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Article ; Online: Is Trypanosoma cruzi PCR useful for the follow-up of patients with Chagas disease?

Sánchez Martín, Nieves / Domínguez Castellano, Ángel

2023 Volume 56, Page(s) 102665

MeSH term(s)	Humans ; Trypanosoma cruzi/genetics ; Follow-Up Studies ; Chagas Disease/diagnosis ; Chagas Cardiomyopathy ; Polymerase Chain Reaction
Language	English
Publishing date	2023-11-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2023.102665
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Article ; Online: Tratamiento de la malaria en adultos en países no endémicos.

Domínguez-Castellano, Angel

Medicina clinica

2014 Volume 143, Issue 5, Page(s) 216–221

Title translation	Treatment of malaria in adults in non-endemic countries.
MeSH term(s)	Adult ; Antimalarials/therapeutic use ; Humans ; Malaria/drug therapy ; Malaria, Falciparum/drug therapy ; Severity of Illness Index
Chemical Substances	Antimalarials
Language	Spanish
Publishing date	2014-09-09
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2014.01.006
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Article ; Online: Hypocholesterolemia in patients with active tuberculosis: Not just a matter of weight.

Sojo-Dorado, Jesús / Batista-Díaz, Nínive / Domínguez-Castellano, Ángel

Medicina clinica

2017 Volume 148, Issue 4, Page(s) 189–190

Title translation	Hipocolesterolemia en pacientes con tuberculosis activa: no solo una cuestión de peso.
Language	Spanish
Publishing date	2017-02-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2016.09.049
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Article ; Online: Rickettsioses imported by travellers and migrants to Spain attended in the +Redivi network, 2009-2020.

Llenas-García, Jara / Cañaveral, Ramiro / Arsuaga, Marta / Monge-Maillo, Begoña / Oliveira-Souto, Inés / Torrús-Tendero, Diego / Rodríguez Guardado, Azucena / Calabuig, Eva / Sánchez-Montalvá, Adrián / Domínguez-Castellano, Ángel / de la Calle-Prieto, Fernando / Pérez-Molina, José A

Journal of travel medicine

2023 Volume 30, Issue 3

Abstract: Background: Rickettsioses are emerging zoonotic diseases with worldwide prevalence, recognized as a cause of imported fever in travellers and migrants. Our objective is to describe the microbiological, clinical and epidemiological characteristics of ... ...

Abstract	Background: Rickettsioses are emerging zoonotic diseases with worldwide prevalence, recognized as a cause of imported fever in travellers and migrants. Our objective is to describe the microbiological, clinical and epidemiological characteristics of imported rickettsioses in travellers and migrants included in a Spanish collaborative network database. Methods: This multicentre retrospective observational study was nested in +Redivi, the Cooperative Network for the Study of Infections Imported by Immigrants and Travellers. We asked collaborating centres for microbiological, clinical and epidemiological data on the rickettsiosis cases from the inception of the network in 2009 to December 2020. Results: Fifty-four cases of imported rickettsioses were included; 35 (64.8%) patients were men, and the median age was 37 years (interquartile range 26, 51.2). Only 7.4% of patients were travellers visiting friends and relatives, and 5.6% were migrants. The most frequent travel destination (38.9%) was South Africa, and 90.7% engaged in a high-risk activity. Twenty-seven patients (50.0%) started presenting symptoms after their return to Spain. The most frequent symptoms were febrile syndrome (55.6%) and cutaneous manifestations (27.8%). Most diagnoses (63.0%) were confirmed by serology. Only a few cases (9.3%) required hospitalization. All participants had a full recovery. Conclusions: Clinicians should suspect rickettsial diseases in travellers coming from high-risk areas, especially Southern Africa, who have engaged in activities in rural areas and natural parks. Doxycycline should be considered in the empiric treatment of imported fever of travellers coming from those areas or who have engaged in high-risk activities. There is a need to improve access to molecular diagnosis of rickettsiosis in Spain.
MeSH term(s)	Male ; Animals ; Humans ; Adult ; Female ; Spain/epidemiology ; Transients and Migrants ; Rickettsia Infections/diagnosis ; Retrospective Studies ; Zoonoses ; Travel
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad050
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Article ; Online: Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study.

PloS one

2023 Volume 18, Issue 8, Page(s) e0285917

Abstract: Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions ... ...

Abstract	Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Methods: Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. Results: We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. Conclusion: In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.
MeSH term(s)	Adult ; Humans ; Cohort Studies ; Prospective Studies ; Tuberculosis/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Latent Tuberculosis
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285917
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Article ; Online: Varón subsahariano de 34 años con epigastralgia y vómitos de cinco meses de evolución.

Domínguez-Castellano, Angel / Molina Gil-Bermejo, José

Medicina clinica

2011 Volume 136, Issue 10, Page(s) 447–453

Title translation	34-year old sub-saharan male with epigastralgia and vomits for five months evolution.
MeSH term(s)	Adult ; Animals ; Diagnosis, Differential ; HIV Infections/complications ; HIV Infections/diagnosis ; HTLV-I Infections/complications ; HTLV-I Infections/diagnosis ; Humans ; Male ; Pain/etiology ; Stomach ; Strongyloides stercoralis ; Strongyloidiasis/complications ; Strongyloidiasis/diagnosis ; Time Factors
Language	Spanish
Publishing date	2011-04-16
Publishing country	Spain
Document type	Case Reports ; Clinical Conference ; Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2010.10.001
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Article ; Online: Low Incidence of Adverse Effects Using a Progressive Regimen of Benznidazole in Chagas Disease.

Navarrete, Miguel Nicolas / Gutiérrez-Gutiérrez, Belen / de Arellano-Ramos, Ramirez / Del Castillo, Sandoval-Fernández / Domínguez-Castellano, Ángel

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2016 Volume 62, Issue 8, Page(s) 1052

MeSH term(s)	Chagas Disease/drug therapy ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Humans ; Male ; Nitroimidazoles/adverse effects ; Trypanocidal Agents/adverse effects
Chemical Substances	Nitroimidazoles ; Trypanocidal Agents
Language	English
Publishing date	2016-04-15
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciw009
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Article ; Online: Mononucleosis infecciosa grave asociada a virus Epstein Barr en dos hermanos jóvenes.

Sojo Dorado, Jesús / Domínguez Castellano, Angel / Ramírez de Arellano, Encarnación / Rodríguez Baño, Jesús

Enfermedades infecciosas y microbiologia clinica

2012 Volume 30, Issue 4, Page(s) 221–222

Title translation	Severe Epstein Barr virus-related infectious mononucleosis in two brothers.
MeSH term(s)	Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Ascites/etiology ; DNA, Viral/blood ; Genetic Predisposition to Disease ; Hepatomegaly/etiology ; Herpesvirus 4, Human/isolation & purification ; Humans ; Hyperbilirubinemia/etiology ; Immunocompetence ; Infectious Mononucleosis/complications ; Infectious Mononucleosis/drug therapy ; Infectious Mononucleosis/virology ; Male ; Methylprednisolone/therapeutic use ; Pleural Effusion/etiology ; Pulmonary Atelectasis/etiology ; Siblings ; Splenomegaly/etiology ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; DNA, Viral ; Methylprednisolone (X4W7ZR7023)
Language	Spanish
Publishing date	2012-04
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2011.10.015
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Article ; Online: Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network.

Herrador, Zaida / Pérez-Molina, José A / Henríquez Camacho, César Augusto / Rodriguez-Guardado, Azucena / Bosch-Nicolau, Pau / Calabuig, Eva / Domínguez-Castellano, Angel / Pérez-Jacoiste, María Asunción / Ladrón de Guevara, M Concepción / Mena, Ana / Ruiz-Giardin, Jose Manuel / Torrús, Diego / Wikman-Jorgensen, Philip / Benito, Agustín / López-Vélez, Rogelio

Travel medicine and infectious disease

2020 Volume 37, Page(s) 101683

Abstract: Background: Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe.: Methodology: Retrospective case series ...

Abstract	Background: Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology: Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results: 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions: Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened.
MeSH term(s)	Adult ; Cysticercosis ; Europe ; Humans ; Male ; Neurocysticercosis ; Retrospective Studies ; Spain
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2020.101683
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Article ; Online: Effective treatment of pulmonary tuberculosis restores plasma leptin levels.

Perna, Victoria / Pérez-Pérez, Antonio / Fernández-Riejos, Patricia / Polo-Padillo, Juan / Batista, Nínive / Domínguez-Castellano, Angel / Sánchez-Margalet, Víctor

European cytokine network

2013 Volume 24, Issue 4, Page(s) 157–161

Abstract: An impaired immune response in tuberculosis patients seems to be related to weight loss that coexists with an immunoendocrine imbalance. Thus, wasting is well-recognised as a prominent feature of tuberculosis (TB), which may not be reversed even after ... ...

Abstract	An impaired immune response in tuberculosis patients seems to be related to weight loss that coexists with an immunoendocrine imbalance. Thus, wasting is well-recognised as a prominent feature of tuberculosis (TB), which may not be reversed even after six months of treatment. Adipokines may play a role in the immune response to M. tuberculosis, and TB may impair the expression of inflammatory adipokines, such as leptin. We aimed to study patients with pulmonary TB before and six months after treatment, by measuring plasma leptin, soluble leptin receptor and adiponectin, weight and body mass index. Nineteen patients with a diagnosis of pulmonary TB were included in the study. Blood samples were obtained before and six months after treatment, to measure plasma adipokine levels. We found an increase in plasma leptin levels after treatment (p<0.05). Even though BMI also increased, the extent was not enough to account for the changes in the leptin levels. On the other hand, plasma soluble leptin receptor and adiponectin levels did not change significantly after treatment. In conclusion, these results suggest that active TB infection may affect the expression of leptin, in addition to the wasting that may occur in these patients, and that effective TB treatment increases circulating leptin levels, probably restoring normal immunological competence.
MeSH term(s)	Adiponectin/blood ; Adult ; Aged ; Body Mass Index ; Body Weight ; Female ; Humans ; Leptin/biosynthesis ; Leptin/blood ; Male ; Middle Aged ; Receptors, Leptin/blood ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/immunology ; Wasting Syndrome/complications ; Weight Loss ; Young Adult
Chemical Substances	Adiponectin ; Leptin ; Receptors, Leptin
Language	English
Publishing date	2013-10
Publishing country	France
Document type	Journal Article
ZDB-ID	1118857-1
ISSN	1952-4005 ; 1148-5493
ISSN (online)	1952-4005
ISSN	1148-5493
DOI	10.1684/ecn.2014.0346
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