Article ; Online: Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.
Journal of medicinal chemistry
2024 Volume 67, Issue 5, Page(s) 3571–3589
Abstract: PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS ... ...
| Abstract | PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS hit |
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| MeSH term(s) | Animals ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Macaca fascicularis ; Quinoxalines/pharmacology ; Quinoxalines/therapeutic use ; Receptors, Thrombin ; Thrombin ; Hemorrhage ; Thrombosis/drug therapy ; Thrombosis/prevention & control ; Receptor, PAR-1 ; Blood Platelets ; Platelet Aggregation | ||||||||||
| Chemical Substances | protease-activated receptor 4 (JWE1M73YZN) ; Fibrinolytic Agents ; Quinoxalines ; Receptors, Thrombin ; Thrombin (EC 3.4.21.5) ; Receptor, PAR-1 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2024-02-22 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 218133-2 | ||||||||||
| ISSN | 1520-4804 ; 0022-2623 | ||||||||||
| ISSN (online) | 1520-4804 | ||||||||||
| ISSN | 0022-2623 | ||||||||||
| DOI | 10.1021/acs.jmedchem.3c01986 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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