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Article ; Online: Update Alert: Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-analysis for a Clinical Guideline by the American College of Physicians.

Dobrescu, Andreea Iulia / Persad, Emma / Klerings, Irma / Gartlehner, Gerald

2024 Volume 177, Issue 4, Page(s) eL230441

MeSH term(s)	Adult ; Humans ; Depressive Disorder, Major/drug therapy ; Network Meta-Analysis ; Physicians
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L23-0441
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Article ; Online: Characteristics and recovery methods of studies falsely excluded during literature screening-a systematic review.

Affengruber, Lisa / Dobrescu, Andreea / Persad, Emma / Klerings, Irma / Wagner, Gernot / Sommer, Isolde / Gartlehner, Gerald

Systematic reviews

2022 Volume 11, Issue 1, Page(s) 236

Abstract: Background: Due to the growing need to provide evidence syntheses under time constraints, researchers have begun focusing on the exploration of rapid review methods, which often employ single-reviewer literature screening. However, single-reviewer ... ...

Abstract	Background: Due to the growing need to provide evidence syntheses under time constraints, researchers have begun focusing on the exploration of rapid review methods, which often employ single-reviewer literature screening. However, single-reviewer screening misses, on average, 13% of relevant studies, compared to 3% with dual-reviewer screening. Little guidance exists regarding methods to recover studies falsely excluded during literature screening. Likewise, it is unclear whether specific study characteristics can predict an increased risk of false exclusion. This systematic review aimed to identify supplementary search methods that can be used to recover studies falsely excluded during literature screening. Moreover, it strove to identify study-level predictors that indicate an elevated risk of false exclusions of studies during literature screening. Methods: We performed literature searches for eligible studies in MEDLINE, Science Citation Index Expanded, Social Sciences Citation Index, Current Contents Connect, Embase, Epistemonikos.org, and Information Science & Technology Abstracts from 1999 to June 23, 2020. We searched for gray literature, checked reference lists, and conducted hand searches in two relevant journals and similar article searches current to January 28, 2021. Two investigators independently screened the literature; one investigator performed the data extraction, and a second investigator checked for correctness and completeness. Two reviewers assessed the risk of bias of eligible studies. We synthesized the results narratively. Results: Three method studies, two with a case-study design and one with a case-series design, met the inclusion criteria. One study reported that all falsely excluded publications (8%) could be recovered through reference list checking compared to other supplementary search methods. No included methods study analyzed the impact of recovered studies on conclusions or meta-analyses. Two studies reported that up to 8% of studies were falsely excluded due to uninformative titles and abstracts, and one study showed that 11% of non-English studies were falsely excluded. Conclusions: Due to the limited evidence based on two case studies and one case series, we can draw no firm conclusion about the most reliable and most valid method to recover studies falsely excluded during literature screening or about the characteristics that might predict a higher risk of false exclusion. Systematic review registration: https://osf.io/v2pjr/.
MeSH term(s)	Humans ; Mass Screening ; MEDLINE
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-022-02109-w
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Article ; Online: Full publication of preprint articles in prevention research: an analysis of publication proportions and results consistency.

Sommer, Isolde / Sunder-Plassmann, Vincent / Ratajczak, Piotr / Emprechtinger, Robert / Dobrescu, Andreea / Griebler, Ursula / Gartlehner, Gerald

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17034

Abstract: There is concern that preprint articles will lead to an increase in the amount of scientifically invalid work available. The objectives of this study were to determine the proportion of prevention preprints published within 12 months, the consistency of ... ...

Abstract	There is concern that preprint articles will lead to an increase in the amount of scientifically invalid work available. The objectives of this study were to determine the proportion of prevention preprints published within 12 months, the consistency of the effect estimates and conclusions between preprint and published articles, and the reasons for the nonpublication of preprints. Of the 329 prevention preprints that met our eligibility criteria, almost half (48.9%) were published in a peer-reviewed journal within 12 months of being posted. While 16.8% published preprints showed some change in the magnitude of the primary outcome effect estimate, 4.4% were classified as having a major change. The style or wording of the conclusion changed in 42.2%, the content in 3.1%. Preprints on chemoprevention, with a cross-sectional design, and with public and noncommercial funding had the highest probabilities of publication. The main reasons for the nonpublication of preprints were journal rejection or lack of time. The reliability of preprint articles for evidence-based decision-making is questionable. Less than half of the preprint articles on prevention research are published in a peer-reviewed journal within 12 months, and significant changes in effect sizes and/or conclusions are still possible during the peer-review process.
MeSH term(s)	Cross-Sectional Studies ; Reproducibility of Results ; Health Services Research
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44291-4
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Article ; Online: Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Evidence Review for the American College of Physicians (Version 2).

Sommer, Isolde / Ledinger, Dominic / Thaler, Kylie / Dobrescu, Andreea / Persad, Emma / Fangmeyer, Martin / Klerings, Irma / Gartlehner, Gerald

Annals of internal medicine

2023 Volume 176, Issue 10, Page(s) 1377–1385

Abstract: Background: Clinicians and patients want to know the benefits and harms of outpatient treatment options for the Omicron variant of SARS-CoV-2.: Purpose: To assess the benefits and harms of 22 different COVID-19 treatments.: Data sources: The ... ...

Abstract	Background: Clinicians and patients want to know the benefits and harms of outpatient treatment options for the Omicron variant of SARS-CoV-2. Purpose: To assess the benefits and harms of 22 different COVID-19 treatments. Data sources: The Epistemonikos COVID-19 L·OVE platform, the iSearch COVID-19 portfolio, and the World Health Organization (WHO) COVID-19 Research Database from 26 November 2021 to 2 March 2023. Study selection: Two reviewers independently screened abstracts and full texts against a priori-defined criteria. Data extraction: One reviewer extracted the data and assessed the risk of bias and certainty of evidence (COE). A second reviewer verified the data abstraction and assessments. Data synthesis: Two randomized controlled trials and 6 retrospective cohort studies were included. Nirmatrelvir-ritonavir was associated with a reduction in hospitalization due to COVID-19 (for example, 0.7% vs. 1.2%; moderate COE) and all-cause mortality (for example, <0.1% vs. 0.2%; moderate COE). Molnupiravir led to a higher recovery rate (31.8% vs. 22.6%; moderate COE) and reduced time to recovery (9 vs. 15 median days; moderate COE) but had no effect on all-cause mortality (0.02% vs. 0.04%; moderate COE) and the incidence of serious adverse events (0.4% vs. 0.3%; moderate COE). Ivermectin had no effect on time to recovery (moderate COE) and resulted in no difference in adverse events compared with placebo (low COE). Sotrovimab resulted in no difference in all-cause mortality compared with no treatment (low COE). No eligible studies for all other treatments of interest were identified. Limitation: Evidence for nirmatrelvir-ritonavir and sotrovimab is based on nonrandomized studies only. Conclusion: Nirmatrelvir-ritonavir and molnupiravir probably improve outcomes for outpatients with mild to moderate COVID-19. Primary funding source: American College of Physicians. (PROSPERO: CRD42023406456).
MeSH term(s)	Humans ; Outpatients ; Ritonavir/therapeutic use ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; Physicians ; COVID-19 Drug Treatment
Chemical Substances	molnupiravir (YA84KI1VEW) ; nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825)
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M23-1626
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Values and Preferences of Patients With Depressive Disorders Regarding Pharmacologic and Nonpharmacologic Treatments : A Rapid Review.

Affengruber, Lisa / Wagner, Gernot / Dobrescu, Andreea / Toromanova, Ana / Chapman, Andrea / Persad, Emma / Klerings, Irma / Gartlehner, Gerald

Annals of internal medicine

2023 Volume 176, Issue 2, Page(s) 217–223

Abstract: Background: Developers of clinical practice guidelines need to take patient values and preferences into consideration when weighing benefits and harms of treatment options for depressive disorder.: Purpose: To assess patient values and preferences ... ...

Abstract	Background: Developers of clinical practice guidelines need to take patient values and preferences into consideration when weighing benefits and harms of treatment options for depressive disorder. Purpose: To assess patient values and preferences regarding pharmacologic and nonpharmacologic treatments of depressive disorder. Data sources: MEDLINE (Ovid) and PsycINFO (EBSCO) were searched for eligible studies published from 1 January 2014 to 30 November 2022. Study selection: Pairs of reviewers independently screened 30% of search results. The remaining 70% of the abstracts were screened by single reviewers; excluded abstracts were checked by a second reviewer. Pairs of reviewers independently screened full texts. Data extraction: One reviewer extracted data and assessed the certainty of evidence, and a second reviewer checked for completeness and accuracy. Two reviewers independently assessed risk of bias. Data synthesis: The review included 11 studies: 4 randomized controlled trials, 5 cross-sectional studies, and 2 qualitative studies. In 1 randomized controlled trial, participants reported at the start of therapy that they expected supportive-expressive psychotherapy and antidepressants to yield similar improvements. A cross-sectional study reported that non-Hispanic White participants and men generally preferred antidepressants over talk therapy, whereas Hispanic and non-Hispanic Black participants and women generally did not have a preference. Another cross-sectional study reported that the most important nonserious adverse events for patients treated with antidepressants were insomnia, anxiety, fatigue, weight gain, agitation, and sexual dysfunction. For other comparisons and outcomes, no conclusions could be drawn because of the insufficient certainty of evidence. Limitations: The main limitation of this review is the low or insufficient certainty of evidence for most outcomes. No evidence was available on second-step depression treatment or differences in values and preferences based on gender, race/ethnicity, age, and depression severity. Conclusion: Low-certainty evidence suggests that there may be some differences in preferences for talk therapy or pharmacologic treatment of depressive disorders based on gender or race/ethnicity. In addition, low-certainty evidence suggests that insomnia, anxiety, fatigue, weight gain, agitation, and sexual dysfunction may be the most important nonserious adverse events for patients treated with antidepressants. Evidence is lacking or insufficient to draw any further conclusions about patients' weighing or valuation of the benefits and harms of depression treatments. Primary funding source: American College of Physicians. (PROSPERO: CRD42020212442).
MeSH term(s)	Male ; Humans ; Female ; Cross-Sectional Studies ; Sleep Initiation and Maintenance Disorders/drug therapy ; Antidepressive Agents/adverse effects ; Depressive Disorder ; Fatigue
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M22-1900
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cost-Effectiveness of First- and Second-Step Treatment Strategies for Major Depressive Disorder : A Rapid Review.

Dobrescu, Andreea / Chapman, Andrea / Affengruber, Lisa / Persad, Emma / Toromanova, Ana / Wagner, Gernot / Klerings, Irma / Emprechtinger, Robert / Gartlehner, Gerald

Annals of internal medicine

2023 Volume 176, Issue 2, Page(s) 212–216

Abstract: Background: Major depressive disorder (MDD) is the most prevalent, disabling form of depression, with a high economic effect.: Purpose: To assess evidence on cost-effectiveness of pharmacologic and nonpharmacologic interventions as first- and second- ... ...

Abstract	Background: Major depressive disorder (MDD) is the most prevalent, disabling form of depression, with a high economic effect. Purpose: To assess evidence on cost-effectiveness of pharmacologic and nonpharmacologic interventions as first- and second-step treatments in patients with MDD. Data sources: Multiple electronic databases limited to English language were searched (1 January 2015 to 29 November 2022). Study selection: Two investigators independently screened the literature. Seven economic modeling studies fulfilled the eligibility criteria. Data extraction: Data abstraction by a single investigator was confirmed by a second; 2 investigators independently rated risk of bias. One investigator determined certainty of evidence, and another checked for plausibility. Data synthesis: Seven modeling studies met the eligibility criteria. In a U.S. setting over a 5-year time horizon, cognitive behavioral therapy (CBT) was cost-effective compared with second-generation antidepressants (SGAs) as a first-step treatment from the societal and health care sector perspectives. However, the certainty of evidence is low, and the findings should be interpreted cautiously. For second-step treatment, only switch strategies between SGAs were assessed. The evidence is insufficient to draw any conclusions. Limitations: Methodologically heterogeneous studies, which compared only CBT and some SGAs, were included. No evidence on other psychotherapies or complementary and alternative treatments as first-step treatment or augmentation strategies as second-step treatment was available. Conclusion: Although CBT may be cost-effective compared with SGAs as a first-step treatment at a 5-year time horizon from the societal and health care sector perspectives, the certainty of evidence is low, and the findings need to be interpreted cautiously. For other comparisons, the evidence was entirely missing or insufficient to draw conclusions. Primary funding source: American College of Physicians.
MeSH term(s)	Humans ; Depressive Disorder, Major/therapy ; Cost-Benefit Analysis ; Psychotherapy ; Cognitive Behavioral Therapy ; Antidepressive Agents, Second-Generation/therapeutic use
Chemical Substances	Antidepressive Agents, Second-Generation
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M22-1872
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-analysis for a Clinical Guideline by the American College of Physicians.

Gartlehner, Gerald / Dobrescu, Andreea / Chapman, Andrea / Toromanova, Ana / Emprechtinger, Robert / Persad, Emma / Affengruber, Lisa / Pieh, Christoph / Klerings, Irma / Wagner, Gernot

Annals of internal medicine

2023 Volume 176, Issue 2, Page(s) 196–211

Abstract: Background: Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD).: Purpose: To compare the benefits and harms of nonpharmacologic treatments with second- ... ...

Abstract	Background: Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD). Purpose: To compare the benefits and harms of nonpharmacologic treatments with second-generation antidepressants as first-step interventions for acute MDD, and to compare second-step treatment strategies for patients who did not achieve remission after an initial attempt with antidepressants. Data sources: English-language studies from several electronic databases from 1 January 1990 to 8 August 2022, trial registries, gray literature databases, and reference lists to identify unpublished research. Study selection: 2 investigators independently selected randomized trials of at least 6 weeks' duration. Data extraction: Reviewers abstracted data about study design and conduct, participants, interventions, and outcomes. They dually rated the risk of bias of studies and the certainty of evidence for outcomes of interest. Data synthesis: 65 randomized trials met the inclusion criteria; eligible data from nonrandomized studies were not found. Meta-analyses and network meta-analyses indicated similar benefits of most nonpharmacologic treatments and antidepressants as first-step treatments. Antidepressants had higher risks for discontinuation because of adverse events than most other treatments. For second-step therapies, different switching and augmentation strategies provided similar symptomatic relief. The certainty of evidence for most comparisons is low; findings should be interpreted cautiously. Limitations: Many studies had methodological limitations or dosing inequalities; publication bias might have affected some comparisons. In some cases, conclusions could not be drawn because of insufficient evidence. Conclusion: Although benefits seem to be similar among first- and second-step MDD treatments, the certainty of evidence is low for most comparisons. Clinicians and patients should focus on options with the most reliable evidence and take adverse event profiles and patient preferences into consideration. Primary funding source: American College of Physicians. (PROSPERO: CRD42020204703).
MeSH term(s)	Humans ; Adult ; Depressive Disorder, Major/drug therapy ; Network Meta-Analysis ; Antidepressive Agents/therapeutic use ; Antidepressive Agents, Second-Generation/adverse effects ; Physicians
Chemical Substances	Antidepressive Agents ; Antidepressive Agents, Second-Generation
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M22-1845
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Wahrnehmungen und Erfahrungen beteiligter Stakeholder in Bezug auf Faktoren, die Inanspruchnahme, Durchführung und Angebot von Vorsorgeuntersuchungen beeinflussen: eine qualitative Evidenzsynthese

Sommer, Isolde / Harlfinger, Julia / Toromanova, Ana / Dobrescu, Andreea / Affengruber, Lisa / Klerings, Irma / Kien, Christina

Das Gesundheitswesen

2023 Volume 85, Issue S 04

Event/congress	Vom Wir zum Ich - Vom Ich zum Wir. Braucht es [noch] eine Solidargemeinschaft?, St. Pölten, Österreich, 2023-05-25
Language	German
Publishing date	2023-10-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1101426-x
ISSN	1439-4421 ; 0941-3790 ; 0949-7013
ISSN (online)	1439-4421
ISSN	0941-3790 ; 0949-7013
DOI	10.1055/s-0043-1773706
Database	Thieme publisher's database

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Article: Novel Propagation Strategy of Saccharomyces cerevisiae for Enhanced Xylose Metabolism during Fermentation on Softwood Hydrolysate

Dobrescu, Andreea Cristina / Veras, Henrique César Teixeira / Varrone, Cristiano / Knudsen, Jan Dines

Fermentation. 2021 Nov. 29, v. 7, no. 4

2021

Abstract: An economically viable production of second-generation bioethanol by recombinant xylose-fermenting Saccharomyces cerevisiae requires higher xylose fermentation rates and improved glucose–xylose co-consumption. Moreover, xylose-fermenting S. cerevisiae ... ...

Abstract	An economically viable production of second-generation bioethanol by recombinant xylose-fermenting Saccharomyces cerevisiae requires higher xylose fermentation rates and improved glucose–xylose co-consumption. Moreover, xylose-fermenting S. cerevisiae recognises xylose as a non-fermentable rather than a fermentable carbon source, which might partly explain why xylose is not fermented into ethanol as efficiently as glucose. This study proposes propagating S. cerevisiae on non-fermentable carbon sources to enhance xylose metabolism during fermentation. When compared to yeast grown on sucrose, cells propagated on a mix of ethanol and glycerol in shake flasks showed up to 50% higher xylose utilisation rate (in a defined xylose medium) and a double maximum fermentation rate, together with an improved C5/C6 co-consumption (on an industrial softwood hydrolysate). Based on these results, an automated propagation protocol was developed, using a fed-batch approach and the respiratory quotient to guide the ethanol and glycerol-containing feed. This successfully produced 71.29 ± 0.91 g/L yeast with an average productivity of 1.03 ± 0.05 g/L/h. These empirical findings provide the basis for the design of a simple, yet effective yeast production strategy to be used in the second-generation bioethanol industry for increased fermentation efficiency.
Keywords	Saccharomyces cerevisiae ; automation ; bioenergy industry ; bioethanol ; carbon ; economic sustainability ; ethanol ; fermentation ; glucose ; glycerol ; hydrolysates ; respiratory quotient ; softwood ; sucrose ; xylose ; yeasts
Language	English
Dates of publication	2021-1129
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation7040288
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effectiveness and safety of measures to prevent infections and other complications associated with peripheral intravenous catheters: A systematic review and meta-analysis.

Dobrescu, Andreea / Constantin, Alexandru Marian / Pinte, Larisa / Chapman, Andrea / Ratajczak, Piotr / Klerings, Irma / Emprechtinger, Robert / Allegranzi, Benedetta / Zingg, Walter / Grayson, M Lindsay / Toledo, Joao / Gartlehner, Gerald / Nussbaumer-Streit, Barbara

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: Background: Peripheral intravenous catheters (PIVCs) contribute substantially to the global burden of infections. This systematic review assessed 24 infection prevention and control (IPC) interventions to prevent PIVC-associated infections and other ... ...

Abstract	Background: Peripheral intravenous catheters (PIVCs) contribute substantially to the global burden of infections. This systematic review assessed 24 infection prevention and control (IPC) interventions to prevent PIVC-associated infections and other complications. Methods: We searched Ovid MEDLINE, Embase, Cochrane Library, WHO Global Index Medicus, CINAHL and reference lists for controlled studies, from January 1, 1980-March 16, 2023. We dually selected studies, assessed risk of bias, extracted data, and rated the certainty of evidence (COE). For outcomes with three or more trials, we conducted Bayesian random-effects meta-analyses. Results: 105 studies met our prespecified eligibility criteria, addressing 16 of the 24 research questions; no studies were identified for eight research questions.Based on findings of low to high COE, wearing gloves reduced the risk for overall adverse events related to insertion compared to no gloves (one non-randomised controlled trial [RCT]; adjusted risk ratio [RR]: 0.52, 95% confidence interval 0.33-0.85), and catheter removal based on defined schedules potentially resulted in a lower phlebitis/thrombophlebitis incidence (10 RCTs; RR: 0.74, 95% credible interval 0.49-1.01) compared to clinically indicated removal in adults. In neonates, chlorhexidine reduced the phlebitis score compared to non-chlorhexidine-containing disinfection (one RCT; 0.14 versus 0.68, p = 0.003). No statistically significant differences were found for other measures. Conclusions: Despite their frequent use and concern about PIVC-associated complications, this review underscores the urgent need for more high-quality studies on effective IPC methods regarding safe PIVC management. In the absence of valid evidence, adherence to standard precaution measures and documentation remain the most important principles to curb PIVC complications.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae195
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