LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Increased breast cancer mortality due to treatment delay and needle biopsy type: a retrospective analysis of SEER-medicare.

    Pathak, Rashmi / Leslie, Macall / Dondapati, Priya / Davis, Rachel / Tanaka, Kenichi / Jett, Elizabeth / Chervoneva, Inna / Tanaka, Takemi

    Breast cancer (Tokyo, Japan)

    2023  Volume 30, Issue 4, Page(s) 627–636

    Abstract: Background: Substantial evidence indicates that delay of first treatment after diagnosis is associated with poorer survival outcomes in breast cancer. Accordingly, the Commission on Cancer introduced a quality measure for receipt of therapeutic surgery ... ...

    Abstract Background: Substantial evidence indicates that delay of first treatment after diagnosis is associated with poorer survival outcomes in breast cancer. Accordingly, the Commission on Cancer introduced a quality measure for receipt of therapeutic surgery within 60 days of diagnostic biopsy for stage I-III breast cancer patients in the non-neoadjuvant setting. It is unknown, however, what may contribute to mortality associated with treatment delay. Therefore, we investigated whether biopsy type moderates the effect of the mortality risk posed by treatment delay.
    Methods: Retrospective analysis of 31,306 women with stage I-III breast cancer diagnosed between 2003 and 2013 selected from the SEER-Medicare database was performed to determine whether needle biopsy type [core needle biopsy (CNB) or vacuum-assisted biopsy (VAB)] impacts time to treatment (TTT)-associated survival outcomes. Multivariable Fine-Gray competing risk survival models, adjusted for inverse propensity score weights, were used to determine the association between biopsy type, TTT, and breast cancer-specific mortality (BCSM).
    Results: TTT ≥ 60 days was associated with 45% higher risk of BCSM (sHR = 1.45, 95% CI 1.24-1.69) compared to those with TTT < 60 days in stage I-III cases. Independent of TTT, CNB was associated with 28% higher risk of BCSM compared to VAB in stage II-III cases (sHR = 1.28, 95% CI 1.11-1.36), translating to a 2.7% and 4.0% absolute difference in BCSM at 5 and 10 years, respectively. However, in stage I cases, the BCSM risk was not associated with type of biopsy.
    Conclusions: Our results suggest that treatment delay ≥ 60 days is independently associated with poorer survival outcomes in breast cancer patients. In stage II-III, CNB is associated with higher BCSM than VAB. However, type of biopsy does not underlie TTT-associated breast cancer mortality risk.
    MeSH term(s) United States/epidemiology ; Female ; Humans ; Aged ; Breast Neoplasms/therapy ; Breast Neoplasms/pathology ; Time-to-Treatment ; Retrospective Studies ; Medicare ; Breast/pathology ; Biopsy, Large-Core Needle/methods
    Language English
    Publishing date 2023-05-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-023-01456-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5536: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay.

    Kameyama, Hiroyasu / Dondapati, Priya / Simmons, Reese / Leslie, Macall / Langenheim, John F / Sun, Yunguang / Yi, Misung / Rottschaefer, Aubrey / Pathak, Rashmi / Nuguri, Shreya / Fung, Kar-Ming / Tsaih, Shirng-Wern / Chervoneva, Inna / Rui, Hallgeir / Tanaka, Takemi

    Cell reports. Medicine

    2023  Volume 4, Issue 12, Page(s) 101330

    Abstract: Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a ... ...

    Abstract Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis. We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the COX-2/PGE
    MeSH term(s) Humans ; Animals ; Mice ; Female ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cyclooxygenase 2 ; Biopsy, Needle
    Chemical Substances Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101330
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Sustained Inflammation of Breast Tumors after Needle Biopsy.

    McCarty, Cruz / Yi, Misung / Sous, Senna / Leslie, Macall / Tariq, Ezza / Dondapati, Priya / Kameyama, Hiroyasu / Nuguri, Shreya / Hills, Natalie / Wilkerson, Marielle / Davis, Rachel / Mesiya, Sidra / Rui, Hallgeir / Chervoneva, Inna / Zhang, Roy / Tanaka, Takemi

    Pathobiology : journal of immunopathology, molecular and cellular biology

    2022  Volume 90, Issue 2, Page(s) 114–122

    Abstract: Introduction: Needle biopsy is essential for definitive diagnosis of breast malignancy. Significant histologic changes due to tissue damage have been reported in solid tumors. This study investigated the association between time from needle biopsy and ... ...

    Abstract Introduction: Needle biopsy is essential for definitive diagnosis of breast malignancy. Significant histologic changes due to tissue damage have been reported in solid tumors. This study investigated the association between time from needle biopsy and inflammation in breast tumors.
    Methods: A total of 73 stage I-II invasive breast cancer cases diagnosed by image-guided needle biopsy who had surgery as their first definitive treatment were retrospectively analyzed. Time from biopsy to surgical excision ranged from 8 to 252 days. Histological sections of surgically resected tumors with a visible needle tract were reviewed by histologic evaluation. Data were analyzed by McNemar's test for proportional differences, and the Benjamini-Hochberg procedure was used to assess the association between immune cell prevalence and clinical variables.
    Results: Characteristic histology changes, including foreign body giant-cell reaction, synovial-cell metaplasia, desmoplastic repair changes, granulation tissue, fat necrosis, and inflammation, were frequently detected adjacent to the needle tract. Spatial comparison indicated that a higher proportion of cases had neutrophils, eosinophils, and macrophages adjacent to the needle tract than tumors distant from it. The presence of inflammatory cells adjacent to the needle tract was not associated with time from biopsy or subtype. Still, plasma cells were associated with residual carrier material from biopsy markers.
    Conclusion: Macrophages and eosinophils are highly abundant and retained adjacent to the needle tract regardless of time from the biopsy.
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Biopsy, Needle/methods ; Breast Neoplasms/pathology ; Breast/pathology
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1022703-9
    ISSN 1423-0291 ; 1015-2008
    ISSN (online) 1423-0291
    ISSN 1015-2008
    DOI 10.1159/000524668
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Matrix Metalloproteinases: A challenging paradigm of cancer management.

    Alaseem, Ali / Alhazzani, Khalid / Dondapati, Priya / Alobid, Saad / Bishayee, Anupam / Rathinavelu, Appu

    Seminars in cancer biology

    2017  Volume 56, Page(s) 100–115

    Abstract: Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. ... ...

    Abstract Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has made them an attractive therapeutic target. Early generations of broad-spectrum MMP inhibitors exhibited potent inhibitory activities, which subsequently led to clinical trials. Unexpectedly, these trials failed to meet the desired goals, mainly due to the lack of efficacy, poor oral bioavailability, and toxicity. In this review, we discuss the regulatory role of MMPs in cancer progression, current strategies in targeting MMPs for cancer treatment including prodrug design and tumor imaging, and therapeutic value of MMPs as biomarkers in breast, lung, and prostate cancers.
    MeSH term(s) Animals ; Biomarkers ; Disease Management ; Disease Progression ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use ; Matrix Metalloproteinases/chemistry ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Molecular Targeted Therapy ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/etiology ; Neoplasms/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship
    Chemical Substances Biomarkers ; Matrix Metalloproteinase Inhibitors ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2017-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2017.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Focal Adhesion Kinase in Ovarian Cancer: A Potential Therapeutic Target for Platinum and Taxane-Resistant Tumors.

    Levy, Arkene / Alhazzani, Khalid / Dondapati, Priya / Alaseem, Ali / Cheema, Khadijah / Thallapureddy, Keerthi / Kaur, Paramjot / Alobid, Saad / Rathinavelu, Appu

    Current cancer drug targets

    2018  Volume 19, Issue 3, Page(s) 179–188

    Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, which is an essential player in regulating cell migration, invasion, adhesion, proliferation, and survival. Its overexpression and activation have been identified in sixty-eight percent of ... ...

    Abstract Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, which is an essential player in regulating cell migration, invasion, adhesion, proliferation, and survival. Its overexpression and activation have been identified in sixty-eight percent of epithelial ovarian cancer patients and this is significantly associated with higher tumor stage, metastasis, and shorter overall survival of these patients. Most recently, a new role has emerged for FAK in promoting resistance to taxane and platinum-based therapy in ovarian and other cancers. The development of resistance is a complex network of molecular processes that make the identification of a targetable biomarker in platinum and taxane-resistant ovarian cancer a major challenge. FAK overexpression upregulates ALDH and XIAP activity in platinum-resistant and increases CD44, YB1, and MDR-1 activity in taxaneresistant tumors. FAK is therefore now emerging as a prognostically significant candidate in this regard, with mounting evidence from recent successes in preclinical and clinical trials using small molecule FAK inhibitors. This review will summarize the significance and function of FAK in ovarian cancer, and its emerging role in chemotherapeutic resistance. We will discuss the current status of FAK inhibitors in ovarian cancers, their therapeutic competencies and limitations, and further propose that the combination of FAK inhibitors with platinum and taxane-based therapies could be an efficacious approach in chemotherapeutic resistant disease.
    MeSH term(s) Bridged-Ring Compounds/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Female ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Humans ; Molecular Targeted Therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/enzymology ; Ovarian Neoplasms/pathology ; Platinum/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Taxoids/pharmacology
    Chemical Substances Bridged-Ring Compounds ; Protein Kinase Inhibitors ; Taxoids ; taxane (1605-68-1) ; Platinum (49DFR088MY) ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; PTK2 protein, human (EC 2.7.10.2)
    Language English
    Publishing date 2018-06-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/1568009618666180706165222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: MDM2 Overexpression Modulates the Angiogenesis-Related Gene Expression Profile of Prostate Cancer Cells.

    Venkatesan, Thiagarajan / Alaseem, Ali / Chinnaiyan, Aiyavu / Dhandayuthapani, Sivanesan / Kanagasabai, Thanigaivelan / Alhazzani, Khalid / Dondapati, Priya / Alobid, Saad / Natarajan, Umamaheswari / Schwartz, Ruben / Rathinavelu, Appu

    Cells

    2018  Volume 7, Issue 5

    Abstract: The Murine Double Minute 2 (MDM2) amplification or overexpression has been found in many tumors with high metastatic and angiogenic ability. Our experiments were designed to explore the impact of MDM2 overexpression, specifically on the levels of ... ...

    Abstract The Murine Double Minute 2 (MDM2) amplification or overexpression has been found in many tumors with high metastatic and angiogenic ability. Our experiments were designed to explore the impact of MDM2 overexpression, specifically on the levels of angiogenesis-related genes, which can also play a major role in tumor propagation and increase its metastatic potential. In the present study, we have used the human angiogenesis RT² profiler PCR array to compare the gene expression profile between LNCaP and LNCaP-MST (MDM2 transfected) prostate cancer cells, along with LNCaP-MST cells treated with Nutlin-3, an MDM2 specific inhibitor. As a result of the overexpression of
    Language English
    Publishing date 2018--10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells7050041
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top