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  1. Book ; Online ; E-Book: Autophagy in health and disease

    Rothermel, Beverly / Diwan, Abhinav

    2022  

    Abstract: Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The book covers the history, trajectory of the research field, mechanisms of autophagy, ...

    Author's details editors, Beverly Rothermel, Abhinav Diwan
    Abstract "Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The book covers the history, trajectory of the research field, mechanisms of autophagy, and its regulation, developmental aspects, including stem cells, embryogenesis, hematopoiesis and paligenosis and focus on several systems, including Metabolic control and Diabetes, Cardiovascular, Nervous, Immune, Gastrointestinal, and Skeletal. The final chapters provide additional disease considerations, covering cancer, longevity, disease mechanisms, and the therapeutic targeting of autophagy. This book is invaluable to anyone looking for a broader understanding of autophagy outside their specific field"--
    Keywords Cell death ; Autophagic vacuoles ; Homeostasis
    Subject code 571.655
    Language English
    Size 1 online resource (456 pages)
    Edition Second edition.
    Publisher Academic press
    Publishing place London, England ; San Diego, California ; Cambridge, Massachusetts
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-822004-X ; 0-12-822003-1 ; 978-0-12-822004-7 ; 978-0-12-822003-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?

    Diwan, Abhinav

    The Journal of clinical investigation

    2023  Volume 133, Issue 14

    Abstract: Hypertrophic cardiomyopathy and pathological cardiac hypertrophy are characterized by mitochondrial structural and functional abnormalities. In this issue of the JCI, Zhuang et al. discovered 1-deoxynojirimycin (DNJ) through a screen of mitochondrially ... ...

    Abstract Hypertrophic cardiomyopathy and pathological cardiac hypertrophy are characterized by mitochondrial structural and functional abnormalities. In this issue of the JCI, Zhuang et al. discovered 1-deoxynojirimycin (DNJ) through a screen of mitochondrially targeted compounds. The authors described the effects of DNJ in restoring mitochondria and preventing cardiac myocyte hypertrophy in cellular models carrying a mutant mitochondrial gene, MT-RNR2, which is causally implicated in familial hypertrophic cardiomyopathy. DNJ worked via stabilization of the mitochondrial inner-membrane GTPase OPA1 and other, hitherto unknown, mechanisms to preserve mitochondrial crista and respiratory chain components. The discovery is likely to spur development of a class of therapeutics that restore mitochondrial health to prevent cardiomyopathy and heart failure.
    MeSH term(s) Humans ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/therapy ; Cardiomyopathy, Hypertrophic/pathology ; Mitochondria/genetics ; Mitochondria/pathology ; Mutation ; Heart Failure/genetics ; Heart Failure/therapy ; Heart Failure/pathology ; DNA, Mitochondrial/genetics ; Mitochondria, Heart/genetics ; Mitochondria, Heart/pathology
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI171965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: More Energy to Relax: Targeting Epigenetic Effects of Acute Renal Injury to Prevent HFpEF.

    Diwan, Abhinav

    JACC. Basic to translational science

    2021  Volume 6, Issue 2, Page(s) 134–136

    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2020.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Autophagy in the LVAD-Supported Heart: A Sign of Hope or a Marker of Unloading.

    Rawnsley, David R / Diwan, Abhinav

    JACC. Basic to translational science

    2023  Volume 8, Issue 9, Page(s) 1057–1059

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response by Dhingra et al to Letter Regarding Article, "Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy".

    Dhingra, Rimpy / Javaheri, Ali / Diwan, Abhinav / Kirshenbaum, Lorrie A

    Circulation

    2023  Volume 147, Issue 13, Page(s) 1051–1052

    MeSH term(s) Humans ; TNF Receptor-Associated Factor 2 ; Cardiomyopathies/chemically induced ; Ubiquitin-Protein Ligases/metabolism ; Mitochondria/metabolism ; Doxorubicin/adverse effects
    Chemical Substances TNF Receptor-Associated Factor 2 ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.063546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  6. Article ; Online: Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.

    Rawnsley, David R / Diwan, Abhinav

    EBioMedicine

    2020  Volume 56, Page(s) 102824

    Abstract: Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of ... ...

    Abstract Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained results.
    MeSH term(s) Diabetes Mellitus ; Humans ; Inflammation ; Lysosomes ; Metabolic Syndrome ; Obesity
    Language English
    Publishing date 2020-06-12
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  7. Article ; Online: Sensing Protein Quality in Cardiac Myocytes p62 Triggers a Lysosomal Response.

    Diwan, Abhinav / Gottlieb, Roberta A

    Circulation research

    2020  Volume 127, Issue 4, Page(s) 519–521

    MeSH term(s) Calcineurin ; Lysosomes ; Macroautophagy ; Myocytes, Cardiac ; Proteasome Endopeptidase Complex
    Chemical Substances Calcineurin (EC 3.1.3.16) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.120.317567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  8. Article ; Online: NO to Lysosomes: A Signal for Insulin Resistance in Obesity.

    Javaheri, Ali / Diwan, Abhinav

    Cellular and molecular gastroenterology and hepatology

    2019  Volume 8, Issue 1, Page(s) 153–154

    MeSH term(s) Autophagy ; Humans ; Insulin Resistance ; Lysosomes ; Obesity
    Language English
    Publishing date 2019-05-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2019.04.006
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  9. Article ; Online: Metabolic control of mitophagy.

    Zimmermann, Andreas / Madeo, Frank / Diwan, Abhinav / Sadoshima, Junichi / Sedej, Simon / Kroemer, Guido / Abdellatif, Mahmoud

    European journal of clinical investigation

    2023  Volume 54, Issue 4, Page(s) e14138

    Abstract: Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival. The ... ...

    Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival. The central role of mitochondria in cellular metabolism places mitochondrial removal at the interface of key metabolic pathways affecting the biosynthesis or catabolism of acetyl-coenzyme A, nicotinamide adenine dinucleotide, polyamines, as well as fatty acids and amino acids. Molecular switches that integrate the metabolic status of the cell, like AMP-dependent protein kinase, protein kinase A, mechanistic target of rapamycin and sirtuins, have also emerged as important regulators of mitophagy. In this review, we discuss how metabolic regulation intersects with mitophagy. We place special emphasis on the metabolic regulatory circuits that may be therapeutically targeted to delay ageing and mitochondria-associated chronic diseases. Moreover, we identify outstanding knowledge gaps, such as the ill-defined distinction between basal and damage-induced mitophagy, which must be resolved to boost progress in this area.
    MeSH term(s) Humans ; Mitophagy/physiology ; Mitochondria/physiology ; Autophagy ; Homeostasis
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Drugging the Hippo (Pathway): A Strategy to Stimulate Cardiac Regeneration?

    Mani, Kartik / Diwan, Abhinav

    JACC. Basic to translational science

    2018  Volume 3, Issue 5, Page(s) 654–656

    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2018.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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