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Article ; Online: Finite-temperature-based time-dependent density-functional theory method for static electron correlation systems.

Yoshikawa, Takeshi / Doi, Toshiki / Nakai, Hiromi

2020 Volume 152, Issue 24, Page(s) 244111

Abstract: In this study, we developed a time-dependent density-functional theory (TDDFT) with a finite-temperature (FT) scheme, denoted as FT-TDDFT. We introduced the concept of fractional occupation numbers for random phase approximation equation and evaluated ... ...

Abstract	In this study, we developed a time-dependent density-functional theory (TDDFT) with a finite-temperature (FT) scheme, denoted as FT-TDDFT. We introduced the concept of fractional occupation numbers for random phase approximation equation and evaluated the excited-state electronic entropy terms with excited-state occupation number. The orbital occupation numbers for the excited state were evaluated from the change in the ground-state electron configuration with excitation and deexcitation coefficients. Furthermore, we extended the FT formulation to the time-dependent density-functional tight-binding (TDDFTB) method for larger systems, denoted as FT-TDDFTB. Numerical assessment for the FT-(TD)DFT method showed smooth potential curves for double-bond rotation of ethylene in both ground and excited states. Excited-state calculations based on the FT-TDDFTB method were applied to the uniform π-stacking columns composed of trioxotriangulene, possessing neutral radicals in strong correlation systems.
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5144527
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Article ; Online: Relationships of hyperchloremia with hypertension and proteinuria in patients with chronic kidney disease.

Takahashi, Akira / Maeda, Kazuya / Sasaki, Kensuke / Doi, Shigehiro / Nakashima, Ayumu / Doi, Toshiki / Masaki, Takao

Clinical and experimental nephrology

2022 Volume 26, Issue 9, Page(s) 880–885

Abstract: Background: A few previous clinical studies have shown that chloride (Cl) contributes to the progression and development of hypertension or proteinuria. Therefore, we aimed to determine whether hyperchloremia is associated with hypertension or ... ...

Abstract	Background: A few previous clinical studies have shown that chloride (Cl) contributes to the progression and development of hypertension or proteinuria. Therefore, we aimed to determine whether hyperchloremia is associated with hypertension or proteinuria in patients with chronic kidney disease (CKD) and to define the relationships between the reduction in serum Cl concentration associated with CKD treatment and improvements in hypertension and/or proteinuria. Methods: We performed a retrospective observational study of new or referred patients with CKD who had hyperchloremia, moderate proteinuria, renal dysfunction, and hypertension. Patients taking medication for metabolic acidosis or with a history of dialysis were excluded. The participants' systolic and diastolic blood pressure (BP), serum sodium (Na) and Cl concentrations, and urinary protein (UP) concentration were measured at baseline and after 1 month of CKD treatment. Results: Fifty-one patients with CKD were included in the study. Their serum Cl concentration independently correlated with sBP and UP at baseline (P = 0.022 and P = 0.033, respectively). After 1 month's CKD treatment, their serum Na and Cl concentrations, sBP, and UP were significantly lower. The change in sBP during the month (ΔsBP) correlated with the change in serum Cl (ΔCl) (P = 0.012) but not with the change in serum Na. Multivariate analysis showed that ΔsBP was independently associated with ΔCl (P = 0.029). Conclusions: Hyperchloremia is an independent predictor of hypertension and proteinuria for patients with CKD.
MeSH term(s)	Blood Pressure ; Humans ; Hypertension ; Proteinuria/complications ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Water-Electrolyte Imbalance
Language	English
Publishing date	2022-05-07
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-022-02229-6
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Article ; Online: A case report of atypical anti-glomerular basement membrane disease.

Tamura, Ryo / Doi, Toshiki / Hirashio, Shuma / Sasaki, Kensuke / Masuda, Yukinari / Shimizu, Akira / Masaki, Takao

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 373

Abstract: Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic necrotizing glomerulonephritis, with linear deposits of immunoglobulin G (IgG) in the GBM. Classic anti-GBM disease is clinically associated with rapidly ... ...

Abstract	Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic necrotizing glomerulonephritis, with linear deposits of immunoglobulin G (IgG) in the GBM. Classic anti-GBM disease is clinically associated with rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Some patients have a better renal prognosis and milder symptoms than those with classic anti-GBM disease, which is termed atypical anti-GBM disease. Case presentation: A 43-year-old Japanese woman was admitted to our hospital complaining of hematuria that had persisted for more than one month. Serological examination revealed negativity for anti-nuclear, anti-neutrophilic cytoplasmic, and anti-GBM antibodies. However, renal biopsy showed cellular crescents. Immunofluorescence revealed strong diffuse linear capillary loop staining for IgG. An indirect immunofluorescence antibody method was performed by applying the patient serum to normal kidney tissue to confirm the presence of autoantibodies binding to the GBM. Using this method, anti-GBM antibodies were detected. The patient was treated with high-dose steroids, cyclophosphamide, and plasma exchange. Aggressive treatment resolved proteinuria and hematuria and improved renal function. Conclusions: Renal biopsy is crucial in the diagnosis of anti-GBM disease, especially when serological tests are negative. Accurately identifying the presence of anti-GBM disease is important to initiate optimal treatment.
MeSH term(s)	Humans ; Female ; Adult ; Anti-Glomerular Basement Membrane Disease/complications ; Anti-Glomerular Basement Membrane Disease/diagnosis ; Anti-Glomerular Basement Membrane Disease/therapy ; Hematuria/pathology ; Kidney/pathology ; Plasma Exchange ; Immunoglobulin G
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-03007-y
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Article ; Online: Membranous nephropathy after multiple Hymenoptera stings: a case report.

Morii, Kenichi / Doi, Toshiki / Yuba, Yoshio / Okubo, Aiko / Yamashita, Kazuomi / Mizuiri, Sonoo / Nishizawa, Yoshiko / Shigemoto, Kenichiro / Shimizu, Akira / Masaki, Takao

CEN case reports

2023

Abstract: An association between Hymenoptera (bee and wasp) stings and nephrotic syndrome has been rarely reported. We report a case of nephrotic syndrome after multiple Hymenoptera stings, and membranous nephropathy was later diagnosed by a kidney biopsy. The ... ...

Abstract	An association between Hymenoptera (bee and wasp) stings and nephrotic syndrome has been rarely reported. We report a case of nephrotic syndrome after multiple Hymenoptera stings, and membranous nephropathy was later diagnosed by a kidney biopsy. The patient was a 79-year-old woman who was stung by Hymenoptera at seven sites on her body. A weight gain of 3.7 kg was observed in the patient at 1 week after being stung, and she had considerable edema in both lower extremities. A urine protein concentration of 14.8 g/g creatinine and a serum albumin concentration of 1.7 g/dL led to the diagnosis of nephrotic syndrome. A percutaneous kidney biopsy 8 days after the Hymenoptera stings showed stage I membranous nephropathy. She was in complete remission 1 week after the administration of oral prednisolone 40 mg/day, which was started 14 days after Hymenoptera stings, and had no relapse of nephrotic syndrome. To the best of our knowledge, this is the first report of biopsy-proven membranous nephropathy caused by Hymenoptera stings.
Language	English
Publishing date	2023-11-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-023-00834-2
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Article ; Online: Effects of overhydration, Kt/Vurea, β2-microglobulin on coronary artery calcification and mortality in haemodialysis patients.

Mizuiri, Sonoo / Nishizawa, Yoshiko / Yamashita, Kazuomi / Doi, Toshiki / Okubo, Aiko / Morii, Kenichi / Usui, Koji / Arita, Michiko / Naito, Takayuki / Shigemoto, Kenichiro / Masaki, Takao

Nephrology (Carlton, Vic.)

2024

Abstract: Aim: We studied the effects of overhydration (OH), Kt/Vurea and β2-microglobulin (β2-MG) on coronary artery calcification and mortality in patients undergoing haemodialysis (HD).: Methods: The Agatston coronary artery calcium score (CACS), ... ...

Abstract	Aim: We studied the effects of overhydration (OH), Kt/Vurea and β2-microglobulin (β2-MG) on coronary artery calcification and mortality in patients undergoing haemodialysis (HD). Methods: The Agatston coronary artery calcium score (CACS), postdialysis body composition using bioimpedance analysis, single-pool Kt/Vurea and predialysis β2-MG at baseline were assessed and followed up for 3 years in patients undergoing HD. We performed logistic regression analyses for a CACS ≥400 and Cox proportional hazard analyses for all-cause and cardiovascular mortality. Results: The study involved 338 patients with a median age of 67 (56-74) years, dialysis duration of 70 (33-141) months and diabetes prevalence of 39.1% (132/338). Patients with a CACS ≥400 (n = 222) had significantly higher age, dialysis duration, male prevalence, diabetes prevalence, C-reactive protein, predialysis β2-MG, OH, extracellular water/total body water and overhydration/extracellular water (OH/ECW) but significantly lower Kt/Vurea than patients with a CACS <400 (n = 116) (p < .05). OH/ECW, Kt/Vurea and predialysis β2-MG were significant predictors of a CACS ≥400 (p < .05) after adjusting for age, dialysis duration, serum phosphate and magnesium. In all patients, cut-off values of OH/ECW, Kt/Vurea and predialysis β2-MG for a CACS ≥400 were 16%, 1.74 and 28 mg/L, respectively. After adjusting for dialysis duration, OH/ECW ≥16%, Kt/Vurea ≥1.74 and β2-MG ≥28 mg/L were significant predictors of 3-year all-cause mortality but not 3-year cardiovascular mortality. Conclusion: Higher OH/ECW, higher predialysis β2-MG and lower Kt/Vurea values are significant risk factors for a CACS ≥400 and 3-year all-cause mortality in patients undergoing maintenance HD.
Language	English
Publishing date	2024-03-21
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.14290
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Article ; Online: Absolute iron deficiency, coronary artery calcification and cardiovascular mortality in maintenance haemodialysis patients.

Mizuiri, Sonoo / Nishizawa, Yoshiko / Yamashita, Kazuomi / Doi, Toshiki / Okubo, Aiko / Morii, Kenichi / Usui, Koji / Arita, Michiko / Naito, Takayuki / Shigemoto, Kenichiro / Masaki, Takao

Nephrology (Carlton, Vic.)

2024

Abstract: Aim: The effects of iron on vascular calcification in rats and vascular smooth muscle cells were recently reported, but clinical studies on iron and vascular calcification are scant. We studied the associations of absolute iron deficiency, coronary ... ...

Abstract	Aim: The effects of iron on vascular calcification in rats and vascular smooth muscle cells were recently reported, but clinical studies on iron and vascular calcification are scant. We studied the associations of absolute iron deficiency, coronary artery calcification and mortality in patients with maintenance haemodialysis (MHD). Methods: Transferrin saturation (TSAT), ferritin, mean corpuscular haemoglobin (MCH) and Agatston coronary artery calcium score (CACS) were studied at baseline in MHD patients and followed up for 3 years. Cox proportional hazard analyses for mortality and linear regression analyses for CACS were performed. Results: In 306 patients, the median age was 67 (56-81) years, dialysis duration was 76 (38-142) months, and diabetes prevalence was 42.5%. Fifty-two patients had died by 3 years. Patients with absolute iron deficiency (TSAT <20% and ferritin <100 ng/mL) (n = 102) showed significantly higher CACS (p = .0266) and C-reactive protein (p = .0011), but a lower frequency of iron formulation administration compared with patients without absolute iron deficiency at baseline (n = 204). Absolute iron deficiency was a significant predictor for 3-year cardiovascular (CV) mortality (hazard ratio: 2.08; p = .0466), but not for 3-year all-cause mortality. CACS was significant predictor for both 3-year CV and all-cause mortality (p <.05). Absolute iron deficiency and MCH were significant determinants of CACS (p < .05). Conclusion: MHD patients with absolute iron deficiency showed significantly higher CACS than others, and absolute iron deficiency was a significant risk factor for coronary artery calcification and 3-year CV mortality in MHD patients, but was not a significant predictor for 3-year all-cause mortality.
Language	English
Publishing date	2024-03-19
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.14289
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Article: Low-Vacuum Scanning Electron Microscopy to Assess Histopathological Resolution of Class V Lupus Nephritis: A Case Report.

Yoshida, Maria / Hirashio, Shuma / Doi, Toshiki / Masuda, Yukinari / Shimizu, Akira / Masaki, Takao

Case reports in nephrology and dialysis

2021 Volume 11, Issue 1, Page(s) 36–47

Abstract: Lupus nephritis (LN) is most frequently associated with poor outcomes in patients with systemic lupus erythematosus (SLE). LN manifests as histopathological changes in the kidney caused by immune complex formation and deposition. In particular, ... ...

Abstract	Lupus nephritis (LN) is most frequently associated with poor outcomes in patients with systemic lupus erythematosus (SLE). LN manifests as histopathological changes in the kidney caused by immune complex formation and deposition. In particular, immunoglobulin G (IgG) deposits are frequently observed by immunofluorescence staining, which helps to establish the diagnosis of LN. In this case report, we describe a 57-year-old woman with SLE who had been undergoing treatment on an outpatient basis for 11 years. Her first and second renal biopsies revealed class V LN with a coarsely granular pattern of IgG deposition in the peripheral capillary walls. However, her third renal biopsy showed no IgG deposition, which indicated histopathological resolution of her class V LN. We used low-vacuum scanning electron microscopy (LV-SEM) to examine the three-dimensional structural alterations in her glomerular basement membranes. In this report, we describe findings that indicated resorption of epithelial deposits, that is, resolution of LN. The results of repeated kidney biopsies confirmed by LV-SEM suggested the possibility of a state unrelated to LN.
Language	English
Publishing date	2021-02-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2809879-1
ISSN	2296-9705
ISSN	2296-9705
DOI	10.1159/000509470
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Article ; Online: Convection volume, β2-microglobulin and α1-microglobulin reduction ratios, and body composition in pre-dilution online haemodiafiltration.

Mizuiri, Sonoo / Nishizawa, Yoshiko / Doi, Toshiki / Okubo, Aiko / Shigemoto, Kenichiro / Usui, Koji / Arita, Michiko / Naito, Takayuki / Doi, Shigehiro / Masaki, Takao

Nephrology (Carlton, Vic.)

2022 Volume 27, Issue 7, Page(s) 601–609

Abstract: Aim: The effect of convection volume (CV) in patients on pre-dilution online haemodiafiltration (Pre-OL-HDF) was evaluated.: Methods: We conducted a retrospective, cross-sectional study in 126 patients on Pre-OL-HDF. Dialysis conditions, laboratory ... ...

Abstract	Aim: The effect of convection volume (CV) in patients on pre-dilution online haemodiafiltration (Pre-OL-HDF) was evaluated. Methods: We conducted a retrospective, cross-sectional study in 126 patients on Pre-OL-HDF. Dialysis conditions, laboratory data, and same day post-dialysis body composition measurements using bioimpedance spectroscopy were assessed. Patients were divided into two groups according to their CV: ≥ median value and < median value. Linear regression analyses for reduction ratios (RRs) of β2-microglobulin and α1-microglobulin, and body composition, were conducted. Results: Age, dialysis vintage, and CVs of the study patients were 64 ± 12 years, 81 (48-154) months, and 43.2 (38.5-55.9) L/session, respectively. The higher CV (≥ 43 L/session) group (n = 66) had significantly higher RRs of β2-microglobulin and α1-microglobulin, lean tissue index, body cell mass index, total body water (TBW), extracellular water (ECW), and intracellular water (ICW) compared with the lower CV (< 43 L/session) group (n = 60, p < .01). Serum albumin and fat tissue index were not significantly different between the groups. CV/ECW, CV/TBW, and CV/ICW but not un-adjusted CV, were significant determinants for β2-microglobulin and α1-microglobulin RRs (p < .05). Lean tissue and body cell mass indexes, but not the fat tissue index, showed significant associations with CV, and RRs of β2-microglobulin and α1-microglobulin (p < kb.05). Conclusions: Among patients on Pre-OL-HDF, higher values in the lean tissue index and body cell mass index were observed in those with higher CV versus lower CV, and CV adjusted to body water may be useful to prescribe individualized conditions for Pre-OL-HDF.
MeSH term(s)	Aged ; Body Composition ; Convection ; Cross-Sectional Studies ; Hemodiafiltration/adverse effects ; Hemodiafiltration/methods ; Humans ; Middle Aged ; Renal Dialysis/methods ; Retrospective Studies ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-03-24
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1303661-0
ISSN	1440-1797 ; 1320-5358
ISSN (online)	1440-1797
ISSN	1320-5358
DOI	10.1111/nep.14038
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Article ; Online: Coronary artery calcification is a risk factor for intradialytic hypotension in patients undergoing hemodialysis.

Mizuiri, Sonoo / Nishizawa, Yoshiko / Doi, Toshiki / Yamashita, Kazuomi / Shigemoto, Kenichiro / Usui, Koji / Arita, Michiko / Naito, Takayuki / Doi, Shigehiro / Masaki, Takao

Hemodialysis international. International Symposium on Home Hemodialysis

2022 Volume 26, Issue 3, Page(s) 335–344

Abstract: Introduction: We investigated the association between intradialytic hypotension (IDH) and coronary artery calcification and their effects on mortality in hemodialysis (HD) patients.: Methods: Consecutive patients undergoing maintenance HD were ... ...

Abstract	Introduction: We investigated the association between intradialytic hypotension (IDH) and coronary artery calcification and their effects on mortality in hemodialysis (HD) patients. Methods: Consecutive patients undergoing maintenance HD were enrolled. The study timeline included the baseline (day 1), exposure assessment (day 1-day 22), and outcome assessment (day 23-3 years) periods. IDH was defined as a nadir systolic blood pressure (SBP) of <100 mmHg or vasopressor use during at least 2 of 10 HD sessions in the exposure assessment period. The clinical data at baseline and the Agatston coronary artery calcium score (CACS) were assessed in the exposure assessment period. Findings: The median age and dialysis vintage were 67 years [60-75 years] and 73 months [37-138 months], respectively. IDH occurred in 37 patients (21.4%), and the CACS was higher in the IDH group than in the non-IDH group (p = 0.08). IDH was associated with CACS, diabetes mellitus, mean predialysis SBP, and mean ultrafiltration volume (p < 0.05). The cutoff CACS for mortality was 1829 (sensitivity: 69%, specificity: 77%). In all, 45 all-cause deaths and 19 cardiovascular deaths occurred over 3 years. Patients with both IDH and a CACS of ≥1829 had a lower 3-year cumulative survival from cardiovascular death (66.7%) than those with a CACS of ≥1829 (80.3%), IDH (88.5%), or neither (95.5%) (p < 0.01). IDH, a CACS of ≥1829, and IDH + CACS of ≥1829 were predictors of 3-year all-cause and cardiovascular mortality (p < 0.05). The hazard ratio for cardiovascular mortality was highest in the group with IDH + CACS ≥ 1829. Discussion: A high CACS may be a biomarker for IDH. Both IDH and CACS were risk factors for all-cause and cardiovascular mortality in patients undergoing HD, and there was a synergistic interaction between IDH and high CACS for cardiovascular mortality.
MeSH term(s)	Blood Pressure ; Coronary Vessels ; Humans ; Hypotension/etiology ; Kidney Failure, Chronic/complications ; Renal Dialysis/adverse effects ; Risk Factors
Language	English
Publishing date	2022-04-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.13016
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Article: Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis

Naito, Takayuki / Doi, Toshiki / Morii, Kenichi / Usui, Koji / Arita, Michiko / Yamashita, Kazuomi / Shigemoto, Kenichiro / Nishizawa, Yoshiko / Mizuiri, Sonoo / Sasaki, Kensuke / Masaki, Takao

Nutrients. 2022 June 09, v. 14, no. 12

2022

Abstract: This study aimed to investigate whether a combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for mortality in patients treated by chronic hemodialysis. We analyzed ... ...

Abstract	This study aimed to investigate whether a combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for mortality in patients treated by chronic hemodialysis. We analyzed 499 patients on hemodialysis for five years. We set each cut-off value as the high (≥92) and low (<92) GNRI groups and the high (≥21 mg/kg/day) and low (<21 mg/kg/day) mCI groups, and divided them into four subgroups: G1, high GNRI + high mCI; G2, high GNRI + low mCI; G3, low GNRI + high mCI; and G4, low GNRI + low mCI. The survival rate was evaluated and time-to-event analysis was performed. All-cause death occurred in 142 (28%) patients. Kaplan–Meier curves showed that G2 and G4 had a significantly worse outcome (p < 0.05) than G1 but not G3. Using the multivariable-adjusted model, only G4 was significantly associated with all-cause mortality compared with G1. Our study suggests that the synergistic effects of the GNRI and the mCI are helpful in predicting all-cause mortality. The combination of these indices may be superior to a single method to distinguish patients who are well or moderately ill from potentially severely ill.
Keywords	creatinine ; death ; hemodialysis ; models ; nutrition risk assessment ; survival rate
Language	English
Dates of publication	2022-0609
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122398
Database	NAL-Catalogue (AGRICOLA)

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