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Book ; Online: Viejos y nuevos clivajes de la desigualdad educativa en Iberoamérica

Domínguez i Amorós, Màrius / Aguerre, Fernández / Tuñón, Ianina

2019

Keywords	History of education ; Social classes ; History of the Americas ; Education ; Sociology ; History ; Latin American Studies
Language	Spanish
Size	1 Online-Ressource
Publisher	CLACSO
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030609358
ISBN	9789877224306 ; 9877224305
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides.

Vázquez-Domínguez, Irene / Garanto, Alejandro

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2434, Page(s) 267–279

Abstract: Over the last decades, animal models have become increasingly important in therapeutic drug development and assessment. The use of these models, mainly mice and rats, allow evaluating drugs in the real-organism environment and context. However, several ... ...

Abstract	Over the last decades, animal models have become increasingly important in therapeutic drug development and assessment. The use of these models, mainly mice and rats, allow evaluating drugs in the real-organism environment and context. However, several molecular therapeutic approaches are sequence-dependent, and therefore, the humanization of such models is required to assess the efficacy. The generation of genetically modified humanized mouse models is often an expensive and laborious process that may not always recapitulate the human molecular and/or physiological phenotype. In this chapter, we summarize basic aspects to consider before designing and generating humanized models, especially when they are aimed to test antisense-based therapies.
MeSH term(s)	Animals ; Disease Models, Animal ; Mice ; Oligonucleotides, Antisense/genetics ; Rats
Chemical Substances	Oligonucleotides, Antisense
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2010-6_18
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Instabilities triggered in different conducting fluid geometries due to slowly time-dependent magnetic fields.

Cortés-Domínguez, I / Burguete, J

Chaos (Woodbury, N.Y.)

2018 Volume 28, Issue 7, Page(s) 75514

Abstract: The main objective of this work is the study and analysis of non-linearities forced through oscillating magnetic fields in a conducting fluid where the instabilities are triggered due to magnetohydrodynamic forces. Different geometries have been studied ... ...

Abstract	The main objective of this work is the study and analysis of non-linearities forced through oscillating magnetic fields in a conducting fluid where the instabilities are triggered due to magnetohydrodynamic forces. Different geometries have been studied and different surface patterns that break the symmetries have been observed. First, an InGaSn drop of fluid where the system breaks the azimuthal and radial symmetries depending on the volume is observed. Second, we extend the study to an InGaSn annular configuration where the presence of patterns opens the door to discuss the possibility to extend these results to other configurations as biological systems, where the conducting fluid is an electrolyte. This configuration has an added interest, as it has been proposed that the vertigoes triggered on patients in an MRI test could be generated by the interaction of the magnetic field with the electrolyte present in the inner ear.
Language	English
Publishing date	2018-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/1.5027674
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Simultaneous Generation of Surface Plasmon and Lossy Mode Resonances in the Same Planar Platform.

Fuentes, O / Del Villar, I / Dominguez, I / Corres, J M / Matías, I R

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 4

Abstract: A planar waveguide consisting of a coverslip for a microscope glass slide was deposited in one of its two faces with two materials: silver and indium tin oxide (ITO). The incidence of light by the edge of the coverslip permitted the generation of both ... ...

Abstract	A planar waveguide consisting of a coverslip for a microscope glass slide was deposited in one of its two faces with two materials: silver and indium tin oxide (ITO). The incidence of light by the edge of the coverslip permitted the generation of both surface plasmon and lossy mode resonances (SPRs and LMRs) in the same transmission spectrum with a single optical source and detector. This proves the ability of this optical platform to be used as a benchmark for comparing different optical phenomena generated by both metal and dielectric materials, which can be used to progress in the assessment of different sensing technologies. Here the SPR and the LMR were compared in terms of sensitivity to refractive index and figure of merit (FoM), at the same time it was demonstrated that both resonances can operate independently when silver and ITO coated regions are surrounded by different refractive index liquids. The results were supported with numerical results that confirm the experimental ones.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22041505
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Instabilities of conducting fluid layers in weak time-dependent magnetic fields.

Cortés-Domínguez, I / Burguete, J

Physical review. E

2017 Volume 96, Issue 1-1, Page(s) 13103

Abstract: We present the experimental analysis of the instabilities generated on a large drop of liquid metal by a time-dependent magnetic field. The study is done exploring the range of tiny values of the control parameter (the ratio between the Lorentz forces ... ...

Abstract	We present the experimental analysis of the instabilities generated on a large drop of liquid metal by a time-dependent magnetic field. The study is done exploring the range of tiny values of the control parameter (the ratio between the Lorentz forces and inertia) avoiding nonlinear effects. Two different instabilities break the symmetries generating spatial patterns that appear without a threshold for some specific frequencies (up to the experimental precision) and have been observed for parameter values two orders of magnitude lower than in previously published experiments [J. Fluid Mech. 239, 383 (1992)JFLSA70022-112010.1017/S0022112092004452]. One of the instabilities corresponds to a boundary condition oscillation that generates surface waves and breaks the azimuthal symmetry. The other corresponds to a parametric forcing through a modulation of the Lorentz force. The competition between these two mechanisms produces time-dependent patterns near codimension-2 points.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.96.013103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 vaccines: a look at the ethics of the clinical research involving children.

Cabiedes-Miragaya, Laura / Galende-Domínguez, Inés

Journal of medical ethics

2022

Abstract: Currently, millions of minors are being inoculated against SARS-CoV-2 in many countries in the world. Ethical concerns about clinical research involving children have barely been addressed in the literature, despite the fact that the paediatric ... ...

Abstract	Currently, millions of minors are being inoculated against SARS-CoV-2 in many countries in the world. Ethical concerns about clinical research involving children have barely been addressed in the literature, despite the fact that the paediatric population is particularly vulnerable within this context. Children should be included in the research plans for COVID-19 vaccines. Nevertheless, it is necessary to critically assess to what extent clinical trials are being conducted according to methodological and ethical criteria that allow us to conclude that the results are valid and, in consequence, how far the vaccination plans for children are scientifically justified.The principal aim of this article is to analyse critically the process of clinical research on COVID-19 vaccines involving children, highlighting the ethical concerns that arise, including the need to stratify the results from older adolescents separately for analysis before proceeding, if further research is warranted, in descending age order. The development of COVID-19 vaccines is examined, with a special look at the participation of children throughout their clinical development, including a review of the clinical trials registered in three international databases. We also offer some additional considerations about the inclusion of minors in vaccination plans. Finally, we conclude with some recommendations, with particular emphasis on the following ethical duties: research in children should be carried out only once the relevant research in adults has previously been conducted; issues that concern children's needs and rights should be specifically addressed; and, therefore, the highest standards of ethical and scientific quality should be met.
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	194927-5
ISSN	1473-4257 ; 0306-6800
ISSN (online)	1473-4257
ISSN	0306-6800
DOI	10.1136/medethics-2021-107941
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1163: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Developing a Practical Medical Educator Training Program: Meeting A Need in Faculty Development.

Dominguez, Isabel / Zumwalt, Ann

MedEdPublish (2016)

2020 Volume 9, Page(s) 271

Abstract: This article was migrated. The article was marked as recommended. Faculty who teach in medical schools typically do so because of their knowledge and expertise in their field, yet few receive training in best practices in teaching. Educator development ... ...

Abstract	This article was migrated. The article was marked as recommended. Faculty who teach in medical schools typically do so because of their knowledge and expertise in their field, yet few receive training in best practices in teaching. Educator development programs that help faculty enhance their teaching skills while continuing to fulfill their existing professional responsibilities can help address this gap. Such programs may be developed and implemented locally by individuals within the institution. This guide is intended for individuals who are interested in developing educator training programs but who lack experience in program development. The article describes practical strategies for designing, implementing, and evaluating a collaborative program to teach skills and best practices in medical education. Key themes in program design, program implementation, and program evaluation and dissemination include appropriate goal setting, setting clear expectations, strong communication, and the benefits of diversity in collaboration. Educator training programs provide enhanced teaching skills and opportunities for career advancement for participants at all career stages, which in turn benefits the institution and the medical profession.
Language	English
Publishing date	2020-12-04
Publishing country	Scotland
Document type	Journal Article
ISSN	2312-7996
ISSN (online)	2312-7996
DOI	10.15694/mep.2020.000271.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrating the basic sciences in medical curricula: focus on the basic scientists.

Dominguez, Isabel / Zumwalt, Ann C

Advances in physiology education

2020 Volume 44, Issue 2, Page(s) 119–123

Abstract: Basic science educators are not trained as clinicians, yet are expected to adjust their content to mesh appropriately with its clinical application. While achievable, this is a challenge that requires intentional effort on the part of the basic science ... ...

Abstract	Basic science educators are not trained as clinicians, yet are expected to adjust their content to mesh appropriately with its clinical application. While achievable, this is a challenge that requires intentional effort on the part of the basic science educators. A practical solution to facilitate curricular integration is to create experiential opportunities for basic scientists to observe the clinical application of their content and to pair these initiatives with training in effective medical education practices.
MeSH term(s)	Biological Science Disciplines/education ; Biological Science Disciplines/methods ; Biological Science Disciplines/trends ; Curriculum/trends ; Education, Medical/methods ; Education, Medical/trends ; Humans ; Laboratory Personnel/trends
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Editorial
ZDB-ID	1024917-5
ISSN	1522-1229 ; 1043-4046
ISSN (online)	1522-1229
ISSN	1043-4046
DOI	10.1152/advan.00172.2019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5611: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Uc I Zs.89: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Resultados y complicaciones de la enfermedad del segmento adyacente tratada mediante artrodesis intersomática lateral mínimamente invasiva.

Luque, R / Echevarría, M / Alcobía, B / Urda, A / Domínguez, I / Marco, F

Acta ortopedica mexicana

2021 Volume 34, Issue 6, Page(s) 388–398

Abstract: Introduction: A comparative clinical study has been conducted on patients involved using lateral intersomatic arthrodesis for the treatment of adjacent segment disease using titanium and PEEK intersomatic devices.: Material and methods: Clinical (EVA ...

Title translation	Results and complications of adjacent segment disease treated by minimally invasive lateral intersomatic arthrodesis.
Abstract	Introduction: A comparative clinical study has been conducted on patients involved using lateral intersomatic arthrodesis for the treatment of adjacent segment disease using titanium and PEEK intersomatic devices. Material and methods: Clinical (EVA and oswestry disability index ODI) and radiological (alignment and fusion), complications (major and minor) and quality of life (EQ5D) of 32 patients intervened from September 2015 to September 2018 have been analyzed and compared, with an average follow-up of 25 months (46-18). The average age in surgery was 66 years (39-89) and 68% of patients were women. Results: The most common segment involved was L3-L4 (62%) right retroperitoneal approach 86%. Lumbar EVA improved from 6.2 ± 2.12 to 4.1 ± 1.71 (p = 0.028). The LEG EVA descended from 5.3 ± 2.26 to 1.9 ± 1.58 (p = 0.02). The ODI scales improved from 50.2 ± 18.9 to 33.3 ± 10.2 (p = 0.025) and the EQ5D went from 0.52 to 0.73 (p = 0.039) with no statistically significant differences between the groups (ODI p = 0.18, EQ5D p = 0.293). Radiologically increased intervertebral height, lumbar and segmental lordosis, decreased Cobb's angle and the overall melting rate was 84.3% (88% Ti/82% PEEK), with no differences between the groups. Conclusion: Lateral lumbar interbody fusion is an effective method for treating adjacent segment disease with clinical-radiological results and literature-like complications. No differences have been found between Ti and PEEK implants.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Spinal Fusion ; Treatment Outcome
Language	Spanish
Publishing date	2021-05-21
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Design and Backdrivability Modeling of a Portable High Torque Robotic Knee Prosthesis With Intrinsic Compliance For Agile Activities.

Zhu, Junxi / Jiao, Chunhai / Dominguez, Israel / Yu, Shuangyue / Su, Hao

IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division

2022 Volume 27, Issue 4, Page(s) 1837–1845

Abstract: High-performance prostheses are crucial to enable versatile activities like walking, squatting, and running for lower extremity amputees. State-of-the-art prostheses are either not powerful enough to support demanding activities or have low compliance ( ... ...

Abstract	High-performance prostheses are crucial to enable versatile activities like walking, squatting, and running for lower extremity amputees. State-of-the-art prostheses are either not powerful enough to support demanding activities or have low compliance (low backdrivability) due to the use of high speed ratio transmission. Besides speed ratio, gearbox design is also crucial to the compliance of wearable robots, but its role is typically ignored in the design process. This paper proposed an analytical backdrive torque model that accurately estimate the backdrive torque from both motor and transmission to inform the robot design. Following this model, this paper also proposed methods for gear transmission design to improve compliance by reducing inertia of the knee prosthesis. We developed a knee prosthesis using a high torque actuator (built-in 9:1 planetary gear) with a customized 4:1 low-inertia planetary gearbox. Benchtop experiments show the backdrive torque model is accurate and proposed prosthesis can produce 200 Nm high peak torque (shield temperature <60°C), high compliance (2.6 Nm backdrive torque), and high control accuracy (2.7/8.1/1.7 Nm RMS tracking errors for 1.25 m/s walking, 2 m/s running, and 0.25 Hz squatting, that are 5.4%/4.1%/1.4% of desired peak torques). Three able-bodied subject experiments showed our prosthesis could support agile and high-demanding activities.
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article
ISSN	1083-4435
ISSN	1083-4435
DOI	10.1109/tmech.2022.3176255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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