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  1. Book ; Thesis: Effekte des siRNA-abhängigen Knockdowns der Cardiolipin-Synthase auf Mitochondrien und Proliferation von C6-Gliomazellen

    Le, Do Viet / Kirches, Elmar / Kunz, Wolfram

    2018  

    Title variant small interfering RNA (ribonucleic acid)
    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details vorgelegt von Do Viet Le
    Language German
    Size IX, 61 Blätter, Illustrationen, Diagramme, 31 cm
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Magdeburg, 2018
    HBZ-ID HT019965680
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 E 208 order for loan Magazin

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  2. Article ; Online: Surface engineering for stable electrocatalysis.

    Do, Viet-Hung / Lee, Jong-Min

    Chemical Society reviews

    2024  Volume 53, Issue 5, Page(s) 2693–2737

    Abstract: In recent decades, significant progress has been achieved in rational developments of electrocatalysts through constructing novel atomistic structures and modulating catalytic surface topography, realizing substantial enhancement in electrocatalytic ... ...

    Abstract In recent decades, significant progress has been achieved in rational developments of electrocatalysts through constructing novel atomistic structures and modulating catalytic surface topography, realizing substantial enhancement in electrocatalytic activities. Numerous advanced catalysts were developed for electrochemical energy conversion, exhibiting low overpotential, high intrinsic activity, and selectivity. Yet, maintaining the high catalytic performance under working conditions with high polarization and vigorous microkinetics that induce intensive degradation of surface nanostructures presents a significant challenge for commercial applications. Recently, advanced
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d3cs00292f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Orbital Occupancy and Spin Polarization: From Mechanistic Study to Rational Design of Transition Metal-Based Electrocatalysts toward Energy Applications.

    Do, Viet-Hung / Lee, Jong-Min

    ACS nano

    2022  Volume 16, Issue 11, Page(s) 17847–17890

    Abstract: Over the past few decades, development of electrocatalysts for energy applications has extensively transitioned from trial-and-error methodologies to more rational and directed designs at the atomic levels via either nanogeometric optimization or ... ...

    Abstract Over the past few decades, development of electrocatalysts for energy applications has extensively transitioned from trial-and-error methodologies to more rational and directed designs at the atomic levels via either nanogeometric optimization or modulating electronic properties of active sites. Regarding the modulation of electronic properties, nonprecious transition metal-based materials have been attracting large interest due to the capability of versatile tuning d-electron configurations expressed through the flexible orbital occupancy and various possible degrees of spin polarization. Herein, recent advances in tailoring electronic properties of the transition-metal atoms for intrinsically enhanced electrocatalytic performances are reviewed. We start with discussions on how orbital occupancy and spin polarization can govern the essential atomic level processes, including the transport of electron charge and spin in bulk, reactive species adsorption on the catalytic surface, and the electron transfer between catalytic centers and adsorbed species as well as reaction mechanisms. Subsequently, different techniques currently adopted in tuning electronic structures are discussed with particular emphasis on theoretical rationale and recent practical achievements. We also highlight the promises of the recently established computational design approaches in developing electrocatalysts for energy applications. Lastly, the discussion is concluded with perspectives on current challenges and future opportunities. We hope this review will present the beauty of the structure-activity relationships in catalysis sciences and contribute to advance the rational development of electrocatalysts for energy conversion applications.
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c08919
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  4. Conference proceedings: Fuchs-Uveitis-Syndrom: wie erkannt und behandelt?

    Le, Do Viet / Höhn, F.

    2023  , Page(s) 23vnda09

    Event/congress 72. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Osnabrück; Vereinigung Norddeutscher Augenärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23vnda09
    Database German Medical Science

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  5. Article: Reducing the margin in prostate radiotherapy: optimizing radiotherapy with a general-purpose linear accelerator using an in-house position monitoring system.

    Arumugam, Sankar / Wong, Karen / Do, Viet / Sidhom, Mark

    Frontiers in oncology

    2023  Volume 13, Page(s) 1116999

    Abstract: Purpose: To study the feasibility of optimizing the Clinical Target Volume to Planning Target Volume (CTV-PTV) margin in prostate radiotherapy(RT) with a general-purpose linear accelerator using an in-house developed position monitoring system, ... ...

    Abstract Purpose: To study the feasibility of optimizing the Clinical Target Volume to Planning Target Volume (CTV-PTV) margin in prostate radiotherapy(RT) with a general-purpose linear accelerator using an in-house developed position monitoring system, SeedTracker.
    Methods: A cohort of 30 patients having definitive prostate radiotherapy treated within an ethics-approved prospective trial was considered for this study. The intrafraction prostate motion and the position deviations were measured using SeedTracker system during each treatment fraction. Using this data the CTV-PTV margin required to cover 90% of the patients with a minimum of 95% of the prescription dose to CTV was calculated using van Herk's formula. The margin calculations were performed for treatment scenarios both with and without applying the position corrections for observed position deviations. The feasibility of margin reduction with real-time monitoring was studied by assessing the delivered dose that incorporates the actual target position during treatment delivery and comparing it with the planned dose. This assessment was performed for plans generated with reduced CTV-PTV margin in the range of 7mm-3mm.
    Results: With real-time monitoring and position corrections applied the margin of 2.0mm, 2.1mm and 2.1mm in LR, AP and SI directions were required to meet the criteria of 90% population to receive 95% of the dose prescription to CTV. Without position corrections applied for observed position deviations a margin of 3.1mm, 4.0mm and 3.0mm was required in LR, AP and SI directions to meet the same criteria. A mean ± SD reduction of 0.5 ± 1.8% and 3 ± 7% of V60 for the rectum and bladder can be achieved for every 1mm reduction of PTV margin. With position corrections applied, the CTV D99 can be delivered within -0.2 ± 0.3 Gy of the planned dose for plans with a 3mm margin. Without applying corrections for position deviations the CTV D99 was reduced by a maximum of 1.1 ± 1.1 Gy for the 3mm margin plan and there was a statistically significant difference between planned and delivered dose for 3mm and 4mm margin plans.
    Conclusion: This study demonstrates the feasibility of reducing the margin in prostate radiotherapy with SeedTracker system without compromising the dose delivery accuracy to CTV while reducing dose to critical structures.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1116999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heel Reconstruction Utilizing the Medial Plantar Artery Flap.

    Kaura, Arminder / Fahrenkopf, Matthew P / Do, Viet H

    Eplasty

    2022  Volume 22, Page(s) ic8

    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2412803-X
    ISSN 1937-5719
    ISSN 1937-5719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Lisinopril-Induced Small Bowel Angioedema: An Unusual Cause of Severe Abdominal Pain.

    Johnson, Brooks W / Rydburg, Ann M / Do, Viet D

    The American journal of case reports

    2022  Volume 23, Page(s) e937895

    Abstract: BACKGROUND Angiotensin-converting enzyme inhibitors (ACE-I) are one of the most frequently prescribed classes of medications with the rare adverse effect of angioedema, and isolated small bowel angioedema is a small subset of these cases. Isolated ... ...

    Abstract BACKGROUND Angiotensin-converting enzyme inhibitors (ACE-I) are one of the most frequently prescribed classes of medications with the rare adverse effect of angioedema, and isolated small bowel angioedema is a small subset of these cases. Isolated angioedema of the small bowel is a rare adverse effect of this commonly prescribed medication, and it mimics, symptomatically and radiographically, several other illnesses and is often misdiagnosed. While ACE-I are thought to be safe, the risk of angioedema is approximately 0.7%. Isolated small bowel angioedema is often not diagnosed in a timely manner, and misdiagnosis leads to significant morbidity in afflicted patients. CASE REPORT We present the case of a 63-year-old woman with angioedema of the small bowel causing abdominal pain, nausea, vomiting, and diarrhea. Computed tomography demonstrated small bowel edema and ascites. The patient had been taking lisinopril for 7 years prior to presentation and had previously been seen by multiple physicians for abdominal pain. A diagnosis of ACE-I-induced small bowel angioedema was made and lisinopril therapy was immediately stopped. Her symptoms improved with cessation of lisinopril, and follow-up imaging showed resolution of the angioedema 3 months later. CONCLUSIONS The course of ACE-I-induced angioedema is unpredictable and often overlooked as a cause of abdominal pain. It commonly presents soon after starting ACE-I therapy, but can present years after therapy initiation, as in this case. Significant morbidity, including unnecessary exploratory laparotomy, is associated with misdiagnosis of ACE-I-induced angioedema of the small bowel. Prompt recognition and cessation of the offending drug is crucial but often delayed.
    MeSH term(s) Female ; Humans ; Middle Aged ; Lisinopril/adverse effects ; Angioedema/chemically induced ; Angioedema/diagnosis ; Abdominal Pain/chemically induced ; Abdominal Pain/diagnosis ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Abdomen
    Chemical Substances Lisinopril (E7199S1YWR) ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.937895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Combined Therapeutic Plasma Exchange and Continuous Renal Replacement Therapy in Children With Dengue-Associated Acute Liver Failure and Shock Syndrome: Single-Center Cohort From Vietnam.

    Vo, Luan Thanh / Do, Viet Chau / Trinh, Tung Huu / Vu, Thien / Nguyen, Thanh Tat

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2023  Volume 24, Issue 10, Page(s) 818–828

    Abstract: Objectives: Pediatric acute liver failure (PALF) is a fatal complication in patients with severe dengue. To date, clinical data on the combination of therapeutic plasma exchange (TPE) and continuous renal replacement therapy (CRRT) for managing dengue- ... ...

    Abstract Objectives: Pediatric acute liver failure (PALF) is a fatal complication in patients with severe dengue. To date, clinical data on the combination of therapeutic plasma exchange (TPE) and continuous renal replacement therapy (CRRT) for managing dengue-associated PALF concomitant with shock syndrome are limited.
    Design: Retrospective cohort study (January 2013 to June 2022).
    Patients: Thirty-four children.
    Setting: PICU of tertiary Children's Hospital No. 2 in Vietnam.
    Interventions: We assessed a before-versus-after practice change at our center of using combined TPE and CRRT (2018 to 2022) versus CRRT alone (2013 to 2017) in managing children with dengue-associated acute liver failure and shock syndrome. Clinical and laboratory data were reviewed from PICU admission, before and 24 h after CRRT and TPE treatments. The main study outcomes were 28-day in-hospital mortality, hemodynamics, clinical hepatoencephalopathy, and liver function normalization.
    Measurements and main results: A total of 34 children with a median age of 10 years (interquartile range: 7-11 yr) underwent standard-volume TPE and/or CRRT treatments. Combined TPE and CRRT ( n = 19), versus CRRT alone ( n = 15), was associated with lower proportion of mortality 7 of 19 (37%) versus 13 of 15 (87%), difference 50% (95% CI, 22-78; p < 0.01). Use of combined TPE and CRRT was associated with substantial advancements in clinical hepatoencephalopathy, liver transaminases, coagulation profiles, and blood lactate and ammonia levels (all p values < 0.001).
    Conclusions: In our experience of children with dengue-associated PALF and shock syndrome, combined use of TPE and CRRT, versus CRRT alone, is associated with better outcomes. Such combination intervention was associated with normalization of liver function, neurological status, and biochemistry. In our center we continue to use combined TPE and CRRT rather than CRRT alone.
    MeSH term(s) Child ; Humans ; Continuous Renal Replacement Therapy ; Plasma Exchange ; Retrospective Studies ; Vietnam ; Renal Replacement Therapy ; Shock/therapy ; Liver Failure, Acute/etiology ; Liver Failure, Acute/therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Dengue/therapy
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 472: Show issues

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  9. Article ; Online: Subnanometric Osmium Clusters Confined on Palladium Metallenes for Enhanced Hydrogen Evolution and Oxygen Reduction Catalysis.

    Prabhu, P / Do, Viet-Hung / Yoshida, Takefumi / Zhou, Yingtang / Ariga-Miwa, Hiroko / Kaneko, Takuma / Uruga, Tomoya / Iwasawa, Yasuhiro / Lee, Jong-Min

    ACS nano

    2024  Volume 18, Issue 14, Page(s) 9942–9957

    Abstract: Highly efficient, cost-effective, and durable electrocatalysts, capable of accelerating sluggish reaction kinetics and attaining high performance, are essential for developing sustainable energy technologies but remain a great challenge. Here, we ... ...

    Abstract Highly efficient, cost-effective, and durable electrocatalysts, capable of accelerating sluggish reaction kinetics and attaining high performance, are essential for developing sustainable energy technologies but remain a great challenge. Here, we leverage a facile heterostructure design strategy to construct atomically thin Os@Pd metallenes, with atomic-scale Os nanoclusters of varying geometries confined on the surface layer of the Pd lattice, which exhibit excellent bifunctional properties for catalyzing both hydrogen evolution (HER) and oxygen reduction reactions (ORR). Importantly, Os
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c10219
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  10. Article: Assessment of subjective well-being of healthcare workers in response to heat and personal protective equipment under controlled conditions using a standardized protocol.

    Quartucci, Caroline / Wibowo, Razan / Do, Viet / Bose-O Reilly, Stephan / Nowak, Dennis / Weilnhammer, Veronika / Weinmann, Tobias / Rakete, Stefan

    Journal of occupational medicine and toxicology (London, England)

    2024  Volume 19, Issue 1, Page(s) 16

    Abstract: Background: Due to climate change, the increasing frequency of hot summer days and heat waves can result in occupational heat strain, especially in non-air-conditioned workplaces. Healthcare workers (HCW) engaged in patient care are particularly ... ...

    Abstract Background: Due to climate change, the increasing frequency of hot summer days and heat waves can result in occupational heat strain, especially in non-air-conditioned workplaces. Healthcare workers (HCW) engaged in patient care are particularly affected, as they are additionally exposed to physical stress. The use of personal protective equipment (PPE) can aggravate heat strain in HCW. This study aimed to examine the subjective well-being of HCW when exposed to heat and PPE under controlled conditions.
    Methods: This study was designed as a randomized crossover trial. Participants performed standardized healthcare tasks in a climatic chamber for approximately 3.5 h at different indoor temperatures (22 °C and 27 °C) and varied working conditions (with or without PPE). The effects on participants' subjective well-being, encompassing thermal, physiological and psychological stress were assessed using a customized questionnaire.
    Results: Heat had a greater effect than PPE on thermal, physical and psychological stress. Conversely, PPE had a greater effect on physical demand and effort. For the majority of outcomes, combined exposure to heat and PPE resulted in the highest perceived discomfort. Furthermore, the participants reported increased sweating and other discomforts when working at elevated temperatures or with PPE.
    Conclusions: In this study, heat and PPE, but particularly the combination of both factors, were identified as unfavorable working environments. Although the trials were conducted in a controlled environment, the outcomes provide valuable information about the effect of heat and PPE on HCW in a real-life setting. Furthermore, the design used in this study can be beneficial in evaluating the effect of mitigation strategies.
    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2223190-0
    ISSN 1745-6673
    ISSN 1745-6673
    DOI 10.1186/s12995-024-00418-5
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