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Article ; Online: Cost-effectiveness of extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: A modelling study.

Doan, Tan N / Rashford, Stephen / Pincus, Jason / Bosley, Emma

Resuscitation plus

2022 Volume 12, Page(s) 100309

Abstract: Background: Extracorporeal cardiopulmonary resuscitation (E-CPR) is a method of CPR that passes the patient's blood through an extracorporeal membrane oxygenation (ECMO) device to provide mechanical haemodynamic and oxygenation support in cardiac arrest ...

Abstract	Background: Extracorporeal cardiopulmonary resuscitation (E-CPR) is a method of CPR that passes the patient's blood through an extracorporeal membrane oxygenation (ECMO) device to provide mechanical haemodynamic and oxygenation support in cardiac arrest patients who are not responsive to conventional CPR (C-CPR). E-CPR is being adopted rapidly worldwide despite the absence of high quality trial data and its substantial cost. Published cost-effectiveness data for E-CPR are scarce. Methods: We developed a mathematical model to estimate the cost-effectiveness of E-CPR relative to C-CPR in adult patients with refractory out-of-hospital cardiac arrest (OHCA). The model was a combination of a decision tree for the acute treatment phase and a Markov model for long-term periods. Cost-effectiveness was evaluated from the Australian health system perspective over lifetime. Cost-effectiveness was expressed as Australian dollars (AUD, 2021 value) per quality-adjusted life year (QALY) gained. Variables were parameterised using published data. Probabilistic and univariate sensitivity analyses were performed. Results: The incremental cost-effectiveness ratio (ICER) of E-CPR was estimated to be AUD 45,716 per QALY gained over lifetime (95% uncertainty range 22,102-292,904). The cost-effectiveness of E-CPR was most sensitive to the outcome of the therapy. Conclusion: E-CPR has median ICER that is below common accepted willingness-to-pay thresholds. Local factors within the health care system need to be considered to determine the feasibility of implementing an effective E-CPR program.
Language	English
Publishing date	2022-09-24
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2022.100309
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Article ; Online: Characteristics associated with frequent health system use by Australian adults with intellectual disability: A cohort study.

Song, Menghuan / Ware, Robert S / Doan, Tan N / Harley, David

Journal of applied research in intellectual disabilities : JARID

2022 Volume 35, Issue 6, Page(s) 1403–1417

Abstract: Background: In a cohort of adults with intellectual disability who were followed for up to 16-years, we investigated characteristics associated with frequent emergency department (ED) presentations, hospitalisation, and psychiatric care.: Method: ... ...

Abstract	Background: In a cohort of adults with intellectual disability who were followed for up to 16-years, we investigated characteristics associated with frequent emergency department (ED) presentations, hospitalisation, and psychiatric care. Method: Community-dwelling adults with intellectual disability residing in Queensland, Australia, were followed from 1999 to 2015. Healthcare presentations were extracted from administrative databases. Adults who presented frequently were identified and characteristics associated with frequent presentations were identified. Results: Data from 445 adults were analysed. Chronic disease and challenging behaviour were associated with frequent ED presentations (adjusted odds ratio = 1.8, 95% confidence interval = 1.1-3.0 and aOR = 2.2, 95% CI = 1.2-3.9 respectively). Chronic disease and severe/profound intellectual disability were associated with frequent hospitalisations (aOR = 1.9, 95% CI = 1.2-3.2 and aOR = 2.0, 95% CI = 1.2-3.3 respectively). Psychotropic medication use was associated with frequent psychiatric presentations (aOR = 1.9, 95% CI = 1.0-3.4). Conclusions: Adults at high risk of frequent healthcare presentations should be identified for programmes of optimising health system use, and potentially improving health care quality.
MeSH term(s)	Adult ; Australia ; Chronic Disease ; Cohort Studies ; Humans ; Intellectual Disability/psychology ; Psychotropic Drugs/therapeutic use
Chemical Substances	Psychotropic Drugs
Language	English
Publishing date	2022-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1326222-1
ISSN	1468-3148 ; 0952-9608 ; 1360-2322
ISSN (online)	1468-3148
ISSN	0952-9608 ; 1360-2322
DOI	10.1111/jar.13029
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Zs.A 4157: Show issues

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Article ; Online: Epidemiology of out-of-hospital cardiac arrests that occur secondary to chemical asphyxiants: A retrospective series.

Schultz, Brendan V / Rolley, Adam / Doan, Tan N / Isoardi, Katherine

Resuscitation

2022 Volume 175, Page(s) 113–119

Abstract: Aim: To determine the epidemiological characteristics, temporal trends and survival outcomes of OHCAs precipitated by chemical asphyxiation.: Methods: We conducted a retrospective cohort analysis of OHCAs attended by paramedics in Queensland, ... ...

Abstract	Aim: To determine the epidemiological characteristics, temporal trends and survival outcomes of OHCAs precipitated by chemical asphyxiation. Methods: We conducted a retrospective cohort analysis of OHCAs attended by paramedics in Queensland, Australia between 2011 and 2020. Patients were classified into two groups depending on the asphyxiating agent involved; simple (argon, carbon dioxide, helium, liquified petroleum gas, nitrogen) and systemic (carbon monoxide, cyanides, hydrogen sulfide, methemoglobin-inducing substances, smoke inhalation). Incidence rates, characteristics and outcomes were described for the entire cohort and independently for each group, with the groups then compared. Temporal trends of asphyxiant utilisation were also described. Results: During the study period, 50,669 OHCAs were attended, with 551 (1.1%) attributable to chemical asphyxiation. The incidence rate was 1.1 per 100,000 population with no significant temporal changes. Suspected suicide was the primary cause of exposure (-95.8%), with systemic asphyixants the dominant agent reported in comparison to simple agents (66.4% vs 33.6%). Over the 10-year period, events precipitated by carbon monoxide decreased by 26.2% (p for trend < 0.001), helium remained unchanged (p for trend = 0.302) and incidents involving nitrogen increased by 28.7% (p for trend < 0.001). Overall, 14.2% (78/551) of the study cohort received a resuscitation attempt by paramedics with 6.4% of these incidents witnessed and 2.6% involving patients presenting in a shockable rhythm. Survival rates were low, with 6.4% surviving the index event, and 1.3% surviving to hospital discharge with a normal neurocognitive function. Conclusion: OHCA precipitated by chemical asphyxiation is relatively infrequent and associated with poor survival outcomes.
MeSH term(s)	Asphyxia/complications ; Asphyxia/epidemiology ; Carbon Monoxide ; Cardiopulmonary Resuscitation/adverse effects ; Emergency Medical Services ; Helium ; Humans ; Nitrogen ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/etiology ; Out-of-Hospital Cardiac Arrest/therapy ; Registries ; Retrospective Studies
Chemical Substances	Helium (206GF3GB41) ; Carbon Monoxide (7U1EE4V452) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-03-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2022.03.019
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Zs.A 1048: Show issues

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Article ; Online: Use of psychotropic medications in adults with intellectual disability: A systematic review and meta-analysis.

Song, Menghuan / Rubin, Bryn S / Ha, Justin Wt / Ware, Robert S / Doan, Tan N / Harley, David

The Australian and New Zealand journal of psychiatry

2023 Volume 57, Issue 5, Page(s) 661–674

Abstract: Objective: This study presents the proportion of adults with intellectual disability using psychotropic medications including antipsychotics, antidepressants, anxiolytics, hypnotics and sedatives, and psychostimulants.: Methods: A search was ... ...

Abstract	Objective: This study presents the proportion of adults with intellectual disability using psychotropic medications including antipsychotics, antidepressants, anxiolytics, hypnotics and sedatives, and psychostimulants. Methods: A search was performed in PubMed, Embase, PsycINFO, Web of Science, and Scopus up to 31 December 2021. Articles were included if they reported the proportion of adults with intellectual disability using psychotropic medications. Frequency of use was estimated using a random effects meta-analysis. Meta-regression analysis was used to assess the association between study-level characteristics and variability in estimates, when heterogeneity was considerable. Results: Twenty-four articles were included in pooled analysis. The pooled prevalence of psychotropic medications was 41% (95% confidence interval: 35-46%). Pooled prevalences of subclasses were as follows: antipsychotics 31% (27-35%), antidepressants 14% (9-19%), anxiolytics 9% (4-15%), hypnotics/sedatives 5% (2-8%), and psychostimulants 1% (1-2%). Heterogeneity was considerable between studies, except for psychostimulants. There was no significant association between assessed characteristics and variability in prevalence estimates. Conclusion: Two-fifths of adults with intellectual disability were prescribed psychotropic medications. Antipsychotics and antidepressants were used by one-third and one-seventh of adults, respectively. There was considerable variability between studies, and further investigation is required to determine the source of variability. More studies are needed to better characterise prescribed psychotropic medications, including effectiveness and adverse effects, to ensure appropriate use of these drugs.
MeSH term(s)	Humans ; Adult ; Anti-Anxiety Agents/therapeutic use ; Intellectual Disability/drug therapy ; Intellectual Disability/epidemiology ; Psychotropic Drugs/therapeutic use ; Antipsychotic Agents/therapeutic use ; Antidepressive Agents/therapeutic use ; Hypnotics and Sedatives/therapeutic use ; Central Nervous System Stimulants/therapeutic use
Chemical Substances	Anti-Anxiety Agents ; Psychotropic Drugs ; Antipsychotic Agents ; Antidepressive Agents ; Hypnotics and Sedatives ; Central Nervous System Stimulants
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	221140-3
ISSN	1440-1614 ; 0004-8674
ISSN (online)	1440-1614
ISSN	0004-8674
DOI	10.1177/00048674221149864
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Zs.A 856: Show issues

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Article ; Online: Suicide-Related Out-of-Hospital Cardiac Arrests in Queensland, Australia: Temporal Trends of Characteristics and Outcomes over 14 Years.

Doan, Tan N / Rashford, Stephen / Sims, Louise / Wilson, Kirsten / Garner, Sandra / Bosley, Emma

Prehospital emergency care

2023 Volume 28, Issue 3, Page(s) 431–437

Abstract: Background: Research into suicide-related out-of-hospital cardiac arrests (OHCA) using OHCA registries is scant. A more complete understanding of methods, patient characteristics, and outcomes is essential to inform prehospital management strategies and ...

Abstract	Background: Research into suicide-related out-of-hospital cardiac arrests (OHCA) using OHCA registries is scant. A more complete understanding of methods, patient characteristics, and outcomes is essential to inform prehospital management strategies and public health interventions. Methods: Included were all OHCA attended by Queensland Ambulance Service (Australia) paramedics between 1 January 2007 and 31 December 2020, where suicide-related causes could be identified. Age- and sex-standardized incidence rates were calculated. Suicide methods, patient characteristics, and survival outcomes were described. Factors associated with survival outcomes were investigated. Results: Seven thousand three hundred and fifty-six suicide-related OHCA cases were included. The incidence rates increased from 9.0 per 100,000 population in 2007 to 12.4 in 2020. The incidence rates for males were four times those for females; however, incidence rates for females have increased faster than for males. Hanging was the most common suicide method (63%). Twenty-three percent of patients received resuscitation attempts by paramedics. Among those, the rates of return of spontaneous circulation (ROSC) sustained to hospital arrival, survival to hospital discharge, and survival to 30 days were 28.6, 8.5, and 8.0%, respectively. Over time, the rates of ROSC upon hospital arrival increased, whereas the rates of survival to discharge and 30-day survival remained stable. Conclusion: The incidence of prehospital-identified suicide-related OHCA in Queensland has increased over time. The prognosis of suicide-related OHCA is poor. Prevention measures should focus on early identification and treatment of individuals having a high risk of suicide. Emergency medical services need to have sufficient training for telecommunicators and paramedics in suicide risk assessment and identification.
MeSH term(s)	Female ; Male ; Humans ; Queensland/epidemiology ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Cardiopulmonary Resuscitation/methods ; Emergency Medical Services ; Australia ; Suicide
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2023.2230595
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Zs.A 4762: Show issues

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Article ; Online: Epidemiology and survival outcomes of out-of-hospital cardiac arrest following volatile substance use in Queensland, Australia.

Schultz, Brendan V / Rolley, Adam / Doan, Tan N / Bodnar, Daniel / Isoardi, Katherine

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 9, Page(s) 649–655

Abstract: Introduction: The deliberate inhalation of volatile substances for their psychotropic properties is a recognised public health issue that can precipitate sudden death. This study aimed to describe the epidemiological characteristics and survival ... ...

Abstract	Introduction: The deliberate inhalation of volatile substances for their psychotropic properties is a recognised public health issue that can precipitate sudden death. This study aimed to describe the epidemiological characteristics and survival outcomes of patients with out-of-hospital cardiac arrests following volatile substance use. Methods: We conducted a retrospective cohort analysis of all out-of-hospital cardiac arrest attended by the Queensland Ambulance Service over a ten-year period (2012-2021). Incidents were extracted from the Queensland Ambulance Service cardiac arrest registry, which collects clinical information using the Utstein-style guidelines and linked hospital data. Results: During the study period, 52,102 out-of-hospital cardiac arrests were attended, with 22 (0.04%) occurring following volatile substance use. The incidence rate was 0.04 per 100,000 population, with no temporal trends identified. The most commonly used product was deodorant cans (19/22), followed by butane canisters (2/22), and nitrous oxide canisters (1/22). The median age of patients was 15 years (interquartile range 13-23), with 14/22 male and 8/22 Indigenous Australians. Overall, 16/22 patients received a resuscitation attempt by paramedics. Of these, 12/16 were bystander witnessed, 10/16 presented in an initial shockable rhythm, and 9/16 received bystander chest compressions. The rates of event survival, survival to hospital discharge, and survival with good neurological outcome (Cerebral Performance Category 1-2) were 69% (11/16, 95% CI 41-89%), 38% (6/16, 95% CI 15-65%) and 31% (5/16, 11-59%), respectively. Eight patients in the paramedic-treated cohort that used hydrocarbon-based products were administered epinephrine during resuscitation. Of these, none subsequently survived to hospital discharge. In contrast, all six patients that did not receive epinephrine survived to hospital discharge, with 5/6 having a good neurological outcome. Conclusion: Out-of-hospital cardiac arrest following volatile substance use is rare and associated with relatively favourable survival rates. Patients were predominately aged in their adolescence with Indigenous Australians disproportionately represented.
MeSH term(s)	Adolescent ; Humans ; Male ; Aged ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Cardiopulmonary Resuscitation ; Retrospective Studies ; Queensland/epidemiology ; Australia ; Registries ; Epinephrine ; Emergency Medical Services
Chemical Substances	Epinephrine (YKH834O4BH)
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2023.2267172
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Zs.B 419: Show issues

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Article ; Online: Ambient temperatures, heatwaves and out-of-hospital cardiac arrest in Brisbane, Australia.

Doan, Tan N / Wilson, Daniel / Rashford, Stephen / Bosley, Emma

Occupational and environmental medicine

2021

Abstract: Background: The health impacts of temperatures are gaining attention in Australia and worldwide. While a number of studies have investigated the association of temperatures with the risk of cardiovascular diseases, few examined out-of-hospital cardiac ... ...

Abstract	Background: The health impacts of temperatures are gaining attention in Australia and worldwide. While a number of studies have investigated the association of temperatures with the risk of cardiovascular diseases, few examined out-of-hospital cardiac arrest (OHCA) and none have done so in Australia. This study examined the exposure-response relationship between temperatures, including heatwaves and OHCA in Brisbane, Australia. Methods: A quasi-Poisson regression model coupled with a distributed lag non-linear model was employed, using OHCA and meteorological data between 1 January 2007 and 31 December 2019. Reference temperature was chosen to be the temperature of minimum risk (21.4°C). Heatwaves were defined as daily average temperatures at or above a heat threshold (90th, 95th, 98th, 99th percentile of the yearly temperature distribution) for at least two consecutive days. Results: The effect of any temperature above the reference temperature was not statistically significant; whereas low temperatures (below reference temperature) increased OHCA risk. The effect of low temperatures was delayed for 1 day, sustained up to 3 days, peaking at 2 days following exposures. Heatwaves significantly increased OHCA risk across the operational definitions. When a threshold of 95th percentile of yearly temperature distribution was used to define heatwaves, OHCA risk increased 1.25 (95% CI 1.04 to 1.50) times. When the heat threshold for defining heatwaves increased to 99th percentile, the relative risk increased to 1.48 (1.11 to 1.96). Conclusions: Low temperatures and defined heatwaves increase OHCA risk. The findings of this study have important public health implications for mitigating strategies aimed at minimising temperature-related OHCA.
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2020-107018
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Article ; Online: SONNET: A Self-Guided Ordinal Regression Neural Network for Segmentation and Classification of Nuclei in Large-Scale Multi-Tissue Histology Images.

Doan, Tan N N / Song, Boram / Vuong, Trinh T L / Kim, Kyungeun / Kwak, Jin T

IEEE journal of biomedical and health informatics

2022 Volume 26, Issue 7, Page(s) 3218–3228

Abstract: Automated nuclei segmentation and classification are the keys to analyze and understand the cellular characteristics and functionality, supporting computer-aided digital pathology in disease diagnosis. However, the task still remains challenging due to ... ...

Abstract	Automated nuclei segmentation and classification are the keys to analyze and understand the cellular characteristics and functionality, supporting computer-aided digital pathology in disease diagnosis. However, the task still remains challenging due to the intrinsic variations in size, intensity, and morphology of different types of nuclei. Herein, we propose a self-guided ordinal regression neural network for simultaneous nuclear segmentation and classification that can exploit the intrinsic characteristics of nuclei and focus on highly uncertain areas during training. The proposed network formulates nuclei segmentation as an ordinal regression learning by introducing a distance decreasing discretization strategy, which stratifies nuclei in a way that inner regions forming a regular shape of nuclei are separated from outer regions forming an irregular shape. It also adopts a self-guided training strategy to adaptively adjust the weights associated with nuclear pixels, depending on the difficulty of the pixels that is assessed by the network itself. To evaluate the performance of the proposed network, we employ large-scale multi-tissue datasets with 276349 exhaustively annotated nuclei. We show that the proposed network achieves the state-of-the-art performance in both nuclei segmentation and classification in comparison to several methods that are recently developed for segmentation and/or classification.
MeSH term(s)	Cell Nucleus ; Histological Techniques/methods ; Humans ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3149936
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Zs.A 5483: Show issues

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Article ; Online: Effect of a national awareness campaign on ambulance attendances for chest pain and out-of-hospital cardiac arrest.

Nehme, Ziad / Cameron, Peter / Nehme, Emily / Finn, Judith / Bosley, Emma / Brink, Deon / Ball, Stephen / Doan, Tan N / Bray, Janet E

Resuscitation

2023 Volume 191, Page(s) 109932

Abstract: Aim: Awareness of heart attack symptoms may enhance health-seeking behaviour and prevent premature deaths from out-of-hospital cardiac arrest (OHCA). We sought to investigate the impact of a national awareness campaign on emergency medical service (EMS) ...

Abstract	Aim: Awareness of heart attack symptoms may enhance health-seeking behaviour and prevent premature deaths from out-of-hospital cardiac arrest (OHCA). We sought to investigate the impact of a national awareness campaign on emergency medical service (EMS) attendances for chest pain and OHCA. Methods: Between January 2005 and December 2017, we included registry data for 97,860 EMS-attended OHCA cases from 3 Australian regions and dispatch data for 1,631,217 EMS attendances for chest pain across 5 Australian regions. Regions were exposed to between 11 and 28 months of television, radio, and print media activity. Multivariable negative binomial models were used to explore the effect of campaign activity on the monthly incidence of EMS attendances for chest pain and OHCA. Results: Months with campaign activity were associated with an 8.8% (IRR 1.09, 95% CI: 1.07, 1.11) increase in the incidence of EMS attendances for chest pain and a 5.6% (IRR 0.94, 95% CI: 0.92, 0.97) reduction in OHCA attendances. Larger intervention effects were associated with increasing months of campaign activity, increasing monthly media spending and media exposure in 2013. In stratified analyses of OHCA cases, the largest reduction in incidence during campaign months was observed for unwitnessed arrests (IRR 0.93, 95% CI: 0.90, 0.96), initial non-shockable arrests (IRR 0.93, 95% CI: 0.90, 0.97) and arrests occurring in private residences (IRR 0.95, 95% CI: 0.91, 0.98). Conclusion: A national awareness campaign targeting knowledge of heart attack symptoms was associated with an increase in EMS use for chest pain and a reduction in OHCA incidence and may serve as an effective primary prevention strategy for OHCA.
MeSH term(s)	Humans ; Ambulances ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Out-of-Hospital Cardiac Arrest/diagnosis ; Cardiopulmonary Resuscitation ; Australia ; Emergency Medical Services ; Myocardial Infarction ; Chest Pain/epidemiology ; Chest Pain/etiology ; Chest Pain/prevention & control ; Registries
Language	English
Publishing date	2023-08-08
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2023.109932
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Zs.A 1048: Show issues

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Article ; Online: Surviving out-of-hospital cardiac arrest: The important role of bystander interventions.

Doan, Tan N / Schultz, Brendan V / Rashford, Stephen / Bosley, Emma

Australasian emergency care

2020 Volume 23, Issue 1, Page(s) 47–54

Abstract: Background: Substantial variations exist in relation to the characteristics and outcomes of out-of-hospital cardiac arrest (OHCA). As such, an understanding of region-specific factors is essential for informing strategies to improve OHCA survival.: ... ...

Abstract	Background: Substantial variations exist in relation to the characteristics and outcomes of out-of-hospital cardiac arrest (OHCA). As such, an understanding of region-specific factors is essential for informing strategies to improve OHCA survival. Methods: Analysis of a large state-wide OHCA database of the Queensland Ambulance Service, Australia. Adult patients, attended by paramedics between January 2000 and December 2018 for OHCA of medical origin, where the arrest was not witnessed by paramedics, and resuscitation was attempted, were included. Factors associated with survival were investigated. The number needed to treat (NNT) for bystander interventions was estimated. Results: Across a total of 23,510 patients, event survival, survival to discharge and 30-day survival was 22.6%, 11.9% and 11.5%, respectively. The corresponding figures for the Utstein patient group (initial shockable rhythm, bystander-witnessed) were 38.9%, 27.2% and 26.3%, respectively. Bystander cardiopulmonary resuscitation (CPR) and defibrillation substantially improved the likelihood of survival. The NNT for bystander CPR was 41, 63 and 64 for event survival, survival to discharge, and 30-day survival, respectively. The NNT for bystander defibrillation for these survival outcomes was 10, 14 and 14, respectively. Conclusions: Bystander interventions are critical for OHCA survival. Effort should be invested in strategies to improve the uptake of these interventions.
MeSH term(s)	Aged ; Aged, 80 and over ; Bystander Effect ; Cardiopulmonary Resuscitation/standards ; Cohort Studies ; Female ; Humans ; Logistic Models ; Male ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/psychology ; Queensland ; Survival Analysis ; Survivors/psychology ; Survivors/statistics & numerical data
Language	English
Publishing date	2020-01-08
Publishing country	Australia
Document type	Journal Article
ISSN	2588-994X
ISSN (online)	2588-994X
DOI	10.1016/j.auec.2019.12.003
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In stock of ZB MED Cologne/Königswinter

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Full text online

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Order via subito

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