Article: Prise en charge du syndrome des anticorps antiphospholipides chez l’adulte.
2020 Volume 16, Issue 689, Page(s) 670–674
Abstract: The antiphospholipid syndrome (APS) is a complex autoimmune -disease characterized by the expression of antiphospholipid -antibodies (APL) and a variety of clinical presentation. The latest classification defines APS by the occurrence of vascular ... ...
| Title translation | Management of the antiphospholipid syndrome in adults. | |||||
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| Abstract | The antiphospholipid syndrome (APS) is a complex autoimmune -disease characterized by the expression of antiphospholipid -antibodies (APL) and a variety of clinical presentation. The latest classification defines APS by the occurrence of vascular thrombosis and/or typical obstetrical morbidity together with persistently -detectable APL at least 12 weeks apart. The latest recommendation proposes a risk profile based on the type and titer of APL detected, in order to guide the intensity of prophylactic measures. Based on current knowledge, novel oral anticoagulants should not be used in APS, particularly in patients with a high-risk APL profile or arterial thrombosis. Beyond the mere aspect of anticoagulant treatment, immunomodulatory approaches to the APS such as hydroxychloroquine are under investigation. |
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| MeSH term(s) | Adult ; Antibodies, Antiphospholipid/blood ; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/drug therapy ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Knowledge ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/drug therapy ; Risk Factors ; Thrombosis/blood ; Thrombosis/drug therapy ; Thrombosis/etiology | |||||
| Chemical Substances | Antibodies, Antiphospholipid ; Anticoagulants ; Hydroxychloroquine (4QWG6N8QKH) | |||||
| Language | French | |||||
| Publishing date | 2020-04-09 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2177010-4 | |||||
| ISSN | 1660-9379 | |||||
| ISSN | 1660-9379 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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