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  1. Book ; Thesis: Assembly of the interactome, characterization of functional modules and novel approaches to the analysis of signaling networks in human platelets

    Dittrich, Marcus

    2008  

    Author's details vorgelegt von Marcus Dittrich
    Subject code 612.1
    Language English
    Size 169 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 2008
    HBZ-ID HT015807651
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 D 944 order for loan Magazin

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  2. Book ; Thesis: Systematische Analyse der Proteinsequenzen von GAD65 und Proinsulin mittels Peptid-Bibliotheken zur Detektion krankheitsassoziierter Epitope beim humanen Typ-1-Diabetes

    Dittrich, Marcus

    2008  

    Author's details vorgelegt von Marcus Dittrich
    Subject code 616.4
    Language German
    Size II, 97 S., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 2008
    HBZ-ID HT016186059
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 D 1320 order for loan Magazin

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  3. Article ; Online: Immature platelets in COVID-19.

    Wolny, Monika / Dittrich, Marcus / Knabbe, Cornelius / Birschmann, Ingvild

    Platelets

    2023  Volume 34, Issue 1, Page(s) 2184183

    Abstract: Platelets play a critical role in immune response. Coronavirus disease 2019 (COVID-19) patients with a severe course often show pathological coagulation parameters including thrombocytopenia, and at the same time the proportion of immature platelets ... ...

    Abstract Platelets play a critical role in immune response. Coronavirus disease 2019 (COVID-19) patients with a severe course often show pathological coagulation parameters including thrombocytopenia, and at the same time the proportion of immature platelets increases. In this study, the platelet count and the immature platelet fraction (IPF) of hospitalized patients with different oxygenation requirements was investigated daily over a course of 40 days. In addition, the platelet function of COVID-19 patients was analyzed. It was found that the number of platelets in patients with the most severe course (intubation and extracorporeal membrane oxygenation (ECMO)) was significantly lower (111.5 ∙ 10
    MeSH term(s) Humans ; COVID-19 ; Blood Platelets ; Thrombocytopenia/etiology ; Platelet Count ; Blood Coagulation
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2023.2184183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Integrated analysis of SR-like protein kinases Sky1 and Sky2 links signaling networks with transcriptional regulation in

    Luther, Christian H / Brandt, Philipp / Vylkova, Slavena / Dandekar, Thomas / Müller, Tobias / Dittrich, Marcus

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1108235

    Abstract: Fungal infections are a major global health burden ... ...

    Abstract Fungal infections are a major global health burden where
    MeSH term(s) Humans ; Candida albicans ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Fungal Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; SKY1 protein, S cerevisiae (EC 2.7.1.-)
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1108235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gender differences in trust and reciprocity

    Dittrich, Marcus

    Applied economics Vol. 47, No. 34/36 , p. 3825-3838

    evidence from a large-scale experiment with heterogeneous subjects

    2015  Volume 47, Issue 34, Page(s) 3825–3838

    Author's details Marcus Dittrich
    Keywords trust ; reciprocity ; gender differences ; large-scale experiments ; heterogeneous subjects
    Language English
    Size graph. Darst.
    Publisher Routledge
    Publishing place Abingdon
    Document type Article
    ZDB-ID 280176-0 ; 1473581-7
    ISSN 1466-4283 ; 0003-6846
    ISSN (online) 1466-4283
    ISSN 0003-6846
    Database ECONomics Information System

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  6. Article ; Online: Age-related methylation changes in the human sperm epigenome.

    Bernhardt, Laura / Dittrich, Marcus / Prell, Andreas / Potabattula, Ramya / Drummer, Charis / Behr, Rüdiger / Hahn, Thomas / Schorsch, Martin / Müller, Tobias / Haaf, Thomas

    Aging

    2023  Volume 15, Issue 5, Page(s) 1257–1278

    Abstract: Advanced paternal age is associated with increased risks for reproductive and offspring medical problems. Accumulating evidence suggests age-related changes in the sperm epigenome as one underlying mechanism. Using reduced representation bisulfite ... ...

    Abstract Advanced paternal age is associated with increased risks for reproductive and offspring medical problems. Accumulating evidence suggests age-related changes in the sperm epigenome as one underlying mechanism. Using reduced representation bisulfite sequencing on 73 sperm samples of males attending a fertility center, we identified 1,162 (74%) regions which were significantly (FDR-adjusted) hypomethylated and 403 regions (26%) being hypermethylated with age. There were no significant correlations with paternal BMI, semen quality, or ART outcome. The majority (1,152 of 1,565; 74%) of age-related differentially methylated regions (ageDMRs) were located within genic regions, including 1,002 genes with symbols. Hypomethylated ageDMRs were closer to transcription start sites than hypermethylated DMRs, half of which reside in gene-distal regions. In this and conceptually related genome-wide studies, so far 2,355 genes have been reported with significant sperm ageDMRs, however most (90%) of them in only one study. The 241 genes which have been replicated at least once showed significant functional enrichments in 41 biological processes associated with development and the nervous system and in 10 cellular components associated with synapses and neurons. This supports the hypothesis that paternal age effects on the sperm methylome affect offspring behaviour and neurodevelopment. It is interesting to note that sperm ageDMRs were not randomly distributed throughout the human genome; chromosome 19 showed a highly significant twofold enrichment with sperm ageDMRs. Although the high gene density and CpG content have been conserved, the orthologous marmoset chromosome 22 did not appear to exhibit an increased regulatory potential by age-related DNA methylation changes.
    MeSH term(s) Humans ; Male ; Epigenome ; Epigenesis, Genetic ; Semen Analysis ; Semen ; DNA Methylation ; Spermatozoa/metabolism ; CpG Islands
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: GABA does not regulate stomatal CO2 signalling in Arabidopsis.

    Piechatzek, Adriane / Feng, Xueying / Sai, Na / Yi, Changyu / Hurgobin, Bhavna / Lewsey, Mathew / Herrmann, Johannes / Dittrich, Marcus / Ache, Peter / Müller, Tobias / Kromdijk, Johannes / Hedrich, Rainer / Xu, Bo / Gilliham, Matthew

    Journal of experimental botany

    2024  

    Abstract: Optimal stomatal regulation is important for plant adaptation to changing environmental conditions and for maintaining crop yield. The guard-cell signal GABA is produced from glutamate by Glutamate Decarboxylase (GAD) during a reaction that generates ... ...

    Abstract Optimal stomatal regulation is important for plant adaptation to changing environmental conditions and for maintaining crop yield. The guard-cell signal GABA is produced from glutamate by Glutamate Decarboxylase (GAD) during a reaction that generates carbon dioxide (CO2) as a by-product. Here, we investigated a putative connection between GABA signalling and the more clearly defined CO2 signalling pathway in guard cells. The GABA-deficient mutant lines gad2-1, gad2-2 and gad1/2/4/5 were examined for stomatal sensitivity to various CO2 concentrations. Our findings show a phenotypical discrepancy between the allelic mutant lines gad2-1 and gad2-2 - a weakened CO2 response in gad2-1 (GABI_474_E05) in contrast to a wild-type response in gad2-2 (SALK_028819) and gad1/2/4/5. Through transcriptomic and genomic investigation, we traced the response of gad2-1 to a deletion of full-length Mitogen-activated protein kinase 12 (MPK12) in the GABI-KAT line, thereafter as renamed gad2-1*. Guard cell-specific complementation of MPK12 restored the gad2-1* CO2 phenotype, which confirms the proposed importance of MPK12 to CO2 sensitivity. Additionally, we found that stomatal opening under low atmospheric CO2 occurs independently of the GABA-modulated opening-channel ALMT9. Our results confirm that GABA has a role in modulating the rate of stomatal opening and closing - but not in response to CO2  per se.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 55/29: Show issues

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  8. Book ; Online: Minimum wages and union bargaining in a dual labour market

    Dittrich, Marcus

    (Dresden discussion paper series in economics ; 07,13)

    2007  

    Abstract: The paper analyses the links between a binding minimum wage and union bargaining. A dual labour market model is developed where the first sector outcome is characterised by bargaining between unions and firms, while in the second sector firms have to pay ...

    Author's details Marcus Dittrich
    Series title Dresden discussion paper series in economics ; 07,13
    Abstract The paper analyses the links between a binding minimum wage and union bargaining. A dual labour market model is developed where the first sector outcome is characterised by bargaining between unions and firms, while in the second sector firms have to pay a statutory minimum wage. It is shown that a minimum wage increase has negative employment effects only if the bargaining outcome is described by the Nash solution. However, this result does not hold if the Kalai-Smorodinsky solution is applied to model union bargaining. A higher minimum wage can then lead to more employment in the unionised sector and to a lower unemployment rate.
    Keywords Mindestlohn ; Beschäftigungseffekt ; Verhandlungstheorie des Lohnes ; Nash-Gleichgewicht ; Mehrsektoren-Modell ; Gewerkschaftsmitgliedschaft ; Theorie
    Language English
    Size Online-Ressource, 22 S., Text, graph. Darst.
    Publisher Univ. of Technology, Fac. of Business Management and Economics
    Publishing place Dresden
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  9. Article ; Online: Ribosomal DNA methylation in human and mouse oocytes increases with age.

    Potabattula, Ramya / Trapphoff, Tom / Dittrich, Marcus / Fic, Kinga / Ptak, Grazyna E / Dieterle, Stefan / Haaf, Thomas

    Aging

    2022  Volume 14, Issue 3, Page(s) 1214–1232

    Abstract: An age-dependent increase in ribosomal DNA (rDNA) methylation has been observed across a broad spectrum of somatic tissues and the male mammalian germline. Bisulfite pyrosequencing (BPS) was used to determine the methylation levels of the rDNA core ... ...

    Abstract An age-dependent increase in ribosomal DNA (rDNA) methylation has been observed across a broad spectrum of somatic tissues and the male mammalian germline. Bisulfite pyrosequencing (BPS) was used to determine the methylation levels of the rDNA core promoter and the rDNA upstream control element (UCE) along with two oppositely genomically imprinted control genes (
    MeSH term(s) Aged ; Aging/genetics ; Animals ; DNA Methylation ; DNA, Ribosomal/genetics ; DNA, Ribosomal/metabolism ; Female ; Germ Cells ; Humans ; Mammals ; Mice ; Oocytes/metabolism
    Chemical Substances DNA, Ribosomal
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: covRNA: discovering covariate associations in large-scale gene expression data.

    Urban, Lara / Remmele, Christian W / Dittrich, Marcus / Schwarz, Roland F / Müller, Tobias

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 92

    Abstract: Objective: The biological interpretation of gene expression measurements is a challenging task. While ordination methods are routinely used to identify clusters of samples or co-expressed genes, these methods do not take sample or gene annotations into ... ...

    Abstract Objective: The biological interpretation of gene expression measurements is a challenging task. While ordination methods are routinely used to identify clusters of samples or co-expressed genes, these methods do not take sample or gene annotations into account. We aim to provide a tool that allows users of all backgrounds to assess and visualize the intrinsic correlation structure of complex annotated gene expression data and discover the covariates that jointly affect expression patterns.
    Results: The Bioconductor package covRNA provides a convenient and fast interface for testing and visualizing complex relationships between sample and gene covariates mediated by gene expression data in an entirely unsupervised setting. The relationships between sample and gene covariates are tested by statistical permutation tests and visualized by ordination. The methods are inspired by the fourthcorner and RLQ analyses used in ecological research for the analysis of species abundance data, that we modified to make them suitable for the distributional characteristics of both, RNA-Seq read counts and microarray intensities, and to provide a high-performance parallelized implementation for the analysis of large-scale gene expression data on multi-core computational systems. CovRNA provides additional modules for unsupervised gene filtering and plotting functions to ensure a smooth and coherent analysis workflow.
    MeSH term(s) Computational Biology/methods ; Gene Expression Profiling/methods ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Multivariate Analysis ; Oligonucleotide Array Sequence Analysis/methods ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Reproducibility of Results ; Sequence Analysis, RNA/methods ; Software
    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-04946-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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