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Article: Role of micronutrients in the modulation of immune system and platelet activating factor in patients with COVID-19; a narrative review.

Doaei, Saeid / Mardi, Afrouz / Zare, Maryam

2023 Volume 10, Page(s) 1207237

Abstract: Background: Dietary micronutrients may play important roles in the improvement of the immune responses against SARS-CoV-2. This study aimed to assess the effect of micronutrients on platelet activating factor (PAF) and immunity with a special focus on ... ...

Abstract	Background: Dietary micronutrients may play important roles in the improvement of the immune responses against SARS-CoV-2. This study aimed to assess the effect of micronutrients on platelet activating factor (PAF) and immunity with a special focus on the coronavirus disease 2019 (COVID-19). Methods: All paper published in English on the effects of micronutrients including fat soluble vitamins, water soluble vitamins, and minerals on PAF, immunity, and COVID-19 were collected from online valid databases. Results: Vitamin A may modulate the expression of PAF-receptor gene in patients with COVID-19. Vitamin D may modulate inflammatory response through influencing PAF pathway. Vitamin E may improve COVID-19 related heart injuries by exert anti-PAF activities. Vitamin C status may have PAF related anti-inflammatory and micro-thrombotic effects in SARS-CoV-2 patients. Furthermore, some trace elements such as copper, selenium, and iron may have key roles in strengthens immunity by inactivate PAF acetyl hydrolase. Conclusion: This narrative review study highlighted the importance of micronutrients in the improvement of immune function through modulation of PAF in patients with COVID-19. Further longitudinal studies are warranted.
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1207237
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Article ; Online: The effects of macro-algae supplementation on serum lipid, glycaemic control and anthropometric indices: A systematic review and meta-analysis of clinical trials.

Rezaei, Shahla / Doaei, Saeid / Tabrizi, Reza / Ghobadi, Saeed / Zare, Morteza / Gholamalizadeh, Maryam / Mazloom, Zohreh

Endocrinology, diabetes & metabolism

2023 Volume 6, Issue 5, Page(s) e439

Abstract: Introduction: Macro-algae products have been shown to ameliorate the metabolic disorders state. Thus, highlighting their function as supplementary therapeutic agents can be a novel strategy for clinical therapies. This systematic review and meta- ... ...

Abstract	Introduction: Macro-algae products have been shown to ameliorate the metabolic disorders state. Thus, highlighting their function as supplementary therapeutic agents can be a novel strategy for clinical therapies. This systematic review and meta-analysis of clinical trials aimed to summarize the effect of macro-algae consumption on serum lipid profile, glycaemic control and anthropometric factors. Methods: In this systematic review and meta-analysis, a comprehensive search was performed for relevant studies published up to May 2023. The Cochran's Q test and I-square (I Results: Out of 8602 papers in the initial screening, eight clinical trials with a total of 438 participants were included into this meta-analysis. The results indicated that macro-algae supplementation significantly decreased serum levels of total cholesterol (TC) (WMD = -6.7 mg/dL; 95% CI: -12.59, -0.80; item = 0.026) and low-density lipoprotein cholesterol (LDL-c) (WMD = -8.25 mg/dL; 95% CI: -15.38, -1.12; p-value = .023). There was an increase in level of high-density lipoprotein cholesterol (HDL-c) (WMD = 0.48 mg/dL; 95% CI: -2.05, 3.01; p-value = .71) which was not statistically significant. Macro-algae supplementation reduced body mass index (BMI) (WMD = -0.28 kg/m Conclusions: This meta-analysis indicated that macro-algae supplementation significantly decreased TC and LDL-c level. It can also increase HDL-c level and reduce anthropometric indices and glycaemic control factors.
MeSH term(s)	Humans ; Cholesterol, LDL ; Glycemic Control ; Cholesterol, HDL ; Body Mass Index ; Dietary Supplements
Chemical Substances	Cholesterol, LDL ; Cholesterol, HDL
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2398-9238
ISSN (online)	2398-9238
DOI	10.1002/edm2.439
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Article ; Online: The clinical efficacy of Olibanum gum chewing in patients with Mild-to-Moderate Alzheimer disease: A randomized Parallel-Design controlled trial.

Ghorat, Fereshteh / Sepidarkish, Mahdi / Saadattalab, Farzaneh / Rezghi, Maedeh / Shahrestani, Shamim / Gholamalizadeh, Maryam / Doaei, Saeid

Neuropsychopharmacology reports

2023 Volume 44, Issue 1, Page(s) 109–114

Abstract: Background: Alzheimer's disease is a common neurodegenerative disorder in elderly with progressive decline in cognitive functions. This study aimed to investigate the possible memory-improving effects of Olibanum on patients with Alzheimer's disease.: ...

Abstract	Background: Alzheimer's disease is a common neurodegenerative disorder in elderly with progressive decline in cognitive functions. This study aimed to investigate the possible memory-improving effects of Olibanum on patients with Alzheimer's disease. Research design and method: This double-blind, randomized clinical trial was carried out on 72 participants aged 50-75 years. The intervention group (n = 36) received 1.6 g/day of olibanum chewing gum for 18 weeks. The placebo group (n = 36) received chewing gum without olibanum. Neuropsychological assessments were performed at baseline, every 4 weeks, and after 18 weeks of the intervention. Results: There was no significant difference between (MD: 0.84, 95%CI: -1.10 to 2.78, p = 0.392) at baseline. Both groups had linear improvements over time. There was no significant difference between two groups regarding the improvements after the intervention (F = 0.157, p = 0.693). There were no significant differences between the groups for MMSE score (Mini-Mental State Examination) after the intervention (F = 0.141, p = 0.708). Conclusions: This study revealed that 18 weeks of gum chewing with Olibanum did not change the neuropsychological status. More clinical studies are needed to confirm these findings.
MeSH term(s)	Aged ; Humans ; Alzheimer Disease/psychology ; Frankincense/pharmacology ; Frankincense/therapeutic use ; Chewing Gum ; Cognition ; Treatment Outcome
Chemical Substances	Frankincense (R9XLF1R1WM) ; Chewing Gum
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2574-173X
ISSN (online)	2574-173X
DOI	10.1002/npr2.12398
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Article ; Online: Association of dietary antioxidant index with body mass index in adolescents

Aminnejad, Bahareh / Roumi, Zahra / Hasanpour Ardekanizadeh, Naeemeh / Vahid, Farhad / Gholamalizadeh, Maryam / Kalantari, Naser / Ataei, Asal / Doaei, Saeid

Obesity Science & Practice. 2023 Feb., v. 9, no. 1 p.15-22

2023

Abstract: BACKGROUND: Dietary antioxidants may decrease body fat through reduction of oxidative stress. This study aimed to examine the association between dietary antioxidant index (DAI) and body mass index (BMI) in adolescent boys. METHODS: In this cross‐ ... ...

Abstract	BACKGROUND: Dietary antioxidants may decrease body fat through reduction of oxidative stress. This study aimed to examine the association between dietary antioxidant index (DAI) and body mass index (BMI) in adolescent boys. METHODS: In this cross‐sectional study, 593 adolescent boys aged 12–16 years were randomly selected and were divided into two groups of overweight and non‐overweight individuals. Data on physical activity and anthropometric measurements were collected. Dietary intake was assessed using 168‐item semi quantitative food frequency questionnaire and the DAI score was calculated to measure the antioxidant capacity of the diet. RESULTS: The overweight adolescents had higher intake of energy (2490.55 ± 632.49 vs. 2354.33 ± 632.64 kcal/d, p = 0.01), carbohydrate (290.21 ± 71.41 vs. 272.93 ± 79.22 g/d, p = 0.01), fat (111.51 ± 40.76 vs. 104.51 ± 35.56 g/d, p = 0.04), calcium (811.70 ± 283.70 vs. 741.06 ± 251.17 g/d, p = 0.003), and vitamin D (1.41 ± 1.17 vs. 1.18 ± 1.19 μg/d, p = 0.031) in comparison with normal weight adolescents. The DAI had an inverse association with BMI after adjustment for age and caloric intake (OR: 0.85, 95% CI: 0.76–0.96, p = 0.009). Additional adjustment for dietary intake of vitamin A, vitamin E, vitamin C, zinc, manganese, and selenium did not change the results. CONCLUSION: The results of the study showed that following a diet rich in antioxidants may be effective in preventing obesity in adolescent boys. Further longitudinal studies are needed to confirm these finding and to determine the underlying mechanisms.
Keywords	adolescents ; antioxidant activity ; antioxidants ; ascorbic acid ; body fat ; body mass index ; calcium ; cross-sectional studies ; energy intake ; food frequency questionnaires ; food intake ; manganese ; obesity ; oxidative stress ; physical activity ; selenium ; vitamin A ; vitamin E ; zinc
Language	English
Dates of publication	2023-02
Size	p. 15-22.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2836381-4
ISSN	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.639
Database	NAL-Catalogue (AGRICOLA)

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Article: Potential of macronutrients and probiotics to boost immunity in patients with SARS-COV-2: a narrative review.

Mardi, Afrouz / Kamran, Aziz / Pourfarzi, Farhad / Zare, Maryam / Hajipour, Azadeh / Doaei, Saeid / Abediasl, Negin / Hackett, Daniel

Frontiers in nutrition

2023 Volume 10, Page(s) 1161894

Abstract: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) may cause inflammation and increased cytokine secretion. Dietary factors may play an important role in enhancing the immune responses against infectious diseases such as SARS-COV-2. This ... ...

Abstract	Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) may cause inflammation and increased cytokine secretion. Dietary factors may play an important role in enhancing the immune responses against infectious diseases such as SARS-COV-2. This narrative review aims to determine the effectiveness of macronutrients and probiotics to improve immunity in SARS-COV-2 patients. Dietary proteins may boost pulmonary function in SARS-COV-2 patients through inhibitory effects on the Angiotensin-converting enzyme (ACE) and reduce Angiotensin (ANG-II). Moreover, omega-3 fatty acids may improve oxygenation, acidosis, and renal function. Dietary fiber may also produce anti-inflammatory effects by reducing the level of high-sensitivity C-Reactive Protein (hs-CRP), Interleukin (IL-6), and Tumor necrosis factor (TNF-α). In addition, some evidence indicates that probiotics significantly improve oxygen saturation which may enhance survival rate. In conclusion, the consumption of a healthy diet including adequate macronutrients and probiotic intake may decrease inflammation and oxidative stress. Following this dietary practice is likely to strengthen the immune system and have beneficial effects against SARS-COV-2.
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1161894
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Article: Association between ischemic heart disease and dietary intake of lycopene: a case-control study.

Amjadi, Arezoo / Alami, Farkhondeh / Mohammadian, Mohammad Keshavarz / Mirshafaei, Seyed Reza / Azaryan, Fatemeh / Houshiar-Rad, Anahita / Esmaeili, Mina / Shekari, Soheila / Abdollahi, Morteza / Khoshdooz, Sara / Ajami, Marjan / Doaei, Saeid / Gholamalizadeh, Maryam

Frontiers in nutrition

2024 Volume 10, Page(s) 1281539

Abstract: Aim: The effect of dietary lycopene on ischemic heart disease (IHD) is not clear. Hence, this study aimed to determine the association between dietary lycopene and IHD.: Methods: This case-control study was conducted on 443 patients with physician ... ...

Abstract	Aim: The effect of dietary lycopene on ischemic heart disease (IHD) is not clear. Hence, this study aimed to determine the association between dietary lycopene and IHD. Methods: This case-control study was conducted on 443 patients with physician confirmed diagnosis of IHD as the case group and 443 healthy individuals as the control group. Data on demographic, medical history, anthropometric, and physical activity of the participants were collected. Food intake was evaluated using a 237-item semi-quantitative food frequency questionnaire (FFQ). The dietary intake of lycopene was assessed using Nutritionist IV software. Results: A negative association was found between IHD and lycopene (OR: 0.98, CI 95%: 0.963-0.996, Conclusion: There was a significant inverse relationship between intake of lycopene and IHD. Further prospective studies in different populations are required to elucidate the roles of lycopene against IHD.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1281539
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Article: The Effect of a High-intensity Interval Training on Plasma Vitamin D Level in Obese Male Adolescents.

Haghshenas, Rouhollah / Jamshidi, Zahra / Doaei, Saeid / Gholamalizadeh, Maryam

Indian journal of endocrinology and metabolism

2019 Volume 23, Issue 1, Page(s) 72–75

Abstract: Background: The worldwide increasing vitamin D deficiency in adolescents is alarming. The effect of high-intensity trainings on adolescent health is not clear.: Object: This study aimed to examine the effect of a high-intensity interval training ( ... ...

Abstract	Background: The worldwide increasing vitamin D deficiency in adolescents is alarming. The effect of high-intensity trainings on adolescent health is not clear. Object: This study aimed to examine the effect of a high-intensity interval training (HIIT) on plasma level of vitamin D in overweight male adolescents. Materials and methods: About 96 overweight students aged 12-16 years from two high schools participated in the study. The schools were randomly assigned to the intervention group ( Results: At the end of the study, the vitamin D level was increased to 1.21 ng/dl in the intervention group, whereas it decreased to 1.94 ng/dl in the control group ( Conclusion: About 8 weeks of HIIT improved plasma level of vitamin D in overweight male adolescents. More prolonged interventions consisted of both the sex and broader age ranges are warranted.
Language	English
Publishing date	2019-04-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.IJEM_267_18
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Article ; Online: Correction to: Association of dietary fats with ischemic heart disease (IHD): a case-control study.

Zeinalabedini, Mobina / Ladaninezhad, Maryam / Mobarakeh, Khadijeh Abbasi / Hoshiar-Rad, Anahita / Shekari, Soheila / Askarpour, Seyed Ali / Ardekanizadeh, Naeemeh Hassanpour / Esmaeili, Mina / Abdollahi, Morteza / Doaei, Saeid / Khoshdooz, Sara / Ajami, Marjan / Gholamalizadeh, Maryam

Journal of health, population, and nutrition

2024 Volume 43, Issue 1, Page(s) 51

Language	English
Publishing date	2024-04-16
Publishing country	Bangladesh
Document type	Published Erratum
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-024-00547-x
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Article: Effectiveness of omega-3 fatty acid supplementation for pruritus in patients undergoing hemodialysis.

Rafieipoor, Alireza / Torkaman, Mahdie / Azaryan, Fatemeh / Tavakoli, Aryan / Mohammadian, Mohammad Keshavarz / Kohansal, Atefeh / Shafaei, Hanieh / Mirzaee, Pouya / Motiee Bijarpasi, Zeinab / Bahmani, Parsa / Khosravi, Masoud / Doaei, Saeid / Gholamalizadeh, Maryam

Frontiers in nutrition

2024 Volume 11, Page(s) 1328469

Abstract: Background: Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP).: Objective: The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of ... ...

Abstract	Background: Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP). Objective: The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of CKD-aP in patients undergoing hemodialysis. Methods: In this triple blind, randomized clinical trial, the effect of the omega-3 supplement on uremic CKD-aP was assessed in 112 chronic hemodialysis patients at Caspian Hemodialysis Center in Rasht, Iran. Patients were randomly divided into the intervention group receiving omega-3 supplements (3 g/day) and the control group receiving placebo containing MCT oil for 2 months. Results: Omega-3 supplementation had no effect on CKD-aP. The results did not change after adjusting for age and sex, additional adjustments for weight, height, physical activity, smoking, and alcohol use, additional adjustments for underlying diseases and weight, height, physical activity, smoking, and drinking alcohol, and further adjustments for underlying diseases and biochemical indices. Discussion: Omega-3 supplementation for 2 months had no effect on CKD-aP in patients with CKD. Further studies with longer duration are warranted. Clinical trial registration: https://www.irct.ir/trial/66638, IRCT20151226025699N6.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2024.1328469
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Article ; Online: Association of dietary fats with ischemic heart disease (IHD): a case-control study.

Journal of health, population, and nutrition

2024 Volume 43, Issue 1, Page(s) 19

Abstract: Background: This study aimed to investigate the association between different types of dietary fats with ischemic heart disease (IHD).: Methods: This case-control study was conducted on 443 cases and 453 controls aged 40-80 years in Tehran, Iran. The ...

Abstract	Background: This study aimed to investigate the association between different types of dietary fats with ischemic heart disease (IHD). Methods: This case-control study was conducted on 443 cases and 453 controls aged 40-80 years in Tehran, Iran. The semi-quantitative 237-item food frequency questionnaire (FFQ) was used to assess the amount of food intake. Nutritionist IV was applied to test the amount of consumption of dietary fats. Results: The case group had a lower intake of docosahexaenoic acid (DHA) (11.36 ± 12.58 vs. 14.19 ± 19.57, P = 0.01) than the control group. A negative association was found between IHD and DHA (OR 0.98, CI 95% 0.97-0.99, P = 0.01). No significant association was observed between IHD with the intake of cholesterol, trans fatty acids (TFA), saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), eicosatetraenoic acid (EPA), and α-Linolenic acid (ALA). Conclusion: It was found that DHA may reduce the risk of IHD, whereas there was no significant association between other types of dietary fats with the odds of IHD. If the results of this study are confirmed in future research, a higher intake of DHA in diet can be recommended as a strategy to prevent IHD events.
MeSH term(s)	Humans ; Dietary Fats/adverse effects ; Case-Control Studies ; Iran/epidemiology ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/etiology ; Myocardial Ischemia/prevention & control ; Docosahexaenoic Acids ; Fatty Acids/adverse effects
Chemical Substances	Dietary Fats ; Docosahexaenoic Acids (25167-62-8) ; Fatty Acids
Language	English
Publishing date	2024-02-01
Publishing country	Bangladesh
Document type	Journal Article ; Review
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-023-00489-w
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