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  1. Article ; Online: Construction Digital Library towards Resources Sharing in the ASEAN Countries

    Do Thi Thanh Thuy

    International Journal of Machine Learning and Computing, Vol 4, Iss 1, Pp 63-

    2014  Volume 67

    Abstract: In modem society, information resources have become important strategic resources for our survival and development. Sharing information resources is a common aspiration. Document resources sharing is the basis of modem document services, and also the ... ...

    Abstract In modem society, information resources have become important strategic resources for our survival and development. Sharing information resources is a common aspiration. Document resources sharing is the basis of modem document services, and also the working target of the document workers and the key point is the development of digital resources. The purpose of digital resources development is to use and share library information resources effectively, and ultimately fulfill the Southeast Asia and global sharing. It is impossible for any single library, region or country to achieve the digital resources development alone, but to make libraries in various trades and industries and of the whole world play their roles to carry out the development and sharing. This paper discusses the necessity, feasibility and benefits, of developing and sharing Asian library digital document resources, analyses the significance of library digital document resources development and sharing, puts forward some suggestions on ways of Asian library digital document resources sharing in the network environment. This paper focuses on the necessity, feasibility and benefits, of developing and sharing Asian library digital document resources, analyses the significance of library digital document resources development and sharing, puts forward some suggestions on ways of Southeast Asia library digital document resources sharing.
    Keywords Digital library ; library cooperation ; resources sharing ; southeast asia ; ASEAN. ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Subject code 027
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Analytical validation and clinical utilization of K-4CARE™: a comprehensive genomic profiling assay with personalized MRD detection.

    Nguyen Hoang, Thien-Phuc / Nguyen, Tien Anh / Tran, Nam H B / Nguyen Hoang, Van-Anh / Thi Dao, Hong Thuy / Tran, Vu-Uyen / Nguyen, Yen Nhi / Nguyen, Anh Tuan / Nguyen Thi, Cam Tu / Do Thi, Thanh Thuy / Nguyen, Duy Sinh / Nguyen, Hoai-Nghia / Giang, Hoa / Tu, Lan N

    Frontiers in molecular biosciences

    2024  Volume 11, Page(s) 1334808

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2024.1334808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Multimodal analysis of genome-wide methylation, copy number aberrations, and end motif signatures enhances detection of early-stage breast cancer.

    Pham, Thi Mong Quynh / Phan, Thanh Hai / Jasmine, Thanh Xuan / Tran, Thuy Thi Thu / Huynh, Le Anh Khoa / Vo, Thi Loan / Nai, Thi Huong Thoang / Tran, Thuy Trang / Truong, My Hoang / Tran, Ngan Chau / Nguyen, Van Thien Chi / Nguyen, Trong Hieu / Nguyen, Thi Hue Hanh / Le, Nguyen Duy Khang / Nguyen, Thanh Dat / Nguyen, Duy Sinh / Truong, Dinh Kiet / Do, Thi Thanh Thuy / Phan, Minh-Duy /
    Giang, Hoa / Nguyen, Hoai-Nghia / Tran, Le Son

    Frontiers in oncology

    2023  Volume 13, Page(s) 1127086

    Abstract: Introduction: Breast cancer causes the most cancer-related death in women and is the costliest cancer in the US regarding medical service and prescription drug expenses. Breast cancer screening is recommended by health authorities in the US, but current ...

    Abstract Introduction: Breast cancer causes the most cancer-related death in women and is the costliest cancer in the US regarding medical service and prescription drug expenses. Breast cancer screening is recommended by health authorities in the US, but current screening efforts are often compromised by high false positive rates. Liquid biopsy based on circulating tumor DNA (ctDNA) has emerged as a potential approach to screen for cancer. However, the detection of breast cancer, particularly in early stages, is challenging due to the low amount of ctDNA and heterogeneity of molecular subtypes.
    Methods: Here, we employed a multimodal approach, namely Screen for the Presence of Tumor by DNA Methylation and Size (SPOT-MAS), to simultaneously analyze multiple signatures of cell free DNA (cfDNA) in plasma samples of 239 nonmetastatic breast cancer patients and 278 healthy subjects.
    Results: We identified distinct profiles of genome-wide methylation changes (GWM), copy number alterations (CNA), and 4-nucleotide oligomer (4-mer) end motifs (EM) in cfDNA of breast cancer patients. We further used all three signatures to construct a multi-featured machine learning model and showed that the combination model outperformed base models built from individual features, achieving an AUC of 0.91 (95% CI: 0.87-0.95), a sensitivity of 65% at 96% specificity.
    Discussion: Our findings showed that a multimodal liquid biopsy assay based on analysis of cfDNA methylation, CNA and EM could enhance the accuracy for the detection of early- stage breast cancer.
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1127086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants.

    Nguyen, Thi Hue Hanh / Lu, Y-Thanh / Le, Van Hoi / Bui, Vinh Quang / Nguyen, Lan Hieu / Pham, Nhu Hiep / Phan, Thanh Hai / Nguyen, Huu Thinh / Tran, Van Song / Bui, Chi Viet / Vo, Van Kha / Nguyen, Pham Thanh Nhan / Dang, Ha Huu Phuoc / Pham, Van Dung / Cao, Van Thinh / Nguyen, Thanh Dat / Nguyen, Luu Hong Dang / Phan, Ngoc Minh / Nguyen, Trong Hieu /
    Nguyen, Van Thien Chi / Pham, Thi Mong Quynh / Tran, Vu Uyen / Le, Minh Phong / Vo, Dac Ho / Tran, Thi Minh Thu / Nguyen, Minh Nguyen / Nguyen, Thi Thanh / Tieu, Ba Linh / Nguyen, Huu Tam Phuc / Truong, Dinh Yen An / Cao, Chi Thuy Tien / Nguyen, Van Tung / Le, Thi Le Quyen / Luong, Thi Lan Anh / Doan, Thi Kim Phuong / Dao, Thi Trang / Phan, Canh Duy / Nguyen, Thanh Xuan / Pham, Nguyen Tuong / Nguyen, Bao Toan / Pham, Thi Thu Thuy / Le, Huu Linh / Truong, Cong Thanh / Jasmine, Thanh Xuan / Le, Minh Chi / Phan, Van Bau / Truong, Quang Binh / Tran, Thi Huong Ly / Huynh, Minh Thien / Tran, Tu Quy / Nguyen, Si Tuan / Tran, Vu / Tran, Van Khanh / Nguyen, Huu Nguyen / Nguyen, Duy Sinh / Nguyen, Thi Quynh Tho / Phan, Thi Van / Do, Thi Thanh-Thuy / Truong, Dinh-Kiet / Tang, Hung Sang / Phan, Minh Duy / Giang, Hoa / Nguyen, Hoai Nghia / Tran, Le Son

    Cancer investigation

    2023  , Page(s) 1–17

    Abstract: The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical ... ...

    Abstract The SPOT-MAS assay "Screening for the Presence Of Tumor by Methylation And Size" detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2173773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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