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Article: Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 - a Polish single-centre experience from the pre-vaccine era.

Banasik, Estera / Dobrowolska, Agnieszka / Kołodziejczak, Barbara / Eder, Piotr

2023 Volume 18, Issue 4, Page(s) 409–415

Abstract: Introduction: The data on the relationship between inflammatory bowel diseases (IBD) and the course of COVID-19 from East-Central Europe are scarce.: Aim: To assess the frequency of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ... ...

Abstract	Introduction: The data on the relationship between inflammatory bowel diseases (IBD) and the course of COVID-19 from East-Central Europe are scarce. Aim: To assess the frequency of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in IBD patients and the impact of IBD on the COVID-19 course from the perspective of a Polish tertiary centre. Material and methods: Data on SARS-CoV-2 infection were retrospectively collected among IBD patients hospitalized in a Polish tertiary centre from March 2020 to May 2021. A questionnaire was used assessing the IBD characteristics, other comorbidities, and the course of COVID-19. Results: Among 350 patients, SARS-CoV-2 infection was diagnosed in 32 (9%). Severe COVID-19, defined as the need for hospitalization, was reported in 6 (19%) and mild in 26 (81%) cases. Compared to the mild COVID-19 course, patients with a severe course more often showed a higher IBD activity (3 points [IQR 2.25-3] vs. 1 point [IQR 0-2] in a semi-quantitative scale, Conclusions: IBD is not a risk factor for SARS-CoV-2 infection. Steroids and higher IBD clinical activity may increase the risk of severe COVID-19. The prognosis for COVID-19 in our cohort was good. SARS-CoV-2 infection was a common cause of gastrointestinal symptoms.
Language	English
Publishing date	2023-12-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596134-2
ISSN	1897-4317 ; 1895-5770
ISSN (online)	1897-4317
ISSN	1895-5770
DOI	10.5114/pg.2023.133479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Black esophagus: an unusual etiology of upper gastrointestinal bleeding.

Eder, Piotr / Dobrowolska, Agnieszka

Polish archives of internal medicine

2021 Volume 131, Issue 4, Page(s) 377–378

MeSH term(s)	Causality ; Esophagus/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Humans
Language	English
Publishing date	2021-03-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15876
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Article ; Online: Apoptosis and inflammatory genes variants in primary non-response to anti-TNF therapy in Crohn's disease patients.

Lykowska-Szuber, Liliana / Walczak, Michal / Dobrowolska, Agnieszka / Skrzypczak-Zielinska, Marzena

European journal of gastroenterology & hepatology

2023 Volume 35, Issue 10, Page(s) 1088–1096

Abstract: Anti-TNF therapy has indeed revolutionized the treatment of Crohn's disease, leading to higher rates of response and remission in patients. However, a significant proportion of 20-40% of patients do not respond to the initial therapy, others experience a ...

Abstract	Anti-TNF therapy has indeed revolutionized the treatment of Crohn's disease, leading to higher rates of response and remission in patients. However, a significant proportion of 20-40% of patients do not respond to the initial therapy, others experience a secondary loss of response with ongoing treatment. Adverse drug reactions also occur in some patients. The effectiveness of anti-TNF treatment may be influenced by genetic variability, including FCGR3A, ADAM17, TNFRSF1A, TNFRSF1B, FAS, FASL, IL1B, CASP9 , and MIF genes. In this article, we provide an overview of the current knowledge and findings in the pharmacogenetics of anti-TNF drugs in CD focusing on the aspect of apoptosis and inflammatory genes variants in primary non-response. Pharmacogenetic investigations have been conducted to identify genetic markers that can predict response to anti-TNF therapy. However, large multi-center validation studies and multi-loci algorithms development are required to effectively prognose the treatment effect. The identification of predictive markers of response to anti-TNF therapy can help clinicians make informed decisions about treatment options and minimize adverse drug reactions in patients.
MeSH term(s)	Humans ; Crohn Disease/drug therapy ; Crohn Disease/genetics ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Drug-Related Side Effects and Adverse Reactions ; Apoptosis ; Tumor Necrosis Factor-alpha/genetics ; Infliximab/therapeutic use
Chemical Substances	Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002618
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Article: Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review.

Ratajczak, Alicja Ewa / Festa, Stefano / Aratari, Annalisa / Papi, Claudio / Dobrowolska, Agnieszka / Krela-Kaźmierczak, Iwona

Frontiers in nutrition

2023 Volume 9, Page(s) 1088693

Abstract: Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the ... ...

Abstract	Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the course of IBD. It is known that the group of beneficial bacteria was reduced in the IBD and that the Mediterranean diet (MD)-which is defined as eating habits characterized by high consumption of plant foods, mainly cereals, vegetables, fruit as well as olive oil, and small portions of dairy products, sweets, sugar and meat products-affects gut microbiota, enriching beneficial bacteria, which support gut barrier function and reduce inflammation. Although several studies support different favorable effects of MD on IBD, adherence to MD by IBD patients is generally low, including patients from the Mediterranean Basin. Patients avoid many products which are elements of MD because there cause gastrointestinal symptoms. Patients should be encouraged to have a healthy and well-balanced diet according to individual tolerance of products. A good option seems to be good modified MD, changing hard-to-digest products to easy digest.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1088693
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Article ; Online: Metabolic link between obesity and autoimmune diseases.

Karczewski, Jacek / Zielińska, Aleksandra / Staszewski, Rafał / Eder, Piotr / Dobrowolska, Agnieszka

European cytokine network

2022 Volume 32, Issue 4, Page(s) 64–72

Abstract: The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of ... ...

Abstract	The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of autoimmune diseases. Accumulating evidence suggest that prolonged metabolic overload related to overnutrition, influenced by genetic and epigenetic factors, might affect immunologic self-tolerance through changes in the energy metabolism of immune cells, particularly regulatory T (Treg) cells. A strong activation of nutrient-energy signaling pathways blocks the induction of the transcription factor forkhead P3 (FOXP3), a master regulator of Treg cells, consequently inhibiting their generation and proliferation, thereby promoting proinflammatory response. Expanding our knowledge on the topic, particularly on metabolic T cell flexibility in vivo will provide new insights that can be used to develop therapeutic strategies for various inflammatory diseases, including obesity and autoimmune diseases. Targeting specific metabolic pathways is emerging as an important approach to control immune response and maintain immunological homeostasis.
MeSH term(s)	Autoimmune Diseases ; Forkhead Transcription Factors ; Humans ; Immune Tolerance ; Obesity/complications ; T-Lymphocytes, Regulatory
Chemical Substances	Forkhead Transcription Factors
Language	English
Publishing date	2022-02-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1118857-1
ISSN	1952-4005 ; 1148-5493
ISSN (online)	1952-4005
ISSN	1148-5493
DOI	10.1684/ecn.2021.0474
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Zs.A 3447: Show issues

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Article: Assessment of nutritionnal status and nutrition in patients with arterial hypertension.

Niezgódka-Klósak, Alina / Swora-Cwynar, Ewelina / Dobrowolska, Agnieszka

Przeglad epidemiologiczny

2021 Volume 74, Issue 4, Page(s) 686–694

Abstract: Introduction: The factors predisposing to the occurrence of cardiovascular event are mainly age, visceral obesity and metabolic syndrome. To our knowledge, there are no studies assessing both the nutritional status and diet of hypertensive patients in ... ...

Abstract	Introduction: The factors predisposing to the occurrence of cardiovascular event are mainly age, visceral obesity and metabolic syndrome. To our knowledge, there are no studies assessing both the nutritional status and diet of hypertensive patients in Poland. Aim: Our aim is the assessment of the diet and nutritional status of patients with hypertension. Material and methods: This study included 50 patients (K: 32, M: 18) with hypertension admitted to the Department of Internal Medicine at the Heliodor Święcicki Clinical Hospital in Poznan. Anthropometric measurements (waist and hip circumference), and body composition analysis were used to assess nutritional status. Additionally, we carried out the nutritional interview. Results: We observed that among hypertensive patients, overweight occurred in 18% and obesity (definition based on BMI) in 48% of all patients. We found that visceral obesity (definition based on WHR) concerns 76% of patients. Moreover, we diagnosed a metabolic syndrome in 56% of patients. None of the patients treated the DASH diet, especially recommended for the treatment of hypertension. What's more, as many as 50% of hypertensive patients used salt for meals twice a day. Conclusions: In patients with hypertension the frequent occurrence of obesity and metabolic syndrome may to a large extent result from the dietary support deviating from the rational diet. There is a need to educate patients with arterial hypertension in the field of non-pharmacological treatment methods, especially diet therapy.
MeSH term(s)	Body Mass Index ; Humans ; Hypertension/epidemiology ; Nutritional Status ; Overweight ; Poland
Language	English
Publishing date	2021-04-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421782-2
ISSN	0033-2100
ISSN	0033-2100
DOI	10.32394/pe.74.60
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Article: From an understanding of etiopathogenesis to novel therapies-what is new in the treatment of celiac disease?

Skoracka, Kinga / Hryhorowicz, Szymon / Tovoli, Francesco / Raiteri, Alberto / Rychter, Anna Maria / Słomski, Ryszard / Dobrowolska, Agnieszka / Granito, Alessandro / Krela-Kaźmierczak, Iwona

Frontiers in pharmacology

2024 Volume 15, Page(s) 1378172

Abstract: Celiac disease, a chronic autoimmune disorder caused by genetic factors and exposure to gluten, is increasingly being recognized and diagnosed in both children and adults. Scientists have been searching for a cure for this disease for many years, but ... ...

Abstract	Celiac disease, a chronic autoimmune disorder caused by genetic factors and exposure to gluten, is increasingly being recognized and diagnosed in both children and adults. Scientists have been searching for a cure for this disease for many years, but despite the impressive development of knowledge in this field, a gluten-free diet remains the only recommended therapy for all patients. At the same time, the increasing diagnosis of celiac disease in adults, which was considered a childhood disease in the 20th century, has opened a discussion on the etiopathology of the disease, which is proven to be very complex and involves genetic, immunological, nutritional, environmental and gut microbiota-related factors. In this review, we extensively discuss these factors and summarize the knowledge of the proposed state-of-the-art treatments for celiac disease to address the question of whether a better understanding of the etiopathogenesis of celiac disease has opened new directions for therapy.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1378172
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Book ; Online: FedNST

Mehmood, Haaris / Dobrowolska, Agnieszka / Saravanan, Karthikeyan / Ozay, Mete

Federated Noisy Student Training for Automatic Speech Recognition

2022

Abstract: Federated Learning (FL) enables training state-of-the-art Automatic Speech Recognition (ASR) models on user devices (clients) in distributed systems, hence preventing transmission of raw user data to a central server. A key challenge facing practical ... ...

Abstract	Federated Learning (FL) enables training state-of-the-art Automatic Speech Recognition (ASR) models on user devices (clients) in distributed systems, hence preventing transmission of raw user data to a central server. A key challenge facing practical adoption of FL for ASR is obtaining ground-truth labels on the clients. Existing approaches rely on clients to manually transcribe their speech, which is impractical for obtaining large training corpora. A promising alternative is using semi-/self-supervised learning approaches to leverage unlabelled user data. To this end, we propose FedNST, a novel method for training distributed ASR models using private and unlabelled user data. We explore various facets of FedNST, such as training models with different proportions of labelled and unlabelled data, and evaluate the proposed approach on 1173 simulated clients. Evaluating FedNST on LibriSpeech, where 960 hours of speech data is split equally into server (labelled) and client (unlabelled) data, showed a 22.5% relative word error rate reduction} (WERR) over a supervised baseline trained only on server data. Comment: Accepted at Interspeech 2022
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Artificial Intelligence ; Computer Science - Computation and Language ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Machine Learning ; I.2.11
Subject code	006 ; 004
Publishing date	2022-06-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Selected Organ and Endocrine Complications According to BMI and the Metabolic Category of Obesity: A Single Endocrine Center Study

Milewska, Ewa Malwina / Szczepanek-Parulska, Ewelina / Marciniak, Martyna / Krygier, Aleksandra / Dobrowolska, Agnieszka / Ruchala, Marek

Nutrients. 2022 Mar. 20, v. 14, no. 6

2022

Abstract: Obesity is a chronic and complex disease associated with metabolic, organ and endocrine complications. In the study, we analyzed a group of 105 patients suffering from obesity without any other previously recognized serious disorders who had been ... ...

Abstract	Obesity is a chronic and complex disease associated with metabolic, organ and endocrine complications. In the study, we analyzed a group of 105 patients suffering from obesity without any other previously recognized serious disorders who had been referred to a single endocrine center. The study aimed to assess the prevalence of selected organ and endocrine complications by subdividing the group, firstly according to body mass index (BMI) and secondly with regard to metabolic syndrome (MetS), pre-MetS and the metabolically healthy obesity (MHO) category. We have observed that in our groups, the prevalence of hyperlipidemia, hypertension, asthma, obstructive sleep apnea (OSA) depended on BMI category, whereas the incidence of hyperlipidemia, hypertension, OSA, hypothyroidism, non-alcoholic fatty liver disease, prediabetes, and type 2 diabetes was related to the metabolic category. We concluded that the distribution of particular organ and endocrine complications change significantly with increased BMI and with the shift from MHO to pre-MetS and MetS. Thus, to determine the risk of organ and endocrine complications more effectively, BMI and metabolic status should be assessed during the examination of patients with obesity.
Keywords	asthma ; body mass index ; fatty liver ; hyperlipidemia ; hypertension ; hypothyroidism ; metabolic syndrome ; noninsulin-dependent diabetes mellitus ; obesity ; risk ; sleep apnea
Language	English
Dates of publication	2022-0320
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14061307
Database	NAL-Catalogue (AGRICOLA)

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Article: Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review

Rychter, Anna Maria / Hryhorowicz, Szymon / Słomski, Ryszard / Dobrowolska, Agnieszka / Krela-Kaźmierczak, Iwona

Clinical nutrition. 2022 Apr. 28,

2022

Abstract: Proper dietary habits are a vital element of cardiovascular (CV) treatment, and - according to the current guidelines - a diet rich in antioxidants is generally recommended. It remains, however, inconclusive whether antioxidant nutrients should be ... ...

Abstract	Proper dietary habits are a vital element of cardiovascular (CV) treatment, and - according to the current guidelines - a diet rich in antioxidants is generally recommended. It remains, however, inconclusive whether antioxidant nutrients should be supplemented for CV health, and if so, in which form and dosage. Currently available data suggest that vitamin E may be essential in preventing CVD, especially in coronary heart disease and atherosclerosis – nevertheless, vitamin E supplementation may be questionable and may even be associated with adverse outcomes. Further, current studies highlight a strong need for identifying sex-specific strategies, which could improve guidelines for both the prevention and management of cardiovascular disease (CVD). It should also be emphasized that understanding the role of genetic variants in genes involved in VE metabolism may also be crucial for more precise nutritional recommendations for patients suffering from CVD. Therefore, we summarize the current knowledge regarding vitamin E antioxidant properties, which could be essential from CV perspective, and aim to assess whether vitamin E supplementation can be beneficial in CV prevention, especially in the high-risk group of women with obesity.
Keywords	antioxidants ; atherosclerosis ; clinical nutrition ; coronary disease ; diet ; metabolism ; obesity ; risk ; vitamin E
Language	English
Dates of publication	2022-0428
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2022.04.032
Database	NAL-Catalogue (AGRICOLA)

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