LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 278

Search options

  1. Book ; Thesis: Untersuchung von zahnärztlichen Implantaten mit unterschiedlichen Implantat-Abutment-Verbindungen hinsichtlich ihrer Belastbarkeit und des Versagensmodus in vitro

    Dittmer, Stephanie

    2011  

    Author's details vorgelegt von Stephanie Dittmer
    Language German ; English
    Size 28 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2011
    HBZ-ID HT017080001
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 3936 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Burden of chickenpox complications in Poland, 2006 to 2021: A comprehensive registry-based study.

    Halik, Rafał / Paradowska-Stankiewicz, Iwona / Trochonowicz, Aneta / Dittmer, Swavik

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2024  Volume 29, Issue 9

    Abstract: BackgroundChickenpox, a vaccine-preventable disease caused by the varicella zoster virus, generally presents with mild symptoms but can cause complications necessitating hospitalisation. In Poland, since 2009, vaccination has been obligatory for children ...

    Abstract BackgroundChickenpox, a vaccine-preventable disease caused by the varicella zoster virus, generally presents with mild symptoms but can cause complications necessitating hospitalisation. In Poland, since 2009, vaccination has been obligatory for children up to 12 years of age who are particularly vulnerable to infection and for children in their vicinity.AimTo examine the burden of chickenpox complications and the trends of hospitalisation arising from these complications over time in the Polish population.MethodsData spanning 2006-21 were sourced from the Polish Infectious Diseases Surveillance System, the Nationwide General Hospital Morbidity Study and the Statistics Poland death registry. Standardised and age-specific incidence rates, hospital discharge rates and number of deaths because of chickenpox were calculated. Moreover, the joinpoint regression model was used to analyse trends of annual hospital discharge rates.ResultsOver the analysed timeframe, 25,804 hospitalisations and 52 deaths attributable to chickenpox complications were documented, and 1.0% of chickenpox cases required hospitalisation because of chickenpox. Age-standardised hospitalisation rates varied between 2.3 and 9.6 per 100,000 population. The analysis revealed no statistically significant trend in overall hospital discharge rates from chickenpox complications. However, a notable increase in hospitalisation rates was observed in children aged 0-4 and among inhabitants of rural areas, with annual percentage changes of 4.9% and 3.4% respectively.ConclusionsOur findings suggest that the implementation of a universal chickenpox immunisation programme, supported by health education, should be considered to reduce the number of hospitalisations and nearly eliminate deaths because of chickenpox.
    MeSH term(s) Child ; Humans ; Infant ; Chickenpox/epidemiology ; Chickenpox Vaccine ; Poland/epidemiology ; Herpesvirus 3, Human ; Incidence ; Registries
    Chemical Substances Chickenpox Vaccine
    Language English
    Publishing date 2024-03-01
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2024.29.9.2300355
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5066: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The TPR- and J-domain-containing proteins DJC31 and DJC62 are involved in abiotic stress responses in Arabidopsis thaliana.

    Dittmer, Sophie / Kleine, Tatjana / Schwenkert, Serena

    Journal of cell science

    2021  Volume 134, Issue 19

    Abstract: Molecular chaperones play an important role during the response to different stresses. Since plants are sessile organisms, they need to be able to adapt quickly to different conditions. To do so, plants possess a complex chaperone machinery, composed of ... ...

    Abstract Molecular chaperones play an important role during the response to different stresses. Since plants are sessile organisms, they need to be able to adapt quickly to different conditions. To do so, plants possess a complex chaperone machinery, composed of HSP70, HSP90, J proteins and other factors. In this study we characterized DJC31 (also known as TPR16) and DJC62 (also known as TPR15) of Arabidopsis thaliana, two J proteins that additionally carry clamp-type tetratricopeptide repeat domains. Using cell fractionation and split GFP, we could show that both proteins are attached to the cytosolic side of the endoplasmic reticulum membrane. Moreover, an interaction with cytosolic HSP70.1 and HSP90.2 could be shown using bimolecular fluorescence complementation. Knockout of both DJC31 and DJC62 caused severe defects in growth and development, which affected almost all organs. Furthermore, it could be shown that the double mutant is more sensitive to osmotic stress and treatment with abscisic acid, but surprisingly exhibited enhanced tolerance to drought. Taken together, these findings indicate that DJC31 and DJC62 might act as important regulators of chaperone-dependent signaling pathways involved in plant development and stress responses.
    MeSH term(s) Abscisic Acid ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; HSP90 Heat-Shock Proteins/metabolism ; Plants, Genetically Modified/metabolism ; Stress, Physiological
    Chemical Substances Arabidopsis Proteins ; HSP90 Heat-Shock Proteins ; Abscisic Acid (72S9A8J5GW)
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.259032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 14: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Conference proceedings: Use of a long term complete resorbable synthetic mesh in pre-pectoral implant-based breast reconstruction - results from the learning curve period

    Paepke, S / Klein, E / Dittmer, S / Kiechle, M

    Senologie - Zeitschrift für Mammadiagnostik und -therapie

    2020  Volume 17, Issue 02

    Event/congress 40. Jahrestagung der Deutschen Gesellschaft für Senologie e.V., Congress Center München, 2020-06-25
    Language German
    Publishing date 2020-06-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2174147-5
    ISSN 1611-647X ; 1611-6453
    ISSN (online) 1611-647X
    ISSN 1611-6453
    DOI 10.1055/s-0040-1710663
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Conference proceedings: Use of a long term complete resorbable synthetic mesh in pre-pectoral implant-based breast reconstruction – results from the learning curve period

    Paepke, S / Klein, E / Dittmer, S / Kiechle, M

    Geburtshilfe und Frauenheilkunde

    2020  Volume 80, Issue 06

    Event/congress 40. Jahrestagung der Deutschen Gesellschaft für Senologie e.V., Congress Center München, 2020-06-25
    Language German
    Publishing date 2020-07-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/s-0040-1714604
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 655: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: In Vitro and In Vivo Activity of Luliconazole (NND-502) against Planktonic Cells and Biofilms of Azole Resistant

    Furnica, Dan-Tiberiu / Dittmer, Silke / Sanders, Maike Isabell / Steinmann, Joerg / Rath, Peter-Michael / Kirchhoff, Lisa

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 4

    Abstract: Aspergillus ... ...

    Abstract Aspergillus fumigatus
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8040350
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: In Vitro

    Furnica, Dan-Tiberiu / Dittmer, Silke / Scharmann, Ulrike / Meis, Jacques F / Steinmann, Joerg / Rath, Peter-Michael / Kirchhoff, Lisa

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0513022

    Abstract: Infections ... ...

    Abstract Infections with
    MeSH term(s) Animals ; Humans ; Scedosporium ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Imidazoles/pharmacology ; Imidazoles/therapeutic use
    Chemical Substances Antifungal Agents ; luliconazole (RE91AN4S8G) ; Imidazoles
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05130-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Singular Values for ReLU Layers.

    Dittmer, Soren / King, Emily J / Maass, Peter

    IEEE transactions on neural networks and learning systems

    2019  Volume 31, Issue 9, Page(s) 3594–3605

    Abstract: Despite their prevalence in neural networks, we still lack a thorough theoretical characterization of rectified linear unit (ReLU) layers. This article aims to further our understanding of ReLU layers by studying how the activation function ReLU ... ...

    Abstract Despite their prevalence in neural networks, we still lack a thorough theoretical characterization of rectified linear unit (ReLU) layers. This article aims to further our understanding of ReLU layers by studying how the activation function ReLU interacts with the linear component of the layer and what role this interaction plays in the success of the neural network in achieving its intended task. To this end, we introduce two new tools: ReLU singular values of operators and the Gaussian mean width of operators. By presenting, on the one hand, theoretical justifications, results, and interpretations of these two concepts and, on the other hand, numerical experiments and results of the ReLU singular values and the Gaussian mean width being applied to trained neural networks, we hope to give a comprehensive, singular-value-centric view of ReLU layers. We find that ReLU singular values and the Gaussian mean width do not only enable theoretical insights but also provide one with metrics that seem promising for practical applications. In particular, these measures can be used to distinguish correctly and incorrectly classified data as it traverses the network. We conclude by introducing two tools based on our findings: double layers and harmonic pruning.
    Language English
    Publishing date 2019-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2019.2945113
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Structural components involved in plastid protein import.

    Schwenkert, Serena / Dittmer, Sophie / Soll, Jürgen

    Essays in biochemistry

    2018  Volume 62, Issue 1, Page(s) 65–75

    Abstract: Import of preproteins into chloroplasts is an essential process, requiring two major multisubunit protein complexes that are embedded in the outer and inner chloroplast envelope membrane. Both the translocon of the outer chloroplast membrane (Toc), as ... ...

    Abstract Import of preproteins into chloroplasts is an essential process, requiring two major multisubunit protein complexes that are embedded in the outer and inner chloroplast envelope membrane. Both the translocon of the outer chloroplast membrane (Toc), as well as the translocon of the inner chloroplast membrane (Tic) have been studied intensively with respect to their individual subunit compositions, functions and regulations. Recent advances in crystallography have increased our understanding of the operation of these proteins in terms of their interactions and regulation by conformational switching. Several subdomains of components of the Toc translocon have been studied at the structural level, among them the polypeptide transport-associated (POTRA) domain of the channel protein Toc75 and the GTPase domain of Toc34. In this review, we summarize and discuss the insight that has been gained from these structural analyses. In addition, we present the crystal structure of the Toc64 tetratrico-peptide repeat (TPR) domain in complex with the C-terminal domains of the heat-shock proteins (Hsp) Hsp90 and Hsp70.
    MeSH term(s) Crystallography, X-Ray ; HSP70 Heat-Shock Proteins/chemistry ; HSP90 Heat-Shock Proteins/chemistry ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Plastids/metabolism ; Protein Conformation ; Protein Transport ; Tetratricopeptide Repeat
    Chemical Substances HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins ; Plant Proteins
    Language English
    Publishing date 2018-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1744-1358 ; 0071-1365
    ISSN (online) 1744-1358
    ISSN 0071-1365
    DOI 10.1042/EBC20170093
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Inhibition of azole-resistant Aspergillus fumigatus biofilm at various formation stages by antifungal drugs, including olorofim.

    Kirchhoff, Lisa / Dittmer, Silke / Furnica, Dan-Tiberiu / Buer, Jan / Steinmann, Eike / Rath, Peter-Michael / Steinmann, Joerg

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 6, Page(s) 1645–1654

    Abstract: Objectives: Interest in aspergillosis has increased over the past decades. An increase in the incidence of azole-resistant Aspergillus fumigatus strains has been reported; therefore, the need for novel therapeutic approaches is urgent. The formation of ... ...

    Abstract Objectives: Interest in aspergillosis has increased over the past decades. An increase in the incidence of azole-resistant Aspergillus fumigatus strains has been reported; therefore, the need for novel therapeutic approaches is urgent. The formation of biofilms contributes to pathogen resistance. We investigated the biofilm formation capabilities of azole-resistant A. fumigatus and analysed the susceptibility of biofilms at various developmental stages to three antifungal agents.
    Methods: Biofilm formation of 19 clinical A. fumigatus strains (3 azole-susceptible and 16 azole-resistant strains) was determined by crystal violet staining and by an XTT assay over a period of 48 h. We measured antibiofilm activity of voriconazole, amphotericin B and olorofim. These agents were added before adhesion, after adhesion, after germination and to mature fungal biofilm. Antibiofilm activity was assessed in an XTT assay and in confocal laser scan microscopy. Additionally, a growth-kinetic assay with planktonic A. fumigatus was performed.
    Results: Each of the antifungal agents inhibited the metabolic activity of A. fumigatus biofilms when applied at early stages of biofilm formation. The mature biofilms were more resistant. Olorofim and voriconazole showed promising effects against A. fumigatus adhesion and germination, whereas the mature biofilm was not affected by treatment. In contrast, the biofilm of A. fumigatus showed amphotericin B susceptibility throughout the entire developmental process. The planktonic cells were susceptible to all three antifungal drug classes with an inhibition peak at 12 h after incubation.
    Conclusions: This is the first known study to demonstrate the antibiofilm activity of olorofim, voriconazole and amphotericin B against azole-resistant A. fumigatus.
    MeSH term(s) Acetamides ; Amphotericin B/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillus fumigatus ; Azoles/pharmacology ; Biofilms ; Drug Resistance, Fungal ; Fungal Proteins/metabolism ; Microbial Sensitivity Tests ; Piperazines ; Pyrimidines ; Pyrroles ; Voriconazole/metabolism ; Voriconazole/pharmacology
    Chemical Substances Acetamides ; Antifungal Agents ; Azoles ; Fungal Proteins ; Piperazines ; Pyrimidines ; Pyrroles ; Amphotericin B (7XU7A7DROE) ; Voriconazole (JFU09I87TR) ; olorofim (T34SH2H9HI)
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac062
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top