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  1. Article ; Online: Overview of Current Hepatocellular Carcinoma Staging Systems: Is There an Optimal System?

    Chavez-Villa, Mariana / Domínguez-Rosado, Ismael

    Surgical oncology clinics of North America

    2023  Volume 33, Issue 1, Page(s) 29–41

    Abstract: Multiple hepatocellular carcinoma (HCC) staging systems have been proposed and used clinically over time. These may consider clinical, pathological, radiological, or treatment response factors, depending on the model. Given the heterogeneity of HCC ... ...

    Abstract Multiple hepatocellular carcinoma (HCC) staging systems have been proposed and used clinically over time. These may consider clinical, pathological, radiological, or treatment response factors, depending on the model. Given the heterogeneity of HCC treatment in its different stages and the validation of the systems in different populations, they are not universal. Likewise, the improvement in diagnostic tools, as well as novel therapeutic alternatives, have made these models more complex. Despite this, some have been modified over time in line with advances in the field, and although there is no universally accepted one, each has its usefulness, strengths, and weaknesses.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/pathology ; Neoplasm Staging
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.06.010
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  2. Article ; Online: Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on postoperative day three as a biochemical predictor of clinically significant pancreatic fistula in patients undergoing distal pancreatectomy.

    Sánchez-Morales, G E / Cisneros-Correa, J / Lanzagorta-Ortega, D / Pérez-Soto, R H / Domínguez-Rosado, I / Chan, C

    Revista de gastroenterologia de Mexico (English)

    2023  Volume 89, Issue 1, Page(s) 42–51

    Abstract: Introduction and aims: Distal pancreatectomy is a frequent procedure and postoperative fistula, its most common complication, has an incidence of 30 to 60%. The aim of the present work was to study the role of the neutrophil-to-lymphocyte ratio and the ... ...

    Abstract Introduction and aims: Distal pancreatectomy is a frequent procedure and postoperative fistula, its most common complication, has an incidence of 30 to 60%. The aim of the present work was to study the role of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio, as indicators of inflammatory response in the setting of pancreatic fistula.
    Methods: A retrospective observational study was conducted on patients that underwent distal pancreatectomy. The diagnosis of postoperative pancreatic fistula was made according to the definition proposed by the International Study Group on Pancreatic Fistula. The relation of postoperative pancreatic fistula to the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio was determined in the postoperative evaluation. SPSS v.21 software was utilized for the statistical analysis and a P<.05 was considered statistically significant.
    Results: A total of 12 patients (27.2%) developed grade B or grade C postoperative pancreatic fistula. ROC curves were constructed and a threshold of 8.3 (PPV 0.40, NPV 0.86) was established for the neutrophil-to-lymphocyte ratio, with an area under the curve of 0.71, sensitivity of 0.81, and specificity of 0.62, whereas a threshold of 33.2 (PPV 0.50, NPV 0.84) was established for the platelet-to-lymphocyte ratio, with an area under the curve of 0.72, sensitivity of 0.72, and specificity of 0.71.
    Conclusion: The neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio are serologic markers that can aid in identifying patients that will present with grade B or grade C postoperative pancreatic fistula, thus helping to provide an opportune focus on care and resources.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Pancreatic Fistula/etiology ; Pancreatic Fistula/complications ; Neutrophils ; ROC Curve ; Lymphocytes ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-03-25
    Publishing country Mexico
    Document type Observational Study ; Journal Article
    ZDB-ID 2828765-4
    ISSN 2255-534X ; 2255-534X
    ISSN (online) 2255-534X
    ISSN 2255-534X
    DOI 10.1016/j.rgmxen.2023.03.004
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  3. Article ; Online: Laparoscopic hepatectomy of a hydatid cyst.

    Cisneros-Correa, J / González-Espinoza, K A / Domínguez-Rosado, I

    Revista de gastroenterologia de Mexico (English)

    2020  Volume 86, Issue 2, Page(s) 188–190

    Title translation Hepatectomía laparoscópica de quiste hidatídico.
    MeSH term(s) Echinococcosis ; Hepatectomy ; Humans ; Laparoscopy
    Language Spanish
    Publishing date 2020-09-28
    Publishing country Mexico
    Document type Case Reports
    ZDB-ID 2828765-4
    ISSN 2255-534X ; 2255-534X
    ISSN (online) 2255-534X
    ISSN 2255-534X
    DOI 10.1016/j.rgmx.2020.07.008
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  4. Article: THE FUTURE OF TECHNOLOGY AND ROBOTICS IN SURGERY.

    Domínguez-Rosado, Ismael / Mercado, Miguel A

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2021  Volume 73, Issue 5, Page(s) 326–328

    Abstract: In the past three decades, several technologies designed for other purposes, have been applied in surgery to provide more precision to the surgical procedures and better outcomes. In surgery, innovation requires evidence before widespread implementation ... ...

    Abstract In the past three decades, several technologies designed for other purposes, have been applied in surgery to provide more precision to the surgical procedures and better outcomes. In surgery, innovation requires evidence before widespread implementation of novelties and a continuous quality improvement process to assess benefits and risks. Robotics in surgery has been widely implemented, but in some cases, there are many doubts regarding its clinical benefit and cost utility. The future of surgery lies in the fulfillment of four main conditions: safety, access, efficiency, and efficacy. Innovation and technology should help to accomplish these conditions, but it must not be the center of surgical practice. We present here our perspective on the main issues related to technology and robotics focusing on evidence-based surgery.
    MeSH term(s) General Surgery/trends ; Humans ; Robotic Surgical Procedures ; Robotics ; Technology
    Language English
    Publishing date 2021-10-05
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.21000304
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  5. Article ; Online: BILE DUCT INJURY REPAIR IN A PATIENT WITH SITUS INVERSUS TOTALIS.

    Meira-Júnior, José Donizeti / Ramos-Aranda, Javier / Carrillo-Vidales, Javier / Velásquez-Coria, Erik Rodrigo / Mercado, Miguel Angel / Dominguez-Rosado, Ismael

    Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

    2024  Volume 37, Page(s) e1795

    Abstract: Background: Bile duct injury (BDI) causes significant sequelae for the patient in terms of morbidity, mortality, and long-term quality of life, and should be managed in centers with expertise. Anatomical variants may contribute to a higher risk of BDI ... ...

    Abstract Background: Bile duct injury (BDI) causes significant sequelae for the patient in terms of morbidity, mortality, and long-term quality of life, and should be managed in centers with expertise. Anatomical variants may contribute to a higher risk of BDI during cholecystectomy.
    Aims: To report a case of bile duct injury in a patient with situs inversus totalis.
    Methods: A 42-year-old female patient with a previous history of situs inversus totalis and a BDI was initially operated on simultaneously to the lesion ten years ago by a non-specialized surgeon. She was referred to a specialized center due to recurrent episodes of cholangitis and a cholestatic laboratory pattern. Cholangioresonance revealed a severe anastomotic stricture. Due to her young age and recurrent cholangitis, she was submitted to a redo hepaticojejunostomy with the Hepp-Couinaud technique. To the best of our knowledge, this is the first report of BDI repair in a patient with situs inversus totalis.
    Results: The previous hepaticojejunostomy was undone and remade with the Hepp-Couinaud technique high in the hilar plate with a wide opening in the hepatic confluence of the bile ducts towards the left hepatic duct. The previous Roux limb was maintained. Postoperative recovery was uneventful, the drain was removed on the seventh post-operative day, and the patient is now asymptomatic, with normal bilirubin and canalicular enzymes, and no further episodes of cholestasis or cholangitis.
    Conclusions: Anatomical variants may increase the difficulty of both cholecystectomy and BDI repair. BDI repair should be performed in a specialized center by formal hepato-pancreato-biliary surgeons to assure a safe perioperative management and a good long-term outcome.
    MeSH term(s) Humans ; Female ; Adult ; Quality of Life ; Bile Ducts/surgery ; Bile Ducts/injuries ; Cholecystectomy/methods ; Cholangitis/complications ; Cholangitis/surgery ; Cholestasis/surgery ; Situs Inversus/complications ; Situs Inversus/surgery ; Cholecystectomy, Laparoscopic/methods
    Language English
    Publishing date 2024-03-18
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ISSN 2317-6326
    ISSN (online) 2317-6326
    DOI 10.1590/0102-672020240002e1795
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  6. Article: Precision Oncology in Pancreatic Cancer. From Surgery- to Genetic-Based Chemotherapy.

    Domínguez-Rosado, Ismael / Meléndez-Zajgla, Jorge

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2020  Volume 72, Issue 6, Page(s) 333–336

    Abstract: Pancreatic ductal adenocarcinoma is one of the most lethal forms of solid tumors. These tumors arise from the exocrine component of the pancreas, probably from acinar stem cells1-3. ...

    Abstract Pancreatic ductal adenocarcinoma is one of the most lethal forms of solid tumors. These tumors arise from the exocrine component of the pancreas, probably from acinar stem cells1-3.
    MeSH term(s) Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/surgery ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/surgery ; Precision Medicine ; Pancreatic Neoplasms
    Language English
    Publishing date 2020-12-22
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.20000233
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  7. Article ; Online: Postoperative liver function tests can predict anastomotic dysfunction after bile duct injury repair.

    Sánchez-Morales, Germán / Castro, Emma / Domínguez-Rosado, Ismael / Vilatoba, Mario / Contreras, Alan / Mercado, Miguel

    Updates in surgery

    2022  Volume 74, Issue 3, Page(s) 937–944

    Abstract: Liver function tests help in the follow-up of postoperative patients with iatrogenic bile duct injury. There is not clear evidence regarding their predictive role on anastomosis dysfunction. We describe our experience with postoperative liver function ... ...

    Abstract Liver function tests help in the follow-up of postoperative patients with iatrogenic bile duct injury. There is not clear evidence regarding their predictive role on anastomosis dysfunction. We describe our experience with postoperative liver function tests and a predictive model of long-term patency after repair. This is retrospective cohort study of patients with bilioenteric anastomosis for bile duct injury and their long-term follow-up. A binomial logistic regression model was performed to ascertain the effects of the grade of bile duct injury and liver function test in the postoperative period. A total of 329 patients were considered for the analysis. In the logistic regression model two predictor variables were statistically significant for anastomosis stenosis: type of bilioenteric anastomosis and alkaline phosphatase levels. A ROC curve analysis was made for alkaline phosphatase with an area under the curve of 0.758 (95% CI 0.67-0.84). A threshold of 323 mg/dL was established (OR 6.0, 95% CI 2.60-13.83) with a sensitivity of 75%, specificity of 67%, PPV of 20%, NPV of 96%, PLR of 2.27 and NLR of 0.37. Increased alkaline phosphatase (above 323 mg/dL) after the fourth operative week was found to be a predictor of long-term dysfunction.
    MeSH term(s) Alkaline Phosphatase ; Anastomosis, Surgical/adverse effects ; Bile Duct Diseases/surgery ; Bile Ducts/injuries ; Bile Ducts/surgery ; Humans ; Liver Function Tests ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Period ; Retrospective Studies
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2022-04-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01275-9
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  8. Article ; Online: Resección quirúrgica y sobrevida de metástasis de cáncer renal de células claras a páncreas.

    Sánchez-Morales, Germán E / Osorio-Serrano, Jorge L / Guerrero-Gómez, Alan / Chan, Carlos / Domínguez-Rosado, Ismael

    Cirugia y cirujanos

    2023  

    Abstract: Introduction: Pancreas is considered one of the organs most frequently affected by recurrence after nephrectomy secondary to renal cell carcinoma reporting an incidence of 20%, 85% of these occur within the first 3 years.: Objective: The objective of ...

    Title translation Surgical resection and survival of clear cell renal cancer metastases to the pancreas.
    Abstract Introduction: Pancreas is considered one of the organs most frequently affected by recurrence after nephrectomy secondary to renal cell carcinoma reporting an incidence of 20%, 85% of these occur within the first 3 years.
    Objective: The objective of the study is to evaluate overall survival and disease-free survival in patients with renal cancer and pancreatic metastases who underwent surgical treatment.
    Methods: A retrospective cross-sectional study of patients with histological diagnosis of renal cancer associated with pancreatic metastasis was performed and included those treated by pancreatoduodenectomy or distal pancreatectomy during the period 1987-2020.
    Results: 14 patients with pancreatic metastasis were included. Two groups of patients were obtained: those who underwent pancreatic surgery for metastasis and those who did not undergo surgical procedure. According to the location of the metastasis, 71.4% corresponded to a single location and 28.6% to multiple locations. 57.1% underwent Whipple and 42.9% distal pancreatectomy. Survival after the surgical procedure was 1150 days versus 499 days in non-operated patients.
    Conclusion: Pancreatic metastases due to RCC can be curable, improve morbidity, and increase disease-free survival with surgical treatment.
    Language Spanish
    Publishing date 2023-10-02
    Publishing country Mexico
    Document type English Abstract ; Journal Article
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.22000379
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  9. Article ; Online: Completely laparoscopic left hepatectomy due to biliary mucinous cystadenoma.

    Rueda de León, A / González-Espinoza, K A / Cisneros-Correa, J / Del Ángel-Millán, G / Domínguez-Rosado, I

    Revista de gastroenterologia de Mexico (English)

    2020  Volume 86, Issue 2, Page(s) 208–210

    Title translation Hepatectomía izquierda totalmente laparoscópica por cistoadenoma biliar mucinoso.
    MeSH term(s) Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/surgery ; Cystadenoma, Mucinous/diagnostic imaging ; Cystadenoma, Mucinous/surgery ; Hepatectomy ; Humans ; Laparoscopy
    Language Spanish
    Publishing date 2020-11-26
    Publishing country Mexico
    Document type Case Reports
    ZDB-ID 2828765-4
    ISSN 2255-534X ; 2255-534X
    ISSN (online) 2255-534X
    ISSN 2255-534X
    DOI 10.1016/j.rgmx.2020.06.002
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  10. Article ; Online: Comment on "Early Versus Delayed Surgical Repair and Referral for Patients With Bile Duct Injury: A Systematic Review and Meta-Analysis".

    Rueda-De-Leon, Alexandra / Domínguez-Rosado, Ismael / Mercado, Miguel Angel

    Annals of surgery

    2020  Volume 274, Issue 6, Page(s) e756

    MeSH term(s) Bile Duct Diseases ; Bile Ducts/surgery ; Humans ; Referral and Consultation
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003954
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