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  1. Book ; Thesis: Rolle peripherer Monozyten bei Patienten mit essentieller Hypertonie

    Dörffel, Yvonne

    2002  

    Author's details von Yvonne Dörffel
    Language German
    Size 133 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Habil.-Schr., 2002
    HBZ-ID HT013397433
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Conference proceedings: Sonographische Differentialdiagnostik der primär sklerosierenden Cholangitis (PSC) und Autoimmuncholangitis (AIC)

    Khouja, Slim / Dörffel, Yvonne

    Ultraschall in der Medizin - European Journal of Ultrasound

    2023  Volume 44, Issue S 01

    Event/congress 46. Dreiländertreffen der DEGUM in Zusammenarbeit mit ÖGUM & SGUM, Mainz, 2023-10-11
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/s-0043-1772363
    Database Thieme publisher's database

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  3. Article ; Conference proceedings: Alters- und Geschlechtsverteilung der Gallenblasenadenomyomatose und sonographische Differenzierung von Gallenblasenpolypen in einer medizinischen Universitätsambulanz

    Neumann, Marie / Doerffel, Yvonne / Morgera, Ulrike / Kallenbach, Michael

    Ultraschall in der Medizin - European Journal of Ultrasound

    2023  Volume 44, Issue S 01

    Event/congress 46. Dreiländertreffen der DEGUM in Zusammenarbeit mit ÖGUM & SGUM, Mainz, 2023-10-11
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/s-0043-1772369
    Database Thieme publisher's database

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  4. Article ; Online: Simplification of 2D shear wave elastography by enlarged SWE box and multiple regions of interest in one acquisition.

    Weiher, Moritz / Richtering, Felix Gunnar / Dörffel, Yvonne / Müller, Hans-Peter

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0273769

    Abstract: Two-dimensional (2D) Shear Wave Elastography (SWE) is an easy to perform technique to evaluate the liver stiffness. To simplify the procedure and reduce the acquisition time we enlarged the size of the SWE-box and set ten regions of interest (ROI) in one ...

    Abstract Two-dimensional (2D) Shear Wave Elastography (SWE) is an easy to perform technique to evaluate the liver stiffness. To simplify the procedure and reduce the acquisition time we enlarged the size of the SWE-box and set ten regions of interest (ROI) in one acquisition. We compare the accuracy of this method to ten separate acquisitions in a small box each with a single ROI measurement. Sixty-nine volunteers with diffuse chronic liver disease were studied with 2D-SWE using a Canon Aplio i800 ultrasound system. The shear-wave-speed was measured in the right lobe in ten separate acquisitions and compared to one acquisition with increased size of the SWE-box and ten different ROI measurements. A Bland-Altmann plot was drawn and the interclass correlation coefficient (ICC) was calculated to compare both methods. Finally, 2D-SWE was successfully performed thru both methods in sixty-six participants. Between both methods the ICC is 0.82. The results of this study show a good reliability between ten separate measures and one grouped measure with ten ROI if the mean is below 1.6m/s (7.7kPa). For higher degrees of fibrosis (≥F2) further investigations are needed.
    MeSH term(s) Elasticity Imaging Techniques/methods ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Liver Diseases/diagnostic imaging ; Liver Diseases/pathology ; Reproducibility of Results ; Research Design ; Ultrasonography
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kontrastverstärkte Sonografie (CEUS) zur Diagnostik fokaler Leberläsionen.

    Kallenbach, Michael / Qvartskhava, Natalia / Weigel, Christian / Dörffel, Yvonne / Berger, Jens / Kunze, Georg / Luedde, Tom

    Zeitschrift fur Gastroenterologie

    2023  

    Abstract: Due to the trend towards increased use of imaging and rising awareness among high-risk patients, gastroenterologists and hepatologists are more frequently confronted with patients with focal liver lesions. In the differentiation of these lesions, CT and ... ...

    Title translation Contrast-enhanced ultrasound (CEUS) for characterisation of focal liver lesions.
    Abstract Due to the trend towards increased use of imaging and rising awareness among high-risk patients, gastroenterologists and hepatologists are more frequently confronted with patients with focal liver lesions. In the differentiation of these lesions, CT and MRI have increasingly found their way into primary diagnostic steps in everyday clinical practice. Contrast-enhanced sonography, on the other hand, is a very effective and cost-efficient method for assessing focal liver lesions. The success of the method is not only based on the visualisation of microvascularisation in real time. If sonography is performed by the treating physician, he can use the exact knowledge of history and clinical findings to specifically adapt the examination procedure and to interpret the sonographic findings with greater accuracy ("clinical sonography"). At the same time, the method enables the practitioner to combine diagnostics and management decisions in his or her own hands. To achieve excellent results with contrast-enhanced sonography-as with any other imaging method-it is necessary that the examiner is sufficiently qualified.This article systematically presents the sonographic characteristics of the most common liver lesions and clearly shows their contrast patterns using videos (available via QR code). The article illustrates that CEUS could-and from the authors' point of view, should-have an even greater significance in the future.
    Language German
    Publishing date 2023-10-05
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2145-7461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clue Cells and Pseudo Clue Cells in Different Morphotypes of Bacterial Vaginosis.

    Swidsinski, Alexander / Loening-Baucke, Vera / Swidsinski, Sonja / Sobel, Jack D / Dörffel, Yvonne / Guschin, Alexander

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 905739

    Abstract: Introduction: Clue cells (epithelial cells heavily covered with adherent bacteria) are an accepted clue to the diagnosis of bacterial vaginosis. However, the exact morphologic criteria of clue cells and bacterial adherence were never elaborated.: ... ...

    Abstract Introduction: Clue cells (epithelial cells heavily covered with adherent bacteria) are an accepted clue to the diagnosis of bacterial vaginosis. However, the exact morphologic criteria of clue cells and bacterial adherence were never elaborated.
    Materials and methods: We investigated adhesive and cohesive patterns of main microbiota groups in vaginal discharge using fluorescence
    Results: Bacterial taxa present in vaginal smears were not accidentally assembled according to their relative abundance but were built in group-specific distribution patterns, which can be well described by two features: cohesiveness to each other and adherence to epithelial cells. Accordingly, four patterns can be distinguished: dispersed (non-adherent bacteria), dispersed adherent bacteria, cohesive (non-adherent) bacteria, and cohesive adherent bacteria. Direct cohesive adherence to the epithelial cells representing true clue cells was unique for
    Discussion: Taxon indifferent imaging is inadequate for the exact analysis of the microbial layer adjacent to the vaginal epithelial cells. Morphologically seen bacterial vaginosis is a mix of at least two different conditions: biofilm vaginosis and bacterial excess vaginosis.
    MeSH term(s) Bacteria ; Female ; Gardnerella ; Gardnerella vaginalis ; Humans ; In Situ Hybridization, Fluorescence ; Microbiota ; Vagina/microbiology ; Vaginosis, Bacterial/diagnosis ; Vaginosis, Bacterial/microbiology
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.905739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Molecular characterisation of a rabbit Hepatitis E Virus strain detected in a chronically HEV-infected individual from Germany.

    Klink, Patrycja / Harms, Dominik / Altmann, Britta / Dörffel, Yvonne / Morgera, Ulrike / Zander, Steffen / Bock, C Thomas / Hofmann, Jörg

    One health (Amsterdam, Netherlands)

    2023  Volume 16, Page(s) 100528

    Abstract: In immunocompromised individuals persisting viremia frequently leads to a chronic hepatitis E virus (HEV) infection. Zoonotic transmission of HEV from pigs and wild boar to humans is proven and sporadic infections with rabbit HEV (raHEV) have recently ... ...

    Abstract In immunocompromised individuals persisting viremia frequently leads to a chronic hepatitis E virus (HEV) infection. Zoonotic transmission of HEV from pigs and wild boar to humans is proven and sporadic infections with rabbit HEV (raHEV) have recently been reported. Here, the molecular characterisation of a raHEV strain isolated from an immunocompromised, chronically HEV-infected, heart-transplanted patient is described. After successful ribavirin (RBV) treatment of a HEV infection in 2019, the patient was again tested HEV positive in 2021 and received a second RBV therapy cycle. Full-length HEV genome amplification and next generation sequencing was performed on a plasma sample taken between first and second cycle of RBV therapy and a stool sample taken two months after starting the second cycle. The sequence of plasma (raHEV-83) and stool (raHEV-99) derived virus showed the highest nucleotide sequence identity to a Chinese raHEV and a phylogenetic relationship to a raHEV strain isolated from a French patient. Furthermore, sequence analysis revealed the presence of RBV-associated substitutions V1479I and G1634K in the HEV sequences from plasma and additionally K1398R from stool. The results underline the role of rabbits as putative sources of HEV infection and emphasize the need of a one health concept for a better understanding of HEV epidemiology and to develop tools for prevention and control of HEV infection.
    Language English
    Publishing date 2023-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Kontrastverstärkte Sonografie (CEUS) zur Diagnostik fokaler Leberläsionen

    Kallenbach, Michael / Qvartskhava, Natalia / Weigel, Christian / Dörffel, Yvonne / Berger, Jens / Kunze, Georg / Luedde, Tom

    Zeitschrift für Gastroenterologie

    2023  

    Abstract: Aufgrund des Trends zum vermehrten Einsatz der Bildgebung und der steigenden Awareness bei Risikopatienten werden gastroenterologisch und hepatologisch tätige Ärztinnen und Ärzte häufiger mit Patienten mit unklaren Leberläsionen konfrontiert. In der ... ...

    Abstract Aufgrund des Trends zum vermehrten Einsatz der Bildgebung und der steigenden Awareness bei Risikopatienten werden gastroenterologisch und hepatologisch tätige Ärztinnen und Ärzte häufiger mit Patienten mit unklaren Leberläsionen konfrontiert. In der Differenzierung dieser Raumforderungen hielten CT und MRT im klinischen Alltag zunehmend Einzug in primäre Diagnostikschritte. Die kontrastverstärkte Sonografie stellt demgegenüber ein sehr effektives und kosteneffizientes Verfahren zur Beurteilung fokaler Leberläsionen dar. Der Erfolg der Methode beruht nicht nur auf der Darstellung der Mikrovaskularisation in Echtzeit. Wird die Sonografie vom Behandelnden selbst durchgeführt, kann dieser die genaue Kenntnis der Anamnese und der klinischen Befunde nutzen, um den Untersuchungsablauf gezielt anzupassen und den sonographischen Befund mit größerer Treffsicherheit zu interpretieren („klinische Sonografie“). Gleichzeitig versetzt die Methode den Behandelnden in die Lage, Diagnostik und Therapieentscheidung in den eigenen Händen zusammenzuführen. Exzellente Ergebnisse erzielt die kontrastverstärkte Sonografie – wie alle anderen bildgebenden Verfahren auch – nur bei ausreichender Qualifikation des Untersuchenden. Dieser Beitrag stellt die sonographischen Charakteristika der häufigsten Leberläsionen übersichtlich dar und zeigt deren Kontrastierungsmuster anschaulich anhand von Videos (via QR-Code abrufbar). Der Artikel verdeutlicht, dass die KM-Sonografie aus hepatologischer Sicht in Zukunft einen noch größeren Stellenwert haben könnte und aus Sicht der Autoren haben sollte.
    Keywords kontrastverstärkte Sonografie ; Leberläsionen ; Hämangiom ; Adenom ; FNH ; HCC ; cholangiozelluläres Karzinom ; Bildgebung ; CEUS ; liver lesion ; hemangioma ; adenoma ; HCC ; iCCA ; FNH ; ultrasound ; imaging
    Language German
    Publishing date 2023-10-05
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-2145-7461
    Database Thieme publisher's database

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  9. Article: Antimicrobial Susceptibility of Microbiota in Bacterial Vaginosis Using Fluorescence In Situ Hybridization.

    Swidsinski, Alexander / Guschin, Alexander / Corsini, Lorenzo / Loening-Baucke, Vera / Tisakova, Lenka Podpera / Swidsinski, Sonja / Sobel, Jack D / Dörffel, Yvonne

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Background: Testing of antibiotic resistance of intact vaginal microbiota in pure culture is not feasible.: Methods: Metronidazole, antiseptic octenisept: Results: The probiotic ... ...

    Abstract Background: Testing of antibiotic resistance of intact vaginal microbiota in pure culture is not feasible.
    Methods: Metronidazole, antiseptic octenisept
    Results: The probiotic strain
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11040456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Donating blood on a regular basis reduces blood pressure (in hypertensives): appearances are not deceiving.

    Kamhieh-Milz, Julian / Tauchmann, Yvonne / Kamhieh-Milz, Sundrela / Pruss, Axel / Doerffel, Yvonne / Michalsen, Andreas

    Transfusion

    2019  Volume 59, Issue 4, Page(s) 1405–1406

    MeSH term(s) Blood Donors ; Blood Pressure ; Humans ; Hypertension
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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