Article: Prognostic value of Ki-67 expression in localized cutaneous malignant melanoma.
Journal of the American Academy of Dermatology
2000 Volume 43, Issue 6, Page(s) 991–1000
Abstract: Background: The proliferative activity of some tumors is related to the development of metastatic disease and survival. Thus it could be used as a potential prognostic variable.: Objective: The purpose of this study was to determine the prognostic ... ...
Abstract | Background: The proliferative activity of some tumors is related to the development of metastatic disease and survival. Thus it could be used as a potential prognostic variable. Objective: The purpose of this study was to determine the prognostic value of the Ki-67 index and of a "proliferation-based prognostic index" (PBPI, derived as tumor thickness x Ki-67 index/100) in localized cutaneous malignant melanoma (CMM). Methods: The Ki-67 index (percent of total tumor nuclei) was determined in a series of 84 localized CMMs, with the use of the alkaline phosphatase-antialkaline phosphatase labeling method in formalin-fixed, paraffin-embedded material, and was correlated with other prognostic variables. Survival analysis was performed to determine whether the Ki-67 index and the PBPI could be predictive of metastatic spread or recurrent disease. A stratified analysis of these two parameters according to the tumor thickness was done. Results: An association among the Ki-67 index and location, Clark level, tumor thickness and stage, and prognostic index was detected. Increased Ki-67 index and PBPI were associated with poorer overall survival (P =.03 and P <.0001, respectively) and disease-free survival (P =.01 and P <.0001, respectively). However, after stratification for thickness, only the PBPI showed independent prognostic significance, restricted to tumors thicker than 4 mm (P =. 03). Conclusion: The determination of the PBPI in CMM conveys prognostic information for localized thick (>4 mm) CMM, identifying two groups of patients with distinct outcome. |
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MeSH term(s) | Biomarkers/analysis ; Biopsy, Needle ; Chi-Square Distribution ; Culture Techniques ; Female ; Humans ; Ki-67 Antigen/analysis ; Male ; Melanoma/diagnosis ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/secondary ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Skin Neoplasms/diagnosis ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology |
Chemical Substances | Biomarkers ; Ki-67 Antigen |
Language | English |
Publishing date | 2000-12 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 603641-7 |
ISSN | 1097-6787 ; 0190-9622 |
ISSN (online) | 1097-6787 |
ISSN | 0190-9622 |
DOI | 10.1067/mjd.2000.109282 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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