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  1. Book: Nanoparticle-Mediated Immunotherapy

    Vo-Dinh, Tuan

    (Bioanalysis)

    2021  

    Author's details Tuan Vo-Dinh is R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering, Professor of Chemistry, and Director of the Fitzpatrick Institute for Photonics at Duke University. Dr. Vo-Dinh completed high school education in Saigon (now Ho Chi Minh City) and pursued studies in Europe where he received a B.S. in physics in 1970 from EPFL (Ecole Polytechnique Federal de Lausanne), Lausanne and a Ph.D. in physical chemistry in 1975 from ETH (Swiss Federal Institute of Technology), Zurich, Switzerland. Before joining Duke University in 2006, Dr. Vo-Dinh was Director of the Center for Advanced Biomedical Photonics, Group Leader of Advanced Biomedical Science and Technology Group, and a Corporate Fellow, one of the highest honors for distinguished scientists at Oak Ridge National Laboratory (ORNL). His research has focused on the development of advanced technologies for the protection of the environment and the improvement of human health. His research activities invol
    Series title Bioanalysis
    Keywords multifunctionnanoparticlesinmedicine ; CancerNanotechnology ; nanoparticlecancertreatment ; nanomedicineinoncology ; cancertreatmentnanotechnology ; Cancerimmunotherapy ; multifunction nanoparticles in medicine ; cancer nanotechnology ; nanoparticle cancer treatment ; nanomedicine in oncology ; cancer treatment nanotechnology ; cancer immunotherapy
    Language English
    Size 276 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_11
    Format 160 x 241 x 21
    ISBN 9783030783372 ; 3030783375
    Database PDA

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  2. Book ; Online: Intelligent and Efficient Transport Systems : Design, Modelling, Control and Simulation

    Quang Dinh, Truong

    2020  

    Keywords Transport technology & trades
    Size 1 electronic resource (210 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021045992
    ISBN 9781838805111 ; 1838805117
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Global Perspective on Diabetic Foot Ulcerations

    Dinh, Thanh

    2011  

    Keywords Endocrinology
    Size 1 electronic resource (290 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046125
    ISBN 9789535166023 ; 9535166026
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Solution-Based Ultra-Sensitive Surface-Enhanced Raman Scattering Detection of the Toxin Bacterial Biomarker Pyocyanin in Biological Fluids Using Sharp-Branched Gold Nanostars.

    Atta, Supriya / Vo-Dinh, Tuan

    Analytical chemistry

    2023  Volume 95, Issue 5, Page(s) 2690–2697

    Abstract: There is a critical need for sensitive rapid point-of-care detection of bacterial infection biomarkers in complex biological fluids with minimal sample preparation, which can improve early-stage diagnosis and prevent several bacterial infections and ... ...

    Abstract There is a critical need for sensitive rapid point-of-care detection of bacterial infection biomarkers in complex biological fluids with minimal sample preparation, which can improve early-stage diagnosis and prevent several bacterial infections and fatal diseases. A solution-based surface-enhanced Raman scattering (SERS) detection platform has long been sought after for low cost, rapid, and on-site detection of analyte molecules, but current methods still exhibit poor sensitivity. In this study, we have tuned the morphology of the surfactant-free gold nanostars (GNSs) to achieve sharp protruding spikes for maximum SERS enhancement. We have controlled the GNS spike morphologies and optimized SERS performance in the solution phase using para-mercaptobenzoic acid as an SERS probe. To illustrate the potential for point-of-care applications, we have utilized a portable Raman instrument for measurements. For pathogenic agent sensing applications, we demonstrated rapid and sensitive detection of the toxin biomarker pyocyanin (PYO) used as the bacterial biomarker model system. Pyocyanin is a toxic compound produced and secreted by the common water-borne Gram-negative bacterium
    MeSH term(s) Humans ; Drinking Water ; Pyocyanine/analysis ; Spectrum Analysis, Raman/methods ; Gold ; Biomarkers ; Metal Nanoparticles
    Chemical Substances Drinking Water ; Pyocyanine (9OQM399341) ; Gold (7440-57-5) ; Biomarkers
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c03210
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    Zs.A 4033: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: A hybrid plasmonic nanoprobe using polyvinylpyrrolidone-capped bimetallic silver-gold nanostars for highly sensitive and reproducible solution-based SERS sensing.

    Atta, Supriya / Vo-Dinh, Tuan

    The Analyst

    2023  Volume 148, Issue 8, Page(s) 1786–1796

    Abstract: Practical solution-based assays using surface-enhanced Raman spectroscopy (SERS) with portable instrumentation are currently of particular interest for rapid, efficient, and low-cost detection of analytes. However, current assays still have limited ... ...

    Abstract Practical solution-based assays using surface-enhanced Raman spectroscopy (SERS) with portable instrumentation are currently of particular interest for rapid, efficient, and low-cost detection of analytes. However, current assays still have limited applicability due to their poor sensitivity and reproducibility. Herein, we demonstrate highly stable polyvinylpyrrolidone (PVP)-capped bimetallic silver-coated gold nanostars (BGNS-Ag-PVP) as a solution-based SERS nanoprobe that is capable of producing a strong, uniform, and reproducible SERS signal using a portable Raman instrument. The developed hybrid BGNS-Ag-PVP nanostructure shows tunable optical properties with improved SERS sensitivity and reproducibility as compared to gold nanostars. We have synthesized bimetallic nanoprobes BGNS-Ag-PVP having three different silvers, referred to as BGNS-Ag-PVP-1, BGNS-Ag-PVP-2, and BGNS-Ag-PVP-3. The SERS performance of BGNS-Ag-PVP was studied using methylene blue (Meb) as a probe molecule, and we achieved a detection limit of up to 10 nM indicating the high sensitivity of the solution-based SERS platform. The application of such bimetallic nanoparticles is demonstrated
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d2an01876d
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    Zs.A 2423: Show issues Location:
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  6. Article ; Online: Ultra-trace SERS detection of cocaine and heroin using bimetallic gold-silver nanostars (BGNS-Ag).

    Atta, Supriya / Vo-Dinh, Tuan

    Analytica chimica acta

    2023  Volume 1251, Page(s) 340956

    Abstract: A rapid, in-field, and reliable method for the detection of illegal drugs of abuse in biological fluids without any sample pretreatment would potentially be helpful for law enforcement, drug control officials, and public healthcare. In this study, we ... ...

    Abstract A rapid, in-field, and reliable method for the detection of illegal drugs of abuse in biological fluids without any sample pretreatment would potentially be helpful for law enforcement, drug control officials, and public healthcare. In this study, we presented a cost-effective and highly reproducible solution-based surface-enhanced Raman scattering (SERS) platform utilizing a portable Raman instrument for fast sensitive SERS detection of illegal drugs, such as cocaine, and heroin in human urine without any sample preprocessing. The SERS platform was constructed for the first time by combining the superior SERS enhancement properties of bimetallic silver-coated gold nanostars (BGNS-Ag) and the advantages of suitable alkaline metal salts such as NaI for SERS signal amplification. The effects of the silver thickness of BGNS-Ag and alkaline salts on the SERS performance were investigated in detail; we observed that the maximum SERS enhancement was obtained for BGNS-Ag with the maximum silver thickness (54 ± 5 nm) in presence of NaI salt. Our SERS platform shows ultra-high sensitivity of cocaine and heroin with a limit of detection (LOD) as low as 10 pg/mL for cocaine and 100 pg/mL for heroin, which was 100 times lower than that of the traditional silver nanoparticle-based illegal drug detection. As a demonstration, the platform was further applied to detect cocaine and heroin spiked in human urine without any sample preprocessing achieving a LOD of 100 pg/mL for cocaine and 1 ng/mL for heroin. Overall, our SERS detection platform shows potential for rapid, onsite, ultra-low-cost portable applications for trace detection of illegal drugs and biomarkers.
    MeSH term(s) Humans ; Silver ; Gold ; Heroin ; Metal Nanoparticles ; Cocaine ; Salts ; Spectrum Analysis, Raman/methods ; Biglycan
    Chemical Substances Silver (3M4G523W1G) ; Gold (7440-57-5) ; Heroin (70D95007SX) ; Cocaine (I5Y540LHVR) ; Salts ; BGN protein, human ; Biglycan
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.340956
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  7. Article ; Online: Fallopian Tube Dermoid Tumor.

    Horton, Toni / Dinh, Tri

    Journal of minimally invasive gynecology

    2023  Volume 31, Issue 1, Page(s) 3–4

    MeSH term(s) Female ; Humans ; Dermoid Cyst/diagnosis ; Dermoid Cyst/surgery ; Dermoid Cyst/pathology ; Fallopian Tubes/pathology ; Fallopian Tube Neoplasms/diagnosis ; Fallopian Tube Neoplasms/surgery ; Fallopian Tube Neoplasms/pathology ; Teratoma/pathology
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2023.09.008
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    Zs.A 4205: Show issues Location:
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  8. Article ; Online: A simple low-cost flexible plasmonic patch based on spiky gold nanostars for ultra-sensitive SERS sensing.

    Atta, Supriya / Canning, Aidan J / Vo-Dinh, Tuan

    The Analyst

    2024  Volume 149, Issue 7, Page(s) 2084–2096

    Abstract: Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces. In this study, we proposed a simple cost-effective ... ...

    Abstract Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces. In this study, we proposed a simple cost-effective strategy to develop a flexible SERS patch utilizing multibranched sharp spiked gold nanostars (GNS) decorated on a commercially available adhesive Scotch Tape for achieving ultra-high SERS sensitivity. The experimental SERS measurements were correlated with theoretical finite element modeling (FEM), which indicates that the GNS having a 2.5 nm branch tip diameter (GNS-4) exhibits the strongest SERS enhancement. Using rhodamine 6G (R6G) as a model analyte, the SERS performance of the flexible SERS patch exhibited a minimum detection limit of R6G as low as 1 pM. The enhancement factor of the SERS patch with GNS-4 was calculated as 6.2 × 10
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an02246c
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    Zs.A 2423: Show issues Location:
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  9. Article ; Online: Caged gold nanostars: a novel plasmonic nanoplatform with potential theranostic applications.

    Canning, Aidan J / Vo-Dinh, Tuan

    Nanoscale

    2024  Volume 16, Issue 18, Page(s) 8828–8835

    Abstract: Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS ... ...

    Abstract Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS particles and highlight the benefits of the galvanic replacement-free approach. FEM simulations explore the enhanced plasmonic properties of this novel nanoparticle morphology. Finally, in a proof-of-concept study, we successfully demonstrate
    MeSH term(s) Gold/chemistry ; Animals ; Theranostic Nanomedicine ; Mice ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Humans ; Photothermal Therapy ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Cell Line, Tumor ; Female
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr04130a
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  10. Article ; Online: Rapid SERS assay for determination of the opioid fentanyl using silver-coated sharply branched gold nanostars.

    Atta, Supriya / Canning, Aidan J / Vo-Dinh, Tuan

    Mikrochimica acta

    2024  Volume 191, Issue 2, Page(s) 110

    Abstract: A high-throughput surface-enhanced Raman scattering (SERS)-sensing platform is presented for FNT detection in human urine without any sample preparation. The sensing platform is based on plasmonics-active silver-coated sharply branched gold nanostars ( ... ...

    Abstract A high-throughput surface-enhanced Raman scattering (SERS)-sensing platform is presented for FNT detection in human urine without any sample preparation. The sensing platform is based on plasmonics-active silver-coated sharply branched gold nanostars (SGNS). The effect of silver thickness was investigated experimentally and theoretically, and the results indicated that SERS enhancement was maximum at an optimum silver thickness of 45 nm on the sharply spiked SGNS. The proposed high-throughput SERS platform exhibited ultrahigh sensitivity and excellent enhancement uniformity for a model analyte, i.e., crystal violet. Moreover, the SERS-sensing platform demonstrated good sensitivity of FNT spiked in human urine samples with two differential linear response ranges of 2 to 0.2 µg/mL and 0.1 µg/mL to 100 pg/mL, respectively,  with a detection limit as low as 10.02 pg/mL. The spiked human urine samples show satisfactory recovery values from 92.5 to 102% with relative standard deviations (RSD) of less than 10%. In summary, the high-throughput performance of the proposed microplate-based SERS platform demonstrated great potential for rapid low-cost SERS-based sensing applications.
    MeSH term(s) Humans ; Analgesics, Opioid ; Fentanyl ; Silver ; Biological Assay ; Gold
    Chemical Substances Analgesics, Opioid ; Fentanyl (UF599785JZ) ; Silver (3M4G523W1G) ; Gold (7440-57-5)
    Language English
    Publishing date 2024-01-22
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-06172-5
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