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  1. Article: Computed Tomography Based Radiomics as a Predictor of Survival in Ovarian Cancer Patients: A Systematic Review.

    Rizzo, Stefania / Manganaro, Lucia / Dolciami, Miriam / Gasparri, Maria Luisa / Papadia, Andrea / Del Grande, Filippo

    Cancers

    2021  Volume 13, Issue 3

    Abstract: The objective of this systematic review was to assess the results of radiomics for prediction of overall survival (OS) and progression free survival (PFS) in ovarian cancer (OC) patients. A secondary objective was to evaluate the findings of papers that ... ...

    Abstract The objective of this systematic review was to assess the results of radiomics for prediction of overall survival (OS) and progression free survival (PFS) in ovarian cancer (OC) patients. A secondary objective was to evaluate the findings of papers that based their analyses on inter-site heterogeneity. This systematic review was conducted according to the PRISMA statement. After the initial retrieval of 145 articles, the final systematic review comprised six articles. Association between radiomic features and OS was evaluated in 3/6 studies (50%); all articles showed a significant association between radiomic features and OS. Association with PFS was evaluated in 5/6 (83%) articles; the period of follow-up ranged between six and 36 months. All the articles showed significant association between radiomic models and PFS. Inter-site textural features were used for analysis in 2/6 (33%) articles. They demonstrated that high levels of inter-site textural heterogeneity were significantly associated with incomplete surgical resection in breast cancer gene-negative patients, and that lower heterogeneity was associated with complete resectability. There were some differences among papers in methodology; for example, only 3/6 (50%) articles included validation cohorts. In conclusion, radiomic models have demonstrated promising results as predictors of survival in OC patients, although larger studies are needed to allow clinical applicability.
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13030573
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  2. Article ; Online: Fissureless Technique Might Prevent the Middle Lobe Impairment After Right Upper Lobectomy.

    Vannucci, Jacopo / Mantovani, Sara / Dolciami, Miriam / Bassi, Massimiliano / Venuta, Federico / Anile, Marco

    Surgical innovation

    2021  Volume 28, Issue 5, Page(s) 659–660

    MeSH term(s) Humans ; Lung ; Lung Neoplasms/surgery ; Pneumonectomy/adverse effects ; Pneumonectomy/methods
    Language English
    Publishing date 2021-01-31
    Publishing country United States
    Document type Letter
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/1553350621991227
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  3. Article ; Online: When to ask for an MRI of the scrotum.

    Tsili, Athina C / Argyropoulou, Maria I / Dolciami, Miriam / Ercolani, Giada / Catalano, Carlo / Manganaro, Lucia

    Andrology

    2021  Volume 9, Issue 5, Page(s) 1395–1409

    Abstract: Background: Multiparametric MRI (mpMRI) of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal ... ...

    Abstract Background: Multiparametric MRI (mpMRI) of the scrotum has been established as a useful second-line diagnostic tool for the investigation of scrotal diseases. Recently, recommendations on clinical indications for scrotal MRI were issued by the Scrotal and Penile Imaging Working Group of the European Society of Urogenital Radiology.
    Objective: To update current research on when to ask for an MRI of the scrotum.
    Methods: PubMed database was searched for original articles and reviews published during 2010-2021.
    Results: Eighty-three articles fulfilled the search criteria. Scrotal MRI is mainly recommended after inconclusive US findings or inconsistent with the clinical examination and should be asked in the following cases: differentiation between intratesticular and paratesticular lesions (in rare cases of uncertain US findings), characterization of paratesticular and intratesticular lesions (when US findings are indeterminate), discrimination between germ cell and sex cord-stromal testicular tumors, local staging of testicular malignancies (in patients planned for testis-sparing surgery), differentiation between seminomas and non-seminomatous tumors (when immediate chemotherapy is planned and orchiectomy is delayed), assessment of acute scrotum and scrotal trauma (rarely needed, in cases of non-diagnostic US findings) and detection and localization of undescended testes (in cases of inconlusive US findings). Although preliminary data show promising results in the evaluation of male infertility, no established role for mpMRI still exists.
    Conclusion: Multiparametric MRI of the scrotum, by assessing morphologic and functional data represents a valuable problem-solving tool, helping to improve our understanding on the nature of scrotal pathology and the process of spermatogenesis. The technique may improve patient care and reduce the number of unnecessary surgical procedures.
    MeSH term(s) Diagnosis, Differential ; Humans ; Magnetic Resonance Imaging/standards ; Male ; Practice Guidelines as Topic ; Scrotum/diagnostic imaging ; Societies, Medical ; Testicular Diseases/diagnostic imaging
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13032
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  4. Article ; Online: MRI and Adenomyosis: What Can Radiologists Evaluate?

    Celli, Veronica / Dolciami, Miriam / Ninkova, Roberta / Ercolani, Giada / Rizzo, Stefania / Porpora, Maria Grazia / Catalano, Carlo / Manganaro, Lucia

    International journal of environmental research and public health

    2022  Volume 19, Issue 10

    Abstract: Uterine adenomyosis is a common benign condition defined by the presence of heterotopic endometrial glands and stroma within the myometrium. Adenomyosis is often related to infertility and other adverse pregnancy outcomes. Modern imaging techniques allow ...

    Abstract Uterine adenomyosis is a common benign condition defined by the presence of heterotopic endometrial glands and stroma within the myometrium. Adenomyosis is often related to infertility and other adverse pregnancy outcomes. Modern imaging techniques allow the non-invasive diagnosis of adenomyosis and, in this framework, Magnetic Resonance Imaging (MRI) has assumed a central role due to its high diagnostic accuracy in the detection of adenomyosis. Currently, there is still a lack of international consensus on adenomyosis diagnostic criteria and classification, despite the fact that an agreed reporting system would promote treatment outcomes and research. This review aims to emphasize the important contribution of MRI to the diagnosis of adenomyosis and to highlight how, thanks to the great tissue differentiation provided by MRI, it is possible to identify the main direct (cystic component) and indirect (junctional zone features) signs of adenomyosis and to distinguish its various subtypes according to different MRI-based classifications. We also explored the main MRI criteria to identify the most common pitfalls and differential diagnoses of adenomyosis, whose features should be considered to avoid misdiagnosis.
    MeSH term(s) Adenomyosis/diagnostic imaging ; Adenomyosis/pathology ; Endometrium ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Myometrium/pathology ; Pregnancy ; Radiologists
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19105840
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  5. Article ; Online: The contribution of the

    Dolciami, Miriam / Canese, Rossella / Testa, Claudia / Pernazza, Angelina / Santangelo, Giusi / Palaia, Innocenza / Rocca, Carlo Della / Catalano, Carlo / Manganaro, Lucia

    European radiology experimental

    2022  Volume 6, Issue 1, Page(s) 47

    Abstract: Background: The aim of this study was to investigate the role of the lipid peak derived from : Methods: We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging ... ...

    Abstract Background: The aim of this study was to investigate the role of the lipid peak derived from
    Methods: We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients with LACC were treated with NACT and reassessed by MRI at term. Based on tumour volume reduction, patients were classified as good responder (GR; tumour volume reduction > 50%) and poor responder or nonresponder (PR-or-NR; tumour volume reduction ≤ 50%).
    Results: Of 17 patients, 11 were LACC. Of these 11, only 6 had both completed NACT and had good-quality
    Conclusions: Assessment of lipid peak at
    MeSH term(s) Choline/metabolism ; Choline/therapeutic use ; Female ; Humans ; Lipids/therapeutic use ; Magnetic Resonance Imaging/methods ; Proton Magnetic Resonance Spectroscopy ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
    Chemical Substances Lipids ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ISSN 2509-9280
    ISSN (online) 2509-9280
    DOI 10.1186/s41747-022-00300-1
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  6. Article ; Online: Radiomics systematic review in cervical cancer: gynecological oncologists' perspective.

    Bizzarri, Nicolò / Russo, Luca / Dolciami, Miriam / Zormpas-Petridis, Konstantinos / Boldrini, Luca / Querleu, Denis / Ferrandina, Gabriella / Pedone Anchora, Luigi / Gui, Benedetta / Sala, Evis / Scambia, Giovanni

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 10, Page(s) 1522–1541

    Abstract: Objective: Radiomics is the process of extracting quantitative features from radiological images, and represents a relatively new field in gynecological cancers. Cervical cancer has been the most studied gynecological tumor for what concerns radiomics ... ...

    Abstract Objective: Radiomics is the process of extracting quantitative features from radiological images, and represents a relatively new field in gynecological cancers. Cervical cancer has been the most studied gynecological tumor for what concerns radiomics analysis. The aim of this study was to report on the clinical applications of radiomics combined and/or compared with clinical-pathological variables in patients with cervical cancer.
    Methods: A systematic review of the literature from inception to February 2023 was performed, including studies on cervical cancer analysing a predictive/prognostic radiomics model, which was combined and/or compared with a radiological or a clinical-pathological model.
    Results: A total of 57 of 334 (17.1%) screened studies met inclusion criteria. The majority of studies used magnetic resonance imaging (MRI), but positron emission tomography (PET)/computed tomography (CT) scan, CT scan, and ultrasound scan also underwent radiomics analysis. In apparent early-stage disease, the majority of studies (16/27, 59.3%) analysed the role of radiomics signature in predicting lymph node metastasis; six (22.2%) investigated the prediction of radiomics to detect lymphovascular space involvement, one (3.7%) investigated depth of stromal infiltration, and one investigated (3.7%) parametrial infiltration. Survival prediction was evaluated both in early-stage and locally advanced settings. No study focused on the application of radiomics in metastatic or recurrent disease.
    Conclusion: Radiomics signatures were predictive of pathological and oncological outcomes, particularly if combined with clinical variables. These may be integrated in a model using different clinical-pathological and translational characteristics, with the aim to tailor and personalize the treatment of each patient with cervical cancer.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/pathology ; Positron Emission Tomography Computed Tomography ; Lymphatic Metastasis/pathology ; Magnetic Resonance Imaging/methods ; Tomography, X-Ray Computed ; Retrospective Studies ; Lymph Nodes/pathology
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004589
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  7. Article ; Online: Radiomics in cervical and endometrial cancer.

    Manganaro, Lucia / Nicolino, Gabriele Maria / Dolciami, Miriam / Martorana, Federica / Stathis, Anastasios / Colombo, Ilaria / Rizzo, Stefania

    The British journal of radiology

    2021  Volume 94, Issue 1125, Page(s) 20201314

    Abstract: Radiomics is an emerging field of research that aims to find associations between quantitative information extracted from imaging examinations and clinical data to support the best clinical decision. In the last few years, some papers have been ... ...

    Abstract Radiomics is an emerging field of research that aims to find associations between quantitative information extracted from imaging examinations and clinical data to support the best clinical decision. In the last few years, some papers have been evaluating the role of radiomics in gynecological malignancies, mainly focusing on ovarian cancer. Nonetheless, cervical cancer is the most frequent gynecological malignancy in developing countries and endometrial cancer is the most common in western countries. The purpose of this narrative review is to give an overview of the latest published papers evaluating the role of radiomics in cervical and endometrial cancer, mostly evaluating association with tumor prognostic factors, with response to therapy and with prediction of recurrence and distant metastasis.
    MeSH term(s) Cervix Uteri/diagnostic imaging ; Diagnostic Imaging/methods ; Endometrial Neoplasms/diagnostic imaging ; Endometrium/diagnostic imaging ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Uterine Cervical Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20201314
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  8. Article ; Online: Magnetic Resonance Imaging in endometriosis-associated pain.

    Celli, Veronica / Ciulla, Sandra / Dolciami, Miriam / Satta, Serena / Ercolani, Giada / Porpora, Maria G / Catalano, Carlo / Manganaro, Lucia

    Minerva obstetrics and gynecology

    2021  Volume 73, Issue 5, Page(s) 553–571

    Abstract: Introduction: Endometriosis affects 10%-15% of women in reproductive age and may cause no-cyclic chronic pelvic pain, dysmenorrhea, dyspareunia, urinary tract symptoms, and it is frequently associated with infertility. The peak of incidence is between ... ...

    Abstract Introduction: Endometriosis affects 10%-15% of women in reproductive age and may cause no-cyclic chronic pelvic pain, dysmenorrhea, dyspareunia, urinary tract symptoms, and it is frequently associated with infertility. The peak of incidence is between 24 and 29 years old and the clinical diagnosis of endometriosis is generally delayed by 6-7 years. Laparoscopy with surgical biopsies is the "gold standard" for the diagnosis of endometriosis, with histological verification of endometrial ectopic glands and/or stroma. However, nowadays two different non-invasive modalities are routinely used for a presumptive diagnosis: Transvaginal Ultrasound (TVUS) and Magnetic Resonance Imaging (MRI).
    Evidence acquisition: A structured search using PubMed was performed starting from October 2020 and including all relevant original and review articles published since 2000. The search used the following key word combinations: "endometriosis MRI" AND "DIE and MRI" (45); "MRI endometriosis and pelvic pain" OR "endometriosis and MRI technical development" (296). Ultimately, 87 articles were deemed relevant and used as the literature basis of this review.
    Evidence synthesis: TVUS represents the first imaging approach for endometriosis showing a good diagnostic performance, but it is highly operator dependent. MRI is a second level examination often used in complex cases indeterminate after TVUS and in preoperative planning. MRI is considered the best imaging technique for mapping endometriosis since it provides a more reliable map of deep infiltrating endometriosis than physical examination and transvaginal ultrasound. We have analyzed and described the main forms of endometriosis: adnexal endometriosis, adenomyosis, peritoneal implants and deep infiltrating endometriosis, showing their appearance in the two imaging modalities.
    Conclusions: Endometriosis is one of the most common gynecologic disorders correlated to chronic pelvic pain whose treatment is still today complex and controversial. In this context, MRI has become an important additional non-invasive tool to investigate cases of chronic pelvic pain related to deep infiltrating endometriosis (DIE) with or without neural involvement.
    MeSH term(s) Adenomyosis ; Adult ; Endometriosis/complications ; Female ; Humans ; Magnetic Resonance Imaging ; Pelvic Pain/diagnostic imaging ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2021-04-27
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.21.04782-1
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  9. Article ; Online: Quantitative CT texture analysis in predicting PD-L1 expression in locally advanced or metastatic NSCLC patients.

    Bracci, Stefano / Dolciami, Miriam / Trobiani, Claudio / Izzo, Antonella / Pernazza, Angelina / D'Amati, Giulia / Manganaro, Lucia / Ricci, Paolo

    La Radiologia medica

    2021  Volume 126, Issue 11, Page(s) 1425–1433

    Abstract: Purpose: The assessment of Programmed death-ligand 1 (PD-L1) expression has become a game changer in the treatment of patients with advanced non-small cell lung cancer (NSCLC). We aimed to investigate the ability of Radiomics applied to computed ... ...

    Abstract Purpose: The assessment of Programmed death-ligand 1 (PD-L1) expression has become a game changer in the treatment of patients with advanced non-small cell lung cancer (NSCLC). We aimed to investigate the ability of Radiomics applied to computed tomography (CT) in predicting PD-L1 expression in patients with advanced NSCLC.
    Methods: By applying texture analysis, we retrospectively analyzed 72 patients with advanced NSCLC. The datasets were randomly split into a training cohort (2/3) and a validation cohort (1/3). Forty radiomic features were extracted by manually drawing tumor volumes of interest (VOIs) on baseline contrast-enhanced CT. After selecting features on the training cohort, two predictive models were created using binary logistic regression, one for PD-L1 values ≥ 50% and the other for values between 1 and 49%. The two models were analyzed with ROC curves and tested in the validation cohort.
    Results: The Radiomic Score (Rad-Score) for PD-L1 values ≥ 50%, which consisted of Skewness and Low Gray-Level Zone Emphasis (GLZLM_LGZE), presented a cut-off value of - 0.745 with an area under the curve (AUC) of 0.811 and 0.789 in the training and validation cohort, respectively. The Rad-Score for PD-L1 values between 1 and 49% consisted of Sphericity, Skewness, Conv_Q3 and Gray Level Non-Uniformity (GLZLM_GLNU), showing a cut-off value of 0.111 with AUC of 0.763 and 0.806 in the two population, respectively.
    Conclusion: Rad-Scores obtained from CT texture analysis could be useful for predicting PD-L1 expression and guiding the therapeutic choice in patients with advanced NSCLC.
    MeSH term(s) Aged ; B7-H1 Antigen/biosynthesis ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/secondary ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Chemical Substances B7-H1 Antigen ; CD274 protein, human
    Language English
    Publishing date 2021-08-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-021-01399-9
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  10. Article ; Online: O-RADS MRI: A Systematic Review and Meta-Analysis of Diagnostic Performance and Category-wise Malignancy Rates.

    Rizzo, Stefania / Cozzi, Andrea / Dolciami, Miriam / Del Grande, Filippo / Scarano, Angela L / Papadia, Andrea / Gui, Benedetta / Gandolfo, Nicoletta / Catalano, Carlo / Manganaro, Lucia

    Radiology

    2022  Volume 307, Issue 1, Page(s) e220795

    Abstract: Background US-indeterminate adnexal lesions remain an important indication for gynecologic surgery. MRI can serve as a problem-solving tool through the use of the Ovarian-Adnexal Imaging Reporting and Data System (O-RADS) MRI lexicon, which is based on ... ...

    Abstract Background US-indeterminate adnexal lesions remain an important indication for gynecologic surgery. MRI can serve as a problem-solving tool through the use of the Ovarian-Adnexal Imaging Reporting and Data System (O-RADS) MRI lexicon, which is based on the ADNEX MR scoring system. Purpose To perform a systematic review and meta-analysis of the diagnostic performance of pelvic MRI interpreted using the ADNEX or O-RADS MRI stratification systems to characterize US-indeterminate adnexal lesions and of the category-wise malignancy rates. Materials and Methods A systematic literature search from May 2013 (publication of the ADNEX MR score) to September 2022 was performed. Studies reporting the use of pelvic MRI interpreted with the ADNEX or O-RADS MRI systems to characterize US-indeterminate adnexal lesions, with pathologic examination and/or follow-up as the reference standard, were included. Summary estimates of diagnostic performance were obtained with the bivariate random-effects model, while category-wise summary malignancy rates of O-RADS MRI 2, 3, 4, and 5 lesions were obtained with a random-effects model. Effects of covariates on heterogeneity and diagnostic performance were investigated through meta-regression. Results Thirteen study parts from 12 studies (3731 women, 4520 adnexal lesions) met the inclusion criteria. Diagnostic performance meta-analysis for 4012 lesions found a 92% summary sensitivity (95% CI: 88, 95) and a 91% summary specificity (95% CI: 89, 93). The meta-analysis of malignancy rates for 3641 lesions showed summary malignancy rates of 0.1% (95% CI: 0, 1) among O-RADS MRI 2 lesions, 6% (95% CI: 3, 9) among O-RADS MRI 3 lesions, 60% (95% CI: 52, 67) among O-RADS MRI 4 lesions, and 96% (95% CI: 92, 99) among O-RADS MRI 5 lesions. Conclusion Pelvic MRI interpreted with the Ovarian-Adnexal Reporting and Data System (O-RADS) MRI lexicon had high diagnostic performance for the characterization of US-indeterminate adnexal lesions. Summary estimates of malignancy rates in the O-RADS MRI 4 and O-RADS MRI 5 categories were higher than predicted ones. © RSNA, 2022
    MeSH term(s) Female ; Humans ; Adnexal Diseases/pathology ; Adnexa Uteri/diagnostic imaging ; Ovarian Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Ultrasonography/methods ; Sensitivity and Specificity ; Retrospective Studies
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.220795
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