Article ; Online: The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations.
2020 Volume 9, Issue 12
Abstract: Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We ... ...
| Abstract | Epidemiology of hepatocellular carcinoma (HCC) showed a correlation between incidence and geographical-relevant risk factors. This study aims to compare the distributions of cancer stem cells (CSC) in two distant populations in Asia and Europe. We analyzed 52 and 43 selected HCC patients undergoing hepatectomy in Ho Chi Minh City (Vietnam) and Trieste (Italy). Each patient sample consisted of HCC, peri-HCC, and non-tumoral (distal) tissue. Demographic data were recorded together with clinical findings. The protocol for the collection of tissue samples and RNA was standardized in both laboratories and gene expression analysis was performed in a single laboratory with identical PCR conditions. Baseline data showed comparable laboratory findings between the two cohorts. mRNA distribution showed a comparable pattern of all CSC markers analyzed with the expression of CD90 progressively increasing from distal and peri-HCC to be highest in HCC ( |
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| MeSH term(s) | Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/virology ; Cohort Studies ; Female ; Gene Expression Regulation, Neoplastic ; Hepatitis B/complications ; Hepatitis B/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/virology ; Male ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Thy-1 Antigens/genetics ; Thy-1 Antigens/metabolism |
| Chemical Substances | Biomarkers, Tumor ; RNA, Messenger ; Thy-1 Antigens |
| Language | English |
| Publishing date | 2020-12-12 |
| Publishing country | Switzerland |
| Document type | Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells9122672 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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