LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article: Reducing Dementia Risk: The Latest Evidence to Guide Conversations With Older Adults.

    Do, Justin / Hill, Nikki L

    Journal of gerontological nursing

    2023  Volume 49, Issue 9, Page(s) 3–5

    MeSH term(s) Humans ; Aged ; Communication ; Dementia/prevention & control
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603140-7
    ISSN 0098-9134
    ISSN 0098-9134
    DOI 10.3928/00989134-20230815-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2334: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Patient-provider communication about cognition and the role of memory concerns: a descriptive study.

    Hill, Nikki L / Bratlee-Whitaker, Emily / Jang, Heejung / Bhargava, Sakshi / Sillner, Andrea Yevchak / Do, Justin / Mogle, Jacqueline

    BMC geriatrics

    2023  Volume 23, Issue 1, Page(s) 342

    Abstract: Background: Early identification of cognitive impairment is an important part of health promotion in aging. However, many older adults do not seek help for cognitive problems until their ability to function independently is substantially impacted. The ... ...

    Abstract Background: Early identification of cognitive impairment is an important part of health promotion in aging. However, many older adults do not seek help for cognitive problems until their ability to function independently is substantially impacted. The purpose of this descriptive study was to explore older adults' experiences with patient-provider communication specific to cognition as well as compare barriers and facilitators between those with and without memory concerns.
    Methods: We conducted an online survey with individuals aged 65 + years (n = 409; mean age = 71.4(4.73); 54% female; 79% non-Hispanic White), purposively sampled to include those with and without memory concerns. Questionnaires included measures of subjective memory decline (SMD), memory concerns, past healthcare experiences, as well as open-ended questions regarding patient-provider communication about cognition. Content analysis was used to code open-ended responses. Logistic regression was used to examine differences in facilitators and barriers to communication among three groups: no SMD (n = 130), SMD without memory concerns (n = 143), and SMD with memory concerns (n = 136).
    Results: Only 16.6% of participants reported discussing cognition with a healthcare provider. Of the remaining 83.4%, approximately two-thirds would be open to such discussions in certain circumstances, most frequently if they had worsening memory problems. Over half of participants reported that their provider had never offered cognitive testing. Compared to the no SMD and SMD without memory concerns groups, participants reporting SMD with memory concerns were more likely to: (1) discuss cognition if their healthcare provider initiated the conversation, and (2) avoid discussions of cognitive problems due to fears of losing independence.
    Conclusions: We found that most participants, including those reporting SMD with memory concerns, had never discussed cognition with their healthcare providers. Patient-reported barriers and facilitators to communication about cognition differed in several areas based on SMD status and the presence or absence of memory concerns. Consideration of these differences can guide future efforts to improve early identification of subtle cognitive changes that would benefit from further monitoring or intervention.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/therapy ; Aging ; Communication ; Surveys and Questionnaires
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-023-04053-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Anabolic actions of parathyroid hormone in a hypophosphatasia mouse model.

    Koh, Amy J / Nam, Hwa Kyung / Michalski, Megan N / Do, Justin / McCauley, Laurie K / Hatch, Nan E

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2022  Volume 33, Issue 11, Page(s) 2423–2433

    Abstract: Hypophosphatasia, the rare heritable disorder caused by TNAP enzyme mutations, presents wide-ranging severity of bone hypomineralization and skeletal abnormalities. Intermittent PTH (1-34) increased long bone volume in Alpl: Introduction: ... ...

    Abstract Hypophosphatasia, the rare heritable disorder caused by TNAP enzyme mutations, presents wide-ranging severity of bone hypomineralization and skeletal abnormalities. Intermittent PTH (1-34) increased long bone volume in Alpl
    Introduction: Hypophosphatasia is the rare heritable disorder caused by mutations in the tissue non-specific alkaline phosphatase (TNAP) enzyme leading to TNAP deficiency. Individuals with hypophosphatasia commonly present with bone hypomineralization and skeletal abnormalities. The purpose of this study was to determine the impact of intermittent PTH on the skeletal phenotype of TNAP-deficient Alpl
    Methods: Alpl-/- and Alpl+/+ (wild-type; WT) littermate mice were administered PTH (1-34) (50 µg/kg) or vehicle control from days 4 to 12 and skeletal analyses were performed including gross measurements, micro-CT, histomorphometry, and serum biochemistry.
    Results: Alpl
    Conclusion: PTH increased long bone volume in the Alpl
    MeSH term(s) Alkaline Phosphatase/genetics ; Animals ; Disease Models, Animal ; Hypophosphatasia/complications ; Hypophosphatasia/drug therapy ; Hypophosphatasia/genetics ; Mice ; Osteoporosis ; Parathyroid Hormone/pharmacology
    Chemical Substances Parathyroid Hormone ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2022-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-022-06496-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Parathyroid hormone and trabectedin have differing effects on macrophages and stress fracture repair.

    Zweifler, Laura E / Sinder, Benjamin P / Stephan, Chris / Koh, Amy J / Do, Justin / Ulrich, Emily / Grewal, Jobanpreet / Woo, Cecilia / Batoon, Lena / Kozloff, Kenneth / Roca, Hernan / Mishina, Yuji / McCauley, Laurie K

    Bone

    2023  Volume 179, Page(s) 116983

    Abstract: Stress fractures occur as a result of repeated mechanical stress on bone and are commonly found in the load-bearing lower extremities. Macrophages are key players in the immune system and play an important role in bone remodeling and fracture healing. ... ...

    Abstract Stress fractures occur as a result of repeated mechanical stress on bone and are commonly found in the load-bearing lower extremities. Macrophages are key players in the immune system and play an important role in bone remodeling and fracture healing. However, the role of macrophages in stress fractures has not been adequately addressed. We hypothesize that macrophage infiltration into a stress fracture callus site promotes bone healing. To test this, a unilateral stress fracture induction model was employed in which the murine ulna of four-month-old, C57BL/6 J male mice was repeatedly loaded with a pre-determined force until the bone was displaced a distance below the threshold for complete fracture. Mice were treated daily with parathyroid hormone (PTH, 50 μg/kg/day) starting two days before injury and continued until 24 h before euthanasia either four or six days after injury, or treated with trabectedin (0.15 mg/kg) on the day of stress fracture and euthanized three or seven days after injury. These treatments were used due to their established effects on macrophages. While macrophages have been implicated in the anabolic effects of PTH, trabectedin, an FDA approved chemotherapeutic, compromises macrophage function and reduces bone mass. At three- and four-days post injury, callus macrophage numbers were analyzed histologically. There was a significant increase in macrophages with PTH treatment compared to vehicle in the callus site. By one week of healing, treatments differentially affected the bony callus as analyzed by microcomputed tomography. PTH enhanced callus bone volume. Conversely, callus bone volume was decreased with trabectedin treatment. Interestingly, concurrent treatment with PTH and trabectedin rescued the reduction observed in the callus with trabectedin treatment alone. This study reports on the key involvement of macrophages during stress fracture healing. Given these observed outcomes on macrophage physiology and bone healing, these findings may be important for patients actively receiving either of these FDA-approved therapeutics.
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Infant ; Parathyroid Hormone/pharmacology ; Parathyroid Hormone/therapeutic use ; Trabectedin/pharmacology ; Fractures, Stress/drug therapy ; Fractures, Stress/pathology ; X-Ray Microtomography/methods ; Mice, Inbred C57BL ; Bony Callus/pathology ; Fracture Healing ; Macrophages
    Chemical Substances Parathyroid Hormone ; Trabectedin (ID0YZQ2TCP)
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2023.116983
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1571: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 332: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Factors Affecting Selection of TraineE for Neurointervention (FASTEN).

    Elfil, Mohamed / Morsi, Rami Z / Ghozy, Sherief / Elmashad, Ahmed / Siddiqui, Adnan / Al-Bayati, Alhamza R / Alaraj, Ali / Brook, Allan / Kam, Anthony W / Chatterjee, Arindam Rano / Patsalides, Athos / Waldau, Ben / Prestigiacomo, Charles J / Matouk, Charles / Schirmer, Clemens M / Altschul, David / Parrella, David T / Toth, Gabor / Jindal, Gaurav /
    Shaikh, Hamza A / Dolia, Jaydevsinh N / Fifi, Johanna T / Fraser, Justin F / DO, Justin Thomas / Amuluru, Krishna / Kim, Louis J / Harrigan, Mark / Amans, Matthew R / Kole, Max / Mokin, Max / Abraham, Michael / Jumaa, Mouhammad / Janjua, Nazli / Zaidat, Osama / Youssef, Patrick P / Khandelwal, Priyank / Wang, Qingliang Tony / Grandhi, Ramesh / Hanel, Ricardo / Kellogg, Ryan T / Ortega-Gutierrez, Santiago / Sheth, Sunil / Nguyen, Thanh N / Szeder, Viktor / Hu, Yin C / Yoo, Albert J / Tanweer, Omar / Jankowitz, Brian / Heit, Jeremy J / Williamson, Richard / Kass-Hout, Tareq / Crowley, Richard W / El-Ghanem, Mohammad / Al-Mufti, Fawaz

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2024  , Page(s) 15910199241232726

    Abstract: Background and importance: Neurointervention is a very competitive specialty in the United States due to the limited number of training spots and the larger pool of applicants. The training standards are continuously updated to ensure solid training ... ...

    Abstract Background and importance: Neurointervention is a very competitive specialty in the United States due to the limited number of training spots and the larger pool of applicants. The training standards are continuously updated to ensure solid training experiences. Factors affecting candidate(s) selection have not been fully established yet. Our study aims to investigate the factors influencing the selection process.
    Methods: A 52-question survey was distributed to 93 program directors (PDs). The survey consisted of six categories: (a) Program characteristics, (b) Candidate demographics, (c) Educational credentials, (d) Personal traits, (e) Research and extracurricular activities, and (f) Overall final set of characteristics. The response rate was 59.1%. As per the programs' characteristics, neurosurgery was the most involved specialty in running the training programs (69%). Regarding demographics, the need for visa sponsorship held the greatest prominence with a mean score of 5.9 [standard deviation (SD) 2.9]. For the educational credentials, being a graduate from a neurosurgical residency and the institution where the candidate's residency training is/was scored the highest [5.4 (SD = 2.9), 5.4 (SD = 2.5), respectively]. Regarding the personal traits, assessment by faculty members achieved the highest score [8.9 (SD = 1)]. In terms of research/extracurricular activities, fluency in English had the highest score [7.2 (SD = 1.9)] followed by peer-reviewed/PubMed-indexed publications [6.4 (SD = 2.2)].
    Conclusion: Our survey investigated the factors influencing the final decision when choosing the future neurointerventional trainee, including demographic, educational, research, and extracurricular activities, which might serve as valuable guidance for both applicants and programs to refine the selection process.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/15910199241232726
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6325: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome.

    Saha, Amit K / Schmidt, Brendan R / Wilhelmy, Julie / Nguyen, Vy / Abugherir, Abed / Do, Justin K / Nemat-Gorgani, Mohsen / Davis, Ronald W / Ramasubramanian, Anand K

    Clinical hemorheology and microcirculation

    2018  Volume 71, Issue 1, Page(s) 113–116

    Abstract: Background: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are ... ...

    Abstract Background: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are made worse by physical or mental exertion. While the etiology of the disease is still debated, evidence suggests oxidative damage to immune and hematological systems as one of the pathophysiological mechanisms of the disease. Since red blood cells (RBCs) are well-known scavengers of oxidative stress, and are critical in microvascular perfusion and tissue oxygenation, we hypothesized that RBC deformability is adversely affected in ME/CFS.
    Methods: We used a custom microfluidic platform and high-speed microscopy to assess the difference in deformability of RBCs obtained from ME/CFS patients and age-matched healthy controls.
    Results and conclusion: We observed from various measures of deformability that the RBCs isolated from ME/CFS patients were significantly stiffer than those from healthy controls. Our observations suggest that RBC transport through microcapillaries may explain, at least in part, the ME/CFS phenotype, and promises to be a novel first-pass diagnostic test.
    MeSH term(s) Erythrocyte Deformability/physiology ; Erythrocytes/cytology ; Erythrocytes/metabolism ; Fatigue Syndrome, Chronic/blood ; Female ; Humans ; Male ; Microfluidics
    Language English
    Publishing date 2018-12-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-180469
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top