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  1. Article ; Online: Neither too much nor too little

    Donato D’Angelo / Denis Vecellio Reane / Anna Raffaello

    Frontiers in Molecular Biosciences, Vol

    mitochondrial calcium concentration as a balance between physiological and pathological conditions

    2023  Volume 10

    Abstract: Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+) is a key regulator of oxidative metabolism and cell death. ... ...

    Abstract Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+) is a key regulator of oxidative metabolism and cell death. MitCa2+ uptake is mediated by the mitochondrial Ca2+ uniporter complex (MCUc) localized in the inner mitochondrial membrane (IMM). MitCa2+ uptake stimulates the activity of three key enzymes of the Krebs cycle, thereby modulating ATP production and promoting oxidative metabolism. As Paracelsus stated, “Dosis sola facit venenum,”in pathological conditions, mitCa2+ overload triggers the opening of the mitochondrial permeability transition pore (mPTP), enabling the release of apoptotic factors and ultimately leading to cell death. Excessive mitCa2+ accumulation is also associated with a pathological increase of reactive oxygen species (ROS). In this article, we review the precise regulation and the effectors of mitCa2+ in physiopathological processes.
    Keywords mitochondria ; calcium ; mitochondrial calcium uniporter (MCU) ; cell death ; metabolism ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Concept of healing of recurrent shoulder dislocation

    Donato D'Angelo

    Revista Brasileira de Ortopedia, Vol 49, Iss 4, Pp 420-

    2014  Volume 425

    Abstract: This paper presents the main surgical techniques applied in the treatment of anterior recurrent shoulder dislocation, aiming the achievement of the normality of articulate movements. This was obtained by combining distinct surgical procedures, which ... ...

    Abstract This paper presents the main surgical techniques applied in the treatment of anterior recurrent shoulder dislocation, aiming the achievement of the normality of articulate movements. This was obtained by combining distinct surgical procedures, which allowed the recovery of a complete functional capacity of the shoulder, without jeopardizing the normality of movement, something that has not been recorded in the case of the tense sutures of the surgical procedures of Putti-Platt, Bankart, Latarjet, Dickson-O'Dell and others.The careful review of the methods applied supports the conclusion that recurrent shoulder dislocation can be cured, since cure has been obtained in 97% of the treated cases. However, some degree of limitation in the shoulder movement has been observed in most of the treated cases.Our main goal was to achieve a complete shoulder functional recovery, by treating simultaneously all of the anatomical–pathological lesions, without considering the so-called essential lesions.The period of post-operatory immobilization only last for the healing of soft parts; this takes place in a position of neutral shoulder rotation, since the use of vascular bone graft eliminates the need for long time immobilization, due to the shoulder stabilization provided by rigid fixation of the coracoid at the glenoid edge, as in the Latarjet's technique.Our procedure, used since 1959, comprises the association of several techniques, which has permitted shoulder healing without movement limitation. That was because of the tension reduction in the sutures of the subescapularis, capsule, and coracobraquialis muscles.
    Keywords Luxação do ombro/cirurgia ; Articulação do ombro/cirurgia ; Instabilidade articular ; Medicine ; R ; Orthopedic surgery ; RD701-811
    Language English
    Publishing date 2014-08-01T00:00:00Z
    Publisher Sociedade Brasileira de Ortopedia e Traumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Artroplastia total do quadril pelos acessos lateral direto e póstero-lateral

    Marco Antonio Rocha Afonso / José Sérgio Franco / Fernando José Pina Cabral / Mario Donato D'Angelo / Francisco Robson Vasconcelos Alves

    Acta Ortopédica Brasileira, Vol 16, Iss 2, Pp 74-

    comparação da função de marcha pós operatória Direct lateral and posterolateral approaches for total hip arthroplasty: comparison of postoperative gait function

    2008  Volume 80

    Abstract: Devido ao espantoso desenvolvimento dos materiais cirúrgicos e ao aumento da longevidade da população o procedimento de artoplastia total do quadril vem se tornando cada vez mais freqüente. As técnicas cirúrgicas muito se desenvolveram nos últimos anos, ... ...

    Abstract Devido ao espantoso desenvolvimento dos materiais cirúrgicos e ao aumento da longevidade da população o procedimento de artoplastia total do quadril vem se tornando cada vez mais freqüente. As técnicas cirúrgicas muito se desenvolveram nos últimos anos, entretanto ainda existem controvérsias a serem resolvidas. Nesse artigo o autor realizou a comparação da função de marcha de 33 pacientes submetidos a artroplastia total do quadril pelos acessos lateral e póstero-lateral. Para isso, analisou a função cinemática e a ocorrência do sinal de Trendelenburg em laboratório de marcha de pacientes com pelo menos um ano de pós operatório. Após o estudo verificou que não houve diferenças significativas entre os acessos para os parâmetros analisados. With the overwhelming development of surgical materials and the longer life expectancy of the world population, total hip arthroplasty procedures have been increasingly frequent. Although surgical techniques have greatly improved in recent years, some controversies are still unsolved. In this study, the author compared the gait function in 33 patients submitted to a total hip arthroplasty through lateral and posterolateral approaches. Gait analysis was used to quantify kinematics data and detect the presence of Trendelenburg sign on patients with at least one year of follow-up. In the study, there were no significant differences between both surgical approaches concerning the studied parameters.
    Keywords Artroplastia de quadril ; Marcha ; Estudo comparativo ; Arthroplasty ; Replacement ; Hip ; Gait ; Comparative study ; Medicine ; R ; Orthopedic surgery ; RD701-811
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Ortopedia e Traumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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