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  1. AU="Dobosiewicz, May"
  2. AU="Srivastava, Rakesh"
  3. AU="Grevtsov K.I."

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  1. Artikel ; Online: Reliability of an interneuron response depends on an integrated sensory state.

    Dobosiewicz, May / Liu, Qiang / Bargmann, Cornelia I

    eLife

    2019  Band 8

    Abstract: The central nervous system transforms sensory information into representations that are salient to the animal. Here we define the logic of this transformation in ... ...

    Abstract The central nervous system transforms sensory information into representations that are salient to the animal. Here we define the logic of this transformation in a
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans/physiology ; Calcium/metabolism ; Diacetyl/metabolism ; Gap Junctions/metabolism ; Glutamates/metabolism ; Interneurons/physiology ; Optogenetics ; Pentanols/metabolism ; Sensation/physiology ; Sensory Receptor Cells/physiology ; Synapses/physiology
    Chemische Substanzen Glutamates ; Pentanols ; isopentyl alcohol (DEM9NIT1J4) ; Diacetyl (K324J5K4HM) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2019-11-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.50566
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: C. elegans AWA Olfactory Neurons Fire Calcium-Mediated All-or-None Action Potentials.

    Liu, Qiang / Kidd, Philip B / Dobosiewicz, May / Bargmann, Cornelia I

    Cell

    2018  Band 175, Heft 1, Seite(n) 57–70.e17

    Abstract: Neurons in Caenorhabditis elegans and other nematodes have been thought to lack classical action potentials. Unexpectedly, we observe membrane potential spikes with defining characteristics of action potentials in C. elegans AWA olfactory neurons ... ...

    Abstract Neurons in Caenorhabditis elegans and other nematodes have been thought to lack classical action potentials. Unexpectedly, we observe membrane potential spikes with defining characteristics of action potentials in C. elegans AWA olfactory neurons recorded under current-clamp conditions. Ion substitution experiments, mutant analysis, pharmacology, and modeling indicate that AWA fires calcium spikes, which are initiated by EGL-19 voltage-gated CaV1 calcium channels and terminated by SHK-1 Shaker-type potassium channels. AWA action potentials result in characteristic signals in calcium imaging experiments. These calcium signals are also observed when intact animals are exposed to odors, suggesting that natural odor stimuli induce AWA spiking. The stimuli that elicit action potentials match AWA's specialized function in climbing odor gradients. Our results provide evidence that C. elegans neurons can encode information through regenerative all-or-none action potentials, expand the computational repertoire of its nervous system, and inform future modeling of its neural coding and network dynamics.
    Mesh-Begriff(e) Action Potentials/physiology ; Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Calcium/metabolism ; Calcium Channels/physiology ; Chemotaxis/physiology ; Membrane Potentials/physiology ; Odorants ; Olfactory Nerve/physiology ; Olfactory Receptor Neurons/metabolism ; Smell/physiology
    Chemische Substanzen Caenorhabditis elegans Proteins ; Calcium Channels ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2018-09-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.08.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Regulatory changes in two chemoreceptor genes contribute to a

    Greene, Joshua S / Dobosiewicz, May / Butcher, Rebecca A / McGrath, Patrick T / Bargmann, Cornelia I

    eLife

    2016  Band 5

    Abstract: Natural isolates ... ...

    Abstract Natural isolates of
    Sprache Englisch
    Erscheinungsdatum 2016-11-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.21454
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.

    Dennis, Emily J / Dobosiewicz, May / Jin, Xin / Duvall, Laura B / Hartman, Philip S / Bargmann, Cornelia I / Vosshall, Leslie B

    Nature

    2018  Band 562, Heft 7725, Seite(n) 119–123

    Abstract: DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne ... ...

    Abstract DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Chemotaxis/drug effects ; DEET/pharmacology ; Drug Resistance/drug effects ; Drug Resistance/genetics ; Mutagenesis ; Mutation ; Neurons/drug effects ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
    Chemische Substanzen Receptors, G-Protein-Coupled ; DEET (134-62-3)
    Sprache Englisch
    Erscheinungsdatum 2018-09-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-018-0546-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The role of dopaminergic transmission through D1-like and D2-like receptors in amphetamine-induced rat ultrasonic vocalizations.

    Wright, Jennifer M / Dobosiewicz, May R S / Clarke, Paul B S

    Psychopharmacology

    2012  Band 225, Heft 4, Seite(n) 853–868

    Abstract: Rationale: Systemic amphetamine (AMPH) administration increases the rate of 50-kHz ultrasonic vocalizations (USVs) in adult rats and preferentially enhances the 'trill' subtype; these effects of AMPH critically depend on noradrenergic transmission, but ... ...

    Abstract Rationale: Systemic amphetamine (AMPH) administration increases the rate of 50-kHz ultrasonic vocalizations (USVs) in adult rats and preferentially enhances the 'trill' subtype; these effects of AMPH critically depend on noradrenergic transmission, but the possible contributions of dopamine are unclear.
    Objective: To assess the role of dopamine in 50-kHz USVs emitted drug-free and following systemic AMPH administration.
    Methods: Adult male Long-Evans rats pre-selected for high AMPH-induced calling rates were tested with AMPH (1 mg/kg, intraperitoneal (IP)) and saline following pretreatment with the following dopamine receptor antagonists: SCH 23390 (0.005-0.02 mg/kg, subcutaneous (SC)), SCH 39166 (0.03-0.3 mg/kg, SC), haloperidol (0.1, 0.2 mg/kg, IP), sulpiride (20-80 mg/kg, SC), raclopride (0.1-0.5 mg/kg, SC), clozapine (4 mg/kg, SC), risperidone (0.5 mg/kg, SC), and pimozide (1 mg/kg, IP). The dopamine and noradrenaline reuptake inhibitors (GBR 12909 and nisoxetine, respectively) were also tested, alone and in combination.
    Results: SCH 23390, SCH 39166, haloperidol, and raclopride dose-dependently inhibited vocalizations under AMPH and suppressed the proportion of trill calls. Sulpiride, however, had no discernable effect on call rate or profile, even at a high dose that reduced locomotor activity. Single doses of clozapine, risperidone, and pimozide all markedly decreased calling under saline and AMPH. Finally, GBR 12909 and nisoxetine failed to promote 50-kHz USVs detectably or alter the subtype profile, when tested alone or in combination.
    Conclusions: The rate of 50-kHz USVs and the call subtype profile following systemic AMPH administration depends on dopaminergic neurotransmission through D1-like and D2-like receptors. However, inhibiting dopamine and/or noradrenaline reuptake appears insufficient to induce calling.
    Mesh-Begriff(e) Amphetamine/pharmacology ; Animals ; Dopamine/physiology ; Dopamine Antagonists/pharmacology ; Dopamine D2 Receptor Antagonists ; Dose-Response Relationship, Drug ; Male ; Rats ; Rats, Long-Evans ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/physiology ; Receptors, Dopamine D2/physiology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Ultrasonics ; Vocalization, Animal/drug effects ; Vocalization, Animal/physiology
    Chemische Substanzen Dopamine Antagonists ; Dopamine D2 Receptor Antagonists ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Amphetamine (CK833KGX7E) ; Dopamine (VTD58H1Z2X)
    Sprache Englisch
    Erscheinungsdatum 2012-09-28
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-012-2871-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: α- and β-Adrenergic receptors differentially modulate the emission of spontaneous and amphetamine-induced 50-kHz ultrasonic vocalizations in adult rats.

    Wright, Jennifer M / Dobosiewicz, May R S / Clarke, Paul B S

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2011  Band 37, Heft 3, Seite(n) 808–821

    Abstract: Amphetamine (AMPH) increases adult rat 50-kHz ultrasonic vocalizations, preferentially promoting frequency-modulated (FM) calls that have been proposed to reflect positive affect. The main objective of this study was to investigate a possible ... ...

    Abstract Amphetamine (AMPH) increases adult rat 50-kHz ultrasonic vocalizations, preferentially promoting frequency-modulated (FM) calls that have been proposed to reflect positive affect. The main objective of this study was to investigate a possible noradrenergic contribution to AMPH-induced calling. Adult male Long-Evans rats were tested with AMPH (1 mg/kg intraperitoneal) or saline combined with various systemic pretreatments: clonidine (α2 adrenergic agonist), prazosin (α1 antagonist), atipamezole (α2 antagonist), propranolol, betaxolol, and/or ICI 118,551 (β1/β2, β1, and β2 antagonists, respectively), nadolol (β1/β2 antagonist, peripheral only), or NAD-299 (5HT(1A) antagonist). In addition, effects of cirazoline (α1 adrenergic agonist) and cocaine (0.25-1.5 mg/kg intravenous) were studied alone. AMPH-induced calling was suppressed by low-dose clonidine and prazosin. Cirazoline and atipamezole did not significantly affect calling rate. Propranolol, without affecting the call rate, dose dependently promoted 'flat' calls under AMPH while suppressing 'trills,' thus reversing the effects of AMPH on the 'call subtype profile.' This effect of propranolol seemed to be mediated by simultaneous inhibition of CNS β1 and β2 rather than by 5HT(1A) receptors. Finally, cocaine elicited fewer calls than did AMPH, but produced the same shift in the call subtype profile. Taken together, these results reveal differential drug effects on flat vs trill vs other FM 50-kHz calls. These findings highlight the value of detailed call subtype analyses, and show that 50-kHz calls are associated with adrenergic α1- and β-receptor mechanisms. These preclinical findings suggest that noradrenergic contributions to psychostimulant subjective effects may warrant further investigation.
    Mesh-Begriff(e) Adrenergic Agonists/pharmacology ; Adrenergic Antagonists/pharmacology ; Amphetamine/pharmacology ; Animals ; Central Nervous System Stimulants/pharmacology ; Male ; Rats ; Rats, Long-Evans ; Receptors, Adrenergic, alpha/metabolism ; Receptors, Adrenergic, beta/metabolism ; Vocalization, Animal/drug effects ; Vocalization, Animal/physiology
    Chemische Substanzen Adrenergic Agonists ; Adrenergic Antagonists ; Central Nervous System Stimulants ; Receptors, Adrenergic, alpha ; Receptors, Adrenergic, beta ; Amphetamine (CK833KGX7E)
    Sprache Englisch
    Erscheinungsdatum 2011-10-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/npp.2011.258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Balancing selection shapes density-dependent foraging behaviour.

    Greene, Joshua S / Brown, Maximillian / Dobosiewicz, May / Ishida, Itzel G / Macosko, Evan Z / Zhang, Xinxing / Butcher, Rebecca A / Cline, Devin J / McGrath, Patrick T / Bargmann, Cornelia I

    Nature

    2016  Band 539, Heft 7628, Seite(n) 254–258

    Abstract: The optimal foraging strategy in a given environment depends on the number of competing individuals and their behavioural strategies. Little is known about the genes and neural circuits that integrate social information into foraging decisions. Here we ... ...

    Abstract The optimal foraging strategy in a given environment depends on the number of competing individuals and their behavioural strategies. Little is known about the genes and neural circuits that integrate social information into foraging decisions. Here we show that ascaroside pheromones, small glycolipids that signal population density, suppress exploratory foraging in Caenorhabditis elegans, and that heritable variation in this behaviour generates alternative foraging strategies. We find that natural C. elegans isolates differ in their sensitivity to the potent ascaroside icas#9 (IC-asc-C5). A quantitative trait locus (QTL) regulating icas#9 sensitivity includes srx-43, a G-protein-coupled icas#9 receptor that acts in the ASI class of sensory neurons to suppress exploration. Two ancient haplotypes associated with this QTL confer competitive growth advantages that depend on ascaroside secretion, its detection by srx-43 and the distribution of food. These results suggest that balancing selection at the srx-43 locus generates alternative density-dependent behaviours, fulfilling a prediction of foraging game theory.
    Mesh-Begriff(e) Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/isolation & purification ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Feeding Behavior/drug effects ; Food ; Game Theory ; Haplotypes ; Hexoses/metabolism ; Hexoses/pharmacology ; Indoles/pharmacology ; Male ; Pheromones/metabolism ; Pheromones/pharmacology ; Population Density ; Quantitative Trait Loci ; Receptors, G-Protein-Coupled/metabolism ; Selection, Genetic ; Sensory Receptor Cells/metabolism ; Social Behavior
    Chemische Substanzen Caenorhabditis elegans Proteins ; Hexoses ; Indoles ; Pheromones ; Receptors, G-Protein-Coupled ; SRX-43 protein, C elegans ; indolecarboxyl-ascaroside C5
    Sprache Englisch
    Erscheinungsdatum 2016-10-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature19848
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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