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  1. Article ; Online: Biliary Viability Assessment and Treatment Options of Biliary Injury During Normothermic Liver Perfusion-A Systematic Review.

    Dingfelder, Jule / Rauter, Laurin / Berlakovich, Gabriela A / Kollmann, Dagmar

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10398

    Abstract: In recent years, significant progress has been made in the field of liver machine perfusion. Many large transplant centers have implemented machine perfusion strategies in their clinical routine. Normothermic machine perfusion (NMP) is primarily used to ... ...

    Abstract In recent years, significant progress has been made in the field of liver machine perfusion. Many large transplant centers have implemented machine perfusion strategies in their clinical routine. Normothermic machine perfusion (NMP) is primarily used to determine the quality of extended criteria donor (ECD) organs and for logistical reasons. The vast majority of studies, which assessed the viability of perfused grafts, focused on hepatocellular injury. However, biliary complications are still a leading cause of post-transplant morbidity and the need for re-transplantation. To evaluate the extent of biliary injury during NMP, reliable criteria that consider cholangiocellular damage are needed. In this review, different approaches to assess damage to the biliary tree and the current literature on the possible effects of NMP on the biliary system and biliary injury have been summarized. Additionally, it provides an overview of novel biomarkers and therapeutic strategies that are currently being investigated. Although expectations of NMP to adequately assess biliary injury are high, scant literature is available. There are several biomarkers that can be measured in bile that have been associated with outcomes after transplantation, mainly including pH and electrolytes. However, proper validation of those and other novel markers and investigation of the pathophysiological effect of NMP on the biliary tree is still warranted.
    MeSH term(s) Biliary Tract ; Biomarkers ; Humans ; Liver ; Liver Transplantation/adverse effects ; Organ Preservation ; Perfusion
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus.

    Kretschmann, S / Völkl, S / Reimann, H / Krönke, G / Schett, G / Achenbach, S / Lutzny-Geier, G / Müller, F / Mougiakakos, D / Dingfelder, J / Flamann, C / Hanssens, L / Gary, R / Mackensen, A / Aigner, M

    Transplantation and cellular therapy

    2022  Volume 29, Issue 1, Page(s) 27–33

    Abstract: Although it has been shown that the production of functional chimeric antigen receptor T cells is feasible in patients with B-cell malignancies, it is currently unclear whether sufficient amounts of functional autologous CAR T cells can be generated from ...

    Abstract Although it has been shown that the production of functional chimeric antigen receptor T cells is feasible in patients with B-cell malignancies, it is currently unclear whether sufficient amounts of functional autologous CAR T cells can be generated from patients with autoimmune diseases. Intrinsic T-cell abnormalities and T-cell-targeted immune suppression in patients with autoimmunity may hamper the retrieval of sufficient T cells and their transduction and expansion into CAR T cells. Patients with active systemic lupus erythematosus (SLE) underwent leukapheresis after tapering glucocorticoids and stopping T-cell-suppressive drugs. This material was used as source for manufacturing anti-CD19 CAR T-cell products (CAR) in clinical scale. Cells were transduced with a lentiviral anti-CD19 CAR vector and expanded under good manufacturing practice (GMP) conditions using a closed, semi-automatic system. Functionality of these CAR T cells derived from autoimmune patient cells was tested in vitro. Six SLE patients were analyzed. Leukapheresis could be successfully performed in all patients yielding sufficient T-cell numbers for clinical scale CAR T-cell production. In addition, CAR T cells showed high expansion rates and viability, leading to CAR T cells in sufficient doses and quality for clinical use. CAR T cells from all patients showed specific cytotoxicity against CD19+ cell lines in vitro. GMP grade generation of CD19 CAR T-cell products suitable for clinical use is feasible in patients with autoimmune disease.
    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; T-Lymphocytes ; Cell Line ; B-Lymphocytes ; Lupus Erythematosus, Systemic/therapy
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2022.10.004
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  3. Article ; Online: Fully Human Anti-CD19 CAR T Cells Derived from Systemic Lupus Erythematosus Patients Exhibit Cytotoxicity with Reduced Inflammatory Cytokine Production.

    Dingfelder, Janin / Aigner, Michael / Taubmann, Jule / Minopoulou, Ioanna / Park, Soo / Kaplan, Charles D / Cheng, Joseph K / Van Blarcom, Tom / Schett, Georg / Mackensen, Andreas / Lutzny-Geier, Gloria

    Transplantation and cellular therapy

    2024  

    Abstract: KYV-101 is an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy under investigation for patients with B-cell driven autoimmune diseases. Hu19-CD828Z is a fully human anti-CD19 CAR designed and demonstrated to have a favorable clinical ... ...

    Abstract KYV-101 is an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy under investigation for patients with B-cell driven autoimmune diseases. Hu19-CD828Z is a fully human anti-CD19 CAR designed and demonstrated to have a favorable clinical safety profile. Since anti-CD19 CAR T cells target and kill B cells in both circulation and tissues, the treatment with Hu19-CD828Z CAR T cells offers great potential in depleting autoreactive B cells. Demonstrate that Hu19-CD828Z CAR T cells manufactured from cryopreserved leukaphereses from patients with systemic lupus erythematosus (SLE) exhibit CAR-mediated and CD19-dependent cytokine release, proliferation and cytotoxicity when co-cultured with autologous primary B cells. T cells were enriched from cryopreserved leukaphereses from SLE patients or healthy donors (HD). CAR T cells were generated by transducing these cells with a lentiviral vector encoding Hu19-CD828Z. CAR-mediated and CD19-dependent activity was monitored in vitro in a set of cytotoxicity, cytokine release, and proliferation studies, in response to autologous primary CD19
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2024.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: [No title information]

    Dingfelder, J / Rauter, L / Kacar, S / Silberhumer, G / Mathé, Z / Salat, A / Györi, G / Soliman, T / Kollmann, D / Berlakovich, G

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 08

    Event/congress 55. Jahrestagung & 32. Fortbildungskurs der Österreichischen Gesellschaft für Gastroenterologie & Hepatologie-ÖGGH (Hybrid Veranstaltung), Wien, 2022-09-07
    Language German
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1755737
    Database Thieme publisher's database

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  5. Article ; Online: Recipient hepatectomy technique may affect oncological outcomes of liver transplantation for hepatocellular carcinoma.

    Pravisani, Riccardo / De Martino, Maria / Mocchegiani, Federico / Melandro, Fabio / Patrono, Damiano / Lauterio, Andrea / Di Francesco, Fabrizio / Ravaioli, Matteo / Zambelli, Marco Fabrizio / Bosio, Claudio / Dondossola, Daniele / Lai, Quirino / Zanchetta, Matteo / Dingfelder, Jule / Toti, Luca / Iacomino, Alessandro / Nicolae, Sermed / Ghinolfi, Davide / Romagnoli, Renato /
    De Carlis, Luciano / Gruttadauria, Salvatore / Cescon, Matteo / Colledan, Michele / Carraro, Amedeo / Caccamo, Lucio / Vivarelli, Marco / Rossi, Massimo / Nadalin, Silvio / Gyori, Georg / Tisone, Giuseppe / Vennarecci, Giovanni / Rostved, Andreas / De Simone, Paolo / Isola, Miriam / Baccarani, Umberto

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  

    Abstract: To date, caval sparing (CS) and total caval replacement (TCR) for recipient hepatectomy in liver transplantation (LT) have been compared only in terms of surgical morbidity. Nonetheless, the CS technique is inherently associated with an increased ... ...

    Abstract To date, caval sparing (CS) and total caval replacement (TCR) for recipient hepatectomy in liver transplantation (LT) have been compared only in terms of surgical morbidity. Nonetheless, the CS technique is inherently associated with an increased manipulation of the native liver and later exclusion of the venous outflow, which may increase the risk of intraoperative shedding of tumor cells when LT is performed for HCC. A multicenter, retrospective study was performed to assess the impact of recipient hepatectomy (CS vs. TCR) on the risk of posttransplant HCC recurrence among 16 European transplant centers that used either TCR or CS recipient hepatectomy as an elective protocol technique. Exclusion criteria comprised cases of non-center-protocol recipient hepatectomy technique, living-donor LT, HCC diagnosis suspected on preoperative imaging but not confirmed at the pathological examination of the explanted liver, HCC in close contact with the IVC, and previous liver resection for HCC. In 2420 patients, CS and TCR approaches were used in 1452 (60%) and 968 (40%) cases, respectively. Group adjustment with inverse probability weighting was performed for high-volume center, recipient age, alcohol abuse, viral hepatitis, Child-Pugh class C, Model for End-Stage Liver Disease score, cold ischemia time, clinical HCC stage within Milan criteria, pre-LT downstaging/bridging therapies, pre-LT alphafetoprotein serum levels, number and size of tumor nodules, microvascular invasion, and complete necrosis of all tumor nodules (matched cohort, TCR, n = 938; CS, n = 935). In a multivariate cause-specific hazard model, CS was associated with a higher risk of HCC recurrence (HR: 1.536, p = 0.007). In conclusion, TCR recipient hepatectomy, compared to the CS approach, may be associated with some protective effect against post-LT tumor recurrence.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000373
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  6. Book ; Thesis: Search for anomalous production of single top quarks with the H1 experiment at HERA

    Dingfelder, Jochen

    2003  

    Author's details [presented by Jochen Dingfelder]
    Language English
    Size III, 173 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Heidelberg, 2003
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article: Prostaglandin inhibitors: new treatment for an old nemesis.

    Dingfelder, J R

    The New England journal of medicine

    1982  Volume 307, Issue 12, Page(s) 746–747

    MeSH term(s) Dysmenorrhea/drug therapy ; Female ; Humans ; Prostaglandin Antagonists/therapeutic use ; Prostaglandins/physiology ; Tolmetin/analogs & derivatives ; Tolmetin/therapeutic use
    Chemical Substances Prostaglandin Antagonists ; Prostaglandins ; zomepirac (822G987U9J) ; Tolmetin (D8K2JPN18B)
    Language English
    Publishing date 1982-09-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM198209163071210
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  8. Article: A search for cells carrying the gamma/delta T cell receptor in mice infected with Leishmania major.

    Lohoff, M / Dingfelder, J / Röllinghoff, M

    Current topics in microbiology and immunology

    1991  Volume 173, Page(s) 285–289

    MeSH term(s) Animals ; Female ; Leishmania tropica ; Leishmaniasis, Cutaneous/immunology ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocyte Subsets/immunology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 1991
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-76492-9_39
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  9. Article: Primary dysmenorrhea treatment with prostaglandin inhibitors: a review.

    Dingfelder, J R

    American journal of obstetrics and gynecology

    1981  Volume 140, Issue 8, Page(s) 874–879

    MeSH term(s) Adolescent ; Adult ; Dysmenorrhea/drug therapy ; Female ; Humans ; Ibuprofen/therapeutic use ; Indomethacin/therapeutic use ; Middle Aged ; Naproxen/therapeutic use ; Phenylbutazone/therapeutic use ; Prostaglandin Antagonists/therapeutic use ; ortho-Aminobenzoates/therapeutic use
    Chemical Substances Prostaglandin Antagonists ; ortho-Aminobenzoates ; Naproxen (57Y76R9ATQ) ; fenamic acid (952VN06WBB) ; Phenylbutazone (GN5P7K3T8S) ; Ibuprofen (WK2XYI10QM) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 1981-08-15
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/0002-9378(81)90077-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um I Zs.152: Show issues Location:
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  10. Book ; Thesis: Beitrag zur Lehre von der Sehsphäre

    Dingfelder, Johann

    1895  

    Author's details Johann Dingfelder [aus Lipprichhausen]
    Language German
    Size 30 Seiten, 8°
    Publisher Neue Bayerischen Landeszeitung
    Publishing place Würzburg
    Publishing country XA-DXDE
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Erlangen, 1890
    HBZ-ID HT021392492
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Eu. Diss. Erlangen 1890: Dingfelder order to use in reading room Magazin

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