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  1. Article ; Online: Repurposing

    Lee, Chia-Yin / Nguyen, Anh Thuc / Doan, Ly Hien / Chu, Li-Wei / Chang, Chih-Hung / Liu, Hui-Kang / Lee, I-Lin / Wang, Teng-Hsu / Lai, Jin-Mei / Tsao, Shih-Ming / Liao, Hsiu-Jung / Ping, Yueh-Hsin / Huang, Chi-Ying F

    Viruses

    2023  Volume 15, Issue 3

    Abstract: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to global public health. In an effort to develop novel anti-coronavirus therapeutics and achieve ... ...

    Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to global public health. In an effort to develop novel anti-coronavirus therapeutics and achieve prophylactics, we used gene set enrichment analysis (GSEA) for drug screening and identified that
    MeSH term(s) Humans ; Angiotensin-Converting Enzyme 2/metabolism ; Anti-Inflammatory Agents/pharmacology ; COVID-19 ; Drug Repositioning ; MicroRNAs ; Polysaccharides/pharmacology ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Astragalus propinquus/chemistry
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Anti-Inflammatory Agents ; MicroRNAs ; Polysaccharides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15030641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Honeysuckle (

    Yeh, Yuan-Chieh / Doan, Ly Hien / Huang, Zi-Yi / Chu, Li-Wei / Shi, Tzu-Hau / Lee, Ying-Ray / Wu, Cheng-Tao / Lin, Chao-Hsiung / Chiang, Shu-Tuan / Liu, Hui-Kang / Chuang, Tsung-Hsien / Ping, Yueh-Hsin / Liu, Hsiao-Sheng / Huang, Chi-Ying F

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 765553

    Abstract: COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host ...

    Abstract COVID-19 is threatening human health worldwide but no effective treatment currently exists for this disease. Current therapeutic strategies focus on the inhibition of viral replication or using anti-inflammatory/immunomodulatory compounds to improve host immunity, but not both. Traditional Chinese medicine (TCM) compounds could be promising candidates due to their safety and minimal toxicity. In this study, we have developed a novel
    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.765553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2.

    Doan, Ly Hien / Chu, Li-Wei / Huang, Zi-Yi / Nguyen, Anh Thuc / Lee, Chia-Yin / Huang, Chien-Ling / Chang, Yu-Fen / Hsieh, Wen-Yu / Nguyen, Trang Thi Huyen / Lin, Chao-Hsiung / Su, Chun-Li / Chuang, Tsung-Hsien / Lai, Jin-Mei / Wang, Feng-Sheng / Yang, Chia-Jui / Liu, Hui-Kang / Ping, Yueh-Hsin / Huang, Chi-Ying F

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 905197

    Abstract: Coronavirus disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The infection causes dysregulation of the immune system with a cytokine storm that ... ...

    Abstract Coronavirus disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The infection causes dysregulation of the immune system with a cytokine storm that eventually leads to fatal acute respiratory distress syndrome (ARDS) and further irreversible pulmonary fibrosis. Therefore, the promising way to inhibit infection is to disrupt the binding and fusion between the viral spike and the host ACE2 receptor. A transcriptome-based drug screening platform has been developed for COVID-19 to explore the possibility and potential of the long-established drugs or herbal medicines to reverse the unique genetic signature of COVID-19.
    Language English
    Publishing date 2022-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.905197
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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