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Article ; Online: Investigating the Effects of Diet-Induced Prediabetes on Skeletal Muscle Strength in Male Sprague Dawley Rats.

Dlamini, Mandlakazi / Khathi, Andile

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Type 2 diabetes mellitus, a condition preceded by prediabetes, is documented to compromise skeletal muscle health, consequently affecting skeletal muscle structure, strength, and glucose homeostasis. A disturbance in skeletal muscle functional capacity ... ...

Abstract	Type 2 diabetes mellitus, a condition preceded by prediabetes, is documented to compromise skeletal muscle health, consequently affecting skeletal muscle structure, strength, and glucose homeostasis. A disturbance in skeletal muscle functional capacity has been demonstrated to induce insulin resistance and hyperglycemia. However, the modifications in skeletal muscle function in the prediabetic state are not well elucidated. Hence, this study investigated the effects of diet-induced prediabetes on skeletal muscle strength in a prediabetic model. Male Sprague Dawley rats were randomly assigned to one of the two groups (
MeSH term(s)	Male ; Rats ; Animals ; Rats, Sprague-Dawley ; Prediabetic State/etiology ; Insulin Resistance ; Blood Glucose ; Diabetes Mellitus, Type 2/etiology ; Glycated Hemoglobin ; Diet/adverse effects ; Muscle, Skeletal ; Insulin ; Insulin, Regular, Human ; Hyperglycemia
Chemical Substances	Blood Glucose ; Glycated Hemoglobin ; Insulin ; Insulin, Regular, Human
Language	English
Publishing date	2024-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25074076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review.

Dlamini, Mandlakazi / Khathi, Andile

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: The skeletal muscle plays a critical role in regulating systemic blood glucose homeostasis. Impaired skeletal muscle glucose homeostasis associated with type 2 diabetes mellitus (T2DM) has been observed to significantly affect the whole-body glucose ... ...

Abstract	The skeletal muscle plays a critical role in regulating systemic blood glucose homeostasis. Impaired skeletal muscle glucose homeostasis associated with type 2 diabetes mellitus (T2DM) has been observed to significantly affect the whole-body glucose homeostasis, thereby resulting in other diabetic complications. T2DM does not only affect skeletal muscle glucose homeostasis, but it also affects skeletal muscle structure and functional capacity. Given that T2DM is a global health burden, there is an urgent need to develop therapeutic medical therapies that will aid in the management of T2DM. Prediabetes (PreDM) is a prominent risk factor of T2DM that usually goes unnoticed in many individuals as it is an asymptomatic condition. Hence, research on PreDM is essential because establishing diabetic biomarkers during the prediabetic state would aid in preventing the development of T2DM, as PreDM is a reversible condition if it is detected in the early stages. The literature predominantly documents the changes in skeletal muscle during T2DM, but the changes in skeletal muscle during prediabetes are not well elucidated. In this review, we seek to review the existing literature on PreDM- and T2DM-associated changes in skeletal muscle function.
MeSH term(s)	Humans ; Prediabetic State ; Diabetes Mellitus, Type 2 ; Muscle, Skeletal ; Musculoskeletal Physiological Phenomena ; Blood Glucose
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010469
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Article: Entrepreneurial intention and the three stages of entrepreneurial action: a process approach.

Dlamini, Mzwakhe / Botha, Melodi

Frontiers in psychology

2023 Volume 14, Page(s) 1184390

Abstract: The relationship between entrepreneurial intention (EI) and entrepreneurial action (EA) is a popular topic in entrepreneurship research, owing to the contribution of these constructs in the process leading to the entrepreneurial activity taking place. ... ...

Abstract	The relationship between entrepreneurial intention (EI) and entrepreneurial action (EA) is a popular topic in entrepreneurship research, owing to the contribution of these constructs in the process leading to the entrepreneurial activity taking place. There are still countries that are recording high entrepreneurial intention levels in comparison to their corresponding entrepreneurial action levels that are low. This is a global concern to which South Africa (SA) is also not immune. Most of the research tests the relationship between two single constructs: EI and EA. Our study follows a process approach and investigates the effect of this relationship between EI and the three stages of EA. A quantitative method was employed and a survey utilized whereby data was collected among 597 entrepreneurs in South Africa. The data was analyzed through Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM). The EI construct is supported through the Theory of Planned Behavior, in conjunction with the Motivation Opportunity Ability theory. The Discovery Theory, together with the Creative Theory, supports each of the stages of EA, namely: entrepreneurial opportunity discovery (EODI); entrepreneurial opportunity evaluation (EOEV); and entrepreneurial opportunity exploitation (EOEX). Previous research regarding the relationship between EI and EA measured this relationship from a binary point of view. This study contributes to the entrepreneurship field by employing the process approach to determine the impact of EI on the stages of EA. This study reveals that EI is statistically significant in all three stages of EA. However, the strength of this relationship is found to be strong between EI and the EODI and EOEV stages and moderate between EI and the EOEX stage. Therefore, this study reveals that effective training interventions and development are necessary between EI and the EOEX stage of EA.
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1184390
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Article ; Online: A systematic review on the incidence of influenza viruses in wastewater matrices: Implications for public health.

Dlamini, Mbasa / Msolo, Luyanda / Ehi Ebomah, Kingsley / Nontongana, Nolonwabo / Ifeanyi Okoh, Anthony

PloS one

2024 Volume 19, Issue 4, Page(s) e0291900

Abstract: Influenza viruses pose a significant public health threat, necessitating comprehensive surveillance strategies to enhance early detection and preventive measures. This systematic review investigates the incidence of influenza viruses in wastewater ... ...

Abstract	Influenza viruses pose a significant public health threat, necessitating comprehensive surveillance strategies to enhance early detection and preventive measures. This systematic review investigates the incidence of influenza viruses in wastewater matrices, aiming to elucidate the potential implications for public health. The study synthesizes existing literature, employing rigorous inclusion criteria to identify relevant studies conducted globally. The essence of the problem lies in the gaps of traditional surveillance methods, which often rely on clinical data and may underestimate the true prevalence of influenza within communities. Wastewater-based epidemiology offers a novel approach to supplementing these conventional methods, providing a broader and more representative assessment of viral circulation. This review systematically examines the methodologies employed in the selected studies, including virus concentration techniques and molecular detection methods, to establish a standardized framework for future research. Our findings reveal a consistent presence of influenza viruses in diverse wastewater matrices across different geographic locations and seasons. Recommendations for future research include the standardization of sampling protocols, improvement of virus concentration methods, and the integration of wastewater surveillance into existing public health frameworks. In conclusion, this systematic review contributes to the understanding of influenza dynamics in wastewater matrices, offering valuable insights for public health practitioners and policymakers. Implementation of wastewater surveillance alongside traditional methods can enhance the resilience of public health systems and better prepare communities for the challenges posed by influenza outbreaks.
MeSH term(s)	Wastewater/virology ; Humans ; Public Health ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Incidence ; Orthomyxoviridae/isolation & purification
Chemical Substances	Wastewater
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291900
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Article ; Online: Assessing the Effects of Land Use on Surface Water Quality in the Lower uMfolozi Floodplain System, South Africa.

Dlamini, Mandla / Chirima, George / Jovanovic, Nebo / Adam, Elhadi

International journal of environmental research and public health

2021 Volume 18, Issue 2

Abstract: This study investigated the impacts of cultivation on water and soil quality in the lower uMfolozi floodplain system in KwaZulu-Natal province, South Africa. We did this by assessing seasonal variations in purposefully selected water and soil properties ... ...

Abstract	This study investigated the impacts of cultivation on water and soil quality in the lower uMfolozi floodplain system in KwaZulu-Natal province, South Africa. We did this by assessing seasonal variations in purposefully selected water and soil properties in these two land-use systems. The observed values were statistically analysed by performing Student's paired
MeSH term(s)	Agriculture ; Environmental Monitoring ; Humans ; Sodium/analysis ; Soil ; South Africa ; Water Quality
Chemical Substances	Soil ; Sodium (9NEZ333N27)
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18020561
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Article ; Online: Combinatorial nanodot stripe assay to systematically study cell haptotaxis.

Dlamini, Mcolisi / Kennedy, Timothy E / Juncker, David

Microsystems & nanoengineering

2020 Volume 6, Page(s) 114

Abstract: Haptotaxis is critical to cell guidance and development and has been studied in vitro using either gradients or stripe assays that present a binary choice between full and zero coverage of a protein cue. However, stripes offer only a choice between ... ...

Abstract	Haptotaxis is critical to cell guidance and development and has been studied in vitro using either gradients or stripe assays that present a binary choice between full and zero coverage of a protein cue. However, stripes offer only a choice between extremes, while for gradients, cell receptor saturation, migration history, and directional persistence confound the interpretation of cellular responses. Here, we introduce nanodot stripe assays (NSAs) formed by adjacent stripes of nanodot arrays with different surface coverage. Twenty-one pairwise combinations were designed using 0, 1, 3, 10, 30, 44 and 100% stripes and were patterned with 200 × 200, 400 × 400 or 800 × 800 nm
Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-020-00223-0
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Article: Characterizing Leaf Nutrients of Wetland Plants and Agricultural Crops with Nonparametric Approach Using Sentinel-2 Imagery Data

Dlamini, Mandla / Chirima, George / Sibanda, Mbulisi / Adam, Elhadi / Dube, Timothy

Remote Sensing. 2021 Oct. 22, v. 13, no. 21

2021

Abstract: In arid environments of the world, particularly in sub-Saharan Africa and Asia, floodplain wetlands are a valuable agricultural resource. However, the water reticulation role by wetlands and crop production can negatively impact wetland plants. Knowledge ...

Abstract	In arid environments of the world, particularly in sub-Saharan Africa and Asia, floodplain wetlands are a valuable agricultural resource. However, the water reticulation role by wetlands and crop production can negatively impact wetland plants. Knowledge on the foliar biochemical elements of wetland plants enhances understanding of the impacts of agricultural practices in wetlands. This study thus used Sentinel-2 multispectral data to predict seasonal variations in the concentrations of nine foliar biochemical elements in plant leaves of key floodplain wetland vegetation types and crops in the uMfolozi floodplain system (UFS). Nutrient concentrations in different floodplain plant species were estimated using Sentinel-2 multispectral data derived vegetation indices in concert with the random forest regression. The results showed a mean R² of 0.87 and 0.86 for the dry winter and wet summer seasons, respectively. However, copper, sulphur, and magnesium were poorly correlated (R² ≤ 0.5) with vegetation indices during the summer season. The average % relative root mean square errors (RMSE’s) for seasonal nutrient estimation accuracies for crops and wetland vegetation were 15.2 % and 26.8%, respectively. There was a significant difference in nutrient concentrations between the two plant types, (R² = 0.94 (crops), R² = 0.84 (vegetation). The red-edge position 1 (REP1) and the normalised difference vegetation index (NDVI) were the best nutrient predictors. These results demonstrate the usefulness of Sentinel-2 imagery and random forests regression in predicting seasonal, nutrient concentrations as well as the accumulation of chemicals in wetland vegetation and crops.
Keywords	algorithms ; copper ; crop production ; floodplains ; leaves ; magnesium ; normalized difference vegetation index ; sulfur ; summer ; wetlands ; winter ; Asia ; Sub-Saharan Africa
Language	English
Dates of publication	2021-1022
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13214249
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: TB testing in HIV-positive patients prior to antiretroviral treatment.

Spooner, E / Reddy, S / Ntoyanto, S / Sakadavan, Y / Reddy, T / Mahomed, S / Mlisana, K / Dlamini, M / Daniels, B / Luthuli, N / Ngomane, N / Kiepiela, P / Coutsoudis, A

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2022 Volume 26, Issue 3, Page(s) 224–231

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Humans ; Anti-Retroviral Agents ; HIV Infections/complications ; HIV Infections/drug therapy ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Sensitivity and Specificity ; Sputum ; Tuberculosis/diagnosis
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2022-02-22
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.21.0195
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Article ; Online: Girl Champ in eSwatini: A Strategic Marketing Campaign to Promote Demand for Sexual and Reproductive Health Services Among Young Women.

Brault, Marie A / Christie, Sarah / Manchia, Amanda / Mabuza, Khabonina / Dlamini, Muhle / Linnander, Erika L

AIDS and behavior

2021 Volume 26, Issue 3, Page(s) 853–863

Abstract: Efforts to engage adolescent girls and young women (AGYW) in HIV services have struggled, in part, due to limited awareness of services and stigma. Strategic marketing is a promising approach, but the impact on youth behavior change is unclear. We report ...

Abstract	Efforts to engage adolescent girls and young women (AGYW) in HIV services have struggled, in part, due to limited awareness of services and stigma. Strategic marketing is a promising approach, but the impact on youth behavior change is unclear. We report findings from a mixed methods evaluation of the Girl Champ campaign, designed to generate demand for sexual and reproductive services among AGYW, and piloted in three clinics in the Manzini region of eSwatini. We analyzed and integrated data from longitudinal, clinic-level databases on health service utilization among AGYW before and after the pilot, qualitative interviews with stakeholders responsible for the implementation of the pilot, and participant feedback surveys from attendees of Girl Champ events. Girl Champ was well received by most stakeholders based on event attendance and participant feedback, and associated with longitudinal improvements in demand for HIV services. Findings can inform future HIV demand creation interventions for youth.
MeSH term(s)	Adolescent ; Eswatini ; Female ; HIV Infections/prevention & control ; Humans ; Marketing ; Reproductive Health ; Reproductive Health Services ; Sexual Behavior
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-021-03446-y
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Article ; Online: Costs of distributing HIV self-testing kits in Eswatini through community and workplace models.

McGee, Kathleen / d'Elbée, Marc / Dekova, Ralitza / Sande, Linda A / Dube, Lenhle / Masuku, Sanele / Dlamini, Makhosazana / Mangenah, Collin / Mwenge, Lawrence / Johnson, Cheryl / Hatzold, Karin / Neuman, Melissa / Meyer-Rath, Gesine / Terris-Prestholt, Fern

BMC infectious diseases

2024 Volume 22, Issue Suppl 1, Page(s) 976

Abstract: Background: This study evaluates the implementation and running costs of an HIV self-testing (HIVST) distribution program in Eswatini. HIVST kits were delivered through community-based and workplace models using primary and secondary distribution. ... ...

Abstract	Background: This study evaluates the implementation and running costs of an HIV self-testing (HIVST) distribution program in Eswatini. HIVST kits were delivered through community-based and workplace models using primary and secondary distribution. Primary clients could self-test onsite or offsite. This study presents total running economic costs of kit distribution per model between April 2019 and March 2020, and estimates average cost per HIVST kit distributed, per client self-tested, per client self-tested reactive, per client confirmed positive, and per client initiating antiretroviral therapy (ART). Methods: Distribution data and follow-up phone interviews were analysed to estimate implementation outcomes. Results were presented for each step of the care cascade using best-case and worst-case scenarios. A top-down incremental cost-analysis was conducted from the provider perspective using project expenditures. Sensitivity and scenario analyses explored effects of economic and epidemiological parameters on average costs. Results: Nineteen thousand one hundred fifty-five HIVST kits were distributed to 13,031 individuals over a 12-month period, averaging 1.5 kits per recipient. 83% and 17% of kits were distributed via the community and workplace models, respectively. Clients reached via the workplace model were less likely to opt for onsite testing than clients in the community model (8% vs 29%). 6% of onsite workplace testers tested reactive compared to 2% of onsite community testers. Best-case scenario estimated 17,458 (91%) clients self-tested, 633 (4%) received reactive-test results, 606 (96%) linked to confirmatory testing, and 505 (83%) initiated ART. Personnel and HIVST kits represented 60% and 32% of total costs, respectively. Average costs were: per kit distributed US$17.23, per client tested US$18.91, per client with a reactive test US$521.54, per client confirmed positive US$550.83, and per client initiating ART US$708.60. Lower rates for testing, reactivity, and linkage to care in the worst-case scenario resulted in higher average costs along the treatment cascade. Conclusion: This study fills a significant evidence gap regarding costs of HIVST provision along the client care cascade in Eswatini. Workplace and community-based distribution of HIVST accompanied with effective linkage to care strategies can support countries to reach cascade objectives.
MeSH term(s)	Humans ; Self-Testing ; Eswatini ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Delivery of Health Care ; Workplace ; Mass Screening/methods
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08694-y
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