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  1. Article ; Online: Patient-provider relationships

    Eric Ardman / Patrick C.M. Brown / Dinh Thi Thanh Thuy / Nguyen Thu Hang / Pham Phuong Mai / Gavin Bart / Kim Hoffman / P Todd Korthuis / Le Minh Giang

    Drug and Alcohol Dependence Reports, Vol 7, Iss , Pp 100151- (2023)

    Opioid use disorder and HIV treatment in Vietnam

    2023  

    Abstract: Background: The provider-patient relationship has been implicated as a positive force in health outcomes. This study examined the provider-patient relationship in the setting of integrated, partially-integrated, and non-integrated opioid use disorder ( ... ...

    Abstract Background: The provider-patient relationship has been implicated as a positive force in health outcomes. This study examined the provider-patient relationship in the setting of integrated, partially-integrated, and non-integrated opioid use disorder (OUD) and HIV care models in Vietnam. Objective: To examine the provider-patient relationship in the setting of integrated, partially integrated, and non-integrated OUD and HIV treatment in North Vietnam. Methods: Between 2013 and 2018, we conducted face-to-face qualitative interviews with 44 patients living with HIV and OUD and 43 providers in northern Vietnam. These were analyzed using a semantic, inductive approach to qualitative thematic analysis. Results: Several themes were identified. 1) Trust was important to the patient-provider relationship and sensitive to provider attitudes and competence. 2) Patients perceived greater provider competence and understanding of patient health problems in integrated treatment. 3) Patient-provider relationships were initially superficial but deepened over time, facilitated by continuity of care. Conclusions: Patient perceptions of competence and respect were important to feeling cared for. Providers felt empathy and competence came with more experience caring for patients with OUD and HIV.
    Keywords Patient-provider relationship ; Suboxone ; Methadone ; HIV care ; Treatment integration ; Vietnam ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Family-based intervention for adolescents with substance use disorders in Vietnam.

    Nguyen, Thu Trang / Dinh, Thi Thanh Thuy / Busse, Anja / Kashino, Wataru / Suhartono, Sanita / Le, Minh Giang

    Addictive behaviors reports

    2021  Volume 14, Page(s) 100382

    Abstract: Background: Adolescent substance use is a leading risk factor of medical and social problems in adults. However, evidence-based interventions for substance use disorders (SUD) among youth in resource-limited countries are lacking. Treatnet Family (TF), ... ...

    Abstract Background: Adolescent substance use is a leading risk factor of medical and social problems in adults. However, evidence-based interventions for substance use disorders (SUD) among youth in resource-limited countries are lacking. Treatnet Family (TF), developed by United Nations Office on Drugs and Crime (UNODC), aims to make youth SUD care more affordable and accessible in low- and middle-income countries. This study explores the suitability of TF in Vietnam.
    Method: Twenty interviews were conducted with eight adolescents and their family members who participated in TF, and four practitioners who delivered TF. Questions centred on their experiences with the intervention and suggestions for improvement. Thematic analysis was used to evaluate the data.
    Results: All adolescents were male with an average age of 19.3. Seven of them had left school. Most caregivers were female. Both family members and adolescents expressed a great demand for support, and both groups appreciated the immediate improvement in parent-child communication. However, the impact of TF could be compromised due challenges in recruiting families, possibly arising from the novelty of a family-based intervention in Vietnam and drug-related stigma. The perception of drug use as an acute condition instead of a chronic disorder, and the lack of a continuing care system, also made it difficult to retain participants.
    Conclusion: Vietnamese adolescents with SUD and their family members were in great need of support and access to evidence-based interventions. Building a comprehensive, health-centred substance use disorder treatment and care system would enhance treatment impact.
    Language English
    Publishing date 2021-10-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831558-3
    ISSN 2352-8532 ; 2352-8532
    ISSN (online) 2352-8532
    ISSN 2352-8532
    DOI 10.1016/j.abrep.2021.100382
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  3. Article: Dammarane-type triterpenoids from Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) and their AMPK activation effect in 3T3-L1 cells

    Dinh, Thi Thanh Thuy / Nguyen, Thi Thu / Ngo, Huy Trung / Tran, Thi Hien / Le, Ba Vinh / Pham, Thanh Huyen / Pham, Ha Thanh Tung / Pham, Thanh Ky / Do, Thi Ha

    Phytochemistry. 2022 Aug., v. 200

    2022  

    Abstract: Bioassay-guided fractionation of the 80% ethanol extract of Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) resulted in the isolation and identification of eight undescribed triterpenoids, gycomol VN1, gycomol VN2, and gycomosides VN1–6 ... ...

    Abstract Bioassay-guided fractionation of the 80% ethanol extract of Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) resulted in the isolation and identification of eight undescribed triterpenoids, gycomol VN1, gycomol VN2, and gycomosides VN1–6 from the bioactive n-butanol fraction. The structures of these compounds were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionisation mass spectrometry, and chemical methods. All isolated compounds were evaluated for their 5′-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) activation effects on 3T3-L1 cells. Importantly, gycomol VN2, gycomoside VN1, and gycomosides VN3–5 activated the phosphorylation of AMPK and its downstream substrate ACC in 3T3-L1 cells at a dose of 10 μM. These effects imply that the activation of AMPK and ACC by active compounds from G. compressum has considerable potential for the prevention of obesity and its related disorders by activating AMPK signaling pathways.
    Keywords Gynostemma ; acetyl-CoA carboxylase ; butanol ; electrospray ionization mass spectrometry ; ethanol ; fractionation ; nuclear magnetic resonance spectroscopy ; obesity ; phosphorylation ; plant biochemistry ; protein kinases ; triterpenoids
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2022.113218
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  4. Article ; Online: Stigma as a barrier to integrated substance use and HIV care in Vietnam: A qualitative examination of patient and provider perspectives.

    Nguyen Thu, Trang / Dinh, Thi Thanh Thuy / Nguyen Bich, Diep / Hoffman, Kim / Nguyen Thu, Hang / Edsall, Andrew / Bart, Gavin / Korthuis, P Todd / Le Minh, Giang

    Journal of ethnicity in substance abuse

    2022  Volume 23, Issue 1, Page(s) 182–197

    Abstract: Integration of substance use disorder (SUD) treatment and HIV care can increase antiretroviral therapy coverage among people with opioid use disorder (OUD). However, implementation of integrated treatment models remains limited. Stigma towards people ... ...

    Abstract Integration of substance use disorder (SUD) treatment and HIV care can increase antiretroviral therapy coverage among people with opioid use disorder (OUD). However, implementation of integrated treatment models remains limited. Stigma towards people with OUD poses a barrier to initiation of, and adherence to, HIV treatment. We sought to understand the extent of stigma towards SUD and HIV among people with OUD in Vietnam, and the effect of stigma on integrated OUD and HIV treatment services utilization. Between 2013 and 2015, we conducted in-depth interviews with 43 patients and 43 providers at 7 methadone clinics and 8 HIV clinics across 4 provinces in Vietnam. We used thematic analysis with a mixed deductive and inductive approach at the semantic level to analyze key topics. Two main themes were identified: (1) Confidentiality concerns about HIV status make patients reluctant to receive integrated care at HIV clinics, given the requirements for daily buprenorphine dosing at HIV clinics. (2) Provider stigma existed mostly toward people with OUD and seemed to center on the belief that substance use causes a deterioration in one's morals, and was most frequently manifested in the form of providers' apprehensive approach towards patients. Concerns regarding stigmatization may cause patients to feel reluctant to receive treatment for both OUD and HIV at a single integrated clinic. Interventions to reduce stigma at the clinic and policy levels may thus serve to improve initiation of and adherence to integrated care.
    MeSH term(s) Humans ; Vietnam ; Social Stigma ; HIV Infections/drug therapy ; Stereotyping ; Opioid-Related Disorders/drug therapy ; Opiate Substitution Treatment
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052900-4
    ISSN 1533-2659 ; 1533-2640
    ISSN (online) 1533-2659
    ISSN 1533-2640
    DOI 10.1080/15332640.2022.2080785
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  5. Article ; Online: Familial support in integrated treatment with antiretroviral therapy and medications for opioid use disorder in Vietnam: A qualitative study.

    Brown, Patrick C M / Dinh, Thị Thanh Thuy / Edsall, Andrew / Nguyen, Thu Hang / Mai, Pham Phuong / Hoffman, Kim / Bart, Gavin / Korthuis, P Todd / Le, Minh Giang

    Substance abuse

    2022  Volume 43, Issue 1, Page(s) 1004–1010

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Analgesics, Opioid/therapeutic use ; Buprenorphine/therapeutic use ; HIV Infections/psychology ; Humans ; Methadone/therapeutic use ; Opiate Substitution Treatment ; Opioid-Related Disorders/psychology ; Vietnam
    Chemical Substances Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 0889-7077
    DOI 10.1080/08897077.2022.2060435
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  6. Article ; Online: Dammarane-type triterpenoids from Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) and their AMPK activation effect in 3T3-L1 cells.

    Dinh, Thi Thanh Thuy / Nguyen, Thi Thu / Ngo, Huy Trung / Tran, Thi Hien / Le, Ba Vinh / Pham, Thanh Huyen / Pham, Ha Thanh Tung / Pham, Thanh Ky / Do, Thi Ha

    Phytochemistry

    2022  Volume 200, Page(s) 113218

    Abstract: Bioassay-guided fractionation of the 80% ethanol extract of Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) resulted in the isolation and identification of eight undescribed triterpenoids, gycomol VN1, gycomol VN2, and gycomosides VN1-6 ... ...

    Abstract Bioassay-guided fractionation of the 80% ethanol extract of Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) resulted in the isolation and identification of eight undescribed triterpenoids, gycomol VN1, gycomol VN2, and gycomosides VN1-6 from the bioactive n-butanol fraction. The structures of these compounds were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionisation mass spectrometry, and chemical methods. All isolated compounds were evaluated for their 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) activation effects on 3T3-L1 cells. Importantly, gycomol VN2, gycomoside VN1, and gycomosides VN3-5 activated the phosphorylation of AMPK and its downstream substrate ACC in 3T3-L1 cells at a dose of 10 μM. These effects imply that the activation of AMPK and ACC by active compounds from G. compressum has considerable potential for the prevention of obesity and its related disorders by activating AMPK signaling pathways.
    MeSH term(s) 3T3-L1 Cells ; AMP-Activated Protein Kinases/metabolism ; Animals ; Cucurbitaceae ; Gynostemma/chemistry ; Mice ; Triterpenes/chemistry ; Triterpenes/pharmacology ; Dammaranes
    Chemical Substances Triterpenes ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2022.113218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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