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  1. Article: Ceftazidime-Avibactam as Osteomyelitis Therapy: A Miniseries and Review of the Literature.

    Mancuso, Alessandro / Pipitò, Luca / Rubino, Raffaella / Distefano, Salvatore Antonino / Mangione, Donatella / Cascio, Antonio

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and ... ...

    Abstract Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and safety of ceftazidime-avibactam as a therapy for osteomyelitis and prosthetic joint infections. Here, we present three cases of difficult-to-treat resistant
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increase of multidrug-resistant bacteria after the COVID-19 pandemic in a major teaching Hospital in Sicily (2018-2021).

    Amodio, Emanuele / Pizzo, Stefano / Vella, Giuseppe / De Francisci, Valerio / Distefano, Salvatore Antonino / Giambelluca, Eliana / Graceffa, Domenico / Verso, Maria Gabriella / Piro, Ettore / Giuffrè, Mario / Giammanco, Giovanni Maurizio / Calamusa, Giuseppe

    International journal of antimicrobial agents

    2024  Volume 63, Issue 5, Page(s) 107123

    Abstract: Introduction: The COVID-19 pandemic has further highlighted the continuing threat of antimicrobial resistance (AMR) to global health and economic development. In the last two decades, AMR has raised increasing concern, with an estimated 4.95 million ... ...

    Abstract Introduction: The COVID-19 pandemic has further highlighted the continuing threat of antimicrobial resistance (AMR) to global health and economic development. In the last two decades, AMR has raised increasing concern, with an estimated 4.95 million deaths globally due to bacterial AMR in 2019 alone. The aim of this study was to analyse the impact of the pandemic on the spread of multidrug-resistant organisms (MDROs) using data from the Hospital "P. Giaccone" in Palermo, comparing pre-pandemic and pandemic periods.
    Methods: This observational study involved adult patients who were discharged from the hospital between 01 January 2018 and 31 December 2021. Hospital Discharge Cards were linked with microbiological laboratory reports to assess MDRO isolations. SARS-CoV-2 positivity during hospitalisation was evaluated using the National Institute of Health surveillance system.
    Results: A total of 58 427 hospitalisations were evaluated in this study. Half the patients were aged over 65 years (N=26 984) and most admissions were in the medical area (N=31 716). During the hospitalisation period, there were 2681 patients (5%) with MDROs isolations, and 946 patients (2%) were positive for SARS-CoV-2. Multivariable analyses showed that during 2020 and 2021, there was a significantly increased risk of isolation of Staphylococcus aureus, Acinetobacter baumannii, and Klebsiella pneumoniae. Age, weight of the Diagnosis-Related Group (DRG), wards with higher intensity of care, and length-of-stay were associated with a higher risk of MDRO isolation.
    Conclusion: This study provides new insights into the impact of the COVID-19 pandemic on MDRO isolation and has important implications for infection control and prevention efforts in healthcare facilities. Age, DRG-weight, and longer hospital stays further increased the risk of MDRO isolation. Thus, it is imperative to improve and follow hospital protocols to prevent healthcare-associated infections.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Male ; Drug Resistance, Multiple, Bacterial ; Aged ; Female ; Hospitals, Teaching/statistics & numerical data ; Middle Aged ; Sicily/epidemiology ; Adult ; SARS-CoV-2/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Aged, 80 and over ; Hospitalization/statistics & numerical data ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Bacterial Infections/drug therapy ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Pandemics
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-24
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3368: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Cluster of Legionnaires' Disease in an Italian Prison.

    Fasciana, Teresa / Mascarella, Chiara / Distefano, Salvatore Antonino / Calà, Cinzia / Capra, Giuseppina / Rampulla, Angela / Di Carlo, Paola / Palermo, Mario / Giammanco, Anna

    International journal of environmental research and public health

    2019  Volume 16, Issue 11

    Abstract: Background: Legionella pneumophila: Methods: We collected 93 water samples from nine Sicilian prisons and the bronchoalveolar lavages (BALs) of two prisoners considered cases of LD. These samples were processed following the procedures described in ... ...

    Abstract Background: Legionella pneumophila
    Methods: We collected 93 water samples from nine Sicilian prisons and the bronchoalveolar lavages (BALs) of two prisoners considered cases of LD. These samples were processed following the procedures described in the Italian Guidelines for the Prevention and Control of Legionellosis of 2015. Then, genotyping was performed on 19 Lp colonies (17 from water samples and 2 from clinical samples) using the Sequence-Based Typing (SBT) method, according to European Study Group for Legionella Infections (ESGLI) protocols.
    Results: Lp serogroup (sg) 6 was the most prevalent serogroup isolated from the prisons analyzed (40%), followed by Lp sg 1 (16%). Most of all, in four penitentiary institutions, we detected a high concentration of Lp >10
    Conclusions: In this article, we described the results obtained from environmental and epidemiological investigations of Lp isolated from prisons in Western Sicily. Furthermore, we reported the first cluster of Legionnaires' in an Italian prison and the molecular typing of Lp sg 1 from one prison's water system and two BALs, identified the source of the contamination, and discovered a new ST.
    MeSH term(s) Cluster Analysis ; Environmental Monitoring ; Humans ; Italy/epidemiology ; Legionella pneumophila/isolation & purification ; Legionella pneumophila/pathogenicity ; Legionnaires' Disease/epidemiology ; Prevalence ; Prisons/statistics & numerical data ; Water Microbiology/standards
    Language English
    Publishing date 2019-06-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16112062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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