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  1. Article ; Online: COVID-19 drive-through testing survey: Measuring the burden on healthcare workers.

    Smith, Aaron A / Akerson, Joie / Danahey, James / Dinh, Tam N M / Porter, Paul S

    Journal of the American College of Emergency Physicians open

    2020  Volume 1, Issue 6, Page(s) 1444–1449

    Abstract: Objective: To survey individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at 1 of 4 Trinity Health of New England drive-through testing centers to assess their demographic information, hospitalization rate, ... ...

    Abstract Objective: To survey individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at 1 of 4 Trinity Health of New England drive-through testing centers to assess their demographic information, hospitalization rate, preexisting conditions, possible routes of exposures, duration of symptoms, and subsequent household infections of healthcare workers (HCWs) when compared to non-HCWs.
    Methods: Data were collected via a telephone survey using a standardized script. Between March 1, 2020 and June 17, 2020, 28,903 people were tested at 4 Connecticut drive-through testing centers. Individuals who tested positive between March 16 and April 21, 2020 were randomly contacted. Of those individuals, 100 people agreed to complete the survey. Bivariate analysis and logistic regression were performed.
    Results: HCWs comprised 46% of the 100 survey respondents during the study period. Similarly, HCWs comprised 42.1% of all individuals who tested positive and listed an employer between March 1 and June 17, 2020. HCWs reported a longer duration of symptoms (17.39 vs 13.44 days) and were more likely to report work as their route of exposure (80.4% vs 27.8%) than non-HCWs.
    Conclusions: HCWs may face a disproportionate risk of contracting COVID-19 and self-report a longer duration of symptoms than the general public. The data suggest a need for an increased recovery time away from work than is currently recommended by the Centers for Disease Control and Prevention, as well as an increase in infection precautions for HCWs.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.12286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID‐19 drive‐through testing survey: Measuring the burden on healthcare workers

    Smith, Aaron A. / Akerson, Joie / Danahey, James / Dinh, Tam N.M. / Porter, Paul S.

    J Am Coll Emerg Physicians Open

    Abstract: OBJECTIVE: To survey individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at 1 of 4 Trinity Health of New England drive‐through testing centers to assess their demographic information, hospitalization rate, ... ...

    Abstract OBJECTIVE: To survey individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at 1 of 4 Trinity Health of New England drive‐through testing centers to assess their demographic information, hospitalization rate, preexisting conditions, possible routes of exposures, duration of symptoms, and subsequent household infections of healthcare workers (HCWs) when compared to non‐HCWs. METHODS: Data were collected via a telephone survey using a standardized script. Between March 1, 2020 and June 17, 2020, 28,903 people were tested at 4 Connecticut drive‐through testing centers. Individuals who tested positive between March 16 and April 21, 2020 were randomly contacted. Of those individuals, 100 people agreed to complete the survey. Bivariate analysis and logistic regression were performed. RESULTS: HCWs comprised 46% of the 100 survey respondents during the study period. Similarly, HCWs comprised 42.1% of all individuals who tested positive and listed an employer between March 1 and June 17, 2020. HCWs reported a longer duration of symptoms (17.39 vs 13.44 days) and were more likely to report work as their route of exposure (80.4% vs 27.8%) than non‐HCWs. CONCLUSIONS: HCWs may face a disproportionate risk of contracting COVID‐19 and self‐report a longer duration of symptoms than the general public. The data suggest a need for an increased recovery time away from work than is currently recommended by the Centers for Disease Control and Prevention, as well as an increase in infection precautions for HCWs.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1002/emp2.12286
    Database COVID19

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  3. Article: Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin II.

    Wang, Yutang / Dinh, Tam N / Nield, Alexander / Krishna, Smriti M / Denton, Kate / Golledge, Jonathan

    Frontiers in physiology

    2017  Volume 8, Page(s) 215

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2017-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2017.00215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CD4⁺CD25⁺Foxp3⁺ regulatory T cells suppress cardiac fibrosis in the hypertensive heart.

    Kanellakis, Peter / Dinh, Tam N / Agrotis, Alex / Bobik, Alexander

    Journal of hypertension

    2011  Volume 29, Issue 9, Page(s) 1820–1828

    Abstract: Background: CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs) are potent inhibitors of inflammation and autoimmune diseases. Because inflammation has been associated with development of cardiac fibrosis in experimental hypertension, here we investigated ... ...

    Abstract Background: CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs) are potent inhibitors of inflammation and autoimmune diseases. Because inflammation has been associated with development of cardiac fibrosis in experimental hypertension, here we investigated whether adoptively transferred Tregs would inhibit development of cardiac fibrosis initiated by elevating blood pressure.
    Methods: Cardiac fibrosis was induced in mice by constricting the aorta between the two carotid arteries. Immediately after the operation mice received either vehicle or purified, cultured Tregs (1.5 × 10⁶). Fourteen days later we assessed effects on developing left ventricular fibrosis, blood pressure, inflammation, myofibroblasts and the transforming growth factor-beta1 (TGF-β1) system.
    Results: Fourteen days after aortic constriction, marked left-ventricular fibrosis was apparent and this was greatly reduced in mice receiving adoptively transferred Tregs. This reduction in fibrosis was associated with attenuated inflammatory cell numbers, reduced interstitial myofibroblast numbers and attenuated activity of the TGF-β1 system, indicated by reductions in the expression of TGF-β1 and its receptors activin-like kinase-5 and type II TGF-β receptor. Adoptively transferred Tregs did not affect blood pressure and exerted only a small effect on left-ventricular hypertrophy.
    Conclusions: These data indicate that Tregs attenuate cardiac fibrosis associated with hypertensive heart disease by suppressing inflammation.
    MeSH term(s) Animals ; CD4 Antigens/immunology ; Fibrosis ; Forkhead Transcription Factors/immunology ; Heart ; Hypertension/immunology ; Hypertension/pathology ; Interleukin-2 Receptor alpha Subunit/immunology ; Male ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances CD4 Antigens ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Interleukin-2 Receptor alpha Subunit
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0b013e328349c62d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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