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Article ; Online: Exploring the Complex Link between Autophagy, Regulated Cell Death, and Cell Fate Pathways in Cancer Pathogenesis and Therapy.

Moosavi, Mohammad Amin / Djavaheri-Mergny, Mojgan

2023 Volume 12, Issue 3

Abstract: Autophagy is a catabolic lysosomal-dependent pathway involved in the degradation of cellular materials, supplying precursor compounds and energy for macromolecule synthesis and metabolic needs [ ... ]. ...

Abstract	Autophagy is a catabolic lysosomal-dependent pathway involved in the degradation of cellular materials, supplying precursor compounds and energy for macromolecule synthesis and metabolic needs [...].
MeSH term(s)	Humans ; Neoplasms/therapy ; Regulated Cell Death ; Autophagy/physiology
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12030498
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harnessing G-quadruplex ligands for lung cancer treatment: A comprehensive overview.

Figueiredo, Joana / Djavaheri-Mergny, Mojgan / Ferret, Lucille / Mergny, Jean-Louis / Cruz, Carla

Drug discovery today

2023 Volume 28, Issue 12, Page(s) 103808

Abstract: Lung cancer (LC) remains a leading cause of mortality worldwide, and new therapeutic strategies are urgently needed. One such approach revolves around the utilization of four-stranded nucleic acid secondary structures, known as G-quadruplexes (G4), which ...

Abstract	Lung cancer (LC) remains a leading cause of mortality worldwide, and new therapeutic strategies are urgently needed. One such approach revolves around the utilization of four-stranded nucleic acid secondary structures, known as G-quadruplexes (G4), which are formed by G-rich sequences. Ligands that bind selectively to G4 structures present a promising strategy for regulating crucial cellular processes involved in the progression of LC, rendering them potent agents for lung cancer treatment. In this review, we offer a summary of recent advancements in the development of G4 ligands capable of targeting specific genes associated with the development and progression of lung cancer.
MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; G-Quadruplexes ; Ligands
Chemical Substances	Ligands
Language	English
Publishing date	2023-10-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103808
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Zs.A 4725: Show issues

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Article ; Online: Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia.

Moosavi, Mohammad Amin / Djavaheri-Mergny, Mojgan

International journal of molecular sciences

2019 Volume 20, Issue 14

Abstract: Autophagy is one of the main cellular catabolic pathways controlling a variety of physiological processes, including those involved in self-renewal, differentiation and death. While acute promyelocytic leukemia (APL) cells manifest low levels of ... ...

Abstract	Autophagy is one of the main cellular catabolic pathways controlling a variety of physiological processes, including those involved in self-renewal, differentiation and death. While acute promyelocytic leukemia (APL) cells manifest low levels of expression of autophagy genes associated with reduced autophagy activity, the introduction of all-
MeSH term(s)	Arsenic Trioxide/therapeutic use ; Autophagy/drug effects ; Autophagy/physiology ; Cell Differentiation/drug effects ; Drug Resistance, Neoplasm ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy
Chemical Substances	Arsenic Trioxide (S7V92P67HO)
Language	English
Publishing date	2019-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20143559
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Article: Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.

Beauvarlet, Jennifer / Mergny, Jean-Louis / Djavaheri-Mergny, Mojgan

Molecular & cellular oncology

2019 Volume 6, Issue 4, Page(s) 1604047

Abstract: G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ... ...

Abstract	G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand
Language	English
Publishing date	2019-05-08
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2019.1604047
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Article: Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma.

Djavaheri-Mergny, Mojgan / Giuriato, Sylvie / Tschan, Mario P / Humbert, Magali

Cells

2019 Volume 8, Issue 2

Abstract: Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages. The HSPCs pool is reduced with ageing resulting in few ... ...

Abstract	Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and myeloid lineages. The HSPCs pool is reduced with ageing resulting in few HSPC clones maintaining haematopoiesis thereby reducing blood cell diversity, a phenomenon called clonal haematopoiesis. Clonal expansion of HSPCs carrying specific genetic mutations leads to increased risk for haematological malignancies. Therefore, it comes as no surprise that hematopoietic tumours develop in higher frequency in elderly people. Unfortunately, elderly patients with leukaemia or lymphoma still have an unsatisfactory prognosis compared to younger ones highlighting the need to develop more efficient therapies for this group of patients. Growing evidence indicates that macroautophagy (hereafter referred to as autophagy) is essential for health and longevity. This review is focusing on the role of autophagy in normal haematopoiesis as well as in leukaemia and lymphoma development. Attenuated autophagy may support early hematopoietic neoplasia whereas activation of autophagy in later stages of tumour development and in response to a variety of therapies rather triggers a pro-tumoral response. Novel insights into the role of autophagy in haematopoiesis will be discussed in light of designing new autophagy modulating therapies in hematopoietic cancers.
MeSH term(s)	Animals ; Autophagy ; Clinical Trials as Topic ; Hematopoiesis ; Humans ; Leukemia/pathology ; Lymphoma/pathology
Language	English
Publishing date	2019-01-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8020103
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Article ; Online: G-quadruplex ligands as potent regulators of lysosomes.

Ferret, Lucille / Alvarez-Valadez, Karla / Rivière, Jennifer / Muller, Alexandra / Bohálová, Natalia / Yu, Luo / Guittat, Lionel / Brázda, Vaclav / Kroemer, Guido / Mergny, Jean-Louis / Djavaheri-Mergny, Mojgan

Autophagy

2023 Volume 19, Issue 7, Page(s) 1901–1915

Abstract: Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize ... ...

Abstract	Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, including cancer and infectious diseases. These molecules are called G4 ligands. When the biological effects of G4 ligands are studied, the analysis is often limited to nucleic acid targets. However, recent evidence indicates that G4 ligands may target other cellular components and compartments such as lysosomes and mitochondria. Here, we summarize our current knowledge of the regulation of lysosome by G4 ligands, underlying their potential functional impact on lysosome biology and autophagic flux, as well as on the transcriptional regulation of lysosomal genes. We outline the consequences of these effects on cell fate decisions and we systematically analyzed G4-prone sequences within the promoter of 435 lysosome-related genes. Finally, we propose some hypotheses about the mechanisms involved in the regulation of lysosomes by G4 ligands.
MeSH term(s)	Humans ; Ligands ; Autophagy ; G-Quadruplexes ; DNA/metabolism ; Guanine
Chemical Substances	Ligands ; DNA (9007-49-2) ; Guanine (5Z93L87A1R)
Language	English
Publishing date	2023-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2023.2170071
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Zs.A 6741: Show issues

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Article ; Online: TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.

Airiau, Kelly / Vacher, Pierre / Micheau, Olivier / Prouzet-Mauleon, Valerie / Kroemer, Guido / Moosavi, Mohammad Amin / Djavaheri-Mergny, Mojgan

Cells

2021 Volume 11, Issue 1

Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of ... ...

Abstract	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. Taking advantage of the Gene Expression Profiling Interactive Analysis (GEPIA) project, we first found that leukemia patients present a unique TRAIL receptor gene expression pattern that may reflect their resistance to TRAIL. The exposure of NB4 acute promyelocytic leukemia cells to TRAIL induces intracellular Ca
MeSH term(s)	Apoptosis/drug effects ; Autophagy-Related Proteins/metabolism ; Calcium/metabolism ; Calcium Channels/metabolism ; Cytoprotection/drug effects ; Death Domain Receptor Signaling Adaptor Proteins/metabolism ; Drug Resistance, Neoplasm/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Homeostasis/drug effects ; Humans ; Jurkat Cells ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Sequence Analysis, RNA ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Tretinoin/pharmacology
Chemical Substances	Autophagy-Related Proteins ; Calcium Channels ; Death Domain Receptor Signaling Adaptor Proteins ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand ; Tretinoin (5688UTC01R) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-12-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11010057
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Article ; Online: Erratum: Rémy et al. Isolation and Culture of Human Stem Cells from Apical Papilla under Low Oxygen Concentration Highlight Original Properties.

Rémy, Murielle / Ferraro, Francesca / Le Salver, Pierre / Rey, Sylvie / Genot, Elisabeth / Djavaheri-Mergny, Mojgan / Thébaud, Noélie / Boiziau, Claudine / Boeuf, Hélène

Cells

2021 Volume 10, Issue 5

Abstract: The authors wish to make the following change to their paper [ ... ]. ...

Abstract	The authors wish to make the following change to their paper [...].
Language	English
Publishing date	2021-04-23
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10050988
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Article ; Online: The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1.

He, Wencan / Azzi-Martin, Lamia / Velasco, Valérie / Lehours, Philippe / Dubus, Pierre / Djavaheri-Mergny, Mojgan / Ménard, Armelle

PLoS pathogens

2021 Volume 17, Issue 3, Page(s) e1009320

Abstract: Humans are frequently exposed to bacterial genotoxins of the gut microbiota, such as colibactin and cytolethal distending toxin (CDT). In the present study, whole genome microarray-based identification of differentially expressed genes was performed in ... ...

Abstract	Humans are frequently exposed to bacterial genotoxins of the gut microbiota, such as colibactin and cytolethal distending toxin (CDT). In the present study, whole genome microarray-based identification of differentially expressed genes was performed in vitro on HT29 intestinal cells while following the ectopic expression of the active CdtB subunit of Helicobacter hepaticus CDT. Microarray data showed a CdtB-dependent upregulation of transcripts involved in positive regulation of autophagy concomitant with the downregulation of transcripts involved in negative regulation of autophagy. CdtB promotes the activation of autophagy in intestinal and hepatic cell lines. Experiments with cells lacking autophagy related genes, ATG5 and ATG7 infected with CDT- and colibactin-producing bacteria revealed that autophagy protects cells against the genotoxin-induced apoptotic cell death. Autophagy induction could also be associated with nucleoplasmic reticulum (NR) formation following DNA damage induced by these bacterial genotoxins. In addition, both genotoxins promote the accumulation of the autophagic receptor P62/SQSTM1 aggregates, which colocalized with foci concentrating the RNA binding protein UNR/CSDE1. Some of these aggregates were deeply invaginated in NR in distended nuclei together or in the vicinity of UNR-rich foci. Interestingly, micronuclei-like structures and some vesicles containing chromatin and γH2AX foci were found surrounded with P62/SQSTM1 and/or the autophagosome marker LC3. This study suggests that autophagy and P62/SQSTM1 regulate the abundance of micronuclei-like structures and are involved in cell survival following the DNA damage induced by CDT and colibactin. Similar effects were observed in response to DNA damaging chemotherapeutic agents, offering new insights into the context of resistance of cancer cells to therapies inducing DNA damage.
MeSH term(s)	Autophagy/drug effects ; Autophagy/physiology ; Bacterial Toxins/pharmacology ; Cell Nucleus/metabolism ; DNA-Binding Proteins/metabolism ; Endoplasmic Reticulum Stress/physiology ; Helicobacter hepaticus/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Mutagens/metabolism ; RNA-Binding Proteins/drug effects ; RNA-Binding Proteins/metabolism ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism
Chemical Substances	Bacterial Toxins ; CSDE1 protein, human ; DNA-Binding Proteins ; Mutagens ; RNA-Binding Proteins ; SQSTM1 protein, human ; Sequestosome-1 Protein ; cytolethal distending toxin
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1009320
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Article ; Online: Inhibition of acyl-CoA binding protein (ACBP) by means of a GABA

Cell death & disease

2024 Volume 15, Issue 4, Page(s) 249

Abstract: Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor ( ... ...

Abstract	Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor (GABA
MeSH term(s)	Animals ; Mice ; Diazepam Binding Inhibitor/pharmacology ; gamma-Aminobutyric Acid
Chemical Substances	Diazepam Binding Inhibitor ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06633-6
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