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Article: Contemporary Evidence and Practice on Right Heart Catheterization in Patients with Acute or Chronic Heart Failure.

Manzi, Lina / Sperandeo, Luca / Forzano, Imma / Castiello, Domenico Simone / Florimonte, Domenico / Paolillo, Roberta / Santoro, Ciro / Mancusi, Costantino / Di Serafino, Luigi / Esposito, Giovanni / Gargiulo, Giuseppe

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: Heart failure (HF) has a global prevalence of 1-2%, and the incidence around the world is growing. The prevalence increases with age, from around 1% for those aged ... 10% for those aged 70 years or over. Based on studies in hospitalized ... ...

Abstract	Heart failure (HF) has a global prevalence of 1-2%, and the incidence around the world is growing. The prevalence increases with age, from around 1% for those aged <55 years to >10% for those aged 70 years or over. Based on studies in hospitalized patients, about 50% of patients have heart failure with reduced ejection fraction (HFrEF), and 50% have heart failure with preserved ejection fraction (HFpEF). HF is associated with high morbidity and mortality, and HF-related hospitalizations are common, costly, and impact both quality of life and prognosis. More than 5-10% of patients deteriorate into advanced HF (AdHF) with worse outcomes, up to cardiogenic shock (CS) condition. Right heart catheterization (RHC) is essential to assess hemodynamics in the diagnosis and care of patients with HF. The aim of this article is to review the evidence on RHC in various clinical scenarios of patients with HF.
Language	English
Publishing date	2024-01-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14020136
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Article ; Online: CIR-Based Device-Free People Counting via UWB Signals.

De Sanctis, Mauro / Conte, Aleandro / Rossi, Tommaso / Di Domenico, Simone / Cianca, Ernestina

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 9

Abstract: The outbreak of COVID-19 has resulted in many different policies being adopted across the world to reduce the spread of the virus. These policies include wearing surgical masks, hand hygiene practices, increased social distancing and full country-wide ... ...

Abstract	The outbreak of COVID-19 has resulted in many different policies being adopted across the world to reduce the spread of the virus. These policies include wearing surgical masks, hand hygiene practices, increased social distancing and full country-wide lockdown. Specifically, social distancing involves keeping a certain distance from others and avoiding gathering together in large groups. Automatic crowd density estimation is a technological solution that could help in guaranteeing social distancing by reducing the probability that two persons in a public area come in close proximity to each other while moving around. This paper proposes a novel low complexity RF sensing system for automatic people counting based on low cost UWB transceivers. The proposed system is based on an ordinary classifier that exploits features extracted from the channel impulse response of UWB communication signals. Specifically, features are extracted from the sorted list of singular values obtained from the singular value decomposition applied to the matrix of the channel impulse response vector differences. Experimental results achieved in two different environments show that the proposed system is a promising candidate for future automatic crowd density monitoring systems.
MeSH term(s)	COVID-19 ; Communicable Disease Control ; Hand Hygiene ; Humans ; Masks ; SARS-CoV-2
Language	English
Publishing date	2021-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21093296
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Article ; Online: Salmonella enterica Subsp. houtenae Associated with an Abscess in Young Roe Deer ( Capreolus capreolus )

Adriana Trotta / Laura Del Sambro / Michela Galgano / Stefano Ciccarelli / Erika Ottone / Domenico Simone / Antonio Parisi / Domenico Buonavoglia / Marialaura Corrente

Pathogens, Vol 10, Iss 654, p

2021 Volume 654

Abstract: Background: S. enterica subsp. houtenae has been rarely documented, and very limited genomic information is available. This report describes a rare case of primary extraintestinal salmonellosis in a young roe deer, associated with Salmonella enterica ... ...

Abstract	Background: S. enterica subsp. houtenae has been rarely documented, and very limited genomic information is available. This report describes a rare case of primary extraintestinal salmonellosis in a young roe deer, associated with Salmonella enterica subsp. houtenae. Methods: A traditional cultural-based analysis was carried out from the contents of a neck abscess; biochemical identification and PCR assay were performed to isolate and identify the pathogen. Through whole-genome sequencing (WGS), multilocus sequence typing (MLST), core genome MLST (cgMLST), and the Salmonella pathogenicity islands (SPIs) survey, resistome and virulome genes were investigated to gain insight into the virulence and antimicrobial resistance of S. houtenae . Results: Biochemical identification and PCR confirmed the presence of Salmonella spp. in the swelling. The WGS analysis identified Salmonella enterica subspecies houtenae serovar 43:z4,z23:- and ST 958. The virulence study predicted a multidrug resistance pattern with resistance shown against aminoglycosides, tetracycline, beta-lactamase, fluoroquinolones, fosfomycin, nitroimidazole, aminocoumarin, and peptide. Fifty-three antibiotic-resistant genes were identified. No plasmids were detected. Conclusion: This study demonstrates the importance of continuous surveillance of pathogenic salmonellae. Biomolecular analyses combined with epidemiological data can provide important information about poorly described Salmonella strains and can help to improve animal welfare.
Keywords	extraintestinal salmonellosis ; localized lesion ; abscess ; soft tissue ; roe deer ; AMR resistance ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Energy efficiency and biological interactions define the core microbiome of deep oligotrophic groundwater

Maliheh Mehrshad / Margarita Lopez-Fernandez / John Sundh / Emma Bell / Domenico Simone / Moritz Buck / Rizlan Bernier-Latmani / Stefan Bertilsson / Mark Dopson

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 12

Abstract: Ecological constraints on microbial niches in oligotrophic deep groundwaters remain elusive. This study provides support for the existence of a common core microbiome in two deep groundwater biomes of the Fennoscandian Shield using a genome-resolved, ... ...

Abstract	Ecological constraints on microbial niches in oligotrophic deep groundwaters remain elusive. This study provides support for the existence of a common core microbiome in two deep groundwater biomes of the Fennoscandian Shield using a genome-resolved, integrated omics analysis.
Keywords	Science ; Q
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Emerging Mutations Potentially Related to SARS-CoV-2 Immune Escape

Loredana Capozzi / Domenico Simone / Angelica Bianco / Laura Del Sambro / Valeria Rondinone / Lorenzo Pace / Viviana Manzulli / Michela Iacobellis / Antonio Parisi

Life, Vol 11, Iss 1259, p

The Case of a Long-Term Patient

2021 Volume 1259

Abstract: SARS-CoV-2 isolates from long-term COVID-19 patients play a significant role in understanding the mechanisms of infection and virus persistence. This study describes a SARS-CoV-2 isolate from a 53-year-old woman from Apulia (Italy), who was COVID-19 ... ...

Abstract	SARS-CoV-2 isolates from long-term COVID-19 patients play a significant role in understanding the mechanisms of infection and virus persistence. This study describes a SARS-CoV-2 isolate from a 53-year-old woman from Apulia (Italy), who was COVID-19 positive for approximately four months. In this paper we aimed to investigate any potential correlation between genetic mutations and clinical features of this case of infection. The viral isolate was assigned to lineage B.1.177.51 through whole-genome sequencing (WGS) and harbored a novel set of mutations on the Spike protein (V143D, del144/145 and E484K); furthermore, seroneutralization assays showed impaired response of the surveyed strain to BNT162b2 (Comirnaty) Pfizer/BioNTech vaccine-induced (average reduction of 70%) and convalescent sera (average reduction of 19.04%), when compared to VOC P.1. This study highlights the importance of genomic surveillance for the management of the COVID-19 pandemic, the relevance of monitoring of emerging SARS-CoV-2 mutations in all lineages, and the necessity of testing the response of emerging variants to available therapies and vaccines.
Keywords	COVID-19 ; SARS-CoV-2 ; genomic surveillance ; whole genome sequencing ; Pangolin lineage ; genome mutations ; Science ; Q
Subject code	616
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cangrelor in contemporary patients with ST-segment elevation myocardial infarction pretreated with Ticagrelor: Pharmacodynamic data from the POMPEII study.

Gargiulo, Giuseppe / Cirillo, Plinio / Sperandeo, Luca / Forzano, Imma / Castiello, Domenico Simone / Florimonte, Domenico / Simonetti, Fiorenzo / Paolillo, Roberta / Manzi, Lina / Spinelli, Alessandra / Spaccarotella, Carmen Anna Maria / Piccolo, Raffaele / Di Serafino, Luigi / Franzone, Anna / Capranzano, Piera / Valgimigli, Marco / Esposito, Giovanni

International journal of cardiology. Heart & vasculature

2024 Volume 50, Page(s) 101344

Abstract: Background: There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor.: Methods: The PharmacOdynaMic ... ...

Abstract	Background: There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor. Methods: The PharmacOdynaMic effects of cangrelor in PatiEnts wIth acute or chronIc coronary syndrome undergoing percutaneous coronary intervention (POMPEII) registry (NCT04790032) is a prospective study conducted at Federico II University of Naples enrolling all patients undergoing PCI receiving cangrelor at operator's discretion. PD assessments were performed with 3 assays: (1) the gold standard light transmittance aggregometry (LTA) (20- and 5-μM adenosine diphosphate [ADP] stimuli); (2) VerifyNow P2Y Results: We analyzed 13 STEMI patients pretreated with ticagrelor within 1 h at the time they underwent primary PCI receiving cangrelor. All patients showed low maximal platelet aggregation at 30-minute during cangrelor infusion, as well as at 3 h and 4-6 h (corresponding to 1 h and 2-4 h after stopping cangrelor infusion) with no cases of high residual platelet reactivity. These results were consistent with all assays. Conclusions: PD data show that in contemporary real-world STEMI patients pretreated within 1 h with ticagrelor undergoing primary PCI, adding cangrelor resulted in fast and potent platelet inhibition, thus suggesting that cangrelor may bridge the gap until ticagrelor reaches its effect.
Language	English
Publishing date	2024-01-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2024.101344
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Article: Is There Still a Role for Invasive Assessment of Aortic Gradient?

Angellotti, Domenico / Immobile Molaro, Maddalena / Simonetti, Fiorenzo / Ilardi, Federica / Castiello, Domenico Simone / Mariani, Andrea / Manzo, Rachele / Avvedimento, Marisa / Leone, Attilio / Nappa, Dalila / Piccolo, Raffaele / Losi, Maria Angela / Franzone, Anna / Esposito, Giovanni

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: Advances in technology and imaging have expanded the range of tools for diagnosing aortic stenosis (AS). The accurate assessment of aortic valve area and mean pressure gradient is crucial to determine which patients are appropriate candidates for aortic ... ...

Abstract	Advances in technology and imaging have expanded the range of tools for diagnosing aortic stenosis (AS). The accurate assessment of aortic valve area and mean pressure gradient is crucial to determine which patients are appropriate candidates for aortic valve replacement. Nowadays, these values can be obtained noninvasively or invasively, with similar results. Contrariwise, in the past, cardiac catheterization played a major role in the evaluation of AS severity. In this review, we will discuss the historical role of the invasive assessment of AS. Moreover, we will specifically focus on tips and tricks for properly performing cardiac catheterization in patients with AS. We will also elucidate the role of invasive methods in current clinical practice and their additional value to the information provided through non-invasive techniques.
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13101698
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Article: Renin-angiotensin system inhibitors reduce cardiovascular mortality in hypertensive patients with severe aortic stenosis undergoing transcatheter aortic valve implantation: insights from the EffecTAVI registry.

Basile, Christian / Mancusi, Costantino / Franzone, Anna / Avvedimento, Marisa / Bardi, Luca / Angellotti, Domenico / Castiello, Domenico Simone / Mariani, Andrea / Manzo, Rachele / De Luca, Nicola / Cirillo, Plinio / De Simone, Giovanni / Esposito, Giovanni

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1234368

Abstract: Objectives: Arterial hypertension is associated with the triggering of the renin-angiotensin system, leading to left ventricle fibrosis and worse cardiovascular outcomes. In this study, patients with comorbid arterial hypertension and severe aortic ... ...

Abstract	Objectives: Arterial hypertension is associated with the triggering of the renin-angiotensin system, leading to left ventricle fibrosis and worse cardiovascular outcomes. In this study, patients with comorbid arterial hypertension and severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) were selected from the EffecTAVI registry to evaluate the impact of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on cardiovascular mortality. Methods: We enrolled 327 patients undergoing TAVI from the EffecTAVI registry. Using Kaplan-Meier event rates and study-stratified multivariable Cox proportional hazards regression models, we evaluated 2-year clinical outcomes according to the ACEI/ARB therapy status at enrollment. Results: Among the included patients, 222 (67.9%) were on ACEIs/ARBs at baseline, whereas 105 (32.1%) were not. Treatment with ACEIs/ARBs was significantly associated with a 2-year decrease in the rate of cardiovascular mortality (HR = 0.44, 95% CI: 0.23-0.81, Conclusion: In a cohort of hypertensive patients with severe AS who were selected from the EffecTAVI registry, ACEI/ARB treatment at baseline was found to be independently associated with a lower risk of 2-year cardiovascular mortality, suggesting a potential benefit of this treatment. More trials are needed to validate this finding and to understand the full benefit of this treatment.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1234368
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Article: Echocardiographic Evaluation of Aortic Stenosis: A Comprehensive Review.

Manzo, Rachele / Ilardi, Federica / Nappa, Dalila / Mariani, Andrea / Angellotti, Domenico / Immobile Molaro, Maddalena / Sgherzi, Giulia / Castiello, Domenico Simone / Simonetti, Fiorenzo / Santoro, Ciro / Canonico, Mario Enrico / Avvedimento, Marisa / Piccolo, Raffaele / Franzone, Anna / Esposito, Giovanni

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 15

Abstract: Echocardiography represents the most important diagnostic tool in the evaluation of aortic stenosis. The echocardiographic assessment of its severity should always be performed through a standardized and stepwise approach in order to achieve a ... ...

Abstract	Echocardiography represents the most important diagnostic tool in the evaluation of aortic stenosis. The echocardiographic assessment of its severity should always be performed through a standardized and stepwise approach in order to achieve a comprehensive evaluation. The latest technical innovations in the field of echocardiography have improved diagnostic accuracy, guaranteeing a better and more detailed evaluation of aortic valve anatomy. An early diagnosis is of utmost importance since it shortens treatment delays and improves patient outcomes. Echocardiography plays a key role also in the evaluation of all the structural changes related to aortic stenosis. Detailed evaluation of subtle and subclinical changes in left ventricle function has a prognostic significance: scientific efforts have been addressed to identify the most accurate global longitudinal strain cut-off value able to predict adverse outcomes. Moreover, in recent years the role of artificial intelligence is increasingly emerging as a promising tool able to assist cardiologists in aortic stenosis screening and diagnosis, especially by reducing the rate of aortic stenosis misdiagnosis.
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13152527
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Article ; Online: Acute advanced aortic stenosis.

Avvedimento, Marisa / Angellotti, Domenico / Ilardi, Federica / Leone, Attilio / Scalamogna, Maria / Castiello, Domenico Simone / Manzo, Rachele / Mariani, Andrea / Immobile Molaro, Maddalena / Simonetti, Fiorenzo / Spaccarotella, Carmen Anna Maria / Piccolo, Raffaele / Esposito, Giovanni / Franzone, Anna

Heart failure reviews

2023 Volume 28, Issue 5, Page(s) 1101–1111

Abstract: Acute decompensation often represents the onset of symptoms associated with severe degenerative aortic stenosis (AS) and usually complicates the clinical course of the disease with a dismal impact on survival and quality of life. Several factors may ... ...

Abstract	Acute decompensation often represents the onset of symptoms associated with severe degenerative aortic stenosis (AS) and usually complicates the clinical course of the disease with a dismal impact on survival and quality of life. Several factors may derange the faint balance between left ventricular preload and afterload and precipitate the occurrence of symptoms and signs of acute heart failure (HF). A standardized approach for the management of this condition is currently lacking. Medical therapy finds very limited application in this setting, as drugs usually indicated for the control of acute HF might worsen hemodynamics in the presence of AS. Urgent aortic valve replacement is usually performed by transcatheter than surgical approach whereas, over the last decades, percutaneous balloon valvuloplasty gained renewed space as bridge to definitive therapy. This review focuses on the pathophysiological aspects of acute advanced AS and summarizes current evidence on its management.
MeSH term(s)	Humans ; Quality of Life ; Balloon Valvuloplasty ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/diagnosis ; Aortic Valve/surgery ; Heart Valve Prosthesis ; Heart Failure/therapy ; Heart Failure/complications ; Treatment Outcome
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1336499-6
ISSN	1573-7322 ; 1382-4147
ISSN (online)	1573-7322
ISSN	1382-4147
DOI	10.1007/s10741-023-10312-7
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