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  1. Article ; Online: Healthcare center-based cell therapy laboratories supporting off-site manufactured cell therapies: The experiences of a single academic cell therapy laboratory.

    Dinh, Anh / Stroncek, David F

    Transfusion

    2024  Volume 64, Issue 2, Page(s) 357–366

    Abstract: Background: Healthcare center-based cell therapy laboratories (HC CTLs) evolved from solely processing hematopoietic stem cells for transplantation to manufacturing various advanced cellular therapies. With increasing interest in cellular therapy ... ...

    Abstract Background: Healthcare center-based cell therapy laboratories (HC CTLs) evolved from solely processing hematopoietic stem cells for transplantation to manufacturing various advanced cellular therapies. With increasing interest in cellular therapy applications, off-site manufactured products are becoming more common. HC CTLs play a critical role in supporting these products by shipping out cellular starting material (CSM) for further manufacturing and/or receiving, storing, and distributing final products. The experiences and challenges encountered by a single academic HC CTL in supporting these products are presented.
    Methods: All off-site manufacturing protocols supported before 2023 were reviewed. Collected data included protocol characteristics (treatment indication, product type), process logistics (shipping, receiving, storage, thawing, distribution, documentation), and product handling volumes (CSM shipping and final product infusions).
    Results: Between 2012 and 2022, 15 off-site manufactured cellular therapy early-phase, single- and multicenter clinical trials were supported. Trials were sponsored by academic/research and commercial entities. The number of protocols supported annually increased each year, with few ending. Products included cancer immunotherapies and gene therapies. Autologous CSM was collected and shipped, while autologous and allogeneic final products were received, stored, thawed, and distributed. Process differences among protocols included CSM shipping conditions, laboratory analyses, final product thaw conditions and procedures, number of treatments, and documentation.
    Discussion: HC CTLs must contend with several challenges in supporting off-site manufacturing protocols. As demand for cellular therapies increases, stakeholders should collaborate from the early phases of clinical trials to streamline processes and standardize procedures to increase value, improve safety, and reduce the burden on HC CTLs.
    MeSH term(s) Humans ; Laboratories ; Hematopoietic Stem Cells ; Cell- and Tissue-Based Therapy ; Immunotherapy ; Delivery of Health Care
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Expanding the reach of commercial cell therapies requires changes at medical centers.

    Stroncek, David F / Zhang, Nan / Ren, Jiaqiang / Somerville, Rob / Dinh, Anh

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 181

    Abstract: The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. ... ...

    Abstract The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. However, cell therapies are now increasingly being produced in centralized manufacturing facilities and shipped to medical centers for administration. Typically, these cell therapies are produced from a patient's own cells, which are the critical starting material. For these therapies to achieve their full potential, more medical centers must develop the infrastructure to collect, label, cryopreserve, test, and ship these cells to the centralized laboratories where these cell therapies are manufactured. Medical centers must also develop systems to receive, store, and infuse the finished cell therapy products. Since most cell therapies are cryopreserved for shipment and storage, medical centers using these therapies will require access to liquid nitrogen product storage tanks and develop procedures to thaw cell therapies. These services could be provided by the hospital pharmacy or transfusion service, but the latter is likely most appropriate. Another barrier to implementing these services is the variability among providers of these cell therapies in the processes related to handling cell therapies. The provision of these services by medical centers would be facilitated by establishing a national coordinating center and a network of apheresis centers to collect and cryopreserve the cells needed to begin the manufacturing process and cell therapy laboratories to store and issue the cells. In addition to organizing cell collections, the coordinating center could establish uniform practices for collecting, labeling, shipping, receiving, thawing, and infusing the cell therapy.
    MeSH term(s) Humans ; Academic Medical Centers ; Cell- and Tissue-Based Therapy
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04966-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Growth and Distribution of Boron in Oilseed Rape (

    Dinh, Anh Quang / Naeem, Asif / Mühling, Karl H

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 20

    Abstract: Oilseed rape ( ...

    Abstract Oilseed rape (
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11202746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Giant-Cell Ependymoma of the Cervical Spinal Cord With Syringomyelia and Pathological Presentation: A Case Report and Review of the Literature.

    Thi Phuong Dinh, Hoai / Tomohiko, Hasegawa / Madelar, Rina T / Dinh Anh Hoang, Hao / Yukihiro, Matsuyama

    Cureus

    2022  Volume 14, Issue 12, Page(s) e33174

    Abstract: Ependymomas are unusual neuroepithelial tumors of the central nervous system that arise from clusters of ependymal cells. In adults, ependymomas are the most common primary spinal cord tumors. Nevertheless, only a few cases of large-cell ependymoma have ... ...

    Abstract Ependymomas are unusual neuroepithelial tumors of the central nervous system that arise from clusters of ependymal cells. In adults, ependymomas are the most common primary spinal cord tumors. Nevertheless, only a few cases of large-cell ependymoma have been documented; these cases often involve the brain. Here, we report the case of a 43-year-old man who had a cervical spinal cord ependymoma with syringomyelia. The giant-cell ependymoma (GCE) in the spinal cord discussed in this case emphasizes the characteristics of GCE and the discrepancy between the pathological appearance, the surgical results, and the clinically good prognosis.
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.33174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adaptive-Cognitive Kalman Filter and Neural Network for an Upgraded Nondispersive Thermopile Device to Detect and Analyze Fusarium Spores.

    Pham, Son / Dinh, Anh

    Sensors (Basel, Switzerland)

    2019  Volume 19, Issue 22

    Abstract: Noises such as thermal noise, background noise or burst noise can reduce the reliability and confidence of measurement devices. In this work, a recursive and adaptive Kalman filter is proposed to detect and process burst noise or outliers and thermal ... ...

    Abstract Noises such as thermal noise, background noise or burst noise can reduce the reliability and confidence of measurement devices. In this work, a recursive and adaptive Kalman filter is proposed to detect and process burst noise or outliers and thermal noise, which are popular in electrical and electronic devices. The Kalman filter and neural network are used to preprocess data of three detectors of a nondispersive thermopile device, which is used to detect and quantify Fusarium spores. The detectors are broadband (1 µm to 20 µm), λ 1 (6.09 ± 0.06 µm) and λ 2 (9.49 ± 0.44 µm) thermopiles. Additionally, an artificial neural network (NN) is applied to process background noise effects. The adaptive and cognitive Kalman Filter helps to improve the training time of the neural network and the absolute error of the thermopile data. Without applying the Kalman filter for λ 1 thermopile, it took 12 min 09 s to train the NN and reach the absolute error of 2.7453 × 10
    MeSH term(s) Algorithms ; Fusarium ; Neural Networks, Computer ; Spores, Fungal
    Language English
    Publishing date 2019-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s19224900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Next-generation sequencing technologies: An overview.

    Hu, Taishan / Chitnis, Nilesh / Monos, Dimitri / Dinh, Anh

    Human immunology

    2021  Volume 82, Issue 11, Page(s) 801–811

    Abstract: Since the days of Sanger sequencing, next-generation sequencing technologies have significantly evolved to provide increased data output, efficiencies, and applications. These next generations of technologies can be categorized based on read length. This ...

    Abstract Since the days of Sanger sequencing, next-generation sequencing technologies have significantly evolved to provide increased data output, efficiencies, and applications. These next generations of technologies can be categorized based on read length. This review provides an overview of these technologies as two paradigms: short-read, or "second-generation," technologies, and long-read, or "third-generation," technologies. Herein, short-read sequencing approaches are represented by the most prevalent technologies, Illumina and Ion Torrent, and long-read sequencing approaches are represented by Pacific Biosciences and Oxford Nanopore technologies. All technologies are reviewed along with reported advantages and disadvantages. Until recently, short-read sequencing was thought to provide high accuracy limited by read-length, while long-read technologies afforded much longer read-lengths at the expense of accuracy. Emerging developments for third-generation technologies hold promise for the next wave of sequencing evolution, with the co-existence of longer read lengths and high accuracy.
    MeSH term(s) DNA Probes, HLA ; Genotyping Techniques/instrumentation ; Genotyping Techniques/methods ; HLA Antigens/genetics ; High-Throughput Nucleotide Sequencing/instrumentation ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Sequence Analysis, DNA/instrumentation ; Sequence Analysis, DNA/methods
    Chemical Substances DNA Probes, HLA ; HLA Antigens
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2021.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Estimation of the Chlorophyll-A Concentration of Algae Species Using Electrical Impedance Spectroscopy

    Basak, Rinku / Wahid, Khan A / Dinh, Anh

    Water. 2021 Apr. 28, v. 13, no. 9

    2021  

    Abstract: Algae are a significant component of a biological monitoring program in an aquatic ecosystem. They are ideally suited for water quality assessments because of their nutrient requirements, rapid reproduction rate, and very short life cycle. Algae ... ...

    Abstract Algae are a significant component of a biological monitoring program in an aquatic ecosystem. They are ideally suited for water quality assessments because of their nutrient requirements, rapid reproduction rate, and very short life cycle. Algae composition and temporal variation in abundances are important in determining the trophic level of lakes, and those can be estimated by the Chlorophyll-a (Chl-a) concentration of the species. In this work, a non-destructive method was employed to estimate the Chlorophyll-a concentration of multiple algae species using electrical impedance spectroscopy (EIS). The proposed EIS method is rapid, cheaper, and suitable for in situ measurements compared with the other available non-destructive methods, such as spectrophotometry and hyperspectral or multispectral imaging. The electrical impedances in different frequencies ranging from 1 to 100 kHz were observed using an impedance converter system. Significant observations were identified within 3.5 kHz for multiple algae species and therefore reported in the results. A positive correlation was found between the Chlorophyll-a and the measured impedance of algae species at different frequencies. Later, EIS models were developed for the species in 1–3.5 kHz. A correlation of 90% was found by employing a least squares method and multiple linear regression. The corresponding coefficients of determination were obtained as 0.9, 0.885, and 0.915, respectively for 49 samples of Spirulina, 41 samples of Chlorella, and 26 samples of mixed algae species. The models were later validated using a new and separate set of samples of algae species.
    Keywords Chlorella ; Spirulina ; aquatic ecosystems ; chlorophyll ; dielectric spectroscopy ; nondestructive methods ; reproduction ; temporal variation ; trophic levels ; water ; water quality
    Language English
    Dates of publication 2021-0428
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w13091223
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Using Moving Average Method to Recognize Systole and Diastole on Seismocardiogram without ECG Signal.

    Luu, Loc / Dinh, Anh

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2018  Volume 2018, Page(s) 3796–3799

    Abstract: Seismocardiogram (SCG) is a cardio-mechanical signal generated by the heart activities and it can be obtained by placing an accelerometer on the chest. Recently, SCG was used to estimate heart operation by evaluating systolic and diastolic events but the ...

    Abstract Seismocardiogram (SCG) is a cardio-mechanical signal generated by the heart activities and it can be obtained by placing an accelerometer on the chest. Recently, SCG was used to estimate heart operation by evaluating systolic and diastolic events but the SCG must be coupled to the ECG timing in order to analyze and recognize the events on the SCG waveform. In this study, a low complex algorithm is proposed to identify the regions containing systolic and diastolic points in real time without referencing to the ECG. The method uses the slope, a moving average threshold, and systolic interval constraint to identify the systoles and diastoles. The ECG signal was also collected for manual annotation and comparison. This moving average method has an average error rate of 4% for systolic detection and 9% for diastolic detection on the eight testing subjects. The average processing time of the moving average method is 75.2ms for one-minute data which is suitable for realtime wearable device for healthcare applications.
    MeSH term(s) Algorithms ; Diastole ; Electrocardiography ; Heart ; Systole
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2018.8513297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Artifact Noise Removal Techniques on Seismocardiogram Using Two Tri-Axial Accelerometers.

    Luu, Loc / Dinh, Anh

    Sensors (Basel, Switzerland)

    2018  Volume 18, Issue 4

    Abstract: The aim of this study is on the investigation of motion noise removal techniques using two-accelerometer sensor system and various placements of the sensors on gentle movement and walking of the patients. A Wi-Fi based data acquisition system and a ... ...

    Abstract The aim of this study is on the investigation of motion noise removal techniques using two-accelerometer sensor system and various placements of the sensors on gentle movement and walking of the patients. A Wi-Fi based data acquisition system and a framework on Matlab are developed to collect and process data while the subjects are in motion. The tests include eight volunteers who have no record of heart disease. The walking and running data on the subjects are analyzed to find the minimal-noise bandwidth of the SCG signal. This bandwidth is used to design filters in the motion noise removal techniques and peak signal detection. There are two main techniques of combining signals from the two sensors to mitigate the motion artifact: analog processing and digital processing. The analog processing comprises analog circuits performing adding or subtracting functions and bandpass filter to remove artifact noises before entering the data acquisition system. The digital processing processes all the data using combinations of total acceleration and z-axis only acceleration. The two techniques are tested on three placements of accelerometer sensors including horizontal, vertical, and diagonal on gentle motion and walking. In general, the total acceleration and z-axis acceleration are the best techniques to deal with gentle motion on all sensor placements which improve average systolic signal-noise-ratio (SNR) around 2 times and average diastolic SNR around 3 times comparing to traditional methods using only one accelerometer. With walking motion, ADDER and z-axis acceleration are the best techniques on all placements of the sensors on the body which enhance about 7 times of average systolic SNR and about 11 times of average diastolic SNR comparing to only one accelerometer method. Among the sensor placements, the performance of horizontal placement of the sensors is outstanding comparing with other positions on all motions.
    Language English
    Publishing date 2018-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s18041067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: One-Time Foliar Application and Continuous Resupply via Roots Equally Improved the Growth and Physiological Response of B-Deficient Oilseed Rape.

    Dinh, Anh Quang / Naeem, Asif / Sagervanshi, Amit / Mühling, Karl H

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: Oilseed rape ( ...

    Abstract Oilseed rape (
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10050866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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