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  1. Article: Screening the Pathogen Box to Discover and Characterize New Cruzain and

    do Valle Moreira, Thales / Martins, Luan Carvalho / Diniz, Lucas Abreu / Bernardes, Talita Cristina Diniz / de Oliveira, Renata Barbosa / Ferreira, Rafaela Salgado

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Chagas disease and Human African Trypanosomiasis, caused ... ...

    Abstract Chagas disease and Human African Trypanosomiasis, caused by
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design and synthesis of new 1,2,3-triazoles derived from eugenol and analogues with in vitro and in vivo activity against Trypanosoma cruzi.

    Reis, Rúbia Castro Fernandes Melo / Dos Santos, Elda Gonçalves / Benedetti, Monique Dias / Reis, Adriana Cotta Cardoso / Brandão, Geraldo Célio / Silva, Glenda Nicioli da / Diniz, Lucas Abreu / Ferreira, Rafaela Salgado / Caldas, Ivo Santana / Braga, Saulo Fehelberg Pinto / Souza, Thiago Belarmino de

    European journal of medicinal chemistry

    2023  Volume 258, Page(s) 115622

    Abstract: Chagas disease (CD) is a neglected tropical disease endemic in 21 countries and affects about 8 million people around the world. The pharmacotherapy for this disease is limited to two drugs (Benznidazole and Nifurtimox) and both are associated with ... ...

    Abstract Chagas disease (CD) is a neglected tropical disease endemic in 21 countries and affects about 8 million people around the world. The pharmacotherapy for this disease is limited to two drugs (Benznidazole and Nifurtimox) and both are associated with important limitations, as low cure rate in the chronic phase of the disease, high toxicity and increasing resistance by Trypanosoma cruzi. Recently, we reported a bioactive 1,2,3-triazole (compound 35) active in vitro (IC
    MeSH term(s) Mice ; Rats ; Animals ; Trypanosoma cruzi ; Eugenol/pharmacology ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Parasitemia/drug therapy ; Trypanocidal Agents/toxicity ; Chagas Disease/drug therapy
    Chemical Substances benzonidazole (YC42NRJ1ZD) ; Eugenol (3T8H1794QW) ; Triazoles ; Trypanocidal Agents
    Language English
    Publishing date 2023-07-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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