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Article ; Online: Interleukin-6 as A Useful Predictor of Endometriosis-Associated Infertility

Giosue Giordano Incognito / Federica Di Guardo / Ferdinando Antonio Gulino / Fortunato Genovese / Domenico Benvenuto / Chiara Lello / Marco Palumbo

International Journal of Fertility and Sterility, Vol 17, Iss 4, Pp 226-

A Systematic Review

2023 Volume 230

Abstract: Endometriosis is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside theuterine cavity. Several authors have reported on the association between changes in inflammatory marker levelsand the maintenance or progression ...

Abstract	Endometriosis is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside theuterine cavity. Several authors have reported on the association between changes in inflammatory marker levelsand the maintenance or progression of endometriosis and associated infertility. Interleukin-6 (IL-6) is the moststudied cytokine in endometriosis and has important functions in reproductive physiology. The aim of this study isto review systematically available evidence about altered IL-6 concentrations in endometriosis-related infertility.This is a systematic review including all studies until December 2022 in which IL-6 in serum, peritoneal fluid,follicular fluid, or endometrial biopsy specimens was measured and that correlated their findings with endometriosis-associated infertility. Fifteen studies were included in the systematic review. There seems to be a correlationbetween elevated serum and peritoneal fluid IL-6 concentrations and the occurrence of endometriosis-associatedinfertility. IL-6 may be a potential diagnostic or biomarker tool for the prediction of endometriosis-related infertility.However, the numerous biases affecting the available studies, and challenges in endometriosis research reproducibilitymust be considered. Future investigations should pay attention to factors that may affect the results, suchas the choice of suitable control groups, and carefully consider other pathological conditions affecting the patients,endometriosis stage, and type of lesion.
Keywords	endometriosis ; infertility ; interleukin-6 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Royan Institute (ACECR), Tehran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of the ARIMA model on the COVID-2019 epidemic dataset

Domenico Benvenuto / Marta Giovanetti / Lazzaro Vassallo / Silvia Angeletti / Massimo Ciccozzi

Data in Brief, Vol 29, Iss , Pp - (2020)

2020

Abstract: Coronavirus disease 2019 (COVID-2019) has been recognized as a global threat, and several studies are being conducted using various mathematical models to predict the probable evolution of this epidemic. These mathematical models based on various factors ...

Abstract	Coronavirus disease 2019 (COVID-2019) has been recognized as a global threat, and several studies are being conducted using various mathematical models to predict the probable evolution of this epidemic. These mathematical models based on various factors and analyses are subject to potential bias. Here, we propose a simple econometric model that could be useful to predict the spread of COVID-2019. We performed Auto Regressive Integrated Moving Average (ARIMA) model prediction on the Johns Hopkins epidemiological data to predict the epidemiological trend of the prevalence and incidence of COVID-2019. For further comparison or for future perspective, case definition and data collection have to be maintained in real time. Keywords: COVID-2019 epidemic, ARIMA model, Forecast, Infection control
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Biological Properties of the SARS-CoV-2 Cameroon Variant Spike

Stefano Pascarella / Martina Bianchi / Marta Giovanetti / Domenico Benvenuto / Alessandra Borsetti / Roberto Cauda / Antonio Cassone / Massimo Ciccozzi

Pathogens, Vol 11, Iss 814, p

An Intermediate between the Alpha and Delta Variants

2022 Volume 814

Abstract: An analysis of the structural effect of the mutations of the B.1.640.2 (IHU) Spike Receptor Binding Domain (RBD) and N-terminal Domain (NTD) is reported along with a comparison with the sister lineage B.1.640.1. and a selection of variants of concern. ... ...

Abstract	An analysis of the structural effect of the mutations of the B.1.640.2 (IHU) Spike Receptor Binding Domain (RBD) and N-terminal Domain (NTD) is reported along with a comparison with the sister lineage B.1.640.1. and a selection of variants of concern. The effect of the mutations on the RBD–ACE2 interaction was also assessed. The structural analysis applied computational methods that are able to carry out in silico mutagenesis to calculate energy minimization and the folding energy variation consequent to residue mutations. Tools for electrostatic calculation were applied to quantify and display the protein surface electrostatic potential. Interactions at the RBD–ACE2 interface were scrutinized using computational tools that identify the interactions and predict the contribution of each interface residue to the stability of the complex. The comparison among the RBDs shows that the most evident differences between the variants is in the distribution of the surface electrostatic potential: that of B.1.640.1 is as that of the Alpha RBD, while B.1.640.2 appears to have an intermediate surface potential pattern with characteristics between those of the Alpha and Delta variants. Moreover, the B.1.640.2 Spike includes the mutation E484K that in other variants has been suggested to be involved in immune evasion. These properties may hint at the possibility that B.1.640.2 emerged with a potentially increased infectivity with respect to the sister B.1.640.1 variant, but significantly lower than that of the Delta and Omicron variants. However, the analysis of their NTD domains highlights deletions, destabilizing mutations and charge alterations that can limit the ability of the B.1.640.1 and B.1.640.2 variants to interact with cellular components, such as cell surface receptors.
Keywords	B.1.640.2 ; B.1.640.1 ; IHU ; Alpha variant ; Delta variant ; NTD ; Medicine ; R
Subject code	612
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implications of Possible HBV-Driven Regulation of Gene Expression in Stem Cell-like Subpopulation of Huh-7 Hepatocellular Carcinoma Cell Line

Ayse Banu Demir / Domenico Benvenuto / Bilge Karacicek / Yasemin Erac / Silvia Spoto / Silvia Angeletti / Massimo Ciccozzi / Metiner Tosun

Journal of Personalized Medicine, Vol 12, Iss 2065, p

2022 Volume 2065

Abstract: Elevated levels of STIM1, an endoplasmic reticulum Ca 2+ sensor/buffering protein, appear to be correlated with poor cancer prognosis in which microRNAs are also known to play critical roles. The purpose of this study is to investigate possible HBV ... ...

Abstract	Elevated levels of STIM1, an endoplasmic reticulum Ca 2+ sensor/buffering protein, appear to be correlated with poor cancer prognosis in which microRNAs are also known to play critical roles. The purpose of this study is to investigate possible HBV origins of specific microRNAs we identified in a stem cell-like subpopulation of Huh-7 hepatocellular carcinoma (HCC) cell lines with enhanced STIM1 and/or Orai1 expression that mimicked poor cancer prognosis. Computational strategies including phylogenetic analyses were performed on miRNome data we obtained from an EpCAM- and CD133-expressing Huh-7 HCC stem cell-like subpopulation with enhanced STIM1 and/or Orai1 expression originally cultured in the present work. Results revealed two putative regions in the HBV genome based on the apparent clustering pattern of stem loop sequences of microRNAs, including miR3653. Reciprocal analysis of these regions identified critical human genes, of which their transcripts are among the predicted targets of miR3653, which was increased significantly by STIM1 or Orai1 enhancement. Briefly, this study provides phylogenetic evidence for a possible HBV-driven epigenetic remodeling that alters the expression pattern of Ca 2+ homeostasis-associated genes in STIM1 - or Orai1 overexpressing liver cancer stem-like cells for a possible mutual survival outcome. A novel region on HBV-X protein may affect liver carcinogenesis in a genotype-dependent manner. Therefore, detection of the viral genotype would have a clinical impact on prognosis of HBV-induced liver cancers.
Keywords	hepatocellular carcinoma ; HBx ; miR3653 ; epithelial–mesenchymal transition (EMT) ; molecular evolution ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sars-CoV-2 Envelope and Membrane Proteins

Martina Bianchi / Domenico Benvenuto / Marta Giovanetti / Silvia Angeletti / Massimo Ciccozzi / Stefano Pascarella

BioMed Research International, Vol

Structural Differences Linked to Virus Characteristics?

2020 Volume 2020

Abstract: The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural ... ...

Abstract	The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
Keywords	Medicine ; R ; covid19
Subject code	572
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: “Nutripiatto”

Greta Lattanzi / Claudia Di Rosa / Chiara Spiezia / Roberto Sacco / Samanta Cattafi / Leonardo Romano / Domenico Benvenuto / Silvia Fabris / Laura De Gara / Yeganeh Manon Khazrai

PLoS ONE, Vol 18, Iss

A tool for nutritional education. A survey to assess dietary habits in preschool children

2023 Volume 3

Abstract: Childhood obesity is a global public health concern linked to metabolic and psychological comorbidities. There is growing evidence that children’s lifestyle habits are shifting towards obesity, with dire consequences for their future well-being and ... ...

Abstract	Childhood obesity is a global public health concern linked to metabolic and psychological comorbidities. There is growing evidence that children’s lifestyle habits are shifting towards obesity, with dire consequences for their future well-being and healthcare costs. In this interventional study, we enrolled 115 children aged between 4–5 years (53% females and 47% males) and carried out nutrition education interventions to improve their dietary habits. We introduced “Nutripiatto”, a visual plate icon and easy guide, which was used by the children during the study. We investigated the children’s dietary habits using a Food Frequency Questionnaire at the beginning and end of the study, after one month of using “Nutripiatto”. The results showed that the children significantly increased the portion sizes and frequency of vegetable consumption (P<0.001) and reduced the consumption of several junk foods such as French fries and crisps (P<0.001), reaching the recommended dietary allowances and frequency of consumption. Daily consumption of water also significantly increased, reaching the suggested amount of six glasses per day. Based on these results, “Nutripiatto” can be considered an effective visual guide and helpful tool to achieve small changes and empower families to make healthier food choices. It can also be considered an effective educational tool for nutritionists and healthcare professionals to improve children’s dietary behavior.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: "Nutripiatto"

Greta Lattanzi / Claudia Di Rosa / Chiara Spiezia / Roberto Sacco / Samanta Cattafi / Leonardo Romano / Domenico Benvenuto / Silvia Fabris / Laura De Gara / Yeganeh Manon Khazrai

PLoS ONE, Vol 18, Iss 3, p e

A tool for nutritional education. A survey to assess dietary habits in preschool children.

2023 Volume 0282748

Abstract: Childhood obesity is a global public health concern linked to metabolic and psychological comorbidities. There is growing evidence that children's lifestyle habits are shifting towards obesity, with dire consequences for their future well-being and ... ...

Abstract	Childhood obesity is a global public health concern linked to metabolic and psychological comorbidities. There is growing evidence that children's lifestyle habits are shifting towards obesity, with dire consequences for their future well-being and healthcare costs. In this interventional study, we enrolled 115 children aged between 4-5 years (53% females and 47% males) and carried out nutrition education interventions to improve their dietary habits. We introduced "Nutripiatto", a visual plate icon and easy guide, which was used by the children during the study. We investigated the children's dietary habits using a Food Frequency Questionnaire at the beginning and end of the study, after one month of using "Nutripiatto". The results showed that the children significantly increased the portion sizes and frequency of vegetable consumption (P<0.001) and reduced the consumption of several junk foods such as French fries and crisps (P<0.001), reaching the recommended dietary allowances and frequency of consumption. Daily consumption of water also significantly increased, reaching the suggested amount of six glasses per day. Based on these results, "Nutripiatto" can be considered an effective visual guide and helpful tool to achieve small changes and empower families to make healthier food choices. It can also be considered an effective educational tool for nutritionists and healthcare professionals to improve children's dietary behavior.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Greta Lattanzi / Claudia Di Rosa / Chiara Spiezia / Roberto Sacco / Samanta Cattafi / Leonardo Romano / Domenico Benvenuto / Silvia Fabris / Laura De Gara / Yeganeh Manon Khazrai

PLoS ONE, Vol 18, Iss 11, p e

"Nutripiatto": A tool for nutritional education. A survey to assess dietary habits in preschool children.

2023 Volume 0294738

Abstract: This corrects the article DOI:10.1371/journal.pone.0282748.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0282748.].
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phylogeny of Culex theileri virus flavivirus in Spain, Myanmar, Portugal and Turkey

Eleonora Cella / Domenico Benvenuto / Daniele Donati / Francesco Garilli / Silvia Angeletti / Stefano Pascarella / Massimo Ciccozzi

Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 5, Pp 216-

2019 Volume 223

Abstract: Objective: To study the genetic diversity of Culex theileri flavivirus and the spread of this virus among Spain, Portugal and Turkey. Methods: A database consisting of 55 sequences of the NS5/3’UTR region of Culex theileri flavivirus group downloaded ... ...

Abstract	Objective: To study the genetic diversity of Culex theileri flavivirus and the spread of this virus among Spain, Portugal and Turkey. Methods: A database consisting of 55 sequences of the NS5/3’UTR region of Culex theileri flavivirus group downloaded from GenBank were aligned and manual edited with Bioedit. ModelTest v. 3.7 was used to select the simplest evolutionary model that adequately fitted the sequence data. Maximum likelihood analysis was performed using MEGA7. The phylogenetic signal of the dataset was investigated by the likelihood mapping analysis. Results: The phylogenetic tree showed three clusters. Myanmar sequences clusterd together with Turkish sequences, Spain and Portugal strains grouped together and two Turkish sequences grouped separately. Selective pressure analysis showed a moderate percentage of sites (22.5%) under pervasive negative selection and only 1% under pervasive positive selection. The sites subject to selective pressure in CTFV RdRp NS5 fragments have been located onto the predicted three-dimensional structure. Conclusions: Phylogenetic and evolutionary analysis can be an important tool for understanding the evolutionary impact of the probable contemporary existence between non-pathogenic and pathogenic flaviviruses among these vectors.
Keywords	culex virus ; flaviviridae ; phylogenetic analysis ; evolution ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	572
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aero-Medical Evacuation during SARS-CoV-2 Pandemic

Domenico Benvenuto / Tommaso Ascoli Bartoli / Ambrogio Curtolo / Claudia Palazzolo / Serena Vita / Andrea Mariano / Laura Scorzolini / Giuseppe Ippolito / Luisa Marchioni / Federico Cerini / Gianpiero D’Offizi / Francesco Vaia / Emanuele Nicastri

Journal of Clinical Medicine, Vol 12, Iss 1, p

Extraordinary Measure or Emerging Treatment Option?

2022 Volume 133

Abstract: Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the ... ...

Abstract	Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the clinical course of 17 patients medically evacuated to the “L. Spallanzani” Institute in Rome, Italy from foreign countries, mainly Africa and Eastern Europe, who had COVID-19 pneumonia with, or without, coinfections such as malaria, HIV, tuberculosis and microbiologically confirmed sepsis syndrome. The aero-medical evacuation of patients with infectious diseases has become one of the greatest medical achievements we have reached during this pandemic; in fact, only two patients with life threatening coinfections have died. Although logistically difficult and cost consuming, medical evacuation should be considered as a treatment option more than a single extraordinary measure, especially among complex cases that require specific technical and human resources.
Keywords	medical evacuation ; COVID-19 ; infectious diseases ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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