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  1. Article ; Online: Immunoregulatory Sensory Circuits in Group 3 Innate Lymphoid Cell (ILC3) Function and Tissue Homeostasis.

    Domingues, Rita G / Hepworth, Matthew R

    Frontiers in immunology

    2020  Volume 11, Page(s) 116

    Abstract: Recent years have seen a revolution in our understanding of how cells of the immune system are modulated and regulated not only via complex interactions with other immune cells, but also through a range of ... ...

    Abstract Recent years have seen a revolution in our understanding of how cells of the immune system are modulated and regulated not only via complex interactions with other immune cells, but also through a range of potent
    MeSH term(s) Adaptive Immunity/immunology ; Circadian Clocks/immunology ; Diet ; Gastrointestinal Microbiome/immunology ; Homeostasis/immunology ; Humans ; Immune System Phenomena ; Immunity, Innate/immunology ; Inflammation/immunology ; Intestinal Mucosa/immunology ; Intestines/immunology ; Lymphocytes/immunology ; Neuroimmunomodulation/immunology
    Language English
    Publishing date 2020-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner.

    Papotto, Pedro H / Yilmaz, Bahtiyar / Pimenta, Gonçalo / Mensurado, Sofia / Cunha, Carolina / Fiala, Gina J / Gomes da Costa, Daniel / Gonçalves-Sousa, Natacha / Chan, Brian H K / Blankenhaus, Birte / Domingues, Rita G / Carvalho, Tânia / Hepworth, Matthew R / Macpherson, Andrew J / Allen, Judith E / Silva-Santos, Bruno

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112074

    Abstract: Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient ( ... ...

    Abstract Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ
    MeSH term(s) Animals ; Mice ; Immunity, Innate ; Lymphocytes ; Gastrointestinal Microbiome ; Inflammation ; Lung ; Mice, Inbred C57BL
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit.

    Cardoso, Filipa / Klein Wolterink, Roel G J / Godinho-Silva, Cristina / Domingues, Rita G / Ribeiro, Hélder / da Silva, Joaquim Alves / Mahú, Inês / Domingos, Ana I / Veiga-Fernandes, Henrique

    Nature

    2021  Volume 597, Issue 7876, Page(s) 410–414

    Abstract: Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and ... ...

    Abstract Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and inflammation
    MeSH term(s) Adipose Tissue/cytology ; Adipose Tissue/innervation ; Adipose Tissue/metabolism ; Animals ; Brain/cytology ; Brain/metabolism ; Cues ; Cytokines/metabolism ; Energy Metabolism ; Female ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Gonads/metabolism ; Immunity, Innate/immunology ; Mesoderm/cytology ; Mesoderm/metabolism ; Mice ; Mice, Inbred C57BL ; Neural Pathways ; Neurons/cytology ; Neurons/metabolism ; Obesity/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Proto-Oncogene Proteins c-ret/metabolism ; Receptors, Adrenergic, beta-2/metabolism ; Sympathetic Nervous System/cytology ; Sympathetic Nervous System/metabolism
    Chemical Substances Cytokines ; Glial Cell Line-Derived Neurotrophic Factor ; Receptors, Adrenergic, beta-2 ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; Ret protein, mouse (EC 2.7.10.1)
    Language English
    Publishing date 2021-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03830-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stroma cell priming in enteric lymphoid organ morphogenesis.

    Ferreira, Manuela / Domingues, Rita G / Veiga-Fernandes, Henrique

    Frontiers in immunology

    2012  Volume 3, Page(s) 219

    Abstract: The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses. The development of these peripheral secondary lymphoid organs (SLO) occurs mainly ... ...

    Abstract The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses. The development of these peripheral secondary lymphoid organs (SLO) occurs mainly in utero, while tertiary lymphoid structures can form in adulthood generally in response to persistent infection and inflammation. Regardless of the lymphoid tissue and intrinsic cellular and molecular differences, it is now well established that the recruitment of fully functional lymphoid tissue inducer (LTi) cells to presumptive lymphoid organ sites, and their consequent close and reciprocal interaction with resident stroma cells, are central to SLO formation. In contrast, the nature of events that initially prime resident sessile stroma cells to recruit and retain LTi cells remains poorly understood. Recently, new findings revealed early phases of SLO development putting emphasis on mesenchymal and lymphoid tissue initiator cells. Herein we discuss the main tenets of enteric lymphoid organs genesis and focus in the most recent findings that open new perspectives to the understanding of the early phases of lymphoid morphogenesis.
    Language English
    Publishing date 2012-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2012.00219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism.

    Penny, Hugo A / Domingues, Rita G / Krauss, Maria Z / Melo-Gonzalez, Felipe / Lawson, Melissa A E / Dickson, Suzanna / Parkinson, James / Hurry, Madeleine / Purse, Catherine / Jegham, Emna / Godinho-Silva, Cristina / Rendas, Miguel / Veiga-Fernandes, Henrique / Bechtold, David A / Grencis, Richard K / Toellner, Kai-Michael / Waisman, Ari / Swann, Jonathan R / Gibbs, Julie E /
    Hepworth, Matthew R

    Science immunology

    2022  Volume 7, Issue 75, Page(s) eabk2541

    Abstract: Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits and promote tissue health and homeostasis. Immunoglobulin A (IgA) responses directly determine the ... ...

    Abstract Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits and promote tissue health and homeostasis. Immunoglobulin A (IgA) responses directly determine the composition of commensal species that colonize the intestinal tract but require substantial metabolic resources to fuel antibody production by tissue-resident plasma cells. Here, we demonstrate that IgA responses are subject to diurnal regulation over the course of a circadian day. Specifically, the magnitude of IgA secretion, as well as the transcriptome of intestinal IgA
    MeSH term(s) Animals ; Immunoglobulin A, Secretory ; Intestines ; Mammals ; Microbiota ; Periodicity ; Symbiosis
    Chemical Substances Immunoglobulin A, Secretory
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abk2541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cell Cycle Kinase Polo Is Controlled by a Widespread 3′ Untranslated Region Regulatory Sequence in Drosophila melanogaster

    Oliveira, Marta S. / Freitas, Jaime / Pinto, Pedro A. B. / de Jesus, Ana / Tavares, Joana / Pinho, Mafalda / Domingues, Rita G. / Henriques, Telmo / Lopes, Carla / Conde, Carlos / Sunkel, Claudio E. / Moreira, Alexandra

    Molecular and Cellular Biology. 2019 Aug. 1, v. 39, no. 15 p.e00581-18-

    2019  

    Abstract: Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3′ ... ...

    Abstract Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3′ untranslated region (3′UTR), with critical physiological consequences. Here, we characterized the molecular mechanisms required for polo alternative polyadenylation. We identified a conserved upstream sequence element (USE) close to the polo proximal poly(A) signal. Transgenic flies without this sequence show incorrect selection of polo poly(A) signals with consequent downregulation of Polo expression levels and insufficient/defective activation of Polo kinetochore targets Mps1 and Aurora B. Deletion of the USE results in abnormal mitoses in neuroblasts, revealing a role for this sequence in vivo. We found that Hephaestus binds to the USE RNA and that hephaestus mutants display defects in polo alternative polyadenylation concomitant with a striking reduction in Polo protein levels, leading to mitotic errors and aneuploidy. Bioinformatic analyses show that the USE is preferentially localized upstream of noncanonical polyadenylation signals in Drosophila melanogaster genes. Taken together, our results revealed the molecular mechanisms involved in polo alternative polyadenylation, with remarkable physiological functions in Polo expression and activity at the kinetochores, and disclosed a new in vivo function for USEs in Drosophila melanogaster.
    Keywords Drosophila melanogaster ; RNA ; aneuploidy ; bioinformatics ; genetically modified organisms ; kinetochores ; mitosis ; transcriptomics ; 3′UTR ; alternative polyadenylation ; Heph/PTBP1 ; USE ; cell cycle ; cis regulatory sequences ; Polo
    Language English
    Dates of publication 2019-0801
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00581-18
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.

    Oliveira, Marta S / Freitas, Jaime / Pinto, Pedro A B / de Jesus, Ana / Tavares, Joana / Pinho, Mafalda / Domingues, Rita G / Henriques, Telmo / Lopes, Carla / Conde, Carlos / Sunkel, Claudio E / Moreira, Alexandra

    Molecular and cellular biology

    2019  Volume 39, Issue 15

    Abstract: Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3' ... ...

    Abstract Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3' untranslated region (3'UTR), with critical physiological consequences. Here, we characterized the molecular mechanisms required for
    MeSH term(s) 3' Untranslated Regions ; Animals ; Base Sequence ; Conserved Sequence ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Gene Expression Regulation, Developmental ; Mitosis ; Polyadenylation ; Polypyrimidine Tract-Binding Protein/metabolism ; Protein-Serine-Threonine Kinases/chemistry ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Deletion
    Chemical Substances 3' Untranslated Regions ; Drosophila Proteins ; Heph protein, Drosophila ; RNA, Messenger ; Polypyrimidine Tract-Binding Protein (139076-35-0) ; polo protein, Drosophila (EC 2.7.11.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00581-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.

    Godinho-Silva, Cristina / Domingues, Rita G / Rendas, Miguel / Raposo, Bruno / Ribeiro, Hélder / da Silva, Joaquim Alves / Vieira, Ana / Costa, Rui M / Barbosa-Morais, Nuno L / Carvalho, Tânia / Veiga-Fernandes, Henrique

    Nature

    2019  Volume 574, Issue 7777, Page(s) 254–258

    Abstract: Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, microbiota composition and ... ...

    Abstract Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, microbiota composition and metabolism
    MeSH term(s) ARNTL Transcription Factors/deficiency ; ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Animals ; Biological Clocks/genetics ; Biological Clocks/radiation effects ; Brain/physiology ; Brain/radiation effects ; Circadian Rhythm/genetics ; Circadian Rhythm/immunology ; Circadian Rhythm/physiology ; Circadian Rhythm/radiation effects ; Cues ; Feeding Behavior/radiation effects ; Female ; Gastrointestinal Microbiome/radiation effects ; Homeostasis/radiation effects ; Immunity, Innate/radiation effects ; Intestines/cytology ; Intestines/immunology ; Intestines/radiation effects ; Light ; Lipid Metabolism ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Lymphocytes/radiation effects ; Male ; Mice ; Photoperiod
    Chemical Substances ARNTL Transcription Factors ; Bmal1 protein, mouse
    Language English
    Publishing date 2019-09-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1579-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Author Correction: Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.

    Godinho-Silva, Cristina / Domingues, Rita G / Rendas, Miguel / Raposo, Bruno / Ribeiro, Hélder / da Silva, Joaquim Alves / Vieira, Ana / Costa, Rui M / Barbosa-Morais, Nuno L / Carvalho, Tânia / Veiga-Fernandes, Henrique

    Nature

    2019  Volume 576, Issue 7786, Page(s) E4

    Abstract: An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-11-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1757-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T

    Mayer, Johannes U / Hilligan, Kerry L / Chandler, Jodie S / Eccles, David A / Old, Samuel I / Domingues, Rita G / Yang, Jianping / Webb, Greta R / Munoz-Erazo, Luis / Hyde, Evelyn J / Wakelin, Kirsty A / Tang, Shiau-Choot / Chappell, Sally C / von Daake, Sventja / Brombacher, Frank / Mackay, Charles R / Sher, Alan / Tussiwand, Roxane / Connor, Lisa M /
    Gallego-Ortega, David / Jankovic, Dragana / Le Gros, Graham / Hepworth, Matthew R / Lamiable, Olivier / Ronchese, Franca

    Nature immunology

    2022  Volume 23, Issue 6, Page(s) 985

    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01203-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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