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  1. Article: Canadian aging and inactivity study: Spaceflight-inspired exercises during head-down tilt bedrest blunted reductions in muscle-pump but not cardiac baroreflex in older persons.

    Sadeghian, Farshid / Divsalar, Donya Naz / Fadil, Rabie / Tavakolian, Kouhyar / Blaber, Andrew P

    Frontiers in physiology

    2022  Volume 13, Page(s) 943630

    Abstract: As part of the first Canadian aging and inactivity study (CAIS) we assessed the efficacy of space-based exercise countermeasures for maintenance of cardiac and muscle-pump baroreflex in older persons during bedrest. An initiative of the Canadian Space ... ...

    Abstract As part of the first Canadian aging and inactivity study (CAIS) we assessed the efficacy of space-based exercise countermeasures for maintenance of cardiac and muscle-pump baroreflex in older persons during bedrest. An initiative of the Canadian Space Agency, Canadian Institutes of Health Research and the Canadian Frailty Network, CAIS involved 14 days of 6-degree head-down tilt bedrest (HDBR) with (Exercise) or without (Control) combined upper and lower body strength, aerobic, and high-intensity interval training exercise countermeasures. Twenty healthy men and women aged 55 to 65, randomly divided into control and exercise groups (male control (MC,
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.943630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myths and Methodologies: Understanding the health impact of head down bedrest for the benefit of older adults and astronauts. Study protocol of the Canadian Bedrest Study.

    Hajj-Boutros, Guy / Sonjak, Vita / Faust, Andréa / Balram, Sharmila / Lagacé, Jean-Christophe / St-Martin, Philippe / Divsalar, Donya Naz / Sadeghian, Farshid / Liu-Ambrose, Teresa / Blaber, Andrew P / Dionne, Isabelle J / Duchesne, Simon / Kontulainen, Saija / Theou, Olga / Morais, José A

    Experimental physiology

    2024  Volume 109, Issue 5, Page(s) 812–827

    Abstract: Weightlessness during spaceflight can harm various bodily systems, including bone density, muscle mass, strength and cognitive functions. Exercise appears to somewhat counteract these effects. A terrestrial model for this is head-down bedrest (HDBR), ... ...

    Abstract Weightlessness during spaceflight can harm various bodily systems, including bone density, muscle mass, strength and cognitive functions. Exercise appears to somewhat counteract these effects. A terrestrial model for this is head-down bedrest (HDBR), simulating gravity loss. This mirrors challenges faced by older adults in extended bedrest and space environments. The first Canadian study, backed by the Canadian Space Agency, Canadian Institutes of Health Research, and Canadian Frailty Network, aims to explore these issues. The study seeks to: (1) scrutinize the impact of 14-day HDBR on physiological, psychological and neurocognitive systems, and (2) assess the benefits of exercise during HDBR. Eight teams developed distinct protocols, harmonized in three videoconferences, at the McGill University Health Center. Over 26 days, 23 participants aged 55-65 underwent baseline measurements, 14 days of -6° HDBR, and 7 days of recovery. Half did prescribed exercise thrice daily combining resistance and endurance exercise for a total duration of 1 h. Assessments included demographics, cardiorespiratory fitness, bone health, body composition, quality of life, mental health, cognition, muscle health and biomarkers. This study has yielded some published outcomes, with more forthcoming. Findings will enrich our comprehension of HDBR effects, guiding future strategies for astronaut well-being and aiding bedrest-bound older adults. By outlining evidence-based interventions, this research supports both space travellers and those enduring prolonged bedrest.
    MeSH term(s) Humans ; Bed Rest ; Middle Aged ; Aged ; Canada ; Male ; Female ; Astronauts ; Exercise/physiology ; Space Flight ; Head-Down Tilt/physiology ; Cognition/physiology ; Quality of Life ; Body Composition/physiology ; Mental Health ; Bone Density/physiology ; Cardiorespiratory Fitness/physiology ; Weightlessness/adverse effects
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ansellone J, a Potent in Vitro and ex Vivo HIV-1 Latency Reversal Agent Isolated from a Phorbas sp. Marine Sponge

    Wang, Meng / Sciorillo, Amanda / Read, Silven / Divsalar, Donya Naz / Gyampoh, Kwasi / Zu, Guorui / Yuan, Zhe / Mounzer, Karam / Williams, David E. / Montaner, Luis J. / de Voogd, Nicole / Tietjen, Ian / Andersen, Raymond J.

    Journal of natural products. 2022 May 06, v. 85, no. 5

    2022  

    Abstract: Five new minor sesterterpenoids, ansellones H (4), I (5), J (6), and K (7) and phorone C (8), have been isolated from a Phorbas sp. marine sponge collected in British Columbia. Their structures have been elucidated by detailed analysis of NMR and MS data. ...

    Abstract Five new minor sesterterpenoids, ansellones H (4), I (5), J (6), and K (7) and phorone C (8), have been isolated from a Phorbas sp. marine sponge collected in British Columbia. Their structures have been elucidated by detailed analysis of NMR and MS data. Ansellone J (6) and phorone C (8) are potent in vitro HIV-1 latency reversal agents that are more potent than the reference compound and control protein kinase C activator prostratin (3). The most potent Phorbas sesterterpenoid, ansellone J (6), was evaluated for HIV latency reversal in a primary cell context using CD4+ T cells obtained directly from four combination antiretroviral therapy-suppressed donors with HIV. To a first approximation, ansellone J (6) induced HIV latency reversal at levels similar to prostratin (3) ex vivo, but at a 10-fold lower concentration.
    Keywords Porifera ; antiretroviral agents ; protein kinase C ; British Columbia
    Language English
    Dates of publication 2022-0506
    Size p. 1274-1281.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.1c01225
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Ansellone J, a Potent

    Wang, Meng / Sciorillo, Amanda / Read, Silven / Divsalar, Donya Naz / Gyampoh, Kwasi / Zu, Guorui / Yuan, Zhe / Mounzer, Karam / Williams, David E / Montaner, Luis J / de Voogd, Nicole / Tietjen, Ian / Andersen, Raymond J

    Journal of natural products

    2022  Volume 85, Issue 5, Page(s) 1274–1281

    Abstract: Five new minor sesterterpenoids, ansellones H ( ...

    Abstract Five new minor sesterterpenoids, ansellones H (
    MeSH term(s) Animals ; British Columbia ; CD4-Positive T-Lymphocytes ; HIV Infections ; HIV-1 ; Porifera/chemistry ; Sesterterpenes/chemistry ; Virus Latency
    Chemical Substances Sesterterpenes
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.1c01225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening.

    Divsalar, Donya Naz / Simoben, Conrad Veranso / Schonhofer, Cole / Richard, Khumoekae / Sippl, Wolfgang / Ntie-Kang, Fidele / Tietjen, Ian

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 905

    Abstract: Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental "shock-and-kill" therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir- ... ...

    Abstract Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental "shock-and-kill" therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected cell elimination through viral or host immune cytopathic effects. Several LRAs that function as histone deacetylase (HDAC) inhibitors are reported to reverse HIV latency in cells and in clinical trials; however, none to date have consistently reduced viral reservoirs in humans, prompting a need to identify new LRAs. Toward this goal, we describe here a virtual screening (VS) approach which uses 14 reported HDAC inhibitors to probe PubChem and identifies 60 LRA candidates. We then show that four screening "hits" including (S)-
    Language English
    Publishing date 2020-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.00905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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