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Article ; Online: Acute myocardial infarction following radiofrequency catheter ablation in a child: a case report on the mechanism of coronary artery occlusion assessed by cardiovascular imaging.

Nishio, Ryota / Doi, Shinichiro / Fukunaga, Hideo / Dohi, Tomotaka

European heart journal. Case reports

2024 Volume 8, Issue 4, Page(s) ytae179

Abstract: Background: Radiofrequency ablation is a common treatment for atrioventricular nodal re-entrant tachycardia, even in paediatric patients weighing ≥15 kg, where outcomes are similar to those in adults. However, reports of acute coronary artery occlusion ... ...

Abstract	Background: Radiofrequency ablation is a common treatment for atrioventricular nodal re-entrant tachycardia, even in paediatric patients weighing ≥15 kg, where outcomes are similar to those in adults. However, reports of acute coronary artery occlusion after radiofrequency ablation for atrioventricular nodal re-entrant tachycardia are rare. Case summary: An 11-year-old girl with symptomatic atrioventricular nodal re-entrant tachycardia refractory to drug treatment underwent radiofrequency ablation. During the procedure, ST elevation was observed, and coronary angiography revealed occlusion of the right coronary artery at the segment 4 atrioventricular branch. Intravascular ultrasonography showed a narrowed lumen and an abnormal area of low echogenicity in the adjacent myocardium. After dilation with a 1.5 mm diameter balloon, blood flow was successfully restored. Follow-up coronary computed tomography angiography revealed residual stenosis in the right coronary artery at the segment 4 atrioventricular branch; however, blood flow to the distal occlusion was preserved. The patient was discharged without further complications. Discussion: To the best of our knowledge, this is the first report of coronary artery occlusion following radiofrequency ablation for atrioventricular nodal re-entrant tachycardia, evaluated using intravascular ultrasonography and coronary computed tomography angiography. Based on the imaging findings, direct thermal injury was considered the cause of occlusion.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytae179
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Article ; Online: Do statins have a specific drug effect beyond low-density lipoprotein-cholesterol-lowering in the secondary prevention of coronary artery disease?

Dohi, Tomotaka

Circulation journal : official journal of the Japanese Circulation Society

2015 Volume 79, Issue 1, Page(s) 49–50

MeSH term(s)	Atorvastatin Calcium/therapeutic use ; Cardiovascular Diseases/prevention & control ; Female ; Humans ; Hypercholesterolemia/drug therapy ; Male ; Myocardial Infarction/blood ; Pravastatin/therapeutic use
Chemical Substances	Atorvastatin Calcium (48A5M73Z4Q) ; Pravastatin (KXO2KT9N0G)
Language	English
Publishing date	2015
Publishing country	Japan
Document type	Comment ; Editorial
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-14-1283
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Article ; Online: Stepwise regression of non-culprit lipid-rich plaque observed using serial near-infrared spectroscopy-intravascular ultrasound and optical coherence tomographic measurements after aggressive cholesterol-lowering treatment: a case report.

Takahashi, Norihito / Dohi, Tomotaka / Endo, Hirohisa / Okazaki, Shinya

European heart journal. Case reports

2021 Volume 5, Issue 3, Page(s) ytab095

Abstract: Background: Lipid-rich plaques (LRP) in the non-culprit lesions (NCL) in patients with the acute coronary syndrome may trigger lesion-related, adverse cardiovascular events. Aggressive lipid-lowering therapy may stabilize LRP; however, the times of ... ...

Abstract	Background: Lipid-rich plaques (LRP) in the non-culprit lesions (NCL) in patients with the acute coronary syndrome may trigger lesion-related, adverse cardiovascular events. Aggressive lipid-lowering therapy may stabilize LRP; however, the times of stabilization remain undefined. Case summary: A 60-year-old man presented with unstable angina. Coronary angiography revealed a severely stenotic lesion (culprit lesion) in the left descending artery, and another non-obstructive lesion in the distal left main trunk artery. Near-infrared spectroscopy (NIRS) imaging showed LRP with a maximum lipid core burden index (LCBI) Discussion: During the long-term, 24-month, follow-up using serial NIRS-IVUS imaging, we observed the gradual decrease in LCBI over time, due to aggressive lipid-lowering therapy. Compared with the lowering of low-density lipoprotein cholesterol, the stabilization of vulnerable plaques may require longer times of about 2 years. Evaluation of NCL-related adverse cardiac events by serial intravascular imaging over time, using NIRS-IVUS or OCT, may be warranted in such cases.
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytab095
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Article ; Online: Significant decrease in lipid core burden index following balloon dilation was associated with the leakage of cholesterol crystals in a patient: a case report.

Moriya, Soshi / Isoda, Kikuo / Dohi, Tomotaka / Okazaki, Shinya

European heart journal. Case reports

2020 Volume 4, Issue 4, Page(s) 1–5

Abstract: Background: Near-infrared spectroscopy (NIRS) has been used for analysis the composition of the atherosclerotic plaque in coronary arteries. However, meaning of significant decrease in max lipid core burden index at 4 mm (max LCBI: Case summary: A 64- ...

Abstract	Background: Near-infrared spectroscopy (NIRS) has been used for analysis the composition of the atherosclerotic plaque in coronary arteries. However, meaning of significant decrease in max lipid core burden index at 4 mm (max LCBI Case summary: A 64-year-old male with unstable angina underwent coronary angiography, which demonstrated a hazy tight culprit lesion in the mid-right coronary artery. Pre-intervention NIRS-intravascular ultrasound (NIRS-IVUS) and chemogram showed plaque with high lipid burden at the culprit lesion. Then, we used a distal protection device before PCI because of high max LCBI Discussion: This is the first report directly demonstrated that significant decrease in max LCBI
Language	English
Publishing date	2020-06-17
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa148
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Article: Factors Associated With the Improvement of Left Ventricular Systolic Function by Continuous Positive Airway Pressure Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Obstructive Sleep Apnea.

Naito, Ryo / Kasai, Takatoshi / Dohi, Tomotaka / Takaya, Hisashi / Narui, Koji / Momomura, Shin-Ichi

Frontiers in neurology

2022 Volume 13, Page(s) 781054

Abstract: Background: Obstructive sleep apnea (OSA) is a potential risk factor in cardiovascular diseases, including arrhythmia, coronary artery disease, and heart failure (HF). Continuous positive airway pressure (CPAP) therapy is an effective therapy for OSA ... ...

Abstract	Background: Obstructive sleep apnea (OSA) is a potential risk factor in cardiovascular diseases, including arrhythmia, coronary artery disease, and heart failure (HF). Continuous positive airway pressure (CPAP) therapy is an effective therapy for OSA and the underlying HF, partly through a 5-9% increase in the left ventricular ejection fraction (LVEF). However, the data on the factors associated with the efficacy of CPAP on LVEF in patients with HF complicated by OSA are scarce. This study aimed to investigate whether LVEF improves in patients with OSA and HF after 1 month of CPAP therapy, and to clarify which factors are associated with the degree of LVEF improvement. Method: This was a prospective, single-arm, open-label study. We enrolled moderate-to-severe patients with OSA and HF who were being followed up at the cardiovascular center of Toranomon Hospital (Tokyo, Japan). The parameters of sleep study and LVEF were assessed at the baseline and after 1 month of CPAP. The multivariate regression analyses, with changes in LVEF as a dependent variable, were performed to determine the factors that were associated with the degree of LVEF improvement. Results: We analyzed 55 consecutive patients with OSA and HF (mean age: 60.7 ± 12.2 years, mean LVEF value: 37.2 ± 9.8%). One month of CPAP treatment decreased the apnea-hypopnea index (AHI) from 45.3 ± 16.1 to 5.4 ± 4.1 per hour, and the LVEF improved from 37.2 ± 9.8 to 43.2 ± 11.7%. The multivariate regression analyses demonstrated that age and body mass index (BMI) were significant determinants of LVEF improvement. Conclusion: The LVEF improved significantly after 1 month of CPAP therapy in Japanese patients with OSA and HF. Multivariate regression analyses indicated that an improvement in LVEF was likely to be observed in young patients with obesity.
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.781054
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Article: [JAPAN-ACS (Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome)].

Dohi, Tomotaka / Daida, Hiroyuki

Nihon rinsho. Japanese journal of clinical medicine

2016 Volume 74 Suppl 4 Pt 1, Page(s) 697–702

MeSH term(s)	Acute Coronary Syndrome/drug therapy ; Atorvastatin Calcium/therapeutic use ; Evaluation Studies as Topic ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Prospective Studies ; Quinolines/therapeutic use
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Quinolines ; Atorvastatin Calcium (48A5M73Z4Q) ; pitavastatin (M5681Q5F9P)
Language	Japanese
Publishing date	2016-06-20
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article ; Online: Reply to: "Comment on "Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease" ".

Wada, Hideki / Dohi, Tomotaka / Miyauchi, Katsumi / Daida, Hiroyuki

Atherosclerosis

2018 Volume 280, Page(s) 195–196

MeSH term(s)	Coronary Artery Disease ; Humans ; Mean Platelet Volume ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2018-11-14
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2018.11.023
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Zs.A 226: Show issues

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Article ; Online: Elevated levels of plasma inactive stromal cell derived factor-1α predict poor long-term outcomes in diabetic patients following percutaneous coronary intervention.

Chikata, Yuichi / Iwata, Hiroshi / Miyosawa, Katsutoshi / Naito, Ryo / Koike, Takuma / Moriya, Soshi / Yasuda, Hidetoshi / Funamizu, Takehiro / Doi, Shinichiro / Endo, Hirohisa / Wada, Hideki / Ogita, Manabu / Dohi, Tomotaka / Kasai, Takatoshi / Isoda, Kikuo / Okazaki, Shinya / Miyauchi, Katsumi / Minamino, Tohru

Cardiovascular diabetology

2024 Volume 23, Issue 1, Page(s) 114

Abstract: Background: Since the complication of diabetes mellitus (DM) is a risk for adverse cardiovascular outcomes in patients with coronary artery disease (CAD), appropriate risk estimation is needed in diabetic patients following percutaneous coronary ... ...

Abstract	Background: Since the complication of diabetes mellitus (DM) is a risk for adverse cardiovascular outcomes in patients with coronary artery disease (CAD), appropriate risk estimation is needed in diabetic patients following percutaneous coronary intervention (PCI). However, there is no useful biomarker to predict outcomes in this population. Although stromal cell derived factor-1α (SDF-1α), a circulating chemokine, was shown to have cardioprotective roles, the prognostic impact of SDF-1α in diabetic patients with CAD is yet to be fully elucidated. Moreover, roles of SDF-1α isoforms in outcome prediction remain unclear. Therefore, this study aimed to assess the prognostic implication of three forms of SDF-1α including total, active, and inactive forms of SDF-1α in patients with DM and after PCI. Methods: This single-center retrospective analysis involved consecutive patients with diabetes who underwent PCI for the first time between 2008 and 2018 (n = 849). Primary and secondary outcome measures were all-cause death and the composite of cardiovascular death, non-fatal myocardial infarction, and ischemic stroke (3P-MACE), respectively. For determining plasma levels of SDF-1α, we measured not only total, but also the active type of SDF-1α by ELISA. Inactive isoform of the SDF-1α was calculated by subtracting the active isoform from total SDF-1α. Results: Unadjusted Kaplan-Meier analyses revealed increased risk of both all-cause death and 3P-MACE in patients with elevated levels of inactive SDF-1α. However, plasma levels of total and active SDF-1α were not associated with cumulative incidences of outcome measures. Multivariate Cox hazard analyses repeatedly indicated the 1 higher log-transformed inactive SDF-1α was significantly associated with increased risk of all-cause death (hazard ratio (HR): 2.64, 95% confidence interval (CI): 1.28-5.34, p = 0.008) and 3P-MACE (HR: 2.51, 95% CI: 1.12-5.46, p = 0.02). Moreover, the predictive performance of inactive SDF-1α was higher than that of total SDF-1α (C-statistics of inactive and total SDF-1α for all-cause death: 0.631 vs 0.554, for 3P-MACE: 0.623 vs 0.524, respectively). Conclusion: The study results indicate that elevated levels of plasma inactive SDF-1α might be a useful indicator of poor long-term outcomes in diabetic patients following PCI. Trial registration: This study describes a retrospective analysis of a prospective registry database of patients who underwent PCI at Juntendo University Hospital, Tokyo, Japan (Juntendo Physicians' Alliance for Clinical Trials, J-PACT), which is publicly registered (University Medical Information Network Japan-Clinical Trials Registry, UMIN-CTR 000035587).
MeSH term(s)	Humans ; Chemokine CXCL12 ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Retrospective Studies ; Risk Assessment ; Coronary Artery Disease/surgery ; Coronary Artery Disease/etiology ; Diabetes Mellitus/epidemiology ; Protein Isoforms ; Stromal Cells ; Treatment Outcome ; Risk Factors
Chemical Substances	Chemokine CXCL12 ; Protein Isoforms
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-024-02197-z
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Article ; Online: The Goal of Achieving Atherosclerotic Plaque Regression with Lipid-Lowering Therapy: Insights from IVUS Trials.

Daida, Hiroyuki / Dohi, Tomotaka / Fukushima, Yoshifumi / Ohmura, Hirotoshi / Miyauchi, Katsumi

Journal of atherosclerosis and thrombosis

2019 Volume 26, Issue 7, Page(s) 592–600

Abstract: Enormous effort has been put into the prevention of atherosclerosis through risk modification, especially with lipid-lowering therapies. Regression, that is, the reversal of the atherosclerosis process, has long been a goal of atherosclerosis research ... ...

Abstract	Enormous effort has been put into the prevention of atherosclerosis through risk modification, especially with lipid-lowering therapies. Regression, that is, the reversal of the atherosclerosis process, has long been a goal of atherosclerosis research among basic and clinical investigators. Intravascular ultrasound (IVUS) was developed in the 1990s as an intracoronary imaging technique to observe the details of the vessel walls and to measure the vessel lumen and plaque area with high reproducibility. Compared with the coronary angiogram, IVUS provides far more detailed information on the vessel wall. In this article, we review lipid-lowering trials that have used IVUS and discuss the current understanding of the effectiveness of aggressive lipid-lowering therapy, which inhibits atherosclerotic progression and induces regression and plaque stabilization.
MeSH term(s)	Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Cholesterol, LDL/blood ; Clinical Trials as Topic ; Coronary Angiography ; Endovascular Procedures ; History, 20th Century ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypolipidemic Agents/therapeutic use ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/history ; Risk Factors ; Ultrasonography, Interventional
Chemical Substances	Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypolipidemic Agents
Language	English
Publishing date	2019-05-21
Publishing country	Japan
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.48603
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Zs.A 5192: Show issues

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Article ; Online: Outcome after primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction complicated by cardiogenic shock.

Nozaki, Yui Okada / Yatsu, Shoichiro / Ogita, Manabu / Wada, Hideki / Takahashi, Daigo / Nishio, Ryota / Yasuda, Kentaro / Takeuchi, Mitsuhiro / Takahashi, Norihito / Sonoda, Taketo / Shitara, Jun / Tsuboi, Shuta / Dohi, Tomotaka / Suwa, Satoru / Miyauchi, Katsumi / Minamino, Tohru

Journal of cardiology

2024

Abstract: Background: Primary percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) may reduce the risk of subsequent cardiovascular events but remains challenging. The study aim was ... ...

Abstract	Background: Primary percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) may reduce the risk of subsequent cardiovascular events but remains challenging. The study aim was to evaluate the clinical characteristics and long-term outcomes of patients undergoing primary PCI for STEMI with CS. Methods: We conducted an observational cohort study of patients with STEMI who underwent primary PCI between April 2004 and December 2017 at Juntendo University Shizuoka Hospital. The primary outcome was cardiovascular death (CVD) during the median 3-year follow-up. We performed a landmark analysis for the incidence of CVD from 0 day to 1 year and from 1 to 10 years. Results: Among the 1758 STEMI patients in the cohort, 212 (12.1 %) patients with CS showed significantly higher 30-day CVD rate on admission than those without (26.4 % vs 2.9 %). Landmark Kaplan-Meier analysis showed that CVD from day 0 to year 1 was significantly higher in the patients with CS (log-rank p < 0.0001). Multivariate Cox regression analysis showed that CS was significantly associated with higher cardiovascular mortality (adjusted hazard ratio, 11.8; 95%confidence intervals, 7.78-18.1; p < 0.0001), but the mortality rates from 1 to 10 years were comparable (log-rank p = 0.68). Conclusion: The cardiovascular 1-year mortality rate for patients with STEMI was higher for those with CS on admission than without, but the mortality rates of >1 year were comparable. Surviving the early phase is essential for patients with STEMI and CS to improve long-term outcomes.
Language	English
Publishing date	2024-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2024.02.005
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