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  1. Article ; Online: Antimicrobial Resistance: Addressing a Global Threat to Humanity.

    Walsh, Timothy R / Gales, Ana C / Laxminarayan, Ramanan / Dodd, Philippa C

    PLoS medicine

    2023  Volume 20, Issue 7, Page(s) e1004264

    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Global Health
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1004264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6042: Show issues Location:
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  2. Article: Inhibition of Angiopoietin-2 Production by Myofibrocytes Inhibits Neointimal Hyperplasia After Endoluminal Injury in Mice.

    Chen, Daxin / Li, Ke / Tham, El-Li / Wei, Lin-Lin / Ma, Ning / Dodd, Philippa C / Luo, Yi / Kirchhofer, Daniel / McVey, John H / Dorling, Anthony

    Frontiers in immunology

    2018  Volume 9, Page(s) 1517

    Abstract: Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation after vascular injury, including the immune-mediated injury that occurs after allogeneic ... ...

    Abstract Fibrocytes are myeloid lineage cells implicated in wound healing, repair, and fibrosis. We previously showed that fibrocytes are mobilized into the circulation after vascular injury, including the immune-mediated injury that occurs after allogeneic transplantation. A common response to inflammatory vascular injury is intimal hyperplasia (IH), which, alongside vascular remodeling, results in progressive loss of blood flow, downstream ischemia, and end-organ fibrosis. This forms the pathological basis of transplant arteriosclerosis and other diseases including post-angioplasty re-stenosis. In investigating whether fibrocytes contribute to IH, we previously showed that subpopulations expressing smooth muscle actin and CD31 are recruited to the site of injury and accumulate in the neointima. Expression of tissue factor (TF) by these "CD31+ myofibrocytes" is needed for progressive neointimal expansion, such that TF inhibition limits the neointima to a single layer of cells by day 28 post-injury. The aim of this study was to determine pathophysiological mediators downstream of TF that contribute to myofibrocyte-orchestrated IH. We first show that myofibrocytes make up a significant component of the neointima 28 days following injury. Using a previously defined adoptive transfer model, we then show that CD31+ myofibrocytes get recruited early to the site of injury; this model allows manipulations of the adoptively transferred cells to study how IH develops. Having confirmed that inhibition of TF on adoptively transferred cells prevents IH, we then show that TF, primarily through the generation of thrombin, induces secretion of angiopoietin-2 by myofibrocytes and this directly stimulates proliferation, inhibits apoptosis, and induces CXCL-12 production by neointimal cells, including non-fibrocytes, all of which promote progressive IH
    Language English
    Publishing date 2018-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses.

    Nova-Lamperti, Estefania / Fanelli, Giorgia / Becker, Pablo D / Chana, Prabhjoat / Elgueta, Raul / Dodd, Philippa C / Lord, Graham M / Lombardi, Giovanna / Hernandez-Fuentes, Maria P

    Scientific reports

    2016  Volume 6, Page(s) 20044

    Abstract: A novel subset of human regulatory B-cells has recently been described. They arise from within the transitional B-cell subpopulation and are characterised by the production of IL-10. They appear to be of significant importance in regulating T-cell ... ...

    Abstract A novel subset of human regulatory B-cells has recently been described. They arise from within the transitional B-cell subpopulation and are characterised by the production of IL-10. They appear to be of significant importance in regulating T-cell immunity in vivo. Despite this important function, the molecular mechanisms by which they control T-cell activation are incompletely defined. Here we show that transitional B-cells produced more IL-10 and expressed higher levels of IL-10 receptor after CD40 engagement compared to other B-cell subsets. Furthermore, under this stimulatory condition, CD86 expressed by transitional B-cells was down regulated and T-cell proliferation was reduced. We provide evidence to demonstrate that the down-regulation of CD86 expression by transitional B-cells was due to the autocrine effect of IL-10, which in turn leads to decreased T-cell proliferation and TNF-α production. This analysis was further extended to peripheral B-cells in kidney transplant recipients. We observed that B-cells from patients tolerant to the graft maintained higher IL-10 production after CD40 ligation, which correlates with lower CD86 expression compared to patients with chronic rejection. Hence, the results obtained in this study shed light on a new alternative mechanism by which transitional B-cells inhibit T-cell proliferation and cytokine production.
    MeSH term(s) Adult ; Aged ; Autocrine Communication ; B7-2 Antigen/metabolism ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Down-Regulation ; Female ; Healthy Volunteers ; Humans ; Immune Tolerance ; Interleukin-10/biosynthesis ; Kidney Transplantation ; Male ; Middle Aged ; Precursor Cells, B-Lymphoid/metabolism ; Young Adult
    Chemical Substances B7-2 Antigen ; IL10 protein, human ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2016-01-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep20044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell-dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells.

    Shiu, Kin Yee / McLaughlin, Laura / Rebollo-Mesa, Irene / Zhao, Jingyue / Burton, Hannah / Douthwaite, Harriet / Wilkinson, Hannah / Semik, Vikki / Dodd, Philippa C / Brookes, Paul / Lechler, Robert I / Hernandez-Fuentes, Maria P / Kemper, Claudia / Dorling, Anthony

    Kidney international

    2016  Volume 91, Issue 2, Page(s) 477–492

    Abstract: Chronic antibody-mediated rejection, a common cause of renal transplant failure, has a variable clinical phenotype. Understanding why some with chronic antibody-mediated rejection progress slowly may help develop more effective therapies. B lymphocytes ... ...

    Abstract Chronic antibody-mediated rejection, a common cause of renal transplant failure, has a variable clinical phenotype. Understanding why some with chronic antibody-mediated rejection progress slowly may help develop more effective therapies. B lymphocytes act as antigen-presenting cells for in vitro indirect antidonor interferon-γ production in chronic antibody-mediated rejection, but many patients retain the ability to regulate these responses. Here we test whether particular patterns of T and B cell antidonor response associate with the variability of graft dysfunction in chronic antibody-mediated rejection. Our results confirm that dynamic changes in indirect antidonor CD4
    MeSH term(s) Adult ; Area Under Curve ; Autocrine Communication/drug effects ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Biopsy ; Chi-Square Distribution ; Chronic Disease ; Disease Progression ; Enzyme-Linked Immunospot Assay ; Female ; Glomerular Filtration Rate ; Graft Rejection/blood ; Graft Rejection/drug therapy ; Graft Rejection/immunology ; Graft Rejection/physiopathology ; Graft Survival ; HLA Antigens/immunology ; Histocompatibility ; Humans ; Immunosuppressive Agents/therapeutic use ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interferon-gamma Release Tests ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Isoantibodies/blood ; Kidney/drug effects ; Kidney/immunology ; Kidney/metabolism ; Kidney/physiopathology ; Kidney Transplantation/adverse effects ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; ROC Curve ; Risk Factors ; Signal Transduction ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Time Factors ; Treatment Outcome
    Chemical Substances HLA Antigens ; IFNG protein, human ; IL10 protein, human ; Immunosuppressive Agents ; Isoantibodies ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2016-12-15
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2016.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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