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Article ; Online: Online medical school-a win for accessibility?

Doherty, Patrick

2022 Volume 376, Page(s) o131

MeSH term(s)	Communication ; Education, Distance/trends ; Humans ; Schools, Medical/trends ; Students, Medical
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.o131
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Article ; Online: What are the determinants of change in walking fitness in patients with a history of depression following cardiac rehabilitation?

Sever, Serdar / Harrison, Alexander / Doherty, Patrick

European journal of cardiovascular nursing

2024

Abstract: Aims: This study aims to investigate the demographic, clinical and service level factors determining change in walking fitness in cardiac rehabilitation (CR) patients with a history of depression following the CR programme.: Methods and results: ... ...

Abstract	Aims: This study aims to investigate the demographic, clinical and service level factors determining change in walking fitness in cardiac rehabilitation (CR) patients with a history of depression following the CR programme. Methods and results: National Audit of Cardiac Rehabilitation (NACR) clinical data were used to identify 1476 patients with a history of depression who had their pre and post incremental shuttle walk test (ISWT) recorded between 1st Jan 2016 and 31st Jan 2020. A multiple linear regression was conducted to examine the determinants of change in walking fitness (m) following CR. Mean age was 61 (SD 10.45) and mean ISWT distance at baseline and outcome were 352.06m (SD 169.48) and 463.43m (SD 197.65), respectively. Multivariate analysis revealed that change in walking distance reduced by 1.6m for each year increase in age at baseline (P < 0.001). Females and unemployed patients had less improvement in walking fitness (23.1m and 21.5m, respectively). Having a body mass index >30 was associated with lower improvement (24.2m, p < 0.001), while physically active patients had 14.6m higher change. Higher baseline ISWT quintiles were associated with less improvement, and increased waiting time to start CR was associated with reduced change in walking fitness following CR. Conclusion: Older age, female gender, unemployment, higher baseline BMI, longer waiting time, and lower physical activity were associated with reduced walking fitness improvement in patients with a history of depression. Targeted intervention and prompt access to CR can optimize outcomes.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2151245-0
ISSN	1873-1953 ; 1474-5151
ISSN (online)	1873-1953
ISSN	1474-5151
DOI	10.1093/eurjcn/zvae047
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Book ; Online: Dual Forgetting Operators in the Context of Weakest Sufficient and Strongest Necessary Conditions

Doherty, Patrick / Szalas, Andrzej

2023

Abstract: Forgetting is an important concept in knowledge representation and automated reasoning with widespread applications across a number of disciplines. A standard forgetting operator, characterized in [Lin and Reiter'94] in terms of model-theoretic semantics ...

Abstract	Forgetting is an important concept in knowledge representation and automated reasoning with widespread applications across a number of disciplines. A standard forgetting operator, characterized in [Lin and Reiter'94] in terms of model-theoretic semantics and primarily focusing on the propositional case, opened up a new research subarea. In this paper, a new operator called weak forgetting, dual to standard forgetting, is introduced and both together are shown to offer a new more uniform perspective on forgetting operators in general. Both the weak and standard forgetting operators are characterized in terms of entailment and inference, rather than a model theoretic semantics. This naturally leads to a useful algorithmic perspective based on quantifier elimination and the use of Ackermman's Lemma and its fixpoint generalization. The strong formal relationship between standard forgetting and strongest necessary conditions and weak forgetting and weakest sufficient conditions is also characterized quite naturally through the entailment-based, inferential perspective used. The framework used to characterize the dual forgetting operators is also generalized to the first-order case and includes useful algorithms for computing first-order forgetting operators in special cases. Practical examples are also included to show the importance of both weak and standard forgetting in modeling and representation.
Keywords	Computer Science - Artificial Intelligence ; Computer Science - Logic in Computer Science
Subject code	006
Publishing date	2023-05-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: On clinical research and the pharmaceutical industry.

Santillán-Doherty, Patricio / Pérez-Padilla, Rogelio

Gaceta medica de Mexico

2023 Volume 159, Issue 4, Page(s) 354–355

Title translation	Sobre la investigación clínica y la industria farmacéutica.
MeSH term(s)	Humans ; Drug Industry ; Medicine
Language	English
Publishing date	2023-09-12
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M23000790
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Article ; Online: Factors associated with new-onset depressive symptoms in patients starting cardiac rehabilitation: Pre-COVID-19 and COVID-19 period comparison.

Sever, Serdar / Harrison, Alexander / Doherty, Patrick

Journal of psychosomatic research

2023 Volume 170, Page(s) 111342

Abstract: Objective: We aim to: 1) investigate whether starting cardiac rehabilitation (CR) during the COVID-19 period was influential on new-onset depressive symptoms, 2) examine the relationship between sociodemographic and medical factors with the new-onset of ...

Abstract	Objective: We aim to: 1) investigate whether starting cardiac rehabilitation (CR) during the COVID-19 period was influential on new-onset depressive symptoms, 2) examine the relationship between sociodemographic and medical factors with the new-onset of depressive symptoms before and during the COVID-19 period in UK patients commencing CR. Methods: The national audit of cardiac rehabilitation (NACR) data were used and the two years of data before COVID-19 and during COVID-19 were analysed (Feb,2018 - Nov,2021). Hospital Anxiety and Depression Scale measurement was used to assess depressive symptoms. Bivariate analysis and logistic regression were conducted to examine the influence of the COVID-19 period on new-onset depressive symptoms and the patient characteristics associated with it. Results: 71055 patients screened for new-onset depressive symptoms were included in the analysis. Based on multivariate analysis, patients commencing CR during COVID-19 were 8% more likely to have new onset depressive symptoms compared to patients commencing before COVID-19. Smoking (OR: 1.26, 95%CI: 1.11, 1.43), physical inactivity (OR: 1.86, 95%CI: 1.74, 1.98), high anxiety (OR: 1.45, 95%CI: 1.44, 1.46), being male (OR: 1.21, 95%CI: 1.12, 1.30), single (OR: 1.25, 95%CI: 1.16, 1.35), having comorbidities of arthritis, diabetes, chronic bronchitis, emphysema, claudication (OR range: 1.19 to 1.60), receiving CABG treatment (OR: 1.47, 95%CI: 1.25, 1.73), and having heart failure (OR: 1.33, 95%CI: 1.19, 1.48) were the factors associated with having new-onset depressive symptoms at the start of CR. Conclusion: Our findings have shown that starting CR during the COVID-19 period was associated with increased odds of having new-onset depressive symptoms.
MeSH term(s)	Humans ; Male ; Female ; Cardiac Rehabilitation ; Depression/epidemiology ; Depression/diagnosis ; COVID-19 ; Comorbidity ; Anxiety/epidemiology
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2023.111342
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Article ; Online: Multiple interventions following an acute coronary syndrome event increase uptake into cardiac rehabilitation.

Lawless, M / Harrison, A S / Doherty, P

International journal of cardiology

2020 Volume 326, Page(s) 1–5

Abstract: Aims: Cardiac rehabilitation (CR) improves morbidity and mortality. Uptake varies for patients following acute coronary syndrome (ACS). Entry into CR is often dependent on the management strategy received, lower following percutaneous coronary ... ...

Abstract	Aims: Cardiac rehabilitation (CR) improves morbidity and mortality. Uptake varies for patients following acute coronary syndrome (ACS). Entry into CR is often dependent on the management strategy received, lower following percutaneous coronary intervention (PCI), higher following coronary artery bypass grafting (CABG). This study sought to investigate differences in CR uptake following an ACS event for those patients receiving multiple treatments. Methods: Data was from the National Audit of CR between 2016 and 2019. Patients with ACS were categorised as: no intervention; one treatment (such as any PCI, CABG, any valve surgery and any device therapy); two treatments; or three or more treatments. Baseline demographics and logistic regression were used to analyse the effect of multiple treatment intervention on uptake into CR. Results: A total of 6833 ACS patients were included in the analysis (0 treatments 2014, 1 treatment 3104, ≥2 treatments 2799). Patients who received ≥2 therapeutic interventions were more likely to be male, partnered and >2 comorbidities. Logistic regression showed a positive relationship between uptake total intervention. Similar associations were seen: being younger, male, partnered and having any comorbidity. The hospital stay, history of angina, diabetes and stroke was negatively correlated with an uptake. Conclusion: This study showed for the first time that multiple interventions following ACS is a significant predictor of uptake into CR. The findings align with recent trends with medically managed myocardial infarction uptake. Our findings identify factors associated with poor uptake to CR which should be considered as part of strategy to increase participation.
MeSH term(s)	Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/surgery ; Cardiac Rehabilitation ; Coronary Artery Bypass ; Female ; Humans ; Male ; Myocardial Infarction ; Percutaneous Coronary Intervention ; Treatment Outcome
Language	English
Publishing date	2020-11-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2020.11.005
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Article ; Online: The Red and white: ancient history.

Doherty, Peter

Nature reviews. Immunology

2016 Volume 16, Issue 2, Page(s) 77

MeSH term(s)	Adaptive Immunity/immunology ; Allergy and Immunology/history ; History, 20th Century ; Humans ; Lymphocytes/immunology
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/nri.2016.1
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Book ; Conference proceedings: Biomaterial tissue interfaces

Doherty, P. J.

proceedings of the Ninth European Conference on Biomaterials, Chester, U.K., September 9 - 11, 1991

(Advances in biomaterials ; 10)

1992

Event/congress	European Conference on Biomaterials (9, 1991, Chester)
Author's details	edi. by P. J. Doherty
Series title	Advances in biomaterials ; 10
Collection
Keywords	Biocompatible Materials / congresses ; Polymers / congresses ; Prostheses and Implants / congresses ; Blood Vessel Prosthesis / congresses ; Bone and Bones / surgery / congresses ; Biomaterial ; Gewebe ; Grenzfläche
Subject	Biomedizinisches Material ; Phasengrenze ; Phasengrenzfläche
Size	XII, 533 S. : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book ; Conference proceedings
HBZ-ID	HT004466316
ISBN	0-444-89065-3 ; 978-0-444-89065-8
Database	Catalogue ZB MED Medicine, Health

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1993 A 869	order for loan	Magazin

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Article ; Online: Achieving cardiac rehabilitation uptake targets: What is the value case for commissioners? A UK case-study.

Hinde, S / Harrison, A S / Bojke, L / Doherty, P J

International journal of cardiology

2023 Volume 380, Page(s) 29–34

Abstract: Cardiac Rehabilitation (CR) has become an established intervention to support patient recovery after a cardiac event, with evidence supporting its effectiveness and cost-effectiveness in improving patient health and reducing future burden on healthcare ... ...

Abstract	Cardiac Rehabilitation (CR) has become an established intervention to support patient recovery after a cardiac event, with evidence supporting its effectiveness and cost-effectiveness in improving patient health and reducing future burden on healthcare systems. However, this evidence has focussed on the national value case for CR rather than at the point at which it is commissioned. This analysis uses the UK as a case-study to explore variation in current CR engagement and disassemble the value case from a commissioner perspective. Using data collected by the National Audit of CR (NACR), and an existing model of cost-effectiveness, we present details on the current level of CR uptake by commissioning region (Specialist Clinical Networks) in light of the current UK target of achieving 85% uptake. We then interrogate the value case for achieving the target at a commissioner level, highlighting the expected profile of health benefits and healthcare system costs over the long-term. Importantly we consider where this may differ from the national value case. Each commissioning region has a unique level of CR uptake and sociodemographic profile. Concurrently, the value case for commissioning CR relies on the upfront cost of the service being offset by long-term healthcare savings, and health improvements. The shift in the UK and internationally to more localised commissioning necessitates evidence of cost-effectiveness that better reflects the realities of those decision makers. This paper provides vital additional data to facilitate such commissioners to understand the value case in increasing CR uptake in line with national policy.
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Delivery of Health Care ; United Kingdom/epidemiology ; Cost-Benefit Analysis
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.03.041
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Article ; Online: Optimal outcomes from cardiac rehabilitation are associated with longer-term follow-up and risk factor status at 12 months: An observational registry-based study.

Tang, Lars Hermann / Doherty, Patrick / Skou, Søren T / Harrison, Alexander

International journal of cardiology

2023 Volume 386, Page(s) 134–140

Abstract: Aim: The purpose of Cardiac Rehabilitation (CR) is to promote and reduce risk factors in the short and long term, however, the latter has, to date, been poorly evaluated. We explored characteristics associated with provision and outcomes of a long-term ... ...

Abstract	Aim: The purpose of Cardiac Rehabilitation (CR) is to promote and reduce risk factors in the short and long term, however, the latter has, to date, been poorly evaluated. We explored characteristics associated with provision and outcomes of a long-term assessment in CR. Method: Data from the UK National Audit of CR between April 2015 and March 2020 was used. Programmes were selected if they had an established mechanism and routine methodology to collect the 12-month assessments. Risk factors pre and post phase II CR and at the 12-month assessment were explored; BMI ≤30, ≥150 min of physical activity per week, hospital anxiety and depression scale (HADS) scores <8. The data came from 32 programmes, 24,644 patients with coronary heart disease. Patients being in at least one optimal risk factor stage throughout phase II CR (OR = 1.43 95% CI 1.28 to 1.59) or successfully reaching an optimal stage during phase II CR (OR = 1.61 95% CI 1.44 to 1.80) had an increased likelihood of being assessed at 12 months compared to those who did not. Patients being in the optimal stage upon completion of phase II CR had an increased likelihood of still being in the optimal stage at 12 months. Most prominent was BMI; (OR = 14.6 (95% CI 11.1 to 19.2) for patients reaching an optimal stage throughout phase II CR. Conclusion: Being in an optimal stage upon routine CR completion could be an overlooked predictor in the provision of a long-term CR service and prediction of longer-term risk factor status.
MeSH term(s)	Humans ; Cardiac Rehabilitation/methods ; Follow-Up Studies ; Coronary Disease/rehabilitation ; Risk Factors ; Exercise ; Quality of Life
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.05.028
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