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Article: Correction: Validating the Safe and Effective Use of a Neurorehabilitation System (InTandem) to Improve Walking in the Chronic Stroke Population: Usability Study.

Smayda, Kirsten Elisabeth / Cooper, Sarah Hodsdon / Leyden, Katie / Ulaszek, Jackie / Ferko, Nicole / Dobrin, Annamaria

JMIR rehabilitation and assistive technologies

2024 Volume 11, Page(s) e56041

Abstract: This corrects the article DOI: 10.2196/50438.]. ...

Abstract	[This corrects the article DOI: 10.2196/50438.].
Language	English
Publishing date	2024-02-21
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2798120-4
ISSN	2369-2529
ISSN	2369-2529
DOI	10.2196/56041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Validating the Safe and Effective Use of a Neurorehabilitation System (InTandem) to Improve Walking in the Chronic Stroke Population: Usability Study.

Smayda, Kirsten Elisabeth / Cooper, Sarah Hodsdon / Leyden, Katie / Ulaszek, Jackie / Ferko, Nicole / Dobrin, Annamaria

JMIR rehabilitation and assistive technologies

2023 Volume 10, Page(s) e50438

Abstract: Background: Persistent walking impairment following a stroke is common. Although rehabilitative interventions exist, few exist for use at home in the chronic phase of stroke recovery. InTandem (MedRhythms, Inc) is a neurorehabilitation system intended ... ...

Abstract	Background: Persistent walking impairment following a stroke is common. Although rehabilitative interventions exist, few exist for use at home in the chronic phase of stroke recovery. InTandem (MedRhythms, Inc) is a neurorehabilitation system intended to improve walking and community ambulation in adults with chronic stroke walking impairment. Objective: Using design best practices and human factors engineering principles, the research presented here was conducted to validate the safe and effective use of InTandem. Methods: In total, 15 participants in the chronic phase of stroke recovery (≥6 months after stroke) participated in this validation study. Participants were scored on 8 simulated use tasks, 4 knowledge assessments, and 7 comprehension assessments in a simulated home environment. The number and types of use errors, close calls, and operational difficulties were evaluated. Analyses of task performances, participant behaviors, and follow-up interviews were conducted to determine the root cause of use errors and difficulties. Results: During this validation study, 93% (14/15) of participants were able to successfully complete the critical tasks associated with the simulated use of the InTandem system. Following simulated use task assessments, participants' knowledge and comprehension of the instructions for use and key safety information were evaluated. Overall, participants were able to find and correctly interpret information in the materials in order to answer the knowledge assessment questions. During the comprehension assessment, participants understood warning statements associated with critical tasks presented in the instructions for use. Across the entire study, 3 "use errors" and 1 "success with difficulty" were recorded. No adverse events, including slips, trips, or falls, occurred in this study. Conclusions: In this validation study, people in the chronic phase of stroke recovery were able to safely and effectively use InTandem in the intended use environment. This validation study contributes to the overall understanding of residual use-related risks of InTandem in consideration of the established benefits.
Language	English
Publishing date	2023-11-20
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2798120-4
ISSN	2369-2529
ISSN	2369-2529
DOI	10.2196/50438
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Book ; Online: Homicide data sources

Dobrin, Adam

an interdisciplinary overview for researchers

(SpringerBriefs in criminology)

2015

Author's details	Adam Dobrin
Series title	SpringerBriefs in criminology
Keywords	Homicide/Statistics
Language	English
Size	Online-Ressource (ix, 44 pages)
Publisher	Springer
Publishing place	Cham
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	3319198815 ; 9783319198804 ; 9783319198811 ; 3319198807
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Genetic and Phenotypic Diversities in Experimental Populations of Diploid Inter-Lineage Hybrids in the Human Pathogenic

You, Man / Lin, Yuxin Monica / Dobrin, Annamaria / Xu, Jianping

Microorganisms

2021 Volume 9, Issue 8

Abstract: To better understand the potential factors contributing to genome instability and phenotypic diversity, we conducted mutation accumulation (MA) experiments for 120 days for 7 diploid cryptococcal hybrids under fluconazole (10 MA lines each) and non- ... ...

Abstract	To better understand the potential factors contributing to genome instability and phenotypic diversity, we conducted mutation accumulation (MA) experiments for 120 days for 7 diploid cryptococcal hybrids under fluconazole (10 MA lines each) and non-fluconazole conditions (10 MA lines each). The genomic DNA content, loss of heterozygosity (LOH) rate, growth ability, and fluconazole susceptibility were determined for all 140 evolved cultures. Compared to that of their ancestral clones, the evolved clones showed: (i) genomic DNA content changes ranging from ~22% less to ~27% more, and (ii) reduced, similar, and increased phenotypic values for each tested trait, with most evolved clones displaying increased growth at 40 °C and increased fluconazole resistance. Aside from the ancestral multi-locus genotypes (MLGs) and heterozygosity patterns (MHPs), 77 unique MLGs and 70 unique MPHs were identified among the 140 evolved cultures at day 120. The average LOH rates of the MA lines in the absence and presence of fluconazole were similar at 1.27 × 10
Language	English
Publishing date	2021-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9081579
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Article ; Online: Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies.

Dobrin, Anton / Lindenbergh, Pieter L / Shi, Yuzhe / Perica, Karlo / Xie, Hongyao / Jain, Nayan / Chow, Andrew / Wolchok, Jedd D / Merghoub, Taha / Sadelain, Michel / Hamieh, Mohamad

Nature cancer

2024

Abstract: Chimeric antigen receptor T cells have dramatically improved the treatment of hematologic malignancies. T cell antigen receptor (TCR)-based cell therapies are yet to achieve comparable outcomes. Importantly, chimeric antigen receptors not only target ... ...

Abstract	Chimeric antigen receptor T cells have dramatically improved the treatment of hematologic malignancies. T cell antigen receptor (TCR)-based cell therapies are yet to achieve comparable outcomes. Importantly, chimeric antigen receptors not only target selected antigens but also reprogram T cell functions through the co-stimulatory pathways that they engage upon antigen recognition. We show here that a fusion receptor comprising the CD80 ectodomain and the 4-1BB cytoplasmic domain, termed 80BB, acts as both a ligand and a receptor to engage the CD28 and 4-1BB pathways, thereby increasing the antitumor potency of human leukocyte antigen-independent TCR (HIT) receptor- or TCR-engineered T cells and tumor-infiltrating lymphocytes. Furthermore, 80BB serves as a switch receptor that provides agonistic 4-1BB co-stimulation upon its ligation by the inhibitory CTLA4 molecule. By combining multiple co-stimulatory features in a single antigen-agnostic synthetic receptor, 80BB is a promising tool to sustain CD3-dependent T cell responses in a wide range of targeted immunotherapies.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-024-00744-x
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Article: Monitoring the quality parameters for organic raspberries in order to determine the optimal storage method by packaging

Stan, A. / Bujor, O. C. / Dobrin, A. / Haida, G. / Badulescu, L. / Asanica, A.

Acta horticulturae. 2020 Apr. 20, , no. 1277

2020

Abstract: Beside blueberries and strawberries, raspberries (Rubus ideaus L.) are one of the most economically important soft fruit due to their taste, appearance and biochemical composition. Organic raspberries represent a good source of anthocyanins, vitamins and ...

Abstract	Beside blueberries and strawberries, raspberries (Rubus ideaus L.) are one of the most economically important soft fruit due to their taste, appearance and biochemical composition. Organic raspberries represent a good source of anthocyanins, vitamins and mineral elements. The postharvest storage of organic fresh raspberries is relatively short and the injuries, rapid spoilage, nutritional and moisture loss lead to dramatical reduction of their commercial value. In this way, the aim of this work was to determine the quality indicators variation during cold storage of raspberries packed in two different types of materials, in order to observe which type of packaging is more suitable for organic raspberries. For this purpose raspberries were weighed and packed in PET trays and biofilms (made from certified compostable material), stored at 3°C and 95% relative humidity and analyzed after 9 and 14 days. The ascorbic acid, total anthocyanin content, percentual losses, dry matter (DM%), total soluble solids (TSS) and total titrable acidity (TTA) were analyzed. After 14 days of cold storage at 3°C and 95% RH of the packaged raspberry fruits it can be observed that TSS decreased by 8-15% in both packages. When ascorbic acid content results were compared with initial moment, a decreases with 22% after 9 days and 46% after 14 days for raspberries packed in biofilms, respectively 29% after 9 days and 62% after 14 days for those packed in PET trays was observed. Regarding the differences between above results, this work suggest that biofilm better preserves the quality indicators of organic raspberries, but further studies and trials are required.
Keywords	Rubus idaeus ; anthocyanins ; ascorbic acid ; biofilm ; cold storage ; fruits ; postharvest storage ; raspberries ; relative humidity ; spoilage ; taste ; titratable acidity
Language	English
Dates of publication	2020-0420
Size	p. 461-468.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the XII International Rubus and Ribes Symposium: Innovative Rubus and Ribes Production for High Quality Berries in Changing Environments held June 23-28, 2019, Zurich, Switzerland
ISSN	0567-7572
DOI	10.17660/ActaHortic.2020.1277.66
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Challenges and Burdens in the Coronary Artery Disease Care Pathway for Patients Undergoing Percutaneous Coronary Intervention: A Contemporary Narrative Review.

Kodeboina, Monika / Piayda, Kerstin / Jenniskens, Inge / Vyas, Pearl / Chen, Sara / Pesigan, Ramon Julian / Ferko, Nicole / Patel, Barkha P / Dobrin, Annamaria / Habib, Jayson / Franke, Jennifer

International journal of environmental research and public health

2023 Volume 20, Issue 9

Abstract: Clinical and economic burdens exist within the coronary artery disease (CAD) care pathway despite advances in diagnosis and treatment and the increasing utilization of percutaneous coronary intervention (PCI). However, research presenting a comprehensive ...

Abstract	Clinical and economic burdens exist within the coronary artery disease (CAD) care pathway despite advances in diagnosis and treatment and the increasing utilization of percutaneous coronary intervention (PCI). However, research presenting a comprehensive assessment of the challenges across this pathway is scarce. This contemporary review identifies relevant studies related to inefficiencies in the diagnosis, treatment, and management of CAD, including clinician, patient, and economic burdens. Studies demonstrating the benefits of integration and automation within the catheterization laboratory and across the CAD care pathway were also included. Most studies were published in the last 5-10 years and focused on North America and Europe. The review demonstrated multiple potentially avoidable inefficiencies, with a focus on access, appropriate use, conduct, and follow-up related to PCI. Inefficiencies included misdiagnosis, delays in emergency care, suboptimal testing, longer procedure times, risk of recurrent cardiac events, incomplete treatment, and challenges accessing and adhering to post-acute care. Across the CAD pathway, this review revealed that high clinician burnout, complex technologies, radiation, and contrast media exposure, amongst others, negatively impact workflow and patient care. Potential solutions include greater integration and interoperability between technologies and systems, improved standardization, and increased automation to reduce burdens in CAD and improve patient outcomes.
MeSH term(s)	Humans ; Coronary Artery Disease/surgery ; Coronary Artery Disease/diagnosis ; Percutaneous Coronary Intervention/methods ; Critical Pathways ; Treatment Outcome ; Patients ; Risk Factors
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20095633
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Article ; Online: Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function.

Jain, Nayan / Zhao, Zeguo / Koche, Richard P / Antelope, Chenling / Gozlan, Yosi / Montalbano, Antonino / Brocks, David / Lopez, Michael / Dobrin, Anton / Shi, Yuzhe / Gunset, Gertrude / Giavridis, Theodoros / Sadelain, Michel

Cancer discovery

2023 Volume 14, Issue 1, Page(s) 142–157

Abstract: Suboptimal functional persistence limits the efficacy of adoptive T-cell therapies. CD28-based chimeric antigen receptors (CAR) impart potent effector function to T cells but with a limited lifespan. We show here that the genetic disruption of SUV39H1, ... ...

Abstract	Suboptimal functional persistence limits the efficacy of adoptive T-cell therapies. CD28-based chimeric antigen receptors (CAR) impart potent effector function to T cells but with a limited lifespan. We show here that the genetic disruption of SUV39H1, which encodes a histone-3, lysine-9 methyl-transferase, enhances the early expansion, long-term persistence, and overall antitumor efficacy of human CAR T cells in leukemia and prostate cancer models. Persisting SUV39H1-edited CAR T cells demonstrate improved expansion and tumor rejection upon multiple rechallenges. Transcriptional and genome accessibility profiling of repeatedly challenged CAR T cells shows improved expression and accessibility of memory transcription factors in SUV39H1-edited CAR T cells. SUV39H1 editing also reduces expression of inhibitory receptors and limits exhaustion in CAR T cells that have undergone multiple rechallenges. Our findings thus demonstrate the potential of epigenetic programming of CAR T cells to balance their function and persistence for improved adoptive cell therapies. Significance: T cells engineered with CD28-based CARs possess robust effector function and antigen sensitivity but are hampered by limited persistence, which may result in tumor relapse. We report an epigenetic strategy involving disruption of the SUV39H1-mediated histone-silencing program that promotes the functional persistence of CD28-based CAR T cells. See related article by López-Cobo et al., p. 120. This article is featured in Selected Articles from This Issue, p. 5.
MeSH term(s)	Male ; Humans ; Receptors, Chimeric Antigen ; T-Lymphocytes ; Receptors, Antigen, T-Cell ; Histones/metabolism ; CD28 Antigens/genetics ; CD28 Antigens/metabolism ; Immunotherapy, Adoptive ; Leukemia/metabolism ; Methylation ; Xenograft Model Antitumor Assays ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Histones ; CD28 Antigens ; SUV39H1 protein, human (EC 2.1.1.) ; Methyltransferases (EC 2.1.1.-) ; Repressor Proteins
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-22-1319
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Article ; Online: TET2 guards against unchecked BATF3-induced CAR T cell expansion.

Jain, Nayan / Zhao, Zeguo / Feucht, Judith / Koche, Richard / Iyer, Archana / Dobrin, Anton / Mansilla-Soto, Jorge / Yang, Julie / Zhan, Yingqian / Lopez, Michael / Gunset, Gertrude / Sadelain, Michel

Nature

2023 Volume 615, Issue 7951, Page(s) 315–322

Abstract: Further advances in cell engineering are needed to increase the efficacy of chimeric antigen receptor (CAR) and other T cell-based ... ...

Abstract	Further advances in cell engineering are needed to increase the efficacy of chimeric antigen receptor (CAR) and other T cell-based therapies
MeSH term(s)	Humans ; Male ; Cell Differentiation/genetics ; Cell Proliferation ; Dioxygenases/metabolism ; DNA-Binding Proteins/metabolism ; Immunotherapy, Adoptive/methods ; Immunotherapy, Adoptive/standards ; Lymphocyte Activation ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/metabolism ; Leukemia/immunology ; Prostatic Neoplasms/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Epigenesis, Genetic ; Immunologic Memory ; Basic-Leucine Zipper Transcription Factors/metabolism
Chemical Substances	Dioxygenases (EC 1.13.11.-) ; DNA-Binding Proteins ; Receptors, Chimeric Antigen ; TET2 protein, human (EC 1.13.11.-) ; BATF3 protein, human ; MYC protein, human ; Basic-Leucine Zipper Transcription Factors
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05692-z
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Article ; Online: ОПИСАНИЕ ХАРАКТЕРА РЕГУЛЯЦИИ СЕРДЕЧНОГО РИТМА ДЕТЕЙ С РАЗНЫМИ ЛАТЕРАЛЬНЫМИ ПРЕДПОЧТЕНИЯМИ В ПЕРЕХОДНЫХ СОСТОЯНИЯХ МЕТОДАМИ НЕЛИНЕЙНОГО АНАЛИЗА

Nikolaeva E, . . / Vergunov E, G. / Dobrin A, V.

Journal of Asymmetry, Iss

2015 Volume 1

Abstract: В работе делается попытка проверить предположение о том, что различие в регуляции кардиоритма есть не только у взрослых, но существует уже в детском возрасте, и, возможно, является врожденным качеством людей с разными типами профиля функциональной ... ...

Abstract	В работе делается попытка проверить предположение о том, что различие в регуляции кардиоритма есть не только у взрослых, но существует уже в детском возрасте, и, возможно, является врожденным качеством людей с разными типами профиля функциональной сенсомоторной асимметрии. В исследовании участвовали 150 детей 7-8 лет. У всех детей была проведена запись вариабельности кардиоритма в трёх экспериментальных ситуациях: в состоянии спокойного бодрствования (1), в процессе припоминания ситуаций поощрения (2) и наказания (3) в семье. Для всех детей, обладающих полным левым или полным правым профилем, дан анализ траекторий изменений их сердечного ритма в пространстве этих трех функциональных состояний. Для обработки записей ЭКГ использовалось программное обеспечение Kubios HRV (Kuopio, Finland) и WizWhy (компания WizSoft Ltd., Тель-Авив, Израиль). Показаны значимые различия в регуляции кардиоритма у детей с разными типами профиля.
Keywords	профиль функциональной сенсомоторной асимметрии ; регуляция кардиоритма ; дети 7-8 лет ; траектория состояний кардиоритма в фазовом пространстве функциональных состояний ; квазиаттрактор ; sensorimotor asymmetry profile ; cardiac rhythm regulation ; quasiattractor ; trace cardiac rhythm state in a functional state phase space ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Russian
Publishing date	2015-01-01T00:00:00Z
Publisher	ANO
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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