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  1. Book ; Thesis: Potential der Skelettszintigraphie zur Evaluation von Stressfrakturen bei Sportlern

    Dobrindt, Oliver Björn

    Diagnose und Prognose

    2012  

    Author's details vorgelegt von Oliver Björn Dobrindt
    Language German
    Size 62 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Magdeburg, Univ., Med. Fak., Diss., 2012
    HBZ-ID HT017590080
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 E 304 order for loan Magazin

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  2. Article ; Online: Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study.

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 10, Page(s) 3616–3623

    Abstract: Purpose: Only a few publications considered the influence of the spinopelvic parameters on below-hip anatomy. There is a lack of evidence about the relationship between the anatomic spinopelvic parameters and the posterior tibial slope (PTS). Therefore, ...

    Abstract Purpose: Only a few publications considered the influence of the spinopelvic parameters on below-hip anatomy. There is a lack of evidence about the relationship between the anatomic spinopelvic parameters and the posterior tibial slope (PTS). Therefore, the aim of this study was to analyze the association between fixed anatomic spinopelvic parameters and PTS.
    Methods: Adult patients presenting with lumbar, thoracic, or cervical complaints together with knee pain at a single hospital between 2017 to 2022 with available standing full-spine lateral radiograph and lateral knee radiograph were retrospectively reviewed. The measured parameters included the pelvic incidence (PI), the sacral kyphosis (SK), the pelvisacral angle, the sacral anatomic orientation (SAO), the sacral table angle, the sacropelvic angle and the PTS. Pearson's correlations and linear regression analyses were conducted.
    Results: A total of 80 patients (44 women), median age 63 years were analyzed. A strong positive correlation was identified between PI and PTS (r = 0.70, p < 0.001). A strong negative correlation was observed between PI and SAO (r = - 0.74, p < 0.001). A strong positive correlation was observed between PI and SK (r = 0.81, p < 0.001). A univariable linear regression analysis showed that PTS can be deduced from PI according to the following formula: PTS = 0.174 × PI - 1.138.
    Conclusion: This study is the first to support a positive correlation between the PI and the PTS. We demonstrate that knee anatomy is individually correlated to pelvic shape and therefore influences spinal posture.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Retrospective Studies ; Cross-Sectional Studies ; Sacrum ; Radiography ; Lower Extremity ; Lordosis/diagnostic imaging
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07830-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Answer to the Letter to the Editor of Tugba Ozudogru Celik concerning "Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study" by Caffard T, et al. (Eur Spine J. 2023; doi: 10.1007/s00586-023-07830-1).

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 33, Issue 2, Page(s) 752–753

    MeSH term(s) Humans ; Cross-Sectional Studies ; Retrospective Studies ; Spine ; Spinal Fusion
    Language English
    Publishing date 2023-12-06
    Publishing country Germany
    Document type Letter
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-08061-0
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  4. Article ; Online: Importance of the cervical paraspinal muscles in postoperative patient-reported outcomes and maintenance of sagittal alignment after anterior cervical discectomy and fusion.

    Caffard, Thomas / Arzani, Artine / Verna, Bruno / Tripathi, Vidushi / Chiapparelli, Erika / Schönnagel, Lukas / Zhu, Jiaqi / Medina, Samuel J / Tani, Soji / Camino-Willhuber, Gaston / Guven, Ali E / Amoroso, Krizia / Tan, Ek Tsoon / Carrino, John A / Shue, Jennifer / Dobrindt, Oliver / Zippelius, Timo / Dalton, David / Sama, Andrew A /
    Girardi, Federico P / Cammisa, Frank P / Hughes, Alexander P

    Journal of neurosurgery. Spine

    2024  , Page(s) 1–10

    Abstract: Objective: The aim of this study was to investigate the influence of preoperatively assessed paraspinal muscle parameters on postoperative patient-reported outcomes and maintenance of cervical sagittal alignment after anterior cervical discectomy and ... ...

    Abstract Objective: The aim of this study was to investigate the influence of preoperatively assessed paraspinal muscle parameters on postoperative patient-reported outcomes and maintenance of cervical sagittal alignment after anterior cervical discectomy and fusion (ACDF).
    Methods: Patients with preoperative and postoperative standing cervical spine lateral radiographs and preoperative cervical MRI who underwent an ACDF between 2015 and 2018 were reviewed. Muscles from C3 to C7 were segmented into 4 functional groups: anterior, posteromedial, posterolateral, and sternocleidomastoid. The functional cross-sectional area and also the percent fat infiltration (FI) were calculated for all groups. Radiographic alignment parameters collected preoperatively and postoperatively included C2-7 lordosis and C2-7 sagittal vertical axis (SVA). Neck Disability Index (NDI) scores were recorded preoperatively and at 2 and 4-6 months postoperatively. To investigate the relationship between muscle parameters and postoperative changes in sagittal alignment, multivariable linear mixed models were used. Multivariable linear regression models were used to analyze the correlations between the changes in NDI scores and the muscles' FI.
    Results: A total of 168 patients with NDI and 157 patients with sagittal alignment measurements with a median follow-up of 364 days were reviewed. The mixed models showed that a greater functional cross-sectional area of the posterolateral muscle group at each subaxial level and less FI at C4-6 were significantly associated with less progression of C2-7 SVA over time. Moreover, there was a significant correlation between greater FI of the posteromedial muscle group measured at the C7 level and less NDI improvement at 4-6 months after ACDF.
    Conclusions: The findings highlight the importance of preoperative assessment of the cervical paraspinal muscle morphology as a predictor for patient-reported outcomes and maintenance of C2-7 SVA after ACDF.
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2024.2.SPINE23926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Use of Iloprost in the Treatment of Bone Marrow Edema Syndrome of the Proximal Femur: A Review and Meta-Analysis.

    Zippelius, Timo / Strube, Patrick / Rohe, Sebastian / Schlattmann, Peter / Dobrindt, Oliver / Caffard, Thomas / Awan Malik, Hassan / Lindemann, Chris / Matziolis, Georg / Böhle, Sabrina

    Journal of personalized medicine

    2022  Volume 12, Issue 11

    Abstract: Objective: The aim of this meta-analysis was to investigate the impact of intravenous iloprost therapy on pain, function, edema changes, and follow-up surgery in bone marrow edema syndrome of the proximal femur. Methods: A systematic literature search up ...

    Abstract Objective: The aim of this meta-analysis was to investigate the impact of intravenous iloprost therapy on pain, function, edema changes, and follow-up surgery in bone marrow edema syndrome of the proximal femur. Methods: A systematic literature search up to May 2022 was performed to find relevant papers that made a statement about the outcome of intravenous iloprost therapy alone. Factors such as the Visual Analog Scale (VAS), Harris Hip Score (HHS), edema reduction, and follow-up interventions were considered. These were compared using Forest plots. Results: In 11 studies, 190 proximal femora with bone marrow edema syndrome that received intravenous iloprost therapy without further therapeutic intravenous or surgical intervention such as core decompression were studied. There was a significant mean improvement in VAS by 3.3 cm (2.07−4.5 cm) (p < 0.001) and HHS by 24.36 points (18.23−30.49) (p < 0.001) 3−6 months after receiving iloprost therapy. Only in 9.3% of cases (1.1−24.3%) did no clinical or radiological improvement occur. Conclusions: It could be shown that the existing publications support intravenous therapy with iloprost in patients with bone marrow edema syndrome and result in good clinical outcomes.
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12111757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Conference proceedings: Die Korrelation des Posterioren Tibial Slope mit den anatomischen Spinopelvinen Parametern: Eine retrospektive Querschnittstudie

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    2023  , Page(s) AV62–2944

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit ; posterior tibial slope ; pelvic incidence ; sagittal alignment
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou646
    Database German Medical Science

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  7. Conference proceedings: Einfluss von multiplen Hüft-TEP Revisionen auf Standzeit und Versagensursachen

    Dobrindt, Oliver / Schmelzer, Lisa / Perka, Carsten-Frank / Müller, Michael

    2015  , Page(s) WI19–1061

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2015
    Keywords Medizin, Gesundheit ; H-TEP Revisionen
    Publishing date 2015-10-05
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dkou080
    Database German Medical Science

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  8. Conference proceedings: Geringe diagnostische Wertigkeit des CRP bei low-grade Infektionen von Hüftendoprothesen

    Dobrindt, Oliver / Schmelzer, Lisa / Müller, Michael / Perka, Carsten-Frank

    2014  , Page(s) WI30–1566

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2014
    Keywords Medizin, Gesundheit
    Publishing date 2014-10-13
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/14dkou173
    Database German Medical Science

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  9. Article ; Online: Human osteoblast damage after antiseptic treatment.

    Vörös, Pauline / Dobrindt, Oliver / Perka, Carsten / Windisch, Christoph / Matziolis, Georg / Röhner, Eric

    International orthopaedics

    2013  Volume 38, Issue 1, Page(s) 177–182

    Abstract: Purpose: Antiseptics are powerful medical agents used for wound treatment and decontamination and have a high potential for defeating joint infections in septic surgery. Both chlorhexidine and polyhexanide are frequently used in clinical practice and ... ...

    Abstract Purpose: Antiseptics are powerful medical agents used for wound treatment and decontamination and have a high potential for defeating joint infections in septic surgery. Both chlorhexidine and polyhexanide are frequently used in clinical practice and have a broad antimicrobial range, but their effect on human osteoblasts has not been sufficiently studied. Our objective was to investigate the toxic effects of polyhexanide and chlorhexidine on human osteoblasts in vitro to evaluate their clinical applicability in septic surgery.
    Methods: We isolated and cultivated human osteoblasts in vitro and assayed the toxic effects of chlorhexidine 0.1% and polyhexanide 0.04%, concentrations commonly applied in clinical practice. Toxicity analysis was performed by visualisation of cell structure, lactate dehydrogenase (LDH) activity and evaluation of vital cells. Toxicity was evaluated by microscopic inspection of cell morphology, trypan blue staining and determination of LDH release.
    Results: Damaged cell structure could be shown by microscopy. Both antiseptics promoted LDH activity after incubation with osteoblasts. The evaluation of vital osteoblasts showed a significant decrease of vital cells.
    Conclusions: Both antiseptics induced significant cell death of osteoblasts at optimum exposure. We therefore recommend cautious use of polyhexanide and chlorhexidine in septic surgery to avoid severe osteoblast toxicity.
    MeSH term(s) Anti-Infective Agents, Local/pharmacology ; Biguanides/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; Chlorhexidine/pharmacology ; Dose-Response Relationship, Drug ; Humans ; In Vitro Techniques ; L-Lactate Dehydrogenase/metabolism ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoblasts/pathology
    Chemical Substances Anti-Infective Agents, Local ; Biguanides ; polihexanide (322U039GMF) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2013-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-013-2107-y
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  10. Article ; Online: Hybrid SPECT/CT for the assessment of a painful hip after uncemented total hip arthroplasty.

    Dobrindt, Oliver / Amthauer, Holger / Krueger, Alexander / Ruf, Juri / Wissel, Heiko / Grosser, Oliver S / Seidensticker, Max / Lohmann, Christoph H

    BMC medical imaging

    2015  Volume 15, Page(s) 18

    Abstract: Background: The diagnosis of hip pain after total hip replacement (THR) represents a highly challenging question that is of increasing concern to orthopedic surgeons. This retrospective study assesses bone scintigraphy with Hybrid SPECT/CT for the ... ...

    Abstract Background: The diagnosis of hip pain after total hip replacement (THR) represents a highly challenging question that is of increasing concern to orthopedic surgeons. This retrospective study assesses bone scintigraphy with Hybrid SPECT/CT for the diagnosis of painful THR in a selected cohort of patients.
    Methods: Bone SPECT/CT datasets of 23 patients (mean age 68.9 years) with a painful hip after THR were evaluated. Selection of the patients required an inconclusive radiograph, normal serum levels of inflammatory parameters (CRP and ESR) or a negative aspiration of the hip joint prior to the examination. The standard of reference was established by an interdisciplinary adjudication-panel using all imaging data and clinical follow-up data (>12 month). Pathological and physiological uptake patterns were defined and applied.
    Results: The cause of pain in this study group could be determined in 18 out of 23 cases. Reasons were aseptic loosening (n = 5), spine-related (n = 5), heterotopic ossification (n = 5), neuronal (n = 1), septic loosening (n = 1) and periprosthetic stress fracture (n = 1). In (n = 5) cases the cause of hip pain could not be identified. SPECT/CT imaging correctly identified the cause of pain in (n = 13) cases, in which the integrated CT-information led to the correct diagnosis in (n = 4) cases, mainly through superior anatomic correlation. Loosening was correctly assessed in all cases with a definite diagnosis.
    Conclusions: SPECT/CT of THA reliably detects or rules out loosening and provides valuable information about heterotopic ossifications. Furthermore differential diagnoses may be detected with a whole-body scan and mechanical or osseous failure is covered by CT-imaging. SPECT/CT holds great potential for imaging-based assessment of painful prostheses.
    MeSH term(s) Aged ; Arthralgia/diagnosis ; Arthralgia/etiology ; Arthroplasty, Replacement, Hip/adverse effects ; Bone Cements ; Female ; Hip Joint/diagnostic imaging ; Humans ; Male ; Multimodal Imaging/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Bone Cements
    Language English
    Publishing date 2015-06-02
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-015-0056-1
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