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  1. Article ; Online: Disparate regulation of IMD signaling drives sex differences in infection pathology in

    Vincent, Crystal M / Dionne, Marc S

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 32

    Abstract: Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe- ... ...

    Abstract Male and female animals exhibit differences in infection outcomes. One possible source of sexually dimorphic immunity is the sex-specific costs of immune activity or pathology, but little is known about the independent effects of immune- versus microbe-induced pathology and whether these may differ for the sexes. Here, by measuring metabolic and physiological outputs in
    MeSH term(s) Animals ; Carrier Proteins/genetics ; Carrier Proteins/immunology ; Drosophila Proteins/genetics ; Drosophila Proteins/immunology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/immunology ; Drosophila melanogaster/microbiology ; Escherichia coli Infections/immunology ; Escherichia coli Infections/veterinary ; Female ; Gene Expression Regulation ; Immunity, Innate/physiology ; Male ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/immunology ; Repressor Proteins/genetics ; Repressor Proteins/immunology ; Sex Factors ; Signal Transduction/physiology ; Triglycerides/metabolism
    Chemical Substances Carrier Proteins ; Drosophila Proteins ; Nuclear Proteins ; RYBP protein, Drosophila ; Repressor Proteins ; Tra protein, Drosophila ; Triglycerides ; peptidoglycan recognition protein
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2026554118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  2. Article ; Online: Drosophila versus Mycobacteria: A model for mycobacterial host-pathogen interactions.

    Marshall, Eleanor K P / Dionne, Marc S

    Molecular microbiology

    2021  Volume 117, Issue 3, Page(s) 600–609

    Abstract: Animal models have played an essential role in understanding the host-pathogen interactions of pathogenic mycobacteria, including the Mycobacterium tuberculosis and emerging nontuberculous mycobacteria (NTM) species such as M. avium and M. abscessus. ... ...

    Abstract Animal models have played an essential role in understanding the host-pathogen interactions of pathogenic mycobacteria, including the Mycobacterium tuberculosis and emerging nontuberculous mycobacteria (NTM) species such as M. avium and M. abscessus. Drosophila melanogaster has become a well-established model for the study of innate immunity and is increasingly being used as a tool to study host-pathogen interactions, in part due to its genetic tractability. The use of D. melanogaster has led to greater understanding of the role of the innate immune system in response to mycobacterial infection, including in vitro RNAi screens and in vivo studies. These studies have identified processes and host factors involved in mycobacterial infection, such as those required for cellular entry, those required to control or resist non-pathogenic mycobacteria, or factors that become dysregulated as a result of mycobacterial infection. Developments in genetic tools for manipulating mycobacterial genomes will allow for more detailed studies into how specific host and pathogen factors interact with one another by using D. melanogaster; however, the full potential of this model has not yet been reached. Here we provide an overview of how D. melanogaster has been used to study mycobacterial infection and discuss the current gaps in our understanding.
    MeSH term(s) Animals ; Drosophila ; Drosophila melanogaster ; Host-Pathogen Interactions ; Mycobacterium Infections ; Mycobacterium tuberculosis/genetics
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14819
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    Zs.A 2502: Show issues Location:
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  3. Article: Editorial: Deciphering Phagocyte Functions Across Different Species.

    Feng, Yi / Dionne, Marc S / Stamatiades, Efstathios G / Kierdorf, Katrin

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 712929

    Language English
    Publishing date 2021-07-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.712929
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  4. Article ; Online: Comparative immunology: allorecognition and variable surface receptors outside the jawed vertebrates.

    Dionne, Marc S

    Current opinion in immunology

    2013  Volume 25, Issue 5, Page(s) 608–612

    Abstract: Allograft rejection is one of several undesirable consequences of the adaptive nature of the mammalian immune response. This review examines adaptive immune responses and allorecognition in animals with very different immune responses - jawless ... ...

    Abstract Allograft rejection is one of several undesirable consequences of the adaptive nature of the mammalian immune response. This review examines adaptive immune responses and allorecognition in animals with very different immune responses - jawless vertebrates, arthropods, and two distinct colonial marine invertebrates - with the goal of understanding how immune adaptation and allograft rejection are linked, and conversely how a system works where allograft rejection is a desired outcome rather than an unforeseen consequence.
    MeSH term(s) Allografts/immunology ; Animals ; Graft Rejection ; Humans ; Jaw/immunology ; Lymphocytes/immunology ; Receptors, Immunologic/immunology ; Vertebrates/immunology
    Chemical Substances Receptors, Immunologic
    Language English
    Publishing date 2013-07-24
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2013.07.002
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    Zs.A 2773: Show issues Location:
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  5. Article ; Online: Pre-copulatory reproductive behaviours are preserved in

    Rose, Saloni / Beckwith, Esteban J / Burmester, Charlotte / May, Robin C / Dionne, Marc S / Rezaval, Carolina

    Proceedings. Biological sciences

    2022  Volume 289, Issue 1974, Page(s) 20220492

    Abstract: The activation of the immune system upon infection exerts a huge energetic demand on an individual, likely decreasing available resources for other vital processes, like reproduction. The factors that determine the trade-off between defensive and ... ...

    Abstract The activation of the immune system upon infection exerts a huge energetic demand on an individual, likely decreasing available resources for other vital processes, like reproduction. The factors that determine the trade-off between defensive and reproductive traits remain poorly understood. Here, we exploit the experimental tractability of the fruit fly
    MeSH term(s) Animals ; Bacteria ; Copulation ; Drosophila ; Drosophila melanogaster/physiology ; Female ; Male ; Reproduction/physiology ; Reproductive Behavior ; Sexual Behavior, Animal/physiology
    Language English
    Publishing date 2022-05-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.0492
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    Zs.A 1364: Show issues Location:
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  6. Article ; Online: A humoral stress response protects Drosophila tissues from antimicrobial peptides.

    Rommelaere, Samuel / Carboni, Alexia / Bada Juarez, Juan F / Boquete, Jean-Philippe / Abriata, Luciano A / Teixeira Pinto Meireles, Fernando / Rukes, Verena / Vincent, Crystal / Kondo, Shu / Dionne, Marc S / Dal Peraro, Matteo / Cao, Chan / Lemaitre, Bruno

    Current biology : CB

    2024  Volume 34, Issue 7, Page(s) 1426–1437.e6

    Abstract: 7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the ... ...

    Abstract 7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy.
    MeSH term(s) Animals ; Drosophila/metabolism ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/metabolism ; Antimicrobial Cationic Peptides/pharmacology ; Immunity, Innate/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism
    Chemical Substances Antimicrobial Peptides ; Antimicrobial Cationic Peptides ; Drosophila Proteins
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.02.049
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    Zs.A 3208: Show issues Location:
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  7. Article ; Online: DNA damage signaling in

    Hersperger, Fabian / Meyring, Tim / Weber, Pia / Chhatbar, Chintan / Monaco, Gianni / Dionne, Marc S / Paeschke, Katrin / Prinz, Marco / Groß, Olaf / Classen, Anne-Kathrin / Kierdorf, Katrin

    eLife

    2024  Volume 12

    Abstract: Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue repair. ...

    Abstract Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue repair. Hemocytes, the
    MeSH term(s) Animals ; Drosophila ; Oxidative Stress ; Macrophages ; Arthropods ; Cytokines ; DNA Damage ; Mammals
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86700
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  8. Article ; Online: The Software and Hardware of Macrophages: A Diversity of Options.

    Kierdorf, Katrin / Dionne, Marc S

    Developmental cell

    2016  Volume 38, Issue 2, Page(s) 122–125

    Abstract: Macrophages play important immune and homeostatic roles that depend on the ability to receive and interpret specific signals from environmental stimuli. Here we describe the different activation states these cells can exhibit in response to signals and ... ...

    Abstract Macrophages play important immune and homeostatic roles that depend on the ability to receive and interpret specific signals from environmental stimuli. Here we describe the different activation states these cells can exhibit in response to signals and how these states affect and can be affected by bacterial pathogens.
    MeSH term(s) Animals ; Bacteria/pathogenicity ; Homeostasis/immunology ; Humans ; Immunity, Innate/immunology ; Macrophages/immunology ; Macrophages/microbiology
    Language English
    Publishing date 2016-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2016.07.008
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    Zs.A 5742: Show issues Location:
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  9. Article ; Online: Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster.

    Vincent, Crystal M / Beckwith, Esteban J / Simoes da Silva, Carolina J / Pearson, William H / Kierdorf, Katrin / Gilestro, Giorgio F / Dionne, Marc S

    PLoS pathogens

    2022  Volume 18, Issue 9, Page(s) e1010826

    Abstract: Host behavioural changes are among the most apparent effects of infection. 'Sickness behaviour' can involve a variety of symptoms, including anorexia, depression, and changed activity levels. Here, using a real-time tracking and behavioural profiling ... ...

    Abstract Host behavioural changes are among the most apparent effects of infection. 'Sickness behaviour' can involve a variety of symptoms, including anorexia, depression, and changed activity levels. Here, using a real-time tracking and behavioural profiling platform, we show that in Drosophila melanogaster, several systemic bacterial infections cause significant increases in physical activity, and that the extent of this activity increase is a predictor of survival time in some lethal infections. Using multiple bacteria and D. melanogaster immune and activity mutants, we show that increased activity is driven by at least two different mechanisms. Increased activity after infection with Micrococcus luteus, a Gram-positive bacterium rapidly cleared by the immune response, strictly requires the Toll ligand spätzle. In contrast, increased activity after infection with Francisella novicida, a Gram-negative bacterium that cannot be cleared by the immune response, is entirely independent of both Toll and the parallel IMD pathway. The existence of multiple signalling mechanisms by which bacterial infections drive increases in physical activity implies that this effect may be an important aspect of the host response.
    MeSH term(s) Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster/microbiology ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Immunity, Innate ; Ligands
    Chemical Substances Drosophila Proteins ; Ligands
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010826
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  10. Article: Comparative immunology: allorecognition and variable surface receptors outside the jawed vertebrates

    Dionne, Marc S

    Current Opinion in Immunology. 2013 Oct., v. 25, no. 5

    2013  

    Abstract: Allograft rejection is one of several undesirable consequences of the adaptive nature of the mammalian immune response. This review examines adaptive immune responses and allorecognition in animals with very different immune responses — jawless ... ...

    Abstract Allograft rejection is one of several undesirable consequences of the adaptive nature of the mammalian immune response. This review examines adaptive immune responses and allorecognition in animals with very different immune responses — jawless vertebrates, arthropods, and two distinct colonial marine invertebrates — with the goal of understanding how immune adaptation and allograft rejection are linked, and conversely how a system works where allograft rejection is a desired outcome rather than an unforeseen consequence.
    Keywords adaptive immunity ; aquatic invertebrates ; arthropods ; graft rejection ; mammals ; receptors
    Language English
    Dates of publication 2013-10
    Size p. 608-612.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2013.07.002
    Database NAL-Catalogue (AGRICOLA)

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