jun / Jin, Yonggang / Chen, Xiaohong

    Ear, nose, & throat journal

    2024  , Seite(n) 1455613241253713

    Abstract: Purpose: ...

    Abstract Purpose:
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241253713
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Licorice: Resources, applications in ancient and modern times

    Ding, Yiming / Brand, Eric / Wang, Wenquan / Zhao, Zhongzhen

    Journal of ethnopharmacology. 2022 July 28,

    2022  

    Abstract: Licorice has been widely used as a medicinal herb since ancient times. Licorice is also spelled as "liquorice" and it is known as "Glycyrrhizae Radix et Rhizoma" (Chinese:甘草 gan cao) in the Chinese Pharmacopoeia. Licorice root has a wide range of ... ...

    Abstract Licorice has been widely used as a medicinal herb since ancient times. Licorice is also spelled as "liquorice" and it is known as "Glycyrrhizae Radix et Rhizoma" (Chinese:甘草 gan cao) in the Chinese Pharmacopoeia. Licorice root has a wide range of pharmacological effects, including adrenocortical hormone-like effects, as well as multiple pharmacological effects on the digestive system, immune system, and cardiovascular system. This review aims to comprehensively investigate the history of licorice and its medicinal and industrial applications in China and other nations, including research and application prospects related to the aerial parts of licorice. An extensive review of the literature was carried out, including ancient and modern texts, doctoral and masters’ theses, monographs on medicinal plants, pharmacopoeias and electronic databases, including Web of Science, Springer, CNKI, and Google Scholar. The ancient and modern applications of licorice were systematically investigated. In ancient times, practitioners in China discovered the medicinal potential of licorice and used it widely. In modern times, licorice is widely used in food, medicines and supplements, tobacco, chemical applications, environmental applications, animal husbandry and other industries. The potential of the aerial portion of the plant is also gradually being researched, developed, and utilized. Licorice is one of the oldest and most widely used herbal medicines in the world. This article reviews its medicinal potential and application in various fields, and briefly introduces current research into its aerial parts. This review aims to highlight the importance of licorice and provide direction for its future development.
    Schlagwörter animal husbandry ; calcium oxide ; cardiovascular system ; digestive system ; immune system ; licorice ; medicinal plants ; tobacco ; traditional medicine ; China
    Sprache Englisch
    Erscheinungsverlauf 2022-0728
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115594
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: Licorice: Resources, applications in ancient and modern times.

    Ding, Yiming / Brand, Eric / Wang, Wenquan / Zhao, Zhongzhen

    Journal of ethnopharmacology

    2022  Band 298, Seite(n) 115594

    Abstract: Ethnopharmacological relevance: Licorice has been widely used as a medicinal herb since ancient times. Licorice is also spelled as "liquorice" and it is known as "Glycyrrhizae Radix et Rhizoma" (Chinese: gan cao) in the Chinese Pharmacopoeia. Licorice ... ...

    Abstract Ethnopharmacological relevance: Licorice has been widely used as a medicinal herb since ancient times. Licorice is also spelled as "liquorice" and it is known as "Glycyrrhizae Radix et Rhizoma" (Chinese: gan cao) in the Chinese Pharmacopoeia. Licorice root has a wide range of pharmacological effects, including adrenocortical hormone-like effects, as well as multiple pharmacological effects on the digestive system, immune system, and cardiovascular system.
    Aim of the review: This review aims to comprehensively investigate the history of licorice and its medicinal and industrial applications in China and other nations, including research and application prospects related to the aerial parts of licorice.
    Method: An extensive review of the literature was carried out, including ancient and modern texts, doctoral and masters' theses, monographs on medicinal plants, pharmacopoeias and electronic databases, including Web of Science, Springer, CNKI, and Google Scholar.
    Results: The ancient and modern applications of licorice were systematically investigated. In ancient times, practitioners in China discovered the medicinal potential of licorice and used it widely. In modern times, licorice is widely used in food, medicines and supplements, tobacco, chemical applications, environmental applications, animal husbandry and other industries. The potential of the aerial portion of the plant is also gradually being researched, developed, and utilized.
    Conclusion: Licorice is one of the oldest and most widely used herbal medicines in the world. This article reviews its medicinal potential and application in various fields, and briefly introduces current research into its aerial parts. This review aims to highlight the importance of licorice and provide direction for its future development.
    Mesh-Begriff(e) Animals ; China ; Drugs, Chinese Herbal/pharmacology ; Glycyrrhiza ; Medicine, Chinese Traditional ; Plant Extracts ; Plants, Medicinal ; Triterpenes
    Chemische Substanzen Drugs, Chinese Herbal ; Plant Extracts ; Triterpenes
    Sprache Englisch
    Erscheinungsdatum 2022-08-05
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115594
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  7. Artikel ; Online: Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.

    Ding, Yiming / Liu, Hanjie / Zhang, Chuanbao / Bao, Zhaoshi / Yu, Shuqing

    Aging

    2022  Band 14, Heft 5, Seite(n) 2320–2334

    Abstract: The most prevalent malignant central nervous system (CNS) cancer is glioblastoma multiforme (GBM). PLKs (polo-like kinases) are a kind of serine-threonine kinase that modulate DNA replication, mitosis, and stress responses. PLKs in GBM need to be better ... ...

    Abstract The most prevalent malignant central nervous system (CNS) cancer is glioblastoma multiforme (GBM). PLKs (polo-like kinases) are a kind of serine-threonine kinase that modulate DNA replication, mitosis, and stress responses. PLKs in GBM need to be better studied and examined in terms of their expression, function, along with prognostic significance. Using an existing publicly available data set, we evaluated the expression level and prognostic relevance of PLKs in GBM patients at the molecular level. The biological processes along with cascades of the screened gene were predicted using the functional enrichment of Gene Set Enrichment Analysis, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathways. The data illustrated that PLK1/3/4 contents were greater in GBM tissues than in non-tumorous tissues, but PLK2/5 expression levels were lower. PLK2 expression was also linked to patient outcome in GBM. Our findings imply that PLKs might be useful molecular indicators as well as prospective treatment targets for GBM. A PLK2 inhibitor has been studied for the first time in a glioma cell in this work. In glioma cells, ON1231320 has anticancer effects. Finally, a summary of PLK inhibitors is presented, along with projections for future progress.
    Mesh-Begriff(e) Biomarkers ; Cell Cycle Proteins/metabolism ; Glioblastoma/pathology ; Humans ; Prognosis ; Prospective Studies ; Protein Serine-Threonine Kinases/genetics
    Chemische Substanzen Biomarkers ; Cell Cycle Proteins ; PLK2 protein, human (EC 2.7.11.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2022-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203940
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: A Method for Autonomous Multi-Motion Modes Recognition and Navigation Optimization for Indoor Pedestrian.

    Wang, Zhengchun / Xiong, Zhi / Xing, Li / Ding, Yiming / Sun, Yinshou

    Sensors (Basel, Switzerland)

    2022  Band 22, Heft 13

    Abstract: The indoor navigation method shows great application prospects that is based on a wearable foot-mounted inertial measurement unit and a zero-velocity update principle. Traditional navigation methods mainly support two-dimensional stable motion modes such ...

    Abstract The indoor navigation method shows great application prospects that is based on a wearable foot-mounted inertial measurement unit and a zero-velocity update principle. Traditional navigation methods mainly support two-dimensional stable motion modes such as walking; special tasks such as rescue and disaster relief, medical search and rescue, in addition to normal walking, are usually accompanied by running, going upstairs, going downstairs and other motion modes, which will greatly affect the dynamic performance of the traditional zero-velocity update algorithm. Based on a wearable multi-node inertial sensor network, this paper presents a method of multi-motion modes recognition for indoor pedestrians based on gait segmentation and a long short-term memory artificial neural network, which improves the accuracy of multi-motion modes recognition. In view of the short effective interval of zero-velocity updates in motion modes with fast speeds such as running, different zero-velocity update detection algorithms and integrated navigation methods based on change of waist/foot headings are designed. The experimental results show that the overall recognition rate of the proposed method is 96.77%, and the navigation error is 1.26% of the total distance of the proposed method, which has good application prospects.
    Mesh-Begriff(e) Algorithms ; Foot ; Gait ; Humans ; Pedestrians ; Walking
    Sprache Englisch
    Erscheinungsdatum 2022-07-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22135022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Enhanced Sonodynamic Cancer Therapy through Iron-Doping and Oxygen-Vacancy Engineering of Piezoelectric Bismuth Tungstate Nanosheets.

    Ding, Yiming / Zhao, Yunchao / Yao, Shuncheng / Wang, Shaobo / Wan, Xingyi / Hu, Quanhong / Li, Linlin

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Band 19, Heft 24, Seite(n) e2300327

    Abstract: Sonodynamic therapy (SDT) is regarded as a new-rising strategy for cancer treatment with low invasiveness and high tissue penetration, but the scarcity of high-efficiency sonosensitizers has seriously hindered its application. Herein, the iron-doped and ... ...

    Abstract Sonodynamic therapy (SDT) is regarded as a new-rising strategy for cancer treatment with low invasiveness and high tissue penetration, but the scarcity of high-efficiency sonosensitizers has seriously hindered its application. Herein, the iron-doped and oxygen-deficient bismuth tungstate nanosheets (BWO-Fe NSs) with piezotronic effect are synthesized for enhanced SDT. Due to the existence of oxygen defects introduced through Fe doping, the bandgap of BWO-Fe is significantly narrowed so that BWO-Fe can be more easily activated by exogenous ultrasound (US). The oxygen defects acting as the electron traps inhibit the recombination of US-induced electrons and holes. More importantly, the dynamically renewed piezoelectric potential facilitates the migration of electrons and holes to opposite side and causes energy band bending, which further promotes the production of reactive oxygen species. Furthermore, Fe doping endows BWO-Fe with Fenton reactivity, which converts hydrogen peroxide (H
    Mesh-Begriff(e) Mice ; Animals ; Oxygen ; Bismuth ; Ultrasonic Therapy ; Iron ; Reactive Oxygen Species ; Neoplasms/therapy ; Neoplasms/pathology ; Cell Line, Tumor ; Tumor Microenvironment
    Chemische Substanzen Oxygen (S88TT14065) ; Bismuth (U015TT5I8H) ; tungstate (SW0Y0WQ46I) ; Iron (E1UOL152H7) ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202300327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Comprehensive analysis of the LncRNAs, MiRNAs, and MRNAs acting within the competing endogenous RNA network of LGG.

    Ding, Yiming / Liu, Hanjie / Zhang, Chuanbao / Bao, Zhaoshi / Yu, Shuqing

    Genetica

    2022  Band 150, Heft 1, Seite(n) 41–50

    Abstract: Messenger RNA (mRNA) and long noncoding RNA (lncRNA) targets interact via competitive microRNA (miRNA) binding. However, the roles of cancer-specific lncRNAs in the competing endogenous RNA (ceRNA) networks of low-grade glioma (LGG) remain unclear. This ... ...

    Abstract Messenger RNA (mRNA) and long noncoding RNA (lncRNA) targets interact via competitive microRNA (miRNA) binding. However, the roles of cancer-specific lncRNAs in the competing endogenous RNA (ceRNA) networks of low-grade glioma (LGG) remain unclear. This study obtained RNA sequencing data for normal solid tissue and LGG primary tumour tissue from The Cancer Genome Atlas database. We used a computational method to analyse the relationships among the mRNAs, lncRNAs, and miRNAs in these samples. Gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was used to predict the biological processes (BPs) and pathways associated with these genes. Kaplan-Meier survival analysis was used to evaluate the association between the expression levels of specific mRNAs, lncRNAs, and miRNAs and overall survival. Finally, we created a ceRNA network describing the relationships among these mRNAs, lncRNAs, and miRNAs using Cytoscape 3.5.1. A total of 2555 differentially expressed (DE) mRNAs, 218 DElncRNAs, and 192 DEmiRNAs were identified using R. In addition, GO and KEGG pathway analysis of the mRNAs and lncRNAs in the ceRNA network identified 10 BPs, 10 cell components, 10 molecular functions, and 48 KEGG pathways as selectively enriched. A total of 55 lncRNAs, 50 miRNAs, and 10 mRNAs from this network were shown to be closely associated with overall survival in LGG. Finally, 59 miRNAs, 235 mRNAs, and 17 lncRNAs were used to develop a ceRNA network comprising 313 nodes and 1046 edges. This study helps expand our understanding of ceRNA networks and serves to clarify the underlying pathogenesis mechanism of LGG.
    Mesh-Begriff(e) Gene Regulatory Networks ; Glioma ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemische Substanzen MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2022-01-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2165-9
    ISSN 1573-6857 ; 0016-6707
    ISSN (online) 1573-6857
    ISSN 0016-6707
    DOI 10.1007/s10709-021-00145-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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